Published in Cancer Biol Ther on January 01, 2014
Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway. PLoS One (2015) 0.92
Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells. Biochem Biophys Res Commun (2017) 0.77
Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells. Int J Environ Res Public Health (2015) 0.77
Dihydroartemisinin induces endothelial cell anoikis through the activation of the JNK signaling pathway. Oncol Lett (2016) 0.76
NF-κB signaling maintains the survival of cadmium-exposed human renal glomerular endothelial cells. Int J Mol Med (2016) 0.76
Dihydroartemisinin transiently activates the JNK/SAPK signaling pathway in endothelial cells. Oncol Lett (2016) 0.75
Preeclampsia Downregulates MicroRNAs in Fetal Endothelial Cells: Roles of miR-29a/c-3p in Endothelial Function. J Clin Endocrinol Metab (2017) 0.75
Loss of Complement Factor H in Plasma Increases Endothelial Cell Migration. J Cancer (2017) 0.75
The biology of VEGF and its receptors. Nat Med (2003) 32.13
Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med (1995) 26.60
Mechanisms of angiogenesis. Nature (1997) 18.04
Angiogenesis in life, disease and medicine. Nature (2005) 15.36
Molecular mechanisms and clinical applications of angiogenesis. Nature (2011) 13.36
Angiogenesis as a therapeutic target. Nature (2005) 11.89
Tumor metastasis: mechanistic insights and clinical challenges. Nat Med (2006) 11.06
Structure of an IkappaBalpha/NF-kappaB complex. Cell (1998) 5.67
Qinghaosu (artemisinin): an antimalarial drug from China. Science (1985) 4.95
Endothelial cells and VEGF in vascular development. Nature (2005) 4.92
The crystal structure of the IkappaBalpha/NF-kappaB complex reveals mechanisms of NF-kappaB inactivation. Cell (1998) 4.71
Vascular permeability factor (VPF, VEGF) in tumor biology. Cancer Metastasis Rev (1993) 3.96
flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development (1993) 3.66
The anti-malarial artesunate is also active against cancer. Int J Oncol (2001) 2.56
CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex. J Biol Chem (2008) 1.93
Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes. J Immunol (1993) 1.84
Animal models of choroidal and retinal neovascularization. Prog Retin Eye Res (2010) 1.79
Cloning and functional analysis of the promoter for KDR/flk-1, a receptor for vascular endothelial growth factor. J Biol Chem (1995) 1.78
Artemisinin derivatives: toxic for laboratory animals, safe for humans? Toxicol Lett (2004) 1.76
Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis. J Biol Chem (2002) 1.68
Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem (2001) 1.63
Constitutive NF-kappaB activation in colorectal carcinoma plays a key role in angiogenesis, promoting tumor growth. Clin Cancer Res (2009) 1.49
Artemisinins: pharmacological actions beyond anti-malarial. Pharmacol Ther (2013) 1.45
Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha. Oncogene (2007) 1.36
NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer. Curr Med Chem (2007) 1.34
Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotechnol (2011) 1.29
Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate. Biochem Pharmacol (2004) 1.28
Regulation of the expression of the VEGF/VPS and its receptors: role in tumor angiogenesis. Breast Cancer Res Treat (1995) 1.26
Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro. Pharmacol Res (2003) 1.20
Suppression of retinal neovascularization by the NF-kappaB inhibitor pyrrolidine dithiocarbamate in mice. Invest Ophthalmol Vis Sci (1999) 1.17
Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction. Ann N Y Acad Sci (2000) 1.12
Transforming growth factor-beta 1-mediated inhibition of the flk-1/KDR gene is mediated by a 5'-untranslated region palindromic GATA site. J Biol Chem (2000) 1.11
Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs. Mol Pharmacol (1999) 1.10
Characterization of the endothelium-specific murine vascular endothelial growth factor receptor-2 (Flk-1) promoter. Circ Res (1996) 1.03
Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells. Biochem Pharmacol (2010) 1.00
Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway. Cancer Chemother Pharmacol (2011) 0.99
Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo. Biochem Pharmacol (2012) 0.99
Antimalarial dihydroartemisinin also inhibits angiogenesis. Cancer Chemother Pharmacol (2004) 0.99
Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cells. Vascul Pharmacol (2007) 0.95
Epidermal growth factor activates nuclear factor-kappaB in human proximal tubule cells. Am J Physiol Renal Physiol (2005) 0.94
In vivo and in vitro investigations of the effects of the antimalarial drug dihydroartemisinin (DHA) on rat embryos. Reprod Toxicol (2006) 0.94
The development of new antimalarial drugs: qinghaosu and dihydro-qinghaosu. Chin Med J (Engl) (1999) 0.93
Apoptosis of human umbilical vein endothelial cells induced by artesunate. Vascul Pharmacol (2004) 0.93
Dihydroartemisinin improves the efficiency of chemotherapeutics in lung carcinomas in vivo and inhibits murine Lewis lung carcinoma cell line growth in vitro. Cancer Chemother Pharmacol (2009) 0.92
Induction of apoptosis and inhibition of cell migration and tube-like formation by dihydroartemisinin in murine lymphatic endothelial cells. Pharmacology (2007) 0.89
IkappaB kinase-alpha regulates endothelial cell motility and tumor angiogenesis. Cancer Res (2008) 0.88
Hypoxia modulates the effect of dihydroartemisinin on endothelial cells. Biochem Pharmacol (2011) 0.87
Biological properties of VEGF/VPF receptors. Cancer Metastasis Rev (1996) 0.87
Special features of human retinal angiogenesis. Eye (Lond) (2010) 0.80
Topical dihydroartemisinin inhibits suture-induced neovascularization in rat corneas through ERK1/2 and p38 pathways. Int J Ophthalmol (2011) 0.78
Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature (2012) 15.91
Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov (2011) 4.80
Temporal dynamics of the human vaginal microbiota. Sci Transl Med (2012) 4.58
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type. Cell Metab (2012) 3.81
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas. Nat Genet (2013) 3.51
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus in the Mid-Eastern region of China. Vet J (2007) 2.91
Ectopic notch activation in developing podocytes causes glomerulosclerosis. J Am Soc Nephrol (2008) 2.18
Microbiota of the seminal fluid from healthy and infertile men. Fertil Steril (2013) 2.10
Molecular microbial ecology: land of the one-eyed king. Curr Opin Microbiol (2004) 2.06
Valsartan Upregulates Kir2.1 in Rats Suffering from Myocardial Infarction via Casein Kinase 2. Cardiovasc Drugs Ther (2015) 2.04
Modeling denitrification in terrestrial and aquatic ecosystems at regional scales. Ecol Appl (2006) 1.80
Pharmacological inhibition of BMK1 suppresses tumor growth through promyelocytic leukemia protein. Cancer Cell (2010) 1.72
Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest (2015) 1.51
Alzheimer disease and cancer risk: a meta-analysis. J Cancer Res Clin Oncol (2014) 1.44
Bacterial populations in the vaginas of healthy adolescent women. J Pediatr Adolesc Gynecol (2009) 1.35
Increasing prevalences of overweight and obesity in Northern Plains American Indian children. Arch Pediatr Adolesc Med (2006) 1.29
Fine mapping a QTL qCTB7 for cold tolerance at the booting stage on rice chromosome 7 using a near-isogenic line. Theor Appl Genet (2010) 1.27
High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chem Biol (2011) 1.27
Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett (2012) 1.22
Understanding vaginal microbiome complexity from an ecological perspective. Transl Res (2012) 1.19
GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg Med Chem Lett (2012) 1.16
Comparison of outcomes for laparoscopically assisted and open radical distal gastrectomy with lymphadenectomy for advanced gastric cancer. Surg Endosc (2011) 1.15
Preliminary characterization of the normal microbiota of the human vulva using cultivation-independent methods. J Med Microbiol (2007) 1.12
Cattle mammary bioreactor generated by a novel procedure of transgenic cloning for large-scale production of functional human lactoferrin. PLoS One (2008) 1.11
Biodegradable lipids enabling rapidly eliminated lipid nanoparticles for systemic delivery of RNAi therapeutics. Mol Ther (2013) 1.11
Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells. Int J Oncol (2011) 1.10
Characterization of bioactive recombinant human lysozyme expressed in milk of cloned transgenic cattle. PLoS One (2011) 1.07
Temperature-dependent synthesis of metal-organic frameworks based on a flexible tetradentate ligand with bidirectional coordination donors. J Am Chem Soc (2007) 1.06
Risk factors for preterm birth in five Maternal and Child Health hospitals in Beijing. PLoS One (2012) 1.06
