Published in J Med Chem on March 05, 2008
Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3. J Am Chem Soc (2010) 1.24
Interaction of the Oncofetal Thomsen-Friedenreich Antigen with Galectins in Cancer Progression and Metastasis. Front Oncol (2016) 0.75
Perdeuteration, crystallization, data collection and comparison of five neutron diffraction data sets of complexes of human galectin-3C. Acta Crystallogr D Struct Biol (2016) 0.75
Synthetic glycoconjugates inhibitors of tumor-related galectin-3: an update. Glycoconj J (2016) 0.75
Functional adaptation of BabA, the H. pylori ABO blood group antigen binding adhesin. Science (2004) 3.06
Regulation of alternative macrophage activation by galectin-3. J Immunol (2008) 2.28
Regulation of transforming growth factor-β1-driven lung fibrosis by galectin-3. Am J Respir Crit Care Med (2011) 2.09
Galectin-1, -2, and -3 exhibit differential recognition of sialylated glycans and blood group antigens. J Biol Chem (2008) 2.02
Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell Microbiol (2009) 1.79
Differential roles of galectin-1 and galectin-3 in regulating leukocyte viability and cytokine secretion. J Immunol (2008) 1.51
Phylogenetic analysis of the vertebrate galectin family. Mol Biol Evol (2004) 1.46
Physical properties of Escherichia coli P pili measured by optical tweezers. Biophys J (2004) 1.45
Apical sorting by galectin-3-dependent glycoprotein clustering. Traffic (2007) 1.45
Galectin-4 in normal tissues and cancer. Glycoconj J (2004) 1.42
Dendritic cell maturation results in pronounced changes in glycan expression affecting recognition by siglecs and galectins. J Immunol (2007) 1.34
Protein flexibility and conformational entropy in ligand design targeting the carbohydrate recognition domain of galectin-3. J Am Chem Soc (2010) 1.24
Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. Glycobiology (2007) 1.21
Complex N-glycans are the major ligands for galectin-1, -3, and -8 on Chinese hamster ovary cells. Glycobiology (2005) 1.18
Structural and thermodynamic studies on cation-Pi interactions in lectin-ligand complexes: high-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction. J Am Chem Soc (2005) 1.17
Truncated galectin-3 inhibits tumor growth and metastasis in orthotopic nude mouse model of human breast cancer. Clin Cancer Res (2003) 1.15
Galectin-3 deficiency prevents concanavalin A-induced hepatitis in mice. Hepatology (2012) 1.12
Different affinity of galectins for human serum glycoproteins: galectin-3 binds many protease inhibitors and acute phase proteins. Glycobiology (2008) 1.07
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett (2010) 1.04
Galectin-3 functions as an opsonin and enhances the macrophage clearance of apoptotic neutrophils. Glycobiology (2008) 1.04
Activation of the neutrophil nicotinamide adenine dinucleotide phosphate oxidase by galectin-1. J Immunol (2002) 1.03
Conformational differences in liganded and unliganded states of Galectin-3. Biochemistry (2003) 1.01
Mutational tuning of galectin-3 specificity and biological function. J Biol Chem (2010) 1.01
Ligand induced galectin-3 protein self-association. J Biol Chem (2012) 1.00
The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and diverse. Glycobiology (2002) 1.00
Galectin-3 binds lactosaminylated lipooligosaccharides from Neisseria gonorrhoeae and is selectively expressed by mucosal epithelial cells that are infected. Cell Microbiol (2002) 0.98
Galectin-3 endocytosis by carbohydrate independent and dependent pathways in different macrophage like cell types. Biochim Biophys Acta (2012) 0.96
The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics. Biochemistry (2011) 0.94
C2-symmetrical thiodigalactoside bis-benzamido derivatives as high-affinity inhibitors of galectin-3: efficient lectin inhibition through double arginine-arene interactions. Angew Chem Int Ed Engl (2005) 0.94
Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res (2009) 0.93
C2-symmetric macrocyclic carbohydrate/amino acid hybrids through copper(I)-catalyzed formation of 1,2,3-triazoles. J Org Chem (2005) 0.93
Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries. Org Biomol Chem (2011) 0.93
Identification of a novel streptococcal adhesin P (SadP) protein recognizing galactosyl-α1-4-galactose-containing glycoconjugates: convergent evolution of bacterial pathogens to binding of the same host receptor. J Biol Chem (2011) 0.92
Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides. Chemistry (2008) 0.90
Taloside inhibitors of galectin-1 and galectin-3. Chem Biol Drug Des (2012) 0.90
Galectin-1-binding glycoforms of haptoglobin with altered intracellular trafficking, and increase in metastatic breast cancer patients. PLoS One (2011) 0.89
Monovalent interactions of galectin-1. Biochemistry (2010) 0.89
Fluorescence polarization as an analytical tool to evaluate galectin-ligand interactions. Anal Biochem (2004) 0.88
Low micromolar inhibitors of galectin-3 based on 3'-derivatization of N-acetyllactosamine. Chembiochem (2002) 0.88
Glycosphingolipid composition of epithelial cells isolated along the villus axis of small intestine of a single human individual. Glycobiology (2012) 0.88
The role of integrin glycosylation in galectin-8-mediated trabecular meshwork cell adhesion and spreading. Glycobiology (2008) 0.88
3-(1,2,3-Triazol-1-yl)-1-thio-galactosides as small, efficient, and hydrolytically stable inhibitors of galectin-3. Bioorg Med Chem Lett (2005) 0.88
Intracellular sorting of galectin-8 based on carbohydrate fine specificity. Glycobiology (2007) 0.88
Synthesis of galactose-mimicking 1H-(1,2,3-triazol-1-yl)-mannosides as selective galectin-3 and 9N inhibitors. Carbohydr Res (2007) 0.88
1H-1,2,3-triazol-1-yl thiodigalactoside derivatives as high affinity galectin-3 inhibitors. Bioorg Med Chem (2010) 0.87
Variant size- and glycoforms of the scavenger receptor cysteine-rich protein gp-340 with differential bacterial aggregation. Glycoconj J (2007) 0.87
Synthesis of multivalent lactose derivatives by 1,3-dipolar cycloadditions: selective galectin-1 inhibition. Carbohydr Res (2006) 0.86
Measurements of the binding force between the Helicobacter pylori adhesin BabA and the Lewis b blood group antigen using optical tweezers. J Biomed Opt (2005) 0.86
Galectin-inhibitory thiodigalactoside ester derivatives have antimigratory effects in cultured lung and prostate cancer cells. J Med Chem (2008) 0.85
Enhancement of bound-state residual dipolar couplings: conformational analysis of lactose bound to Galectin-3. Protein Sci (2006) 0.85
Inhibition of galectins with small molecules. Chimia (Aarau) (2011) 0.84
Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease. Autoimmunity (2002) 0.84
Superantigen- and TLR-dependent activation of tonsillar B cells after receptor-mediated endocytosis. J Immunol (2009) 0.84
The anti-angiogenic peptide anginex greatly enhances galectin-1 binding affinity for glycoproteins. J Biol Chem (2011) 0.84
Synthesis of O-galactosyl aldoximes as potent LacNAc-mimetic galectin-3 inhibitors. Bioorg Med Chem Lett (2005) 0.83
Newcastle disease virus neuraminidase primes neutrophils for stimulation by galectin-3 and formyl-Met-Leu-Phe. Exp Cell Res (2004) 0.83
Discovery of potent inhibitors of PapG adhesins from uropathogenic Escherichia coli through synthesis and evaluation of galabiose derivatives. Chembiochem (2002) 0.83
Arene-anion based arginine-binding motif on a galactose scaffold: structure-activity relationships of interactions with arginine-rich galectins. Chemistry (2011) 0.83
Synthesis of a phenyl thio-beta-D-galactopyranoside library from 1,5-difluoro-2,4-dinitrobenzene: discovery of efficient and selective monosaccharide inhibitors of galectin-7. Org Biomol Chem (2005) 0.83
Multimeric lactoside "click clusters" as tools to investigate the effect of linker length in specific interactions with peanut lectin, galectin-1, and -3. Chembiochem (2010) 0.82
Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters. Chembiochem (2007) 0.82
Galectin-3 deficiency protects pancreatic islet cells from cytokine-triggered apoptosis in vitro. J Cell Physiol (2013) 0.81
Structure-activity relationships of galabioside derivatives as inhibitors of E. coli and S. suis adhesins: nanomolar inhibitors of S. suis adhesins. Org Biomol Chem (2005) 0.81
Fluorescence polarization to study galectin-ligand interactions. Methods Enzymol (2003) 0.81
Synthesis and evaluation of new thiodigalactoside-based chemical probes to label galectin-3. Chembiochem (2009) 0.80
Gal-3 regulates the capacity of dendritic cells to promote NKT-cell-induced liver injury. Eur J Immunol (2014) 0.80