Published in Development on February 01, 2002
Generation and regeneration of cells of the liver and pancreas. Science (2008) 4.21
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet (2006) 3.55
Notch signaling controls liver development by regulating biliary differentiation. Development (2009) 2.93
Notch signaling is essential for ventricular chamber development. Dev Cell (2007) 2.53
Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell (2014) 2.43
Liver stem cells and hepatocellular carcinoma. Hepatology (2009) 2.27
Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes. J Clin Invest (2012) 2.26
Hippo pathway activity influences liver cell fate. Cell (2014) 2.24
Ectopic notch activation in developing podocytes causes glomerulosclerosis. J Am Soc Nephrol (2008) 2.18
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest (2007) 2.09
Control of liver cell fate decision by a gradient of TGF beta signaling modulated by Onecut transcription factors. Genes Dev (2005) 2.02
Alagille syndrome: pathogenesis, diagnosis and management. Eur J Hum Genet (2011) 1.94
Notch signaling in human development and disease. Semin Cell Dev Biol (2012) 1.79
Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (2010) 1.78
RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development (2010) 1.72
The association of Notch2 and NF-kappaB accelerates RANKL-induced osteoclastogenesis. Mol Cell Biol (2008) 1.70
Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO J (2005) 1.68
Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors. Development (2006) 1.67
Notch signaling regulates bile duct morphogenesis in mice. PLoS One (2008) 1.59
Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice. Hepatology (2010) 1.53
Notch and the skeleton. Mol Cell Biol (2009) 1.49
Notch and disease: a growing field. Semin Cell Dev Biol (2012) 1.48
Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture. Mol Biol Cell (2007) 1.44
Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development (2011) 1.42
Emerging roles of Notch signaling in liver disease. Hepatology (2014) 1.39
Notch1 signaling stimulates proliferation of immature cardiomyocytes. J Cell Biol (2008) 1.39
Transdifferentiation of mature rat hepatocytes into bile duct-like cells in vitro. Am J Pathol (2005) 1.36
Density of the Notch ligand Delta1 determines generation of B and T cell precursors from hematopoietic stem cells. J Exp Med (2005) 1.35
Molecular insights into segmentation along the proximal-distal axis of the nephron. J Am Soc Nephrol (2007) 1.34
Sox9b is a key regulator of pancreaticobiliary ductal system development. PLoS Genet (2012) 1.30
Reiterative use of the notch signal during zebrafish intrahepatic biliary development. Dev Dyn (2010) 1.29
Analysis of liver repair mechanisms in Alagille syndrome and biliary atresia reveals a role for notch signaling. Am J Pathol (2007) 1.26
Transit-amplifying ductular (oval) cells and their hepatocytic progeny are characterized by a novel and distinctive expression of delta-like protein/preadipocyte factor 1/fetal antigen 1. Am J Pathol (2004) 1.25
Cartilage, SOX9 and Notch signals in chondrogenesis. J Anat (2006) 1.25
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (2012) 1.21
Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face. Development (2010) 1.21
Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver. J Clin Invest (2010) 1.17
The contribution of Notch1 to nephron segmentation in the developing kidney is revealed in a sensitized Notch2 background and can be augmented by reducing Mint dosage. Dev Biol (2009) 1.14
Partitioning the heart: mechanisms of cardiac septation and valve development. Development (2012) 1.13
Of mice and men: molecular genetics of congenital heart disease. Cell Mol Life Sci (2013) 1.10
Notch in the kidney: development and disease. J Pathol (2011) 1.08
Molecular pathways of notch signaling in vascular smooth muscle cells. Front Physiol (2012) 1.07
Notch regulation of bone development and remodeling and related skeletal disorders. Calcif Tissue Int (2011) 1.05
Cranial neural crest ablation of Jagged1 recapitulates the craniofacial phenotype of Alagille syndrome patients. Hum Mol Genet (2011) 1.04
Blood flow reprograms lymphatic vessels to blood vessels. J Clin Invest (2012) 1.04
The extracellular domain of Notch2 increases its cell-surface abundance and ligand responsiveness during kidney development. Dev Cell (2013) 1.02
Liver development, regeneration, and carcinogenesis. J Biomed Biotechnol (2010) 1.02
CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. J Clin Invest (2015) 1.00
Liver progenitor cells fold up a cell monolayer into a double-layered structure during tubular morphogenesis. Mol Biol Cell (2009) 1.00
Notch signaling in skeletal health and disease. Eur J Endocrinol (2013) 1.00
Differentiation of progenitors in the liver: a matter of local choice. J Clin Invest (2013) 1.00
Ductal plates in hepatic ductular reactions. Hypothesis and implications. III. Implications for liver pathology. Virchows Arch (2011) 0.99
Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses. J Exp Med (2014) 0.99
Notch signaling in cardiac development and disease. Pediatr Cardiol (2009) 0.98
Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation. Am J Med Genet C Semin Med Genet (2013) 0.96
Conditional JAG1 mutation shows the developing heart is more sensitive than developing liver to JAG1 dosage. Am J Hum Genet (2003) 0.96
