Published in J Immunol on March 15, 2008
Helminth immunoregulation: the role of parasite secreted proteins in modulating host immunity. Mol Biochem Parasitol (2009) 2.95
A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis (2012) 2.28
Future therapies for food allergies. J Allergy Clin Immunol (2011) 2.04
Helminth infections and host immune regulation. Clin Microbiol Rev (2012) 2.02
The Intestinal Microbiota Contributes to the Ability of Helminths to Modulate Allergic Inflammation. Immunity (2015) 1.79
Helminth-derived immunomodulators: can understanding the worm produce the pill? Nat Rev Immunol (2010) 1.66
Type 2 cytokines: mechanisms and therapeutic strategies. Nat Rev Immunol (2015) 1.57
Helminth-host immunological interactions: prevention and control of immune-mediated diseases. Ann N Y Acad Sci (2012) 1.47
Helminth genomics: The implications for human health. PLoS Negl Trop Dis (2009) 1.26
Translatability of helminth therapy in inflammatory bowel diseases. Int J Parasitol (2012) 1.24
A helminth immunomodulator exploits host signaling events to regulate cytokine production in macrophages. PLoS Pathog (2011) 1.10
Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways. Nat Med (2012) 1.07
Exoerythrocytic Plasmodium parasites secrete a cysteine protease inhibitor involved in sporozoite invasion and capable of blocking cell death of host hepatocytes. PLoS Pathog (2010) 1.07
Food allergy: separating the science from the mythology. Nat Rev Gastroenterol Hepatol (2010) 1.06
The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease. Clin Exp Immunol (2009) 1.01
Modulation of specific and allergy-related immune responses by helminths. J Biomed Biotechnol (2011) 0.98
Hookworm excretory/secretory products induce interleukin-4 (IL-4)+ IL-10+ CD4+ T cell responses and suppress pathology in a mouse model of colitis. Infect Immun (2013) 0.98
Where are we on worms? Curr Opin Gastroenterol (2012) 0.96
The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma. J Immunol (2012) 0.96
The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype. Int J Parasitol (2013) 0.93
Helminth infections decrease host susceptibility to immune-mediated diseases. J Immunol (2014) 0.93
Oesophagostomum dentatum extract modulates T cell-dependent immune responses to bystander antigens and prevents the development of allergy in mice. PLoS One (2013) 0.91
A research agenda for helminth diseases of humans: basic research and enabling technologies to support control and elimination of helminthiases. PLoS Negl Trop Dis (2012) 0.91
Regulation of the host immune system by helminth parasites. J Allergy Clin Immunol (2016) 0.91
A transgenic probiotic secreting a parasite immunomodulator for site-directed treatment of gut inflammation. Mol Ther (2014) 0.87
Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. Int J Parasitol (2014) 0.87
Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replication. Vet Res (2011) 0.86
Eosinophil-derived IL-10 supports chronic nematode infection. J Immunol (2014) 0.85
Interface Molecules of Angiostrongylus cantonensis: Their Role in Parasite Survival and Modulation of Host Defenses. Int J Inflam (2012) 0.85
Crude extracts of Caenorhabditis elegans suppress airway inflammation in a murine model of allergic asthma. PLoS One (2012) 0.84
Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels. PLoS Negl Trop Dis (2014) 0.84
Nematode asparaginyl-tRNA synthetase resolves intestinal inflammation in mice with T-cell transfer colitis. Clin Vaccine Immunol (2012) 0.84
Therapeutic potential of recombinant cystatin from Schistosoma japonicum in TNBS-induced experimental colitis of mice. Parasit Vectors (2016) 0.83
Nematode modulation of inflammatory bowel disease. Protoplasma (2011) 0.83
Parasitic helminth cystatin inhibits DSS-induced intestinal inflammation via IL-10(+)F4/80(+) macrophage recruitment. Korean J Parasitol (2011) 0.82
Chronic filarial infection provides protection against bacterial sepsis by functionally reprogramming macrophages. PLoS Pathog (2015) 0.81
Worm proteins of Schistosoma mansoni reduce the severity of experimental chronic colitis in mice by suppressing colonic proinflammatory immune responses. PLoS One (2014) 0.80
Brugia malayi microfilariae induce a regulatory monocyte/macrophage phenotype that suppresses innate and adaptive immune responses. PLoS Negl Trop Dis (2014) 0.80
The hygiene hypothesis: current perspectives and future therapies. Immunotargets Ther (2015) 0.79
Diplomatic Assistance: Can Helminth-Modulated Macrophages Act as Treatment for Inflammatory Disease? PLoS Pathog (2016) 0.79
The relationship between intestinal parasites and some immune-mediated intestinal conditions. Gastroenterol Hepatol Bed Bench (2015) 0.79
Food allergy diagnosis and therapy: where are we now? Immunotherapy (2013) 0.79
Potential treatment of inflammatory bowel disease: a review of helminths therapy. Gastroenterol Hepatol Bed Bench (2014) 0.79
Particularities of allergy in the Tropics. World Allergy Organ J (2016) 0.79
Nematode-derived proteins suppress proliferation and cytokine production of antigen-specific T cells via induction of cell death. PLoS One (2013) 0.78
