Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells.

PubWeight™: 3.41‹?› | Rank: Top 1%

🔗 View Article (PMC 130581)

Published in Proc Natl Acad Sci U S A on September 19, 2002

Authors

Joachim Lehmann1, Jochen Huehn, Maurus de la Rosa, Frank Maszyna, Ute Kretschmer, Veit Krenn, Monika Brunner, Alexander Scheffold, Alf Hamann

Author Affiliations

1: Experimentelle Rheumatologie, Universitätsklinikum Charité, Humboldt-Universität, c/o Deutsches Rheumaforschungszentrum, 10117 Berlin, Germany.

Articles citing this

(truncated to the top 100)

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 10.00

CD4 T cells: fates, functions, and faults. Blood (2008) 7.03

Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08

Essential role for CD103 in the T cell-mediated regulation of experimental colitis. J Exp Med (2005) 4.47

Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol (2009) 4.07

CD25(+)CD4(+) regulatory T cells from the peripheral blood of asymptomatic HIV-infected individuals regulate CD4(+) and CD8(+) HIV-specific T cell immune responses in vitro and are associated with favorable clinical markers of disease status. J Exp Med (2004) 3.78

CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J Exp Med (2004) 3.57

Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. J Exp Med (2005) 3.29

Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med (2007) 3.17

CD4+ Tregs and immune control. J Clin Invest (2004) 2.85

Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood (2005) 2.55

Conversion of CD4+ CD25- cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus. J Exp Med (2005) 2.42

Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J Immunol (2008) 2.23

IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med (2005) 2.07

Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology (2006) 2.03

Role of beta7 integrins in intestinal lymphocyte homing and retention. Curr Mol Med (2009) 1.94

Foxp3+ CD25- CD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion. Proc Natl Acad Sci U S A (2005) 1.90

Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infection. J Immunol (2010) 1.88

Regulatory T-cell compartmentalization and trafficking. Blood (2006) 1.86

Incomplete depletion and rapid regeneration of Foxp3+ regulatory T cells following anti-CD25 treatment in malaria-infected mice. J Immunol (2007) 1.78

Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest (2007) 1.77

Cutting edge: expression of TNFR2 defines a maximally suppressive subset of mouse CD4+CD25+FoxP3+ T regulatory cells: applicability to tumor-infiltrating T regulatory cells. J Immunol (2008) 1.71

Dendritic cells are specialized accessory cells along with TGF- for the differentiation of Foxp3+ CD4+ regulatory T cells from peripheral Foxp3 precursors. Blood (2007) 1.70

A role for CCR4 in development of mature circulating cutaneous T helper memory cell populations. J Exp Med (2005) 1.54

HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog (2011) 1.53

CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci U S A (2009) 1.52

Phenotypic and functional properties of Helios+ regulatory T cells. PLoS One (2012) 1.52

Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn disease. J Clin Invest (2004) 1.50

Integrin function in T-cell homing to lymphoid and nonlymphoid sites: getting there and staying there. Crit Rev Immunol (2009) 1.49

Development of regulatory T cells requires IL-7Ralpha stimulation by IL-7 or TSLP. Blood (2008) 1.43

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc Natl Acad Sci U S A (2006) 1.41

Retinoic acid and rapamycin differentially affect and synergistically promote the ex vivo expansion of natural human T regulatory cells. PLoS One (2011) 1.39

Review of the activation of TGF-beta in immunity. J Leukoc Biol (2008) 1.35

The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther (2005) 1.34

Suppression of tumour-specific CD4⁺ T cells by regulatory T cells is associated with progression of human colorectal cancer. Gut (2011) 1.33

Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am J Pathol (2006) 1.27

Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol (2008) 1.26

Functional analysis of effector and regulatory T cells in a parasitic nematode infection. Infect Immun (2008) 1.25

Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis. Inflammopharmacology (2011) 1.24

Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44. Blood (2005) 1.19

Regulatory potential and control of Foxp3 expression in newborn CD4+ T cells. Proc Natl Acad Sci U S A (2004) 1.17

Control of alpha4beta7 integrin expression and CD4 T cell homing by the beta1 integrin subunit. J Immunol (2010) 1.16

SHIP limits immunoregulatory capacity in the T-cell compartment. Blood (2009) 1.15

A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis. J Immunol (2008) 1.13

Highly prevalent colorectal cancer-infiltrating LAP⁺ Foxp3⁻ T cells exhibit more potent immunosuppressive activity than Foxp3⁺ regulatory T cells. Mucosal Immunol (2013) 1.12

