Published in Trends Biochem Sci on March 17, 2008
A novel mammalian flavin-dependent histone demethylase. J Biol Chem (2009) 2.25
The SNAG domain of Snail1 functions as a molecular hook for recruiting lysine-specific demethylase 1. EMBO J (2010) 2.04
Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription. Sci Signal (2012) 1.56
Lysine-specific demethylase 1 regulates the embryonic transcriptome and CoREST stability. Mol Cell Biol (2010) 1.51
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer. Genes Cancer (2011) 1.47
Calorie restriction and the exercise of chromatin. Genes Dev (2009) 1.44
Retracted ASXL1 represses retinoic acid receptor-mediated transcription through associating with HP1 and LSD1. J Biol Chem (2009) 1.35
Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties. Cancer Res (2011) 1.35
Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1. J Virol (2009) 1.29
Interaction with Suv39H1 is critical for Snail-mediated E-cadherin repression in breast cancer. Oncogene (2012) 1.21
Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. Diabetes (2013) 1.14
Targeting the PELP1-KDM1 axis as a potential therapeutic strategy for breast cancer. Breast Cancer Res (2012) 1.08
Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex. Structure (2011) 1.06
Oxygen in the evolution of complex life and the price we pay. Am J Respir Cell Mol Biol (2008) 1.05
Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation. Invest Ophthalmol Vis Sci (2013) 1.05
Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci (2011) 1.04
LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition. Proc Natl Acad Sci U S A (2012) 1.02
Epigenetic modifications and diabetic retinopathy. Biomed Res Int (2013) 0.97
Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies. Antioxid Redox Signal (2009) 0.95
Retracted NF-Y substitutes H2A-H2B on active cell-cycle promoters: recruitment of CoREST-KDM1 and fine-tuning of H3 methylations. Nucleic Acids Res (2008) 0.94
A selective phenelzine analogue inhibitor of histone demethylase LSD1. ACS Chem Biol (2014) 0.92
Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase. Epigenetics (2015) 0.91
LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing. Nucleic Acids Res (2011) 0.90
Rare event of histone demethylation can initiate singular gene expression of olfactory receptors. Proc Natl Acad Sci U S A (2013) 0.89
Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1. Cell Rep (2014) 0.88
Chromatin-remodelling proteins of the pea aphid, Acyrthosiphon pisum (Harris). Insect Mol Biol (2010) 0.88
Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation. Proc Natl Acad Sci U S A (2015) 0.86
Histone demethylase LSD1-mediated repression of GATA-2 is critical for erythroid differentiation. Drug Des Devel Ther (2015) 0.85
Azalysine analogues as probes for protein lysine deacetylation and demethylation. J Am Chem Soc (2012) 0.84
KDM1 class flavin-dependent protein lysine demethylases. Biopolymers (2015) 0.84
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett (2011) 0.83
Natural Polyphenols Inhibit Lysine-Specific Demethylase-1 in vitro. J Biochem Pharmacol Res (2013) 0.82
Regulation of lipogenic gene expression by lysine-specific histone demethylase-1 (LSD1). J Biol Chem (2014) 0.82
Flavin-dependent enzymes in cancer prevention. Int J Mol Sci (2012) 0.81
Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro Oncol (2015) 0.79
Molecular dynamics simulations indicate an induced-fit mechanism for LSD1/CoREST-H3-histone molecular recognition. BMC Biophys (2013) 0.78
LSD1/KDM1A promotes hematopoietic commitment of hemangioblasts through downregulation of Etv2. Proc Natl Acad Sci U S A (2015) 0.78
CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression. J Cancer Res Clin Oncol (2014) 0.77
Protein demethylation required for DNA methylation. Nat Genet (2009) 0.77
Epigenetic Regulation of Oxidative Stress in Ischemic Stroke. Aging Dis (2016) 0.77
Inhibition of Lysine-Specific Demethylase-1 (LSD1/KDM1A) Promotes the Adipogenic Differentiation of hESCs Through H3K4 Methylation. Stem Cell Rev (2016) 0.76
Concerted hydrogen atom and electron transfer mechanism for catalysis by lysine-specific demethylase. J Phys Chem B (2013) 0.76
G-quadruplex RNA binding and recognition by the lysine-specific histone demethylase-1 enzyme. RNA (2016) 0.76
Lysine-specific demethylase 1 expression in zebrafish during the early stages of neuronal development. Neural Regen Res (2012) 0.75
GATA2 regulates GATA1 expression through LSD1-mediated histone modification. Am J Transl Res (2016) 0.75
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat Struct Biol (2002) 2.30
A novel mammalian flavin-dependent histone demethylase. J Biol Chem (2009) 2.25
Human histone demethylase LSD1 reads the histone code. J Biol Chem (2005) 2.14
Crystal structure of a Baeyer-Villiger monooxygenase. Proc Natl Acad Sci U S A (2004) 2.07
Structural basis of LSD1-CoREST selectivity in histone H3 recognition. J Biol Chem (2007) 1.92
Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res (2009) 1.87
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett (2005) 1.82
Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc Natl Acad Sci U S A (2003) 1.81
Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Sci Transl Med (2012) 1.78
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. Proc Natl Acad Sci U S A (2005) 1.65
Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2. J Am Chem Soc (2010) 1.61
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder. Structure (2007) 1.59
Structure-function relationships in flavoenzyme-dependent amine oxidations: a comparison of polyamine oxidase and monoamine oxidase. J Biol Chem (2002) 1.56
A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1. J Biol Chem (2006) 1.53
Snapshots of enzymatic Baeyer-Villiger catalysis: oxygen activation and intermediate stabilization. J Biol Chem (2011) 1.35
