Published in J Biol Chem on April 19, 2002
Asparagine synthetase chemotherapy. Annu Rev Biochem (2006) 1.82
Iron starvation triggers the stringent response and induces amino acid biosynthesis for bacillibactin production in Bacillus subtilis. J Bacteriol (2006) 0.92
Arabidopsis photorespiratory serine hydroxymethyltransferase activity requires the mitochondrial accumulation of ferredoxin-dependent glutamate synthase. Plant Cell (2009) 0.88
Crystallization and structural analysis of GADPH from Spinacia oleracea in a new form. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.88
A novel ferredoxin-dependent glutamate synthase from the hydrogen-oxidizing chemoautotrophic bacterium Hydrogenobacter thermophilus TK-6. J Bacteriol (2007) 0.81
Structural analysis of the wheat genes encoding NADH-dependent glutamine-2-oxoglutarate amidotransferases and correlation with grain protein content. PLoS One (2013) 0.81
A combined theoretical and experimental study of the ammonia tunnel in carbamoyl phosphate synthetase. J Am Chem Soc (2009) 0.81
Ferredoxin-dependent glutamate synthase: involvement in ammonium assimilation in Haloferax mediterranei. Extremophiles (2013) 0.79
Carbamate transport in carbamoyl phosphate synthetase: a theoretical and experimental investigation. J Am Chem Soc (2010) 0.79
Crystallization and preliminary X-ray studies of an electron-transfer complex of ferredoxin and ferredoxin-dependent glutamate synthase from the cyanobacterium Leptolyngbya boryana. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.78
Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding. Nat Commun (2016) 0.76
Molecular dynamics simulation of the interaction between the complex iron-sulfur flavoprotein glutamate synthase and its substrates. Protein Sci (2004) 0.76
Multiple complexes of nitrogen assimilatory enzymes in spinach chloroplasts: possible mechanisms for the regulation of enzyme function. PLoS One (2014) 0.76
Changes in Bacillus anthracis CodY regulation under host-specific environmental factor deprived conditions. BMC Genomics (2016) 0.75
Structure, function, and mechanism of proline utilization A (PutA). Arch Biochem Biophys (2017) 0.75
Identification of the ferredoxin interaction sites on ferredoxin-dependent glutamate synthase from Synechocystis sp. PCC 6803. Photosynth Res (2017) 0.75
Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells. Nat Med (2007) 2.85
The role of TOR in autophagy regulation from yeast to plants and mammals. Autophagy (2008) 2.43
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nat Struct Biol (2002) 2.30
A novel mammalian flavin-dependent histone demethylase. J Biol Chem (2009) 2.25
Graft-versus-host disease is enhanced by extracellular ATP activating P2X7R. Nat Med (2010) 2.17
Human histone demethylase LSD1 reads the histone code. J Biol Chem (2005) 2.14
Calcium and apoptosis: facts and hypotheses. Oncogene (2003) 2.12
Crystal structure of a Baeyer-Villiger monooxygenase. Proc Natl Acad Sci U S A (2004) 2.07
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell (2002) 2.05
Structural basis of LSD1-CoREST selectivity in histone H3 recognition. J Biol Chem (2007) 1.92
Structure and functionality in flavivirus NS-proteins: perspectives for drug design. Antiviral Res (2009) 1.87
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process. FEBS Lett (2005) 1.82
Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures. Proc Natl Acad Sci U S A (2003) 1.81
Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Sci Transl Med (2012) 1.78
Alerting and tuning the immune response by extracellular nucleotides. J Leukoc Biol (2003) 1.69
Three-dimensional structure of human monoamine oxidase A (MAO A): relation to the structures of rat MAO A and human MAO B. Proc Natl Acad Sci U S A (2005) 1.65
Biochemical, structural, and biological evaluation of tranylcypromine derivatives as inhibitors of histone demethylases LSD1 and LSD2. J Am Chem Soc (2010) 1.61
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder. Structure (2007) 1.59
The GATA family of transcription factors in Arabidopsis and rice. Plant Physiol (2004) 1.58
Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth. Mol Biol Cell (2005) 1.58
Ammonium assimilation in cyanobacteria. Photosynth Res (2005) 1.57
Structure-function relationships in flavoenzyme-dependent amine oxidations: a comparison of polyamine oxidase and monoamine oxidase. J Biol Chem (2002) 1.56