Daily temporal dynamics of vaginal microbiota before, during and after episodes of bacterial vaginosis. Microbiome (2013) 1.04
Bioactivation of the selective estrogen receptor modulator desmethylated arzoxifene to quinoids: 4'-fluoro substitution prevents quinoid formation. Chem Res Toxicol (2005) 1.04
N-myristoylated c-Abl tyrosine kinase localizes to the endoplasmic reticulum upon binding to an allosteric inhibitor. J Biol Chem (2009) 1.04
Characterization of TAE684 as a potent LRRK2 kinase inhibitor. Bioorg Med Chem Lett (2012) 1.02
SNP identification and allelic-specific PCR markers development for TaGW2, a gene linked to wheat kernel weight. Theor Appl Genet (2012) 1.02
Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation. Cancer Immunol Immunother (2012) 1.01
The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep (2013) 1.01
Quantitation of HBV covalently closed circular DNA in micro formalin fixed paraffin-embedded liver tissue using rolling circle amplification in combination with real-time PCR. Clin Chim Acta (2011) 1.00
Coffee, decaffeinated coffee, caffeine, and tea consumption in young adulthood and atherosclerosis later in life: the CARDIA study. Arterioscler Thromb Vasc Biol (2010) 1.00
Characterization of functional excision repair cross-complementation group 1 variants and their association with lung cancer risk and prognosis. Clin Cancer Res (2008) 0.98
Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PLoS One (2012) 0.98
Oral delivery of tumor-targeting Salmonella exhibits promising therapeutic efficacy and low toxicity. Cancer Sci (2009) 0.98
Extraction spectrophotometric determination of aluminum in dialysis concentrates with 3,5-ditertbutylsalicylfluorone and ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate. J Pharm Biomed Anal (2006) 0.97
A multicolor nanoprobe for detection and imaging of tumor-related mRNAs in living cells. Angew Chem Int Ed Engl (2012) 0.97
Diffusion tensor imaging characterization of occult brain damage in relapsing neuromyelitis optica using 3.0T magnetic resonance imaging techniques. Neuroimage (2011) 0.96
MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas. Acta Neuropathol (2010) 0.96
Inhibition of the PI3K/Akt pathway increases the chemosensitivity of gastric cancer to vincristine. Oncol Rep (2013) 0.95
Intradermal infections of mice by low numbers of african trypanosomes are controlled by innate resistance but enhance susceptibility to reinfection. J Infect Dis (2010) 0.95
Proteomic screening of anaerobically regulated promoters from Salmonella and its antitumor applications. Mol Cell Proteomics (2011) 0.93
The involvement of 5-hydroxymethylcytosine in active DNA demethylation in mice. Biol Reprod (2012) 0.93
Regulation of protein kinase C inactivation by Fas-associated protein with death domain. J Biol Chem (2012) 0.92
Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1. ACS Med Chem Lett (2011) 0.92
An altered peptide ligand of type II collagen suppresses autoimmune arthritis. Crit Rev Immunol (2007) 0.92
A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo. Blood (2008) 0.92
Smac-mimetic-induced epithelial cell death reduces the growth of renal cysts. J Am Soc Nephrol (2013) 0.92
Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice. Arthritis Res Ther (2006) 0.91
High specific and ultrasensitive isothermal detection of microRNA by padlock probe-based exponential rolling circle amplification. Anal Chem (2013) 0.91
A highly sensitive acidic pH fluorescent probe and its application to HepG2 cells. Analyst (2008) 0.91
Salmonella-mediated tumor-targeting TRAIL gene therapy significantly suppresses melanoma growth in mouse model. Cancer Sci (2011) 0.91
Coordination-driven nanosized lanthanide "molecular lantern" with tunable luminescent properties. J Am Chem Soc (2007) 0.90
Regulation of colon cancer cell migration and invasion by CLIC1-mediated RVD. Mol Cell Biochem (2012) 0.90
Suppression of HSP70 expression sensitizes NSCLC cell lines to TRAIL-induced apoptosis by upregulating DR4 and DR5 and downregulating c-FLIP-L expressions. J Mol Med (Berl) (2012) 0.90
Systemic and peritoneal inflammatory response after laparoscopic-assisted gastrectomy and the effect of inflammatory cytokines on adhesion of gastric cancer cells to peritoneal mesothelial cells. Surg Endosc (2010) 0.89
Trends in blood pressure and hypertension detection, treatment, and control 1980 to 2009: the Minnesota Heart Survey. Circulation (2012) 0.89
