Published in J Am Soc Nephrol on March 12, 2008
New insights into epithelial-mesenchymal transition in kidney fibrosis. J Am Soc Nephrol (2009) 3.83
Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans. J Clin Invest (2010) 2.42
Cell biology and pathology of podocytes. Annu Rev Physiol (2011) 2.42
Proteinuria: an enzymatic disease of the podocyte? Kidney Int (2009) 2.17
Advances in the biology and genetics of the podocytopathies: implications for diagnosis and therapy. Arch Pathol Lab Med (2009) 1.49
Notch activation differentially regulates renal progenitors proliferation and differentiation toward the podocyte lineage in glomerular disorders. Stem Cells (2010) 1.36
Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function. Kidney Int (2010) 1.27
Modulation of notch-1 signaling alleviates vascular endothelial growth factor-mediated diabetic nephropathy. Diabetes (2010) 1.21
Notch2 activation in the embryonic kidney depletes nephron progenitors. J Am Soc Nephrol (2010) 1.18
The story of Notch and chronic kidney disease. Curr Opin Nephrol Hypertens (2011) 1.17
The pathogenic role of Notch activation in podocytes. Nephron Exp Nephrol (2009) 1.17
Wt1a, Foxc1a, and the Notch mediator Rbpj physically interact and regulate the formation of podocytes in zebrafish. Dev Biol (2011) 1.17
Downregulation of microRNA-30 facilitates podocyte injury and is prevented by glucocorticoids. J Am Soc Nephrol (2013) 1.12
Notch pathway activation can replace the requirement for Wnt4 and Wnt9b in mesenchymal-to-epithelial transition of nephron stem cells. Development (2011) 1.10
Childhood nephrotic syndrome--current and future therapies. Nat Rev Nephrol (2012) 1.02
Circulating and urinary microRNA profile in focal segmental glomerulosclerosis: a pilot study. Eur J Clin Invest (2015) 1.00
Activation of Notch signaling pathway in HIV-associated nephropathy. AIDS (2010) 0.97
Notch signaling in diabetic nephropathy. Exp Cell Res (2012) 0.95
Notch promotes dynamin-dependent endocytosis of nephrin. J Am Soc Nephrol (2011) 0.91
Reduced Notch signaling leads to renal cysts and papillary microadenomas. J Am Soc Nephrol (2010) 0.91
Slit2 prevents neutrophil recruitment and renal ischemia-reperfusion injury. J Am Soc Nephrol (2013) 0.91
Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis. J Biol Chem (2010) 0.91
The kinetochore protein, CENPF, is mutated in human ciliopathy and microcephaly phenotypes. J Med Genet (2015) 0.90
Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury. Am J Physiol Renal Physiol (2011) 0.89
New insights into the mechanism of notch signalling in fibrosis. Open Rheumatol J (2012) 0.89
Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells. FASEB J (2012) 0.88
The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int (2011) 0.86
Angiotensin II contributes to renal fibrosis independently of Notch pathway activation. PLoS One (2012) 0.85
Repair problems in podocytes: Wnt, Notch, and glomerulosclerosis. Semin Nephrol (2012) 0.85
Notch1 and Notch2 in Podocytes Play Differential Roles During Diabetic Nephropathy Development. Diabetes (2015) 0.84
ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases. J Biomed Sci (2010) 0.83
Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization. J Am Soc Nephrol (2015) 0.83
Getting a notch closer to understanding diabetic kidney disease. Diabetes (2010) 0.83
Notch signaling: a common pathway of injury in podocytopathies? J Am Soc Nephrol (2008) 0.82
Podocytes. F1000Res (2016) 0.81
Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy. Am J Physiol Renal Physiol (2013) 0.80
Notch in fibrosis and as a target of anti-fibrotic therapy. Pharmacol Res (2016) 0.79
Notch: A multi-functional integrating system of microenvironmental signals. Dev Biol (2016) 0.78
Key Fibrogenic Signaling. Curr Pathobiol Rep (2015) 0.78
Effect of Tongxinluo on Nephrin Expression via Inhibition of Notch1/Snail Pathway in Diabetic Rats. Evid Based Complement Alternat Med (2015) 0.78
Kick it up a notch: Notch signaling and kidney fibrosis. Kidney Int Suppl (2011) (2014) 0.78
Understanding podocytopathy and its relevance to clinical nephrology. Indian J Nephrol (2015) 0.77
Increased Wnt and Notch signaling: a clue to the renal disease in Schimke immuno-osseous dysplasia? Orphanet J Rare Dis (2016) 0.76
Absence of miR-146a in podocytes increases risk of diabetic glomerulopathy via upregulation of erbb4 and notch-1. J Biol Chem (2016) 0.75
The role of Notch signaling in kidney podocytes. Clin Exp Nephrol (2016) 0.75
Signalling downstream of activated mammalian Notch. Nature (1995) 11.08
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 10.58
Cell biology of the glomerular podocyte. Physiol Rev (2003) 6.85