Arsenic sensing and resistance system in the cyanobacterium Synechocystis sp. strain PCC 6803. J Bacteriol (2003) 1.56
Histone H2A.Z and homologues of components of the SWR1 complex are required to control immunity in Arabidopsis. Plant J (2007) 1.55
LSD1: oxidative chemistry for multifaceted functions in chromatin regulation. Trends Biochem Sci (2008) 1.54
A highly specific mechanism of histone H3-K4 recognition by histone demethylase LSD1. J Biol Chem (2006) 1.53
Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells. Mol Biol Cell (2003) 1.49
Inhibition of target of rapamycin signaling and stress activate autophagy in Chlamydomonas reinhardtii. Plant Physiol (2010) 1.46
The serotoninergic receptors of human dendritic cells: identification and coupling to cytokine release. J Immunol (2004) 1.44
Stimulation of P2 receptors causes release of IL-1beta-loaded microvesicles from human dendritic cells. Blood (2006) 1.41
Iron incorporation into Escherichia coli Dps gives rise to a ferritin-like microcrystalline core. J Biol Chem (2002) 1.40
Inhibition of target of rapamycin signaling by rapamycin in the unicellular green alga Chlamydomonas reinhardtii. Plant Physiol (2005) 1.40
Snapshots of enzymatic Baeyer-Villiger catalysis: oxygen activation and intermediate stabilization. J Biol Chem (2011) 1.35
A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803. Mol Microbiol (2002) 1.35
Structure and function of human erythrocyte pyruvate kinase. Molecular basis of nonspherocytic hemolytic anemia. J Biol Chem (2002) 1.34
Thioredoxin-linked processes in cyanobacteria are as numerous as in chloroplasts, but targets are different. Proc Natl Acad Sci U S A (2003) 1.33
Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase. Proc Natl Acad Sci U S A (2008) 1.33
ThermoFAD, a Thermofluor-adapted flavin ad hoc detection system for protein folding and ligand binding. FEBS J (2009) 1.32
Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization. Proc Natl Acad Sci U S A (2009) 1.31
5-Hydroxytryptamine modulates cytokine and chemokine production in LPS-primed human monocytes via stimulation of different 5-HTR subtypes. Int Immunol (2005) 1.30
Extracellular adenosine triphosphate and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.30
P2X7 receptor signaling in the pathogenesis of smoke-induced lung inflammation and emphysema. Am J Respir Cell Mol Biol (2010) 1.27
Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein. J Biol Chem (2003) 1.26
A potential role for P2X7R in allergic airway inflammation in mice and humans. Am J Respir Cell Mol Biol (2010) 1.26
Multiple pathways guide oxygen diffusion into flavoenzyme active sites. Proc Natl Acad Sci U S A (2009) 1.25
P2X(7): a growth-promoting receptor-implications for cancer. Purinergic Signal (2009) 1.24
Sphingosine 1-phosphate induces chemotaxis of immature and modulates cytokine-release in mature human dendritic cells for emergence of Th2 immune responses. FASEB J (2002) 1.24
Structural insights into the mechanism of amine oxidation by monoamine oxidases A and B. Arch Biochem Biophys (2007) 1.23
Activation of microglia by amyloid {beta} requires P2X7 receptor expression. J Immunol (2009) 1.23
The enigmatic reaction of flavins with oxygen. Trends Biochem Sci (2012) 1.22
Alternative splicing of the histone demethylase LSD1/KDM1 contributes to the modulation of neurite morphogenesis in the mammalian nervous system. J Neurosci (2010) 1.22
The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. Am J Respir Cell Mol Biol (2005) 1.21
Molecular and mechanistic properties of the membrane-bound mitochondrial monoamine oxidases. Biochemistry (2009) 1.21
Functional role of the "aromatic cage" in human monoamine oxidase B: structures and catalytic properties of Tyr435 mutant proteins. Biochemistry (2006) 1.21
Increased P2X7 receptor expression and function in thyroid papillary cancer: a new potential marker of the disease? Endocrinology (2007) 1.19
Structural studies on flavin reductase PheA2 reveal binding of NAD in an unusual folded conformation and support novel mechanism of action. J Biol Chem (2003) 1.18
Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors. J Biol Chem (2005) 1.18
The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration. Blood (2006) 1.17
SEF, a new protein required for flowering repression in Arabidopsis, interacts with PIE1 and ARP6. Plant Physiol (2006) 1.16
P2X(7) receptor: Death or life? Purinergic Signal (2005) 1.13
