X-ray structure of a prokaryotic pentameric ligand-gated ion channel.

Principles of activation and permeation in an anion-selective Cys-loop receptor. Nature (2011) 5.93

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation. Nature (2008) 5.77

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. Nature (2008) 5.09

GABA A receptors: subtypes provide diversity of function and pharmacology. Neuropharmacology (2008) 3.49

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system. Nat Rev Drug Discov (2009) 3.26

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel. Nature (2011) 3.00

Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A (2009) 2.35

Crystal structure of a human GABAA receptor. Nature (2014) 2.22

Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel. Anesth Analg (2009) 2.15

Membrane proteins bind lipids selectively to modulate their structure and function. Nature (2014) 2.05

Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins. Chem Rev (2010) 1.98

Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor. EMBO J (2009) 1.91

Structure, function, and modulation of GABA(A) receptors. J Biol Chem (2012) 1.91

The gating isomerization of neuromuscular acetylcholine receptors. J Physiol (2009) 1.84

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue. Proc Natl Acad Sci U S A (2010) 1.81

Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes. J R Soc Interface (2009) 1.77

Pore opening and closing of a pentameric ligand-gated ion channel. Proc Natl Acad Sci U S A (2010) 1.71

X-ray structure of the mouse serotonin 5-HT3 receptor. Nature (2014) 1.67

Embedded cholesterol in the nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A (2008) 1.61

Ligand-binding domain of an α7-nicotinic receptor chimera and its complex with agonist. Nat Neurosci (2011) 1.58

Overcoming the challenges of membrane protein crystallography. Curr Opin Struct Biol (2008) 1.57

A locally closed conformation of a bacterial pentameric proton-gated ion channel. Nat Struct Mol Biol (2012) 1.56

Clinical and molecular pharmacology of etomidate. Anesthesiology (2011) 1.55

GABA-induced intersubunit conformational movement in the GABAA receptor alpha 1M1-beta 2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. J Neurosci (2009) 1.50

Cell Number Regulator1 affects plant and organ size in maize: implications for crop yield enhancement and heterosis. Plant Cell (2010) 1.49

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors. Nature (2014) 1.46

Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor. Biophys J (2011) 1.42

Signal Transduction at the Domain Interface of Prokaryotic Pentameric Ligand-Gated Ion Channels. PLoS Biol (2016) 1.42

Mass spectrometry of intact membrane protein complexes. Nat Protoc (2013) 1.41

Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor. J Biol Chem (2013) 1.39

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues. J Physiol (2009) 1.38

Mutations that stabilize the open state of the Erwinia chrisanthemi ligand-gated ion channel fail to change the conformation of the pore domain in crystals. Proc Natl Acad Sci U S A (2012) 1.38

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels. EMBO J (2013) 1.37

Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC. PLoS Biol (2011) 1.37

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel. Nat Struct Mol Biol (2010) 1.36

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat Commun (2013) 1.35

PoreWalker: a novel tool for the identification and characterization of channels in transmembrane proteins from their three-dimensional structure. PLoS Comput Biol (2009) 1.35

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family. Proc Natl Acad Sci U S A (2011) 1.34

Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain. Proc Natl Acad Sci U S A (2010) 1.33

Gating movement of acetylcholine receptor caught by plunge-freezing. J Mol Biol (2012) 1.33

Toward biophysical probes for the 5-HT3 receptor: structure-activity relationship study of granisetron derivatives. J Med Chem (2010) 1.32

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proc Natl Acad Sci U S A (2013) 1.32

Energy and structure of the M2 helix in acetylcholine receptor-channel gating. Biophys J (2009) 1.29

An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance. J Biol Chem (2008) 1.29

Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors. J Physiol (2011) 1.29

An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors. Nat Struct Mol Biol (2009) 1.26

Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine. Nat Commun (2012) 1.26

Bridging the gap between structural models of nicotinic receptor superfamily ion channels and their corresponding functional states. J Mol Biol (2010) 1.25

Binding to gating transduction in nicotinic receptors: Cys-loop energetically couples to pre-M1 and M2-M3 regions. J Neurosci (2009) 1.25

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC). J Biol Chem (2013) 1.22

Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines. Proc Natl Acad Sci U S A (2012) 1.22

A general protocol for the crystallization of membrane proteins for X-ray structural investigation. Nat Protoc (2009) 1.21

Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors. Nat Chem (2012) 1.21

Domain organization and function in GluK2 subtype kainate receptors. Proc Natl Acad Sci U S A (2010) 1.20

Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein. J Biol Chem (2010) 1.18

A lipid-dependent uncoupled conformation of the acetylcholine receptor. J Biol Chem (2009) 1.18

50 years of allosteric interactions: the twists and turns of the models. Nat Rev Mol Cell Biol (2013) 1.17

The nicotinic acetylcholine receptor: the founding father of the pentameric ligand-gated ion channel superfamily. J Biol Chem (2012) 1.17

Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap. PLoS One (2008) 1.16

A gating mechanism of pentameric ligand-gated ion channels. Proc Natl Acad Sci U S A (2013) 1.15

Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels. J Biol Chem (2009) 1.13