Isolation of purified and live Foxp3+ regulatory T cells using FACS sorting on scatter plot. J Mol Cell Biol (2010) 1.11

An intestinal commensal symbiosis factor controls neuroinflammation via TLR2-mediated CD39 signalling. Nat Commun (2014) 1.11

High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation. Gastroenterology (2009) 1.09

Foxp3+ regulatory T cells promote lung epithelial proliferation. Mucosal Immunol (2014) 1.06

Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells. Mucosal Immunol (2010) 1.05

The role of virus-induced regulatory T cells in immunopathology. Springer Semin Immunopathol (2006) 1.05

The importance of regulatory T-cell heterogeneity in maintaining self-tolerance. Immunol Rev (2014) 1.02

Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells. Int Immunopharmacol (2011) 0.99

Induction of antigen-specific regulatory T cells in the liver-draining celiac lymph node following oral antigen administration. Immunology (2005) 0.99

The dendritic cell-regulatory T lymphocyte crosstalk contributes to tumor-induced tolerance. Clin Dev Immunol (2011) 0.99

H3 K79 dimethylation marks developmental activation of the beta-globin gene but is reduced upon LCR-mediated high-level transcription. Blood (2008) 0.98

An early age-related increase in the frequency of CD4+ Foxp3+ cells in BDC2.5NOD mice. Immunology (2007) 0.96

CD4+CD25+ regulatory T cells in autoimmune arthritis. Immunol Rev (2010) 0.96

Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cells. Blood (2005) 0.96

Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun (2014) 0.95

Decreased numbers of blood dendritic cells and defective function of regulatory T cells in antineutrophil cytoplasmic antibody-associated vasculitis. PLoS One (2011) 0.95

Cellular mediators of inflammation: tregs and TH17 cells in gastrointestinal diseases. Mediators Inflamm (2010) 0.94

Inhibitory role of the transcription repressor Gfi1 in the generation of thymus-derived regulatory T cells. Proc Natl Acad Sci U S A (2013) 0.94

T cells with regulatory activity in hepatitis C virus infection: what we know and what we don't. J Leukoc Biol (2008) 0.93

TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis. J Immunol (2010) 0.92

The B10 Idd9.3 locus mediates accumulation of functionally superior CD137(+) regulatory T cells in the nonobese diabetic type 1 diabetes model. J Immunol (2012) 0.92

IL-2 regulates CD103 expression on CD4+ T cells in Scurfy mice that display both CD103-dependent and independent inflammation. J Immunol (2009) 0.92

A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease. J Immunol (2011) 0.91

Loss of CD103+ intestinal dendritic cells during colonic inflammation. World J Gastroenterol (2010) 0.90

Protection against bronchiolitis obliterans syndrome is associated with allograft CCR7+ CD45RA- T regulatory cells. PLoS One (2010) 0.90

The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells. Immunology (2011) 0.90

CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue. J Immunol (2013) 0.90

Regulatory T-cell trafficking: from thymic development to tumor-induced immune suppression. Crit Rev Immunol (2010) 0.90

CD4+ regulatory cells as a potential immunotherapy. Philos Trans R Soc Lond B Biol Sci (2005) 0.90

Modification of the FoxP3 transcription factor principally affects inducible T regulatory cells in a model of experimental autoimmune encephalomyelitis. PLoS One (2013) 0.89

Foxp3+ regulatory T cells are required for recovery from severe sepsis. PLoS One (2013) 0.88

APC activation restores functional CD4(+)CD25(+) regulatory T cells in NOD mice that can prevent diabetes development. PLoS One (2008) 0.86

Phenotypical characterization of regulatory T cells in humans and rodents. Clin Exp Immunol (2016) 0.86

The role of mucosal T lymphocytes in regulating intestinal inflammation. Springer Semin Immunopathol (2005) 0.85

Leukocyte traffic blockade as a therapeutic strategy in inflammatory bowel disease. Curr Drug Targets (2013) 0.84

The role of natural regulatory T cells in infection. Immunol Res (2011) 0.84

Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling. Blood (2009) 0.84

Assessing the role of CD103 in immunity to an intestinal helminth parasite. PLoS One (2011) 0.83

The role of CD103⁺ dendritic cells in the intestinal mucosal immune system. Front Immunol (2011) 0.83

CD4⁺ T cells expressing latency-associated peptide and Foxp3 are an activated subgroup of regulatory T cells enriched in patients with colorectal cancer. PLoS One (2014) 0.82

Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity. PLoS One (2014) 0.81

RORγt+Foxp3+ Cells are an Independent Bifunctional Regulatory T Cell Lineage and Mediate Crescentic GN. J Am Soc Nephrol (2015) 0.81

An anti-CD103 immunotoxin promotes long-term survival of pancreatic islet allografts. Am J Transplant (2009) 0.81

The lysophosphatidylserine receptor GPR174 constrains regulatory T cell development and function. J Exp Med (2015) 0.80

Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor. J Pharmacol Exp Ther (2015) 0.80

Gammadelta T lymphocytes: a new type of regulatory T cells suppressing murine 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. Int J Colorectal Dis (2008) 0.80

CD103 is dispensable for anti-viral immunity and autoimmunity in a mouse model of virally-induced autoimmune diabetes. J Autoimmun (2009) 0.80

Expression QTL mapping in regulatory and helper T cells from the BXD family of strains reveals novel cell-specific genes, gene-gene interactions and candidate genes for auto-immune disease. BMC Genomics (2011) 0.80

IL-33 Receptor-Expressing Regulatory T Cells Are Highly Activated, Th2 Biased and Suppress CD4 T Cell Proliferation through IL-10 and TGFβ Release. PLoS One (2016) 0.79

Alpha E: no more rejection? J Exp Med (2002) 0.79

Mucosal T lymphocytes--peacekeepers and warriors. Springer Semin Immunopathol (2005) 0.79

Mechanisms of T cell organotropism. Cell Mol Life Sci (2016) 0.79

Host-derived CD4+ T cells attenuate stem cell-mediated transfer of autoimmune arthritis in lethally irradiated C57BL/6.g7 mice. Arthritis Rheum (2013) 0.79

CD4+FoxP3+ regulatory T cells from Gαi2-/- mice are functionally active in vitro, but do not prevent colitis. PLoS One (2011) 0.78

Role of CD4CD25FOXP3 Regulatory T Cells in Psoriasis. Ann Dermatol (2010) 0.78

Articles cited by this

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42

Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57

CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J Exp Med (1998) 19.03

Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature (1992) 16.46

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med (2000) 16.09

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity (2000) 15.44

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med (2000) 13.13

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00

Determination of lymphocyte division by flow cytometry. J Immunol Methods (1994) 11.48

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int Immunol (1998) 11.26

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature (1994) 11.22

An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med (1999) 10.67

Regulatory T cells: key controllers of immunologic self-tolerance. Cell (2000) 10.19

Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol (1993) 9.97

Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity (1994) 9.63

Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J Exp Med (2001) 8.69

Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J Exp Med (1996) 8.54

CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity (2002) 8.28

Ex vivo isolation and characterization of CD4(+)CD25(+) T cells with regulatory properties from human blood. J Exp Med (2001) 7.86

Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolated from peripheral blood. J Exp Med (2001) 7.46

Regulatory T cells in the control of immune pathology. Nat Immunol (2001) 6.98

Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity (2000) 6.97

A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells. J Exp Med (1996) 6.73

Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function. J Exp Med (2001) 6.22

Homeostasis and anergy of CD4(+)CD25(+) suppressor T cells in vivo. Nat Immunol (2001) 5.95

Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature (1994) 5.73

Human CD4(+)CD25(+) thymocytes and peripheral T cells have immune suppressive activity in vitro. Eur J Immunol (2001) 4.58

Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol (1994) 4.21

CD25+ CD4+ T cells regulate the expansion of peripheral CD4 T cells through the production of IL-10. J Immunol (2001) 4.07

Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol (2001) 3.86

Generation of anergic and potentially immunoregulatory CD25+CD4 T cells in vivo after induction of peripheral tolerance with intravenous or oral antigen. J Immunol (2001) 3.86

A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J Immunol (2001) 3.63

Regulatory CD4 T cells: expression of IL-2R alpha chain, resistance to clonal deletion and IL-2 dependency. Int Immunol (1998) 3.56

Certified professionals: CD4(+)CD25(+) suppressor T cells. J Exp Med (2001) 3.39

A monoclonal antibody (HML-1) defining a novel membrane molecule present on human intestinal lymphocytes. Eur J Immunol (1987) 3.30

Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol (1999) 3.21

CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and CD25- subpopulations. J Immunol (2000) 2.98

Flow cytometric determination of cytokines in activated murine T helper lymphocytes: expression of interleukin-10 in interferon-gamma and in interleukin-4-expressing cells. Eur J Immunol (1994) 2.65