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia. J Biol Chem (2002) 1.34
Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase. Proc Natl Acad Sci U S A (2008) 1.33
ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding. FEBS J (2009) 1.32
Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc Natl Acad Sci U S A (2009) 1.31
PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism. J Biol Chem (2005) 1.26
Synaptic activity controls dendritic spine morphology by modulating eEF2-dependent BDNF synthesis. J Neurosci (2010) 1.25
Multiple pathways guide oxygen diffusion into flavoenzyme active sites. Proc Natl Acad Sci U S A (2009) 1.25
Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B. Arch Biochem Biophys (2007) 1.23
The enigmatic reaction of flavins with oxygen. Trends Biochem Sci (2012) 1.22
Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system. J Neurosci (2010) 1.22
Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases. Biochemistry (2009) 1.21
Functional role of the "aromatic cage" in human monoamine oxidase B: structures and catalytic properties of Tyr435 mutant proteins. Biochemistry (2006) 1.21
Structural studies on flavin reductase PheA2 reveal binding of NAD in an unusual folded conformation and support novel mechanism of action. J Biol Chem (2003) 1.18
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem (2005) 1.18
Structure of the monooxygenase component of a two-component flavoprotein monooxygenase. Proc Natl Acad Sci U S A (2007) 1.13
Antiviral strategies to control calicivirus infections. Antiviral Res (2010) 1.11
Structural studies on the synchronization of catalytic centers in glutamate synthase. J Biol Chem (2002) 1.08
Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class. J Med Chem (2004) 1.08
Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase. Biochemistry (2007) 1.06
Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex. Structure (2011) 1.06
Enzymes without borders: mobilizing substrates, delivering products. Science (2008) 1.06
Stabilization of C4a-hydroperoxyflavin in a two-component flavin-dependent monooxygenase is achieved through interactions at flavin N5 and C4a atoms. J Biol Chem (2011) 1.05
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. Appl Microbiol Biotechnol (2013) 1.04
Crystal structure of human monoamine oxidase B, a drug target enzyme monotopically inserted into the mitochondrial outer membrane. FEBS Lett (2004) 1.04
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem (2007) 1.03
Identification of a gatekeeper residue that prevents dehydrogenases from acting as oxidases. J Biol Chem (2008) 1.01
Joint functions of protein residues and NADP(H) in oxygen activation by flavin-containing monooxygenase. J Biol Chem (2010) 1.01
New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin. FEBS J (2009) 1.01
CoREST represses the heat shock response mediated by HSF1. Mol Cell (2008) 1.00
Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2. J Neurochem (2013) 1.00
New frontiers in structural flavoenzymology. Curr Opin Struct Biol (2006) 0.97
The active conformation of glutamate synthase and its binding to ferredoxin. J Mol Biol (2003) 0.96
Structures of Michaelis and product complexes of plant cytokinin dehydrogenase: implications for flavoenzyme catalysis. J Mol Biol (2004) 0.95
Structure of FAD-bound L-aspartate oxidase: insight into substrate specificity and catalysis. Biochemistry (2002) 0.95
Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis. J Med Chem (2005) 0.93
Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities. J Med Chem (2013) 0.91
The oxygen-binding vs. oxygen-consuming paradigm in biocatalysis: structural biology and biomolecular simulation. Curr Opin Struct Biol (2009) 0.91
The FAD binding sites of human monoamine oxidases A and B. Neurotoxicology (2004) 0.91
Flavoprotein oxidases: classification and applications. Appl Microbiol Biotechnol (2013) 0.90
Exploring the structural basis of substrate preferences in Baeyer-Villiger monooxygenases: insight from steroid monooxygenase. J Biol Chem (2012) 0.89
Differential properties of transcriptional complexes formed by the CoREST family. Mol Cell Biol (2014) 0.89
Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation. J Biol Chem (2013) 0.88
Inactivation of purified human recombinant monoamine oxidases A and B by rasagiline and its analogues. J Med Chem (2004) 0.88
Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases. Biochemistry (2012) 0.88
A covalent modification of NADP+ revealed by the atomic resolution structure of FprA, a Mycobacterium tuberculosis oxidoreductase. Biochemistry (2002) 0.88
Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies. Curr Top Med Chem (2011) 0.87
Evolutionary genomic remodelling of the human 4q subtelomere (4q35.2). BMC Evol Biol (2007) 0.86
Precursor of ether phospholipids is synthesized by a flavoenzyme through covalent catalysis. Proc Natl Acad Sci U S A (2012) 0.86
Structure and biochemical analysis of Kokobera virus helicase. Proteins (2008) 0.85
The 'gating' residues Ile199 and Tyr326 in human monoamine oxidase B function in substrate and inhibitor recognition. FEBS J (2011) 0.84
Interactions of monoamine oxidases with the antiepileptic drug zonisamide: specificity of inhibition and structure of the human monoamine oxidase B complex. J Med Chem (2010) 0.84
Molecular Insights into Human Monoamine Oxidase B Inhibition by the Glitazone Anti-Diabetes Drugs. ACS Med Chem Lett (2011) 0.83
Structure-based redesign of cofactor binding in putrescine oxidase. Biochemistry (2011) 0.83
Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase. ACS Chem Biol (2013) 0.82
Structural and mechanistic studies of arylalkylhydrazine inhibition of human monoamine oxidases A and B. Biochemistry (2008) 0.82
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity. J Med Chem (2014) 0.82
Structural properties of human monoamine oxidases A and B. Int Rev Neurobiol (2011) 0.81