Notch signaling controls multiple steps of pancreatic differentiation. Proc Natl Acad Sci U S A (2003) 6.55
Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J (2004) 4.77
A new method for large scale isolation of kidney glomeruli from mice. Am J Pathol (2002) 4.63
A transgenic mouse line that retains Cre recombinase activity in mature oocytes irrespective of the cre transgene transmission. Biochem Biophys Res Commun (1997) 4.47
Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev (1995) 4.47
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature (2006) 4.05
Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J (1999) 3.95
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet (2000) 3.82
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol (2002) 3.75
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet (2006) 3.55
The dysregulated podocyte phenotype: a novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol (1999) 3.46
Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development (1995) 3.30
Podocyte biology and response to injury. J Am Soc Nephrol (2002) 3.25
A proposed taxonomy for the podocytopathies: a reassessment of the primary nephrotic diseases. Clin J Am Soc Nephrol (2007) 3.23
A mouse model of Alagille syndrome: Notch2 as a genetic modifier of Jag1 haploinsufficiency. Development (2002) 2.88
Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol (1998) 2.75
Notch2, but not Notch1, is required for proximal fate acquisition in the mammalian nephron. Development (2007) 2.70
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev (2002) 2.64
Donor splice-site mutations in WT1 are responsible for Frasier syndrome. Nat Genet (1997) 2.38
Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development (2001) 2.37
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol (2006) 2.10
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney. Development (2003) 1.87
Notch signaling: the demise of elegant simplicity. Curr Opin Genet Dev (2004) 1.79
WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Hum Mol Genet (2002) 1.70
Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C. Mol Cell Biol (1999) 1.61
Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms. Hum Mol Genet (1998) 1.58
Glomerular-specific gene excision in vivo. J Am Soc Nephrol (2002) 1.51
The notch intracellular domain can function as a coactivator for LEF-1. Mol Cell Biol (2001) 1.45
Segmental expression of Notch and Hairy genes in nephrogenesis. Am J Physiol Renal Physiol (2005) 1.43
The immunoglobulin-like protein Hibris functions as a dose-dependent regulator of myoblast fusion and is differentially controlled by Ras and Notch signaling. Development (2001) 1.41
Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development (2003) 1.40
Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis. Gene Expr Patterns (2004) 1.36
Transforming growth factor-beta induces renal epithelial jagged-1 expression in fibrotic disease. J Am Soc Nephrol (2002) 1.34
Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats. Kidney Int (2001) 1.32
Rapid isolation of glomeruli coupled with gene expression profiling identifies downstream targets in Pod1 knockout mice. J Am Soc Nephrol (2005) 1.24
Dysregulation of podocyte phenotype in idiopathic collapsing glomerulopathy and HIV-associated nephropathy. Nephron (2002) 1.08
WT1 and PAX-2 podocyte expression in Denys-Drash syndrome and isolated diffuse mesangial sclerosis. Am J Pathol (1999) 1.04
Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development. Gene Expr Patterns (2003) 1.02
A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome. Proc Natl Acad Sci U S A (1999) 0.98
CFTR mutation detection by multiplex heteroduplex (mHET) analysis on MDE gel. Methods Mol Med (2002) 0.98
Glomerular mesangiolipidosis in Alagille syndrome (arteriohepatic dysplasia). Pediatr Nephrol (1987) 0.98
Phenotypic change of glomerular podocytes in primary focal segmental glomerulosclerosis: developmental paradigm? Nephrol Dial Transplant (2002) 0.95
The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome. Mol Cell Biol (2004) 0.92
Cre-conditional expression of constitutively active Notch1 in transgenic mice. Genesis (2007) 0.89
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
VEGF inhibition and renal thrombotic microangiopathy. N Engl J Med (2008) 9.87
Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest (2003) 6.44
Early restriction of peripheral and proximal cell lineages during formation of the lung. Proc Natl Acad Sci U S A (2002) 5.54
Conditional and inducible transgene expression in mice through the combinatorial use of Cre-mediated recombination and tetracycline induction. Nucleic Acids Res (2005) 4.08
Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature (2006) 4.05
Insulin signaling to the glomerular podocyte is critical for normal kidney function. Cell Metab (2010) 3.05
Loss of the tumor suppressor Vhlh leads to upregulation of Cxcr4 and rapidly progressive glomerulonephritis in mice. Nat Med (2006) 2.65
Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling. J Am Soc Nephrol (2010) 2.52
Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. Nature (2003) 2.51
GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure. Nat Med (2013) 2.31
The post-natal heart contains a myocardial stem cell population. FEBS Lett (2002) 2.23
Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival. J Am Soc Nephrol (2006) 2.10
Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest (2011) 2.09
Prorenin receptor is essential for normal podocyte structure and function. J Am Soc Nephrol (2011) 2.08
A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis (2002) 2.02
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. J Clin Invest (2009) 2.01
Nck proteins maintain the adult glomerular filtration barrier. J Am Soc Nephrol (2009) 1.92
Role of the VEGF--a signaling pathway in the glomerulus: evidence for crosstalk between components of the glomerular filtration barrier. Nephron Physiol (2007) 1.80
Soluble FLT1 binds lipid microdomains in podocytes to control cell morphology and glomerular barrier function. Cell (2012) 1.79
Large-scale identification of genes implicated in kidney glomerulus development and function. EMBO J (2006) 1.69
Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity. Dev Biol (2008) 1.59
Remission of resistant MPGN type I with mycophenolate mofetil and steroids. Pediatr Nephrol (2008) 1.52
Glomerular-specific gene excision in vivo. J Am Soc Nephrol (2002) 1.51
Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis. Nat Med (2011) 1.46
Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene. Cancer Res (2003) 1.46
The role of VEGF-A in glomerular development and function. Curr Opin Nephrol Hypertens (2004) 1.36
Expression of Hairy/Enhancer of Split genes, Hes1 and Hes5, during murine nephron morphogenesis. Gene Expr Patterns (2004) 1.36
Phosphorylated YDXV motifs and Nck SH2/SH3 adaptors act cooperatively to induce actin reorganization. Mol Cell Biol (2008) 1.34
The Sweet Pee model for Sglt2 mutation. J Am Soc Nephrol (2011) 1.32
Grg1 acts as a lung-specific oncogene in a transgenic mouse model. Cancer Res (2006) 1.31
Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. Development (2004) 1.28
Inhibition of MTOR disrupts autophagic flux in podocytes. J Am Soc Nephrol (2011) 1.24
Rapid isolation of glomeruli coupled with gene expression profiling identifies downstream targets in Pod1 knockout mice. J Am Soc Nephrol (2005) 1.24
Thioredoxin-interacting protein mediates high glucose-induced reactive oxygen species generation by mitochondria and the NADPH oxidase, Nox4, in mesangial cells. J Biol Chem (2013) 1.18
A podocentric view of nephrology. Curr Opin Nephrol Hypertens (2004) 1.18
WT1 activates a glomerular-specific enhancer identified from the human nephrin gene. J Am Soc Nephrol (2004) 1.17
Vegfa protects the glomerular microvasculature in diabetes. Diabetes (2012) 1.16
Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol (2009) 1.12
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Mol Ther (2013) 1.11
How do mesangial and endothelial cells form the glomerular tuft? J Am Soc Nephrol (2008) 1.11
Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium-derived cells into smooth muscle in the developing heart. Dev Biol (2012) 1.10
Pod1 is required in stromal cells for glomerulogenesis. Dev Dyn (2003) 1.09
Molecular basis of organ fibrosis: potential therapeutic approaches. Exp Biol Med (Maywood) (2013) 1.08
A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development. J Am Soc Nephrol (2002) 1.06
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. J Clin Invest (2016) 1.05
Elevated SMAD1/beta-catenin molecular complexes and renal medullary cystic dysplasia in ALK3 transgenic mice. Development (2003) 1.05
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chem Res Toxicol (2005) 1.04
Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation. Cancer Immunol Immunother (2012) 1.01
Enhanced expression of VEGF-A in β cells increases endothelial cell number but impairs islet morphogenesis and β cell proliferation. Dev Biol (2012) 1.01
A lymphatic defect causes ocular hypertension and glaucoma in mice. J Clin Invest (2014) 0.98
Characterization of functional excision repair cross-complementation group 1 variants and their association with lung cancer risk and prognosis. Clin Cancer Res (2008) 0.98