Notch signaling in diabetic nephropathy. Exp Cell Res (2012) 0.95
Transcriptional profiling of Wnt4 mutant mouse kidneys identifies genes expressed during nephron formation. Gene Expr Patterns (2008) 0.94
Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome. Mamm Genome (2004) 0.93
MicroRNA-17~92 is required for nephrogenesis and renal function. J Am Soc Nephrol (2014) 0.93
Genetic interactions between hepatocyte nuclear factor-6 and Notch signaling regulate mouse intrahepatic bile duct development in vivo. Hepatology (2012) 0.93
Role of hepatic progenitor cells in nonalcoholic fatty liver disease development: cellular cross-talks and molecular networks. Int J Mol Sci (2013) 0.93
Cardiac outflow tract anomalies. Wiley Interdiscip Rev Dev Biol (2013) 0.92
Molecular mechanisms of bile duct development. Int J Biochem Cell Biol (2010) 0.92
Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Hepatology (2015) 0.92
Jagged1 functions downstream of Twist1 in the specification of the coronal suture and the formation of a boundary between osteogenic and non-osteogenic cells. Dev Biol (2010) 0.91
Notch pathway regulation of neural crest cell development in vivo. Dev Dyn (2012) 0.89
Botch promotes neurogenesis by antagonizing Notch. Dev Cell (2012) 0.89
Notch exhibits ligand bias and maneuvers stage-specific steering of neural differentiation in embryonic stem cells. Mol Cell Biol (2010) 0.89
Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol (2014) 0.88
Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev Dyn (2012) 0.88
Renal involvement and the role of Notch signalling in Alagille syndrome. Nat Rev Nephrol (2013) 0.87
Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development (2013) 0.87
The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development. Kidney Int (2011) 0.86
Mutations of the RET gene in isolated and syndromic Hirschsprung's disease in human disclose major and modifier alleles at a single locus. J Med Genet (2006) 0.86
Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain. Dev Dyn (2009) 0.86
NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine. Stem Cells Transl Med (2014) 0.85
Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice. BMC Nephrol (2006) 0.84
Notch signaling plays a key role in cardiac cell differentiation. Mech Dev (2006) 0.84
Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling. Genes Dev (2013) 0.84
The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (2015) 0.83
Notch Signaling and the Skeleton. Endocr Rev (2016) 0.82
Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes. Lab Invest (2015) 0.82
Intestinal activation of Notch signaling induces rapid onset hepatic steatosis and insulin resistance. PLoS One (2011) 0.81
Molecular regulation of kidney development. Anat Cell Biol (2013) 0.81
Jagged1 (JAG1): Structure, expression, and disease associations. Gene (2015) 0.80
The Hippo signaling pathway provides novel anti-cancer drug targets. Oncotarget (2016) 0.79
Alagille, Notch, and robustness: why duplicating systems does not ensure redundancy. Pediatr Nephrol (2013) 0.78
Vax1/2 genes counteract Mitf-induced respecification of the retinal pigment epithelium. PLoS One (2013) 0.78
Enhanced Wnt/β-catenin and Notch signalling in the activated canine hepatic progenitor cell niche. BMC Vet Res (2014) 0.78
Enhancement of hepatocyte differentiation from human embryonic stem cells by Chinese medicine Fuzhenghuayu. Sci Rep (2016) 0.78
Autophagy regulates biliary differentiation of hepatic progenitor cells through Notch1 signaling pathway. Cell Cycle (2016) 0.78
The Eye Specification Network in Drosophila. Proc Indian Natl Sci Acad B Biol Sci (2004) 0.77
Maternal undernourished fetal kidneys exhibit differential regulation of nephrogenic genes including downregulation of the Notch signaling pathway. Reprod Sci (2011) 0.77
Vascular patterning sets the stage for macro and micro hepatic architecture. Dev Dyn (2014) 0.76
Rbm24a and Rbm24b are required for normal somitogenesis. PLoS One (2014) 0.76
Immunohistochemical analyses of cell cycle progression and gene expression of biliary epithelial cells during liver regeneration after partial hepatectomy of the mouse. Exp Anim (2015) 0.76
Alagille syndrome and optic pit. Graefes Arch Clin Exp Ophthalmol (2007) 0.75
NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors? Mol Cancer (2016) 0.75
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity (2007) 3.19
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00
Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J Cell Physiol (2005) 2.91
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci U S A (2009) 2.63
The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet (2006) 2.56
The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development (2005) 2.36
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. Blood (2004) 2.06
Critical role of endothelial Notch1 signaling in postnatal angiogenesis. Circ Res (2006) 1.91
Characterization of Notch3-deficient mice: normal embryonic development and absence of genetic interactions with a Notch1 mutation. Genesis (2003) 1.84
Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells. Genes Dev (2005) 1.81
Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology (2007) 1.78
Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev (2003) 1.76
Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1. EMBO J (2008) 1.71
Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol (2008) 1.68