Reciprocal IFN-gamma and TGF-beta responses regulate the occurrence of mucosal inflammation. Immunol Today (1997) 2.52

Regulatory T cells in the control of autoimmunity: the essential role of transforming growth factor beta and interleukin 4 in the prevention of autoimmune thyroiditis in rats by peripheral CD4(+)CD45RC- cells and CD4(+)CD8(-) thymocytes. J Exp Med (1999) 2.51

Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. J Autoimmun (2001) 2.49

Control of immune pathology by regulatory T cells. Curr Opin Immunol (1998) 2.42

Expression and regulation of beta 7(beta p) integrins on mouse lymphocytes: relevance to the mucosal immune system. Eur J Immunol (1991) 2.08

A new surface antigen on intraepithelial lymphocytes in the intestine. Eur J Immunol (1990) 1.89

The third function of the thymus. Immunol Today (2000) 1.72

Repertoire requirements of CD4+ T cells that prevent spontaneous autoimmune encephalomyelitis. J Immunol (2000) 1.70

The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells. Nat Immunol (2001) 1.63

Transforming growth factor beta (TGF-beta)-dependent inhibition of T helper cell 2 (Th2)-induced autoimmunity by self-major histocompatibility complex (MHC) class II-specific, regulatory CD4(+) T cell lines. J Exp Med (1997) 1.51

Regulatory T cells overexpress a subset of Th2 gene transcripts. J Immunol (2002) 1.25

The epithelial cell-specific integrin, CD103 (alpha E integrin), defines a novel subset of alloreactive CD8+ CTL. J Immunol (1997) 1.22

Enhancement of CD3-induced activation of human intestinal intraepithelial lymphocytes by stimulation of the beta 7-containing integrin defined by HML-1 monoclonal antibody. Eur J Immunol (1992) 1.18

Transforming growth factor-beta 1-induced expression of the mucosa-related integrin alpha E on lymphocytes is not associated with mucosa-specific homing. Eur J Immunol (1995) 1.11

Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice. J Immunol (2000) 0.99

High-sensitivity immunofluorescence for detection of the pro- and anti-inflammatory cytokines gamma interferon and interleukin-10 on the surface of cytokine-secreting cells. Nat Med (2000) 0.96

Natural regulatory CD4 T cells expressing CD25. Microbes Infect (2001) 0.83

Lymphocyte adhesion to epithelia and endothelia mediated by the lymphocyte endothelial-epithelial cell adhesion molecule glycoprotein. J Immunol (1999) 0.83

Articles by these authors

Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol (2007) 7.86

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52

Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08

Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity (2012) 4.98

DNA methylation controls Foxp3 gene expression. Eur J Immunol (2008) 4.19

DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells. Eur J Immunol (2007) 3.80

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol (2009) 3.23

Interleukin-2 is essential for CD4+CD25+ regulatory T cell function. Eur J Immunol (2004) 3.08

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97

Direct access to CD4+ T cells specific for defined antigens according to CD154 expression. Nat Med (2005) 2.92

T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity (2012) 2.78

Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue. Cancer Res (2009) 2.75

CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors. Circ Res (2005) 2.62

Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood (2005) 2.55

Chemotactic responsiveness toward ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. J Immunol (2002) 2.37

Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation. Eur J Immunol (2009) 2.22

Alloantigen-specific de novo-induced Foxp3+ Treg revert in vivo and do not protect from experimental GVHD. Eur J Immunol (2009) 2.07

Bone marrow as a priming site for T-cell responses to blood-borne antigen. Nat Med (2003) 2.01

Maternal farm exposure modulates neonatal immune mechanisms through regulatory T cells. J Allergy Clin Immunol (2009) 1.89

Assessment of unspecific near-infrared dyes in laser-induced fluorescence imaging of experimental arthritis. Acad Radiol (2006) 1.80

MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines. Proc Natl Acad Sci U S A (2002) 1.79

Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. J Immunol (2004) 1.77

Dendritic cells govern induction and reprogramming of polarized tissue-selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments. Eur J Immunol (2005) 1.73

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc Natl Acad Sci U S A (2010) 1.71

Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res (2010) 1.66

Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity (2012) 1.61

Cell-wall alterations as an attribute of Mycobacterium tuberculosis in latent infection. J Infect Dis (2003) 1.60

Origin and functional activity of the membrane-bound glucocorticoid receptor. Arthritis Rheum (2011) 1.59