Structure of the monooxygenase component of a two-component flavoprotein monooxygenase. Proc Natl Acad Sci U S A (2007) 1.13
Antiviral strategies to control calicivirus infections. Antiviral Res (2010) 1.11
The glutathione/glutaredoxin system is essential for arsenate reduction in Synechocystis sp. strain PCC 6803. J Bacteriol (2009) 1.11
Purinergic receptor inhibition prevents the development of smoke-induced lung injury and emphysema. J Immunol (2010) 1.11
Stimulation of P2 (P2X7) receptors in human dendritic cells induces the release of tissue factor-bearing microparticles. FASEB J (2007) 1.11
5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo. PLoS One (2009) 1.10
A role for P2X7 in microglial proliferation. J Neurochem (2006) 1.10
Upregulation of interferon-alpha and RANTES in the cervix of HIV-1-seronegative women with high-risk behavior. J Acquir Immune Defic Syndr (2006) 1.09
Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class. J Med Chem (2004) 1.08
The CopRS two-component system is responsible for resistance to copper in the cyanobacterium Synechocystis sp. PCC 6803. Plant Physiol (2012) 1.08
Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors. Blood (2002) 1.08
Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo. Blood (2004) 1.07
Structural analysis of the catalytic mechanism and stereoselectivity in Streptomyces coelicolor alditol oxidase. Biochemistry (2007) 1.06
Stimulation of P2 purinergic receptors induces the release of eosinophil cationic protein and interleukin-8 from human eosinophils. Br J Pharmacol (2003) 1.06
Molecular mimicry and ligand recognition in binding and catalysis by the histone demethylase LSD1-CoREST complex. Structure (2011) 1.06
Enzymes without borders: mobilizing substrates, delivering products. Science (2008) 1.06
Abundant and superficial expression of C-type lectin receptors in ectocervix of women at risk of HIV infection. J Acquir Immune Defic Syndr (2009) 1.05
Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation. Am J Respir Crit Care Med (2011) 1.05
Stabilization of C4a-hydroperoxyflavin in a two-component flavin-dependent monooxygenase is achieved through interactions at flavin N5 and C4a atoms. J Biol Chem (2011) 1.05
The DprE1 enzyme, one of the most vulnerable targets of Mycobacterium tuberculosis. Appl Microbiol Biotechnol (2013) 1.04
Crystal structure of human monoamine oxidase B, a drug target enzyme monotopically inserted into the mitochondrial outer membrane. FEBS Lett (2004) 1.04
The sixth sense: hematopoietic stem cells detect danger through purinergic signaling. Blood (2012) 1.03
Overoxidation of 2-Cys peroxiredoxin in prokaryotes: cyanobacterial 2-Cys peroxiredoxins sensitive to oxidative stress. J Biol Chem (2010) 1.03
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem (2007) 1.03
Thioredoxin targets of the plant chloroplast lumen and their implications for plastid function. Proteomics (2010) 1.01
Identification of a gatekeeper residue that prevents dehydrogenases from acting as oxidases. J Biol Chem (2008) 1.01
Joint functions of protein residues and NADP(H) in oxygen activation by flavin-containing monooxygenase. J Biol Chem (2010) 1.01
New roles of flavoproteins in molecular cell biology: histone demethylase LSD1 and chromatin. FEBS J (2009) 1.01
Extracellular purines promote the differentiation of human bone marrow-derived mesenchymal stem cells to the osteogenic and adipogenic lineages. Stem Cells Dev (2012) 1.01
Phosphorylation of neuronal Lysine-Specific Demethylase 1LSD1/KDM1A impairs transcriptional repression by regulating interaction with CoREST and histone deacetylases HDAC1/2. J Neurochem (2013) 1.00
Extracellular ATP exerts opposite effects on activated and regulatory CD4+ T cells via purinergic P2 receptor activation. J Immunol (2012) 0.99
New frontiers in structural flavoenzymology. Curr Opin Struct Biol (2006) 0.97
Target of rapamycin and LST8 proteins associate with membranes from the endoplasmic reticulum in the unicellular green alga Chlamydomonas reinhardtii. Eukaryot Cell (2007) 0.97
Selecting thioredoxins for disulphide proteomics: target proteomes of three thioredoxins from the cyanobacterium Synechocystis sp. PCC 6803. Proteomics (2006) 0.96
The active conformation of glutamate synthase and its binding to ferredoxin. J Mol Biol (2003) 0.96
Structures of Michaelis and product complexes of plant cytokinin dehydrogenase: implications for flavoenzyme catalysis. J Mol Biol (2004) 0.95