Published in Chembiochem on May 05, 2008
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Proc Natl Acad Sci U S A (2010) 1.30
Controlling reaction specificity in pyridoxal phosphate enzymes. Biochim Biophys Acta (2011) 1.06
Allosteric regulation of substrate channeling and catalysis in the tryptophan synthase bienzyme complex. Arch Biochem Biophys (2012) 1.03
Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry (2013) 0.98
Inhibition of Mycobacterium tuberculosis transaminase BioA by aryl hydrazines and hydrazides. Chembiochem (2014) 0.86
The role of oligomerization and cooperative regulation in protein function: the case of tryptophan synthase. PLoS Comput Biol (2010) 0.84
T-Analyst: a program for efficient analysis of protein conformational changes by torsion angles. J Comput Aided Mol Des (2010) 0.82
Severing of a hydrogen bond disrupts amino acid networks in the catalytically active state of the alpha subunit of tryptophan synthase. Protein Sci (2014) 0.82
Crystallographic snapshots of tyrosine phenol-lyase show that substrate strain plays a role in C-C bond cleavage. J Am Chem Soc (2011) 0.82
Insights into the catalytic mechanism of tyrosine phenol-lyase from X-ray structures of quinonoid intermediates. J Biol Chem (2008) 0.81
Tryptophan synthase: structure and function of the monovalent cation site. Biochemistry (2009) 0.81
NMR crystallography of enzyme active sites: probing chemically detailed, three-dimensional structure in tryptophan synthase. Acc Chem Res (2013) 0.79
Catalytic roles of βLys87 in tryptophan synthase: (15)N solid state NMR studies. Biochim Biophys Acta (2015) 0.79
Protonation states and catalysis: Molecular dynamics studies of intermediates in tryptophan synthase. Protein Sci (2015) 0.77
Switches of hydrogen bonds during ligand-protein association processes determine binding kinetics. J Mol Recognit (2014) 0.76
Effects of hydrostatic pressure on the conformational equilibrium of tryptophan synthase from Salmonella typhimurium. Ann N Y Acad Sci (2010) 0.75
Femtosecond X-ray protein nanocrystallography. Nature (2011) 14.34
A genetically encoded photoactivatable Rac controls the motility of living cells. Nature (2009) 7.25
High-resolution protein structure determination by serial femtosecond crystallography. Science (2012) 6.90
Structure and chemistry of cytochrome P450. Chem Rev (2005) 5.85
Single mimivirus particles intercepted and imaged with an X-ray laser. Nature (2011) 4.63
Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements. Nat Photonics (2012) 3.68
Lipidic phase membrane protein serial femtosecond crystallography. Nat Methods (2012) 2.76
In vivo protein crystallization opens new routes in structural biology. Nat Methods (2012) 2.69
Time-resolved protein nanocrystallography using an X-ray free-electron laser. Opt Express (2012) 2.38
Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase. Nature (2009) 2.15
Crystal structures and molecular mechanism of a light-induced signaling switch: The Phot-LOV1 domain from Chlamydomonas reinhardtii. Biophys J (2003) 2.08
Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser. Phys Rev B Condens Matter Mater Phys (2011) 2.05
Crystal structure and mechanism of a DNA (6-4) photolyase. Angew Chem Int Ed Engl (2008) 1.76
Alternative splicing of Rac1 generates Rac1b, a self-activating GTPase. J Biol Chem (2003) 1.71
Cryoradiolytic reduction of crystalline heme proteins: analysis by UV-Vis spectroscopy and X-ray crystallography. J Synchrotron Radiat (2006) 1.67
The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A (2004) 1.57
Structural insights into the interaction of ROCKI with the switch regions of RhoA. J Biol Chem (2003) 1.44
Structure of a bacterial BLUF photoreceptor: insights into blue light-mediated signal transduction. Proc Natl Acad Sci U S A (2005) 1.43
Anomalous signal from S atoms in protein crystallographic data from an X-ray free-electron laser. Acta Crystallogr D Biol Crystallogr (2013) 1.42
Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37
A survey of active site access channels in cytochromes P450. J Inorg Biochem (2004) 1.32
Tryptophan synthase: the workings of a channeling nanomachine. Trends Biochem Sci (2008) 1.31
Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. Proc Natl Acad Sci U S A (2008) 1.29
Unsupervised classification of single-particle X-ray diffraction snapshots by spectral clustering. Opt Express (2011) 1.27
Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment. Proc Natl Acad Sci U S A (2006) 1.26
Crystal structures of the AppA BLUF domain photoreceptor provide insights into blue light-mediated signal transduction. J Mol Biol (2006) 1.24
The status of high-valent metal oxo complexes in the P450 cytochromes. J Inorg Biochem (2006) 1.22
Crystallography on a chip. Acta Crystallogr D Biol Crystallogr (2012) 1.17
Crystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesis. J Biol Chem (2002) 1.16
Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Structure (2006) 1.15
Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design. Proc Natl Acad Sci U S A (2004) 1.11
Structure and quantum chemical characterization of chloroperoxidase compound 0, a common reaction intermediate of diverse heme enzymes. Proc Natl Acad Sci U S A (2006) 1.11
Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s. Annu Rev Biochem (2004) 1.09
Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes. J Biol Chem (2010) 1.08
Femtosecond free-electron laser x-ray diffraction data sets for algorithm development. Opt Express (2012) 1.07
Molecular models predict light-induced glutamine tautomerization in BLUF photoreceptors. Biophys J (2008) 1.05
Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis. J Biol Chem (2003) 1.05
X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase. J Am Chem Soc (2010) 1.05
Toward unsupervised single-shot diffractive imaging of heterogeneous particles using X-ray free-electron lasers. Opt Express (2013) 1.04
Serial femtosecond X-ray diffraction of 30S ribosomal subunit microcrystals in liquid suspension at ambient temperature using an X-ray free-electron laser. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 1.04
Optimal mapping of x-ray laser diffraction patterns into three dimensions using routing algorithms. Phys Rev E Stat Nonlin Soft Matter Phys (2013) 1.03
Comparative functional analysis of the Rac GTPases. FEBS Lett (2003) 1.03
Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry. Biochemistry (2007) 1.02
Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase-structural models of the short-lived oxygen complexes. Arch Biochem Biophys (2003) 1.02
Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proc Natl Acad Sci U S A (2009) 1.01
Altered HCN4 channel C-linker interaction is associated with familial tachycardia-bradycardia syndrome and atrial fibrillation. Eur Heart J (2012) 1.01
A ternary AppA-PpsR-DNA complex mediates light regulation of photosynthesis-related gene expression. Nat Struct Mol Biol (2013) 1.01
Decrypting cryptochrome: revealing the molecular identity of the photoactivation reaction. J Am Chem Soc (2012) 1.01
Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme. Nucleic Acids Res (2012) 0.99
Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms. J Biol Chem (2003) 0.99
Allosteric regulation of substrate channeling in tryptophan synthase: modulation of the L-serine reaction in stage I of the beta-reaction by alpha-