Homing to suppress: address codes for Treg migration. Trends Immunol (2005) 1.56

Cis- and trans-acting gene regulation is associated with osteoarthritis. Am J Hum Genet (2006) 1.55

Connecting liver and gut: murine liver sinusoidal endothelium induces gut tropism of CD4+ T cells via retinoic acid. Hepatology (2012) 1.53

Induction of organ-selective CD4+ regulatory T cell homing. Eur J Immunol (2007) 1.51

Notch regulates IL-10 production by T helper 1 cells. Proc Natl Acad Sci U S A (2008) 1.51

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells. J Mol Med (Berl) (2010) 1.48

Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency. Nat Biotechnol (2005) 1.47

Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J Immunol (2013) 1.45

Autoregulation of Th1-mediated inflammation by twist1. J Exp Med (2008) 1.43

A helminth immunomodulator reduces allergic and inflammatory responses by induction of IL-10-producing macrophages. J Immunol (2008) 1.43

Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc Natl Acad Sci U S A (2009) 1.38

IL-2 induces in vivo suppression by CD4(+)CD25(+)Foxp3(+) regulatory T cells. Eur J Immunol (2008) 1.34

The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther (2005) 1.34

In vivo differentiated cytokine-producing CD4(+) T cells express functional CCR7. J Immunol (2002) 1.32

Rapid glucocorticoid effects on immune cells. Steroids (2002) 1.32

Competition for cytokines: T(reg) cells take all. Nat Immunol (2007) 1.30

siRNA stabilization prolongs gene knockdown in primary T lymphocytes. Eur J Immunol (2008) 1.30

Distinctive role of CCR7 in migration and functional activity of naive- and effector/memory-like Treg subsets. Eur J Immunol (2007) 1.30

Enhanced antitumor immunity in mice deficient in CD69. J Exp Med (2003) 1.29

IFN-γ production by allogeneic Foxp3+ regulatory T cells is essential for preventing experimental graft-versus-host disease. J Immunol (2012) 1.26

Modified immunohistological staining allows detection of Ziehl-Neelsen-negative Mycobacterium tuberculosis organisms and their precise localization in human tissue. J Pathol (2005) 1.26

Lymph node stromal cells support dendritic cell-induced gut-homing of T cells. J Immunol (2009) 1.26

Self-limitation of Th1-mediated inflammation by IFN-gamma. J Immunol (2006) 1.26

Functional analysis of effector and regulatory T cells in a parasitic nematode infection. Infect Immun (2008) 1.25

Overlapping and selective roles of endothelial intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 in lymphocyte trafficking. J Immunol (2003) 1.25

Synovial tissue of the hip at power Doppler US: correlation between vascularity and power Doppler US signal. Radiology (2002) 1.24

Development and functional consequences of LPS tolerance in sinusoidal endothelial cells of the liver. J Leukoc Biol (2005) 1.24

Diagnosis of periprosthetic joint infection. J Arthroplasty (2013) 1.24

CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza A virus infection. J Virol (2004) 1.23

Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. FASEB J (2004) 1.23

Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis. J Immunol (2009) 1.22

Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur J Immunol (2009) 1.19

Experience-driven development: effector/memory-like alphaE+Foxp3+ regulatory T cells originate from both naive T cells and naturally occurring naive-like regulatory T cells. J Immunol (2008) 1.19

Visualization of peptide presentation following oral application of antigen in normal and Peyer's patches-deficient mice. Eur J Immunol (2003) 1.19

Notch ligands Delta-like1, Delta-like4 and Jagged1 differentially regulate activation of peripheral T helper cells. Eur J Immunol (2005) 1.18

Identification and isolation of murine antigen-reactive T cells according to CD154 expression. Eur J Immunol (2007) 1.15

Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med (2010) 1.13

The composition of intrahepatic lymphocytes: shaped by selective recruitment? Trends Immunol (2004) 1.12

Immunomodulatory effects of the liver: deletion of activated CD4+ effector cells and suppression of IFN-gamma-producing cells after intravenous protein immunization. J Immunol (2002) 1.10

Diagnosis of periprosthetic joint infection. J Orthop Res (2014) 1.08

CD38 low IgG-secreting cells are precursors of various CD38 high-expressing plasma cell populations. J Leukoc Biol (2004) 1.08

Expression of the chemokines MCP-1/CCL2 and RANTES/CCL5 is differentially regulated by infiltrating inflammatory cells. Kidney Int (2002) 1.08

Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection. PLoS Pathog (2009) 1.08