Harnessing the helminth secretome for therapeutic immunomodulators. Biomed Res Int (2014) 0.78
Schistosoma japonicum cystatin attenuates murine collagen-induced arthritis. Parasitol Res (2016) 0.77
The immunology of the allergy epidemic and the hygiene hypothesis. Nat Immunol (2017) 0.76
Analysis of the transcriptome of adult Dictyocaulus filaria and comparison with Dictyocaulus viviparus, with a focus on molecules involved in host-parasite interactions. Int J Parasitol (2014) 0.76
AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. Parasitol Res (2014) 0.76
Cloning, expression and characterisation of a type II cystatin from Schistosoma japonicum, which could regulate macrophage activation. Parasitol Res (2014) 0.76
Nematodes and human therapeutic trials for inflammatory disease. Parasite Immunol (2016) 0.75
Downregulation of the Syk Signaling Pathway in Intestinal Dendritic Cells Is Sufficient To Induce Dendritic Cells That Inhibit Colitis. J Immunol (2016) 0.75
Worming our way closer to the clinic. Int J Parasitol Drugs Drug Resist (2012) 0.75
Applications of Genetically Modified Immunobiotics with High Immunoregulatory Capacity for Treatment of Inflammatory Bowel Diseases. Front Immunol (2017) 0.75
Parasites, probiotics, and piglets: a novel approach to IBD. Mol Ther (2014) 0.75
The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10+ T Cells. PLoS One (2016) 0.75
Role in Allergic Diseases of Immunological Cross-Reactivity between Allergens and Homologues of Parasite Proteins. Crit Rev Immunol (2016) 0.75
Allergy and worms: let's bring back old friends? Wien Med Wochenschr (2014) 0.75
Helminth Immunomodulation in Autoimmune Disease. Front Immunol (2017) 0.75
Parasites and asthma. Parasitol Res (2017) 0.75
Oncogene-induced senescence as an initial barrier in lymphoma development. Nature (2005) 9.16
Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol (2007) 7.86
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08
Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood (2010) 4.99
DNA methylation controls Foxp3 gene expression. Eur J Immunol (2008) 4.19
DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol (2007) 3.80
Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Natl Acad Sci U S A (2002) 3.41
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol (2009) 3.23
Whipple's disease: new aspects of pathogenesis and treatment. Lancet Infect Dis (2008) 2.78
Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology (2005) 2.78
Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res (2009) 2.75
Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood (2005) 2.55
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol (2010) 2.53
Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. Int J Cancer (2009) 2.38
Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. J Immunol (2002) 2.37
Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J Exp Med (2009) 2.28
Early identification of atopy in the prediction of persistent asthma in children. Lancet (2008) 2.27
Production of complex human glycoproteins in yeast. Science (2003) 2.26
Novel murine infection models provide deep insights into the "ménage à trois" of Campylobacter jejuni, microbiota and host innate immunity. PLoS One (2011) 2.20
Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood (2006) 2.19
Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol (2009) 2.17
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. J Clin Invest (2006) 2.15
Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS One (2007) 2.05
Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat Med (2003) 2.01
Aggravation of different types of experimental colitis by depletion or adhesion blockade of neutrophils. Gastroenterology (2007) 1.98
MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut (2010) 1.93
Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. Blood (2005) 1.90
Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J Exp Med (2003) 1.89
Correlation of histopathological findings and magnetic resonance imaging in the spine of patients with ankylosing spondylitis. Arthritis Res Ther (2006) 1.88
Signaling via the MyD88 adaptor protein in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity (2010) 1.75
Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol (2005) 1.73
Growth-associated protein 43-positive sensory nerve fibers accompanied by immature vessels are located in or near peritoneal endometriotic lesions. Fertil Steril (2007) 1.70
Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness. J Exp Med (2008) 1.70
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res (2010) 1.66
New onset of Crohn's disease during treatment of active ankylosing spondylitis with etanercept. J Rheumatol (2008) 1.66
Analysis of IL-17(+) cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated adaptive immune response. Arthritis Res Ther (2011) 1.61
Adenosine 5'-tetraphosphate is a highly potent purinergic endothelium-derived vasoconstrictor. Circ Res (2008) 1.61
Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab. Blood (2010) 1.57
Epigenetic quantification of tumor-infiltrating T-lymphocytes. Epigenetics (2011) 1.57
Homing to suppress: address codes for Treg migration. Trends Immunol (2005) 1.56
Connecting liver and gut: murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid. Hepatology (2012) 1.53
Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence. Cancer Cell (2010) 1.53
Induction of organ-selective CD4+ regulatory T cell homing. Eur J Immunol (2007) 1.51
Tumor-infiltrating macrophages and dendritic cells in human colorectal cancer: relation to local regulatory T cells, systemic T-cell response against tumor-associated antigens and survival. J Transl Med (2007) 1.51
A randomised dose-ranging study of tiotropium Respimat® in children with symptomatic asthma despite inhaled corticosteroids. Respir Res (2015) 1.50
Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. J Mol Med (Berl) (2010) 1.48
Arteriogenesis depends on circulating monocytes and macrophage accumulation and is severely depressed in op/op mice. J Leukoc Biol (2006) 1.48
Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J Immunol (2013) 1.45
Viscoelasticity-based staging of hepatic fibrosis with multifrequency MR elastography. Radiology (2010) 1.45
Efficacy of memantine in delaying clinical worsening in Alzheimer's disease (AD): responder analyses of nine clinical trials with patients with moderate to severe AD. Int J Geriatr Psychiatry (2011) 1.45
Proteasome-mediated degradation of IkappaBalpha and processing of p105 in Crohn disease and ulcerative colitis. J Clin Invest (2006) 1.45
Autoregulation of Th1-mediated inflammation by twist1. J Exp Med (2008) 1.43
FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf. Genes Dev (2007) 1.43
Inflammatory markers in induced sputum of school children born before 32 completed weeks of gestation. J Pediatr (2012) 1.41
Immunohistologic analysis of zygapophyseal joints in patients with ankylosing spondylitis. Arthritis Rheum (2006) 1.38
Establishment of the intestinal microbiota and its role for atopic dermatitis in early childhood. J Allergy Clin Immunol (2013) 1.36
The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther (2005) 1.34
In vivo differentiated cytokine-producing CD4(+) T cells express functional CCR7. J Immunol (2002) 1.32
The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo. Blood (2007) 1.31
Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets. Eur J Immunol (2007) 1.30
Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation. PLoS One (2010) 1.30
Enhanced antitumor immunity in mice deficient in CD69. J Exp Med (2003) 1.29
Immunohistochemical analysis of hip arthritis in ankylosing spondylitis: evaluation of the bone-cartilage interface and subchondral bone marrow. Arthritis Rheum (2006) 1.27
Qualitative and quantitative evaluation of hepatocellular carcinoma and cirrhotic liver enhancement using Gd-EOB-DTPA. AJR Am J Roentgenol (2009) 1.27
High frequency of Tropheryma whipplei in culture-negative endocarditis. J Clin Microbiol (2011) 1.26
Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol (2006) 1.26
Functional analysis of effector and regulatory T cells in a parasitic nematode infection. Infect Immun (2008) 1.25
Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. J Immunol (2003) 1.25
Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver. J Leukoc Biol (2005) 1.24
Prenatal stress enhances susceptibility of murine adult offspring toward airway inflammation. J Immunol (2006) 1.24
CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection. J Virol (2004) 1.23
Small intestinal nematode infection of mice is associated with increased enterobacterial loads alongside the intestinal tract. PLoS One (2013) 1.23
Acute HIV infection induces mucosal infiltration with CD4+ and CD8+ T cells, epithelial apoptosis, and a mucosal barrier defect. Gastroenterology (2010) 1.20
Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur J Immunol (2009) 1.19
Leptospirosis in urban wild boars, Berlin, Germany. Emerg Infect Dis (2007) 1.19
Experience-driven development: effector/memory-like alphaE+Foxp3+ regulatory T cells originate from both naive T cells and naturally occurring naive-like regulatory T cells. J Immunol (2008) 1.19
WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer. EMBO Mol Med (2013) 1.17
The immune reconstitution inflammatory syndrome in whipple disease: a cohort study. Ann Intern Med (2010) 1.17
Phosphatidylethanol: normalization during detoxification, gender aspects and correlation with other biomarkers and self-reports. Addict Biol (2010) 1.15
Diagnosis and staging of chronic graft-versus-host disease in the clinical practice. Biol Blood Marrow Transplant (2010) 1.15
ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. J Natl Cancer Inst (2011) 1.15
Small interfering RNA against transcription factor STAT6 inhibits allergic airway inflammation and hyperreactivity in mice. J Immunol (2009) 1.15
Identification and isolation of murine antigen-reactive T cells according to CD154 expression. Eur J Immunol (2007) 1.15