The gates of ion channels and enzymes. Trends Biochem Sci (2009) 1.13

APBSmem: a graphical interface for electrostatic calculations at the membrane. PLoS One (2010) 1.12

Structures of membrane proteins. Q Rev Biophys (2010) 1.11

An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors. J Gen Physiol (2012) 1.11

Molecular-dynamics simulations of ELIC-a prokaryotic homologue of the nicotinic acetylcholine receptor. Biophys J (2009) 1.11

Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors. J Biol Chem (2009) 1.11

In silico models for the human alpha4beta2 nicotinic acetylcholine receptor. J Phys Chem B (2008) 1.09

Mechanism of activation of the prokaryotic channel ELIC by propylamine: a single-channel study. J Gen Physiol (2015) 1.08

Desensitization mechanism in prokaryotic ligand-gated ion channel. J Biol Chem (2012) 1.07

NMR characterization of membrane protein-detergent micelle solutions by use of microcoil equipment. J Am Chem Soc (2009) 1.07

Structural determinants of Ca2+ permeability and conduction in the human 5-hydroxytryptamine type 3A receptor. J Biol Chem (2008) 1.07

High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors. Protein Sci (2010) 1.06

End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease. Physiol Rev (2012) 1.06

Spontaneous conformational change and toxin binding in alpha7 acetylcholine receptor: insight into channel activation and inhibition. Proc Natl Acad Sci U S A (2008) 1.05

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening. J Gen Physiol (2011) 1.05

Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein. Proc Natl Acad Sci U S A (2012) 1.04

The energy and work of a ligand-gated ion channel. J Mol Biol (2013) 1.04

Single-channel current through nicotinic receptor produced by closure of binding site C-loop. Biophys J (2009) 1.04

Conformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC). J Biol Chem (2012) 1.04

Gating mechanisms in Cys-loop receptors. Eur Biophys J (2009) 1.03

Functional anatomy of an allosteric protein. Nat Commun (2013) 1.03

Intramembrane proton binding site linked to activation of bacterial pentameric ion channel. J Biol Chem (2011) 1.03

Structural rearrangements in loop F of the GABA receptor signal ligand binding, not channel activation. Biophys J (2009) 1.03

Bubbles, gating, and anesthetics in ion channels. Biophys J (2008) 1.02

Mechanosensitivity of ion channels based on protein-lipid interactions. J R Soc Interface (2010) 1.02

The impact of human hyperekplexia mutations on glycine receptor structure and function. Mol Brain (2014) 1.02

Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization. Biochemistry (2010) 1.02

A unified model of the GABA(A) receptor comprising agonist and benzodiazepine binding sites. PLoS One (2013) 1.02

Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computation. PLoS Comput Biol (2013) 1.01

Isoflurane alters the structure and dynamics of GLIC. Biophys J (2011) 1.00

General anesthetic binding to neuronal alpha4beta2 nicotinic acetylcholine receptor and its effects on global dynamics. J Phys Chem B (2009) 1.00

Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor. Sci Rep (2011) 1.00

Hydrophobic gating in ion channels. J Mol Biol (2014) 1.00

Symmetry-constrained analysis of pulsed double electron-electron resonance (DEER) spectroscopy reveals the dynamic nature of the KcsA activation gate. J Am Chem Soc (2012) 0.99

Drying transition in the hydrophobic gate of the GLIC channel blocks ion conduction. Biophys J (2012) 0.99

Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy. J Biol Chem (2009) 0.99

Gating transition of pentameric ligand-gated ion channels. Biophys J (2009) 0.99

Synaptic neurotransmitter-gated receptors. Cold Spring Harb Perspect Biol (2012) 0.98

The unanticipated complexity of the selectivity-filter glutamates of nicotinic receptors. Nat Chem Biol (2012) 0.98

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel. Nature (2008) 5.09

Synergism between halide binding and proton transport in a CLC-type exchanger. J Mol Biol (2006) 1.90

Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5. Nat Struct Mol Biol (2006) 1.85

Ion-binding properties of the ClC chloride selectivity filter. EMBO J (2005) 1.56

The structure of the cytoplasmic domain of the chloride channel ClC-Ka reveals a conserved interaction interface. Structure (2007) 1.40

Ligand activation of the prokaryotic pentameric ligand-gated ion channel ELIC. PLoS Biol (2011) 1.37

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel. Nat Struct Mol Biol (2010) 1.36

Crystal structure of the cytoplasmic domain of the chloride channel ClC-0. Structure (2006) 1.35

A prokaryotic perspective on pentameric ligand-gated ion channel structure. Curr Opin Struct Biol (2009) 1.23

A versatile and efficient high-throughput cloning tool for structural biology. Biochemistry (2011) 1.17

Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations. PLoS Biol (2012) 0.96

X-ray structure of the C-terminal domain of a prokaryotic cation-chloride cotransporter. Structure (2009) 0.91

Functional characterization of a ClC transporter by solid-supported membrane electrophysiology. J Gen Physiol (2013) 0.85

The cytoplasmic domain of the chloride channel ClC-0: structural and dynamic characterization of flexible regions. J Mol Biol (2007) 0.78

Corrigendum: Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family. Nat Struct Mol Biol (2016) 0.75