CFTR mutation detection by multiplex heteroduplex (mHET) analysis on MDE gel. Methods Mol Med (2002) 0.98
Duplication of GTF2I results in separation anxiety in mice and humans. Am J Hum Genet (2012) 0.96
Diffusion tensor imaging characterization of occult brain damage in relapsing neuromyelitis optica using 3.0T magnetic resonance imaging techniques. Neuroimage (2011) 0.96
A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo. Blood (2008) 0.92
Notch promotes dynamin-dependent endocytosis of nephrin. J Am Soc Nephrol (2011) 0.91
Stem cell therapy for the kidney: a cautionary tale. J Am Soc Nephrol (2010) 0.90
Deciphering the renal code: advances in conditional gene targeting. Physiology (Bethesda) (2004) 0.90
Toward a mouse model of diabetic nephropathy: is endothelial nitric oxide synthase the missing link? J Am Soc Nephrol (2007) 0.90
Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis. Cancer Biol Ther (2014) 0.89
Cre-conditional expression of constitutively active Notch1 in transgenic mice. Genesis (2007) 0.89
Biology of anti-angiogenic therapy-induced thrombotic microangiopathy. Semin Nephrol (2010) 0.88
Monitoring and modeling treatment of atypical hemolytic uremic syndrome. Mol Immunol (2012) 0.87
1-(2,4-Dichloro-phen-yl)-5-(2-nitro-anilino)-1H-pyrazole-4-carbonitrile. Acta Crystallogr Sect E Struct Rep Online (2012) 0.86
Murine Notch1 is required for lymphatic vascular morphogenesis during development. Dev Dyn (2014) 0.86
Apolipoprotein l1 and the genetic basis for racial disparity in chronic kidney disease. J Am Soc Nephrol (2011) 0.86
The rationale and design of Insight into Nephrotic Syndrome: Investigating Genes, Health and Therapeutics (INSIGHT): a prospective cohort study of childhood nephrotic syndrome. BMC Nephrol (2013) 0.85
3-(2,4-Dichloro-phen-yl)-5-(4-fluoro-phen-yl)-2-methyl-7-(trifluoro-meth-yl)pyrazolo-[1,5-a]pyrimidine. Acta Crystallogr Sect E Struct Rep Online (2012) 0.85
Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo. Blood (2009) 0.85
Thrombolysis effect of a novel targeted microbubble with low-frequency ultrasound in vivo. Thromb Haemost (2008) 0.85
Characterization, tissue distribution and regulation of agouti-related protein (AgRP) in a cyprinid fish (Schizothorax prenanti). Gene (2013) 0.84
Nestin is not essential for development of the CNS but required for dispersion of acetylcholine receptor clusters at the area of neuromuscular junctions. J Neurosci (2011) 0.83
Constitutive notch signaling in adult transgenic mice inhibits bFGF-induced angiogenesis and blocks ovarian follicle development. Genesis (2014) 0.83
A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme. PLoS One (2012) 0.83
New insights into the pathogenesis of cellular crescents. Curr Opin Nephrol Hypertens (2011) 0.82
CD109 expression is increased in cutaneous squamous cell carcinoma. J Dermatol (2014) 0.81
Cross-correlation frequency-resolved optical gating and dynamics of temporal solitons in silicon nanowire waveguides. Opt Lett (2013) 0.81
Metoprolol-mediated amelioration of sympathetic nerve sprouting after myocardial infarction. Cardiology (2013) 0.81
[Clinical observation on treatment of early diabetic nephropathy by milkvetch injection combined with captopril]. Zhongguo Zhong Xi Yi Jie He Za Zhi (2005) 0.80
A new piece in the nephrotic puzzle. Nat Genet (2006) 0.80
Elevated Expression of CD109 in Esophageal Squamous Cell Carcinoma. Pathol Oncol Res (2015) 0.80
Intramuscular delivery of adenovirus serotype 5 vector expressing humanized protective antigen induces rapid protection against anthrax that may bypass intranasally originated preexisting adenovirus immunity. Clin Vaccine Immunol (2013) 0.80
Unambiguous demonstration of soliton evolution in slow-light silicon photonic crystal waveguides with SFG-XFROG. Opt Express (2015) 0.80
Mouse models to study kidney development, function and disease. Curr Opin Nephrol Hypertens (2011) 0.79
The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier. PLoS One (2012) 0.79
Overcoming 5-Fu resistance of colon cells through inhibition of Glut1 by the specific inhibitor WZB117. Asian Pac J Cancer Prev (2014) 0.79
Heparin binding VEGF isoforms attenuate hyperoxic embryonic lung growth retardation via a FLK1-neuropilin-1-PKC dependent pathway. Respir Res (2014) 0.79
Liposarcoma miRNA signatures identified from genome-wide miRNA expression profiling. Future Oncol (2014) 0.79
Crosstalk in glomerular injury and repair. Curr Opin Nephrol Hypertens (2015) 0.78
Repressors NFI and NFY participate in organ-specific regulation of von Willebrand factor promoter activity in transgenic mice. Arterioscler Thromb Vasc Biol (2010) 0.78
MTOR regulates autophagic flux in the glomerulus. Autophagy (2012) 0.78