Sinomenine inhibits primary CD4+ T-cell proliferation via apoptosis. Cell Biol Int (2007) 0.89
The interplay between DNA repair and autophagy in cancer therapy. Cancer Biol Ther (2015) 0.89
SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. PLoS One (2012) 0.89
A phosphinate-based red fluorescent probe for imaging the superoxide radical anion generated by RAW264.7 macrophages. Chembiochem (2007) 0.89
Consistency between increasing trends in added-sugar intake and body mass index among adults: the Minnesota Heart Survey, 1980-1982 to 2007-2009. Am J Public Health (2012) 0.88
Effects of fenofibrate on plasma oxidized LDL and 8-isoprostane in a sub-cohort of GOLDN participants. Atherosclerosis (2010) 0.88
Hippo pathway in intestinal homeostasis and tumorigenesis. Protein Cell (2012) 0.88
High-level expression of bioactive recombinant human lysozyme in the milk of transgenic mice using a modified human lactoferrin BAC. Transgenic Res (2011) 0.88
Strong red fluorescent probes suitable for detecting hydrogen peroxide generated by mice peritoneal macrophages. Chem Commun (Camb) (2005) 0.88
HDAC6 regulates epidermal growth factor receptor (EGFR) endocytic trafficking and degradation in renal epithelial cells. PLoS One (2012) 0.87
Simultaneous detection of intracellular tumor mRNA with bi-color imaging based on a gold nanoparticle/molecular beacon. Chemistry (2011) 0.87
Characterization of 35 novel microsatellite DNA markers from the duck (Anas platyrhynchos) genome and cross-amplification in other birds. Genet Sel Evol (2005) 0.87
Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol (2011) 0.87
Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J Med Chem (2014) 0.87
New measles virus genotype associated with outbreak, China. Emerg Infect Dis (2010) 0.87
Birth of calves expressing the enhanced green fluorescent protein after transfer of fresh or vitrified/thawed blastocysts produced by somatic cell nuclear transfer. Mol Reprod Dev (2004) 0.87
Study of highly selective and efficient thiol derivatization using selenium reagents by mass spectrometry. Anal Chem (2010) 0.87
Cumulative summation analysis of learning curve for robot-assisted gastrectomy in gastric cancer. J Surg Oncol (2015) 0.87
Twenty-two-year population trends in sodium and potassium consumption: the Minnesota Heart Survey. J Am Heart Assoc (2013) 0.86
Gold nanoparticles modified electrode via a mercapto-diazoaminobenzene monolayer and its development in DNA electrochemical biosensor. Biosens Bioelectron (2010) 0.86
Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb. Bioorg Med Chem (2007) 0.86
X-ray crystal structure of ERK5 (MAPK7) in complex with a specific inhibitor. J Med Chem (2013) 0.86
1-(2,4-Dichloro-phen-yl)-5-(2-nitro-anilino)-1H-pyrazole-4-carbonitrile. Acta Crystallogr Sect E Struct Rep Online (2012) 0.86
mcaGUI: microbial community analysis R-Graphical User Interface (GUI). Bioinformatics (2012) 0.86
Multifunctional core-shell nanoparticles as highly efficient imaging and photosensitizing agents. Langmuir (2009) 0.85
Multiplexed detection and imaging of intracellular mRNAs using a four-color nanoprobe. Anal Chem (2013) 0.85
3-(2,4-Dichloro-phen-yl)-5-(4-fluoro-phen-yl)-2-methyl-7-(trifluoro-meth-yl)pyrazolo-[1,5-a]pyrimidine. Acta Crystallogr Sect E Struct Rep Online (2012) 0.85
Thrombolysis effect of a novel targeted microbubble with low-frequency ultrasound in vivo. Thromb Haemost (2008) 0.85
Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo. Blood (2009) 0.85
The plasma S-adenosylmethionine level is associated with the severity of hepatitis B-related liver disease. Medicine (Baltimore) (2015) 0.85
The polymorphisms in methylenetetrahydrofolate reductase, methionine synthase, methionine synthase reductase, and the risk of colorectal cancer. Int J Biol Sci (2012) 0.85
Cell-based optimization of novel benzamides as potential antimalarial leads. Bioorg Med Chem Lett (2009) 0.85
[Cu(C24H22N4O3)].CH2Cl2: a discrete breathing metallamacrocycle showing selective and reversible guest adsorption with retention of single crystallinity. J Am Chem Soc (2007) 0.85
Relation of adiposity, television and screen time in offspring to their parents. BMC Pediatr (2013) 0.84
Characterization, tissue distribution and regulation of agouti-related protein (AgRP) in a cyprinid fish (Schizothorax prenanti). Gene (2013) 0.84