Loss of notch activity in the developing central nervous system leads to increased cell death. Dev Neurosci (2006) 1.65
Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL. Blood (2010) 1.60
Notch signaling regulates bile duct morphogenesis in mice. PLoS One (2008) 1.59
Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc Natl Acad Sci U S A (2006) 1.58
Smooth muscle Notch1 mediates neointimal formation after vascular injury. Circulation (2009) 1.58
Generation of new Notch2 mutant alleles. Genesis (2006) 1.56
Slug is a novel downstream target of MyoD. Temporal profiling in muscle regeneration. J Biol Chem (2002) 1.50
Multiple functions of Snail family genes during palate development in mice. Development (2007) 1.45
Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development. Dev Dyn (2006) 1.37
Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells. J Clin Invest (2011) 1.29
Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest (2013) 1.27
TCF and Groucho-related genes influence pituitary growth and development. Mol Endocrinol (2003) 1.24
Notch1 activation in mice causes arteriovenous malformations phenocopied by ephrinB2 and EphB4 mutants. Genesis (2010) 1.20
The developmental transcription factor slug is widely expressed in tissues of adult mice. J Histochem Cytochem (2004) 1.20
Cell movements during gastrulation: snail dependent and independent pathways. Curr Opin Genet Dev (2002) 1.16
Generation of a Snail1 (Snai1) conditional null allele. Genesis (2006) 1.14
Segmentation defects of Notch pathway mutants and absence of a synergistic phenotype in lunatic fringe/radical fringe double mutant mice. Genesis (2002) 1.14
Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis. Am J Physiol Lung Cell Mol Physiol (2009) 1.12
Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion. Development (2010) 1.10
Craniosynostosis in Twist heterozygous mice: a model for Saethre-Chotzen syndrome. Anat Rec (2002) 1.09
Role of the Notch signalling pathway in tooth morphogenesis. Arch Oral Biol (2004) 1.08
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Molecular pathways of notch signaling in vascular smooth muscle cells. Front Physiol (2012) 1.07
Notch signaling coordinates the patterning of striatal compartments. Development (2005) 1.05
The archetypal R90C CADASIL-NOTCH3 mutation retains NOTCH3 function in vivo. Hum Mol Genet (2007) 1.04
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist. Biochem Biophys Res Commun (2004) 1.02
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength. J Exp Med (2013) 1.00
Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development. Dev Biol (2011) 0.99
Notch controls the magnitude of T helper cell responses by promoting cellular longevity. Proc Natl Acad Sci U S A (2012) 0.99
Laser surgery for mouse geneticists. Nat Biotechnol (2007) 0.97
Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells. Dev Dyn (2008) 0.96
Notch2 is required for maintaining sustentacular cell function in the adult mouse main olfactory epithelium. Dev Biol (2007) 0.95
Compensatory regulation of the Snai1 and Snai2 genes during chondrogenesis. J Bone Miner Res (2013) 0.95
Epiblast-specific Snai1 deletion results in embryonic lethality due to multiple vascular defects. BMC Res Notes (2009) 0.95
Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. Genetics (2006) 0.95
BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation. Development (2010) 0.92
Slug expression during organogenesis in mice. Anat Rec A Discov Mol Cell Evol Biol (2003) 0.92
Snail1 gene function during early embryo patterning in mice. Cell Cycle (2006) 0.92
Notch2 is required in somatic cells for breakdown of ovarian germ-cell nests and formation of primordial follicles. BMC Biol (2013) 0.91
Notch1 expression and ligand interactions in progenitor cells of the mouse olfactory epithelium. J Mol Histol (2007) 0.90
Generation of mice with a conditional null allele of the Jagged2 gene. Genesis (2010) 0.89
Mutations in snail family genes enhance craniosynostosis of Twist1 haplo-insufficient mice: implications for Saethre-Chotzen Syndrome. Genetics (2005) 0.88
The SNAI1 and SNAI2 proteins occupy their own and each other's promoter during chondrogenesis. Biochem Biophys Res Commun (2013) 0.87
Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice. Genetics (2007) 0.86
Lunatic fringe, FGF, and BMP regulate the Notch pathway during epithelial morphogenesis of teeth. Dev Biol (2002) 0.86
Growth defect in Grg5 null mice is associated with reduced Ihh signaling in growth plates. Dev Dyn (2002) 0.86
Mesenchymal cell remodeling during mouse secondary palate reorientation. Dev Dyn (2010) 0.85
Notch Signaling during Oogenesis in Drosophila melanogaster. Genet Res Int (2012) 0.85
The protein phosphatase 2A B56γ regulatory subunit is required for heart development. Dev Dyn (2014) 0.84
The snail family gene snai3 is not essential for embryogenesis in mice. PLoS One (2013) 0.83
Vascular biology: vessel guidance. Nature (2007) 0.83
Jagged1-mediated Notch signaling regulates mammalian inner ear development independent of lateral inhibition. Acta Otolaryngol (2012) 0.81
The Notch-regulated ankyrin repeat protein is required for proper anterior-posterior somite patterning in mice. Genesis (2012) 0.79
Not all lunatic fringe null female mice are infertile. Development (2006) 0.75
Absence of a major role for the snai1 and snai3 genes in regulating skeletal muscle regeneration in mice. PLoS Curr (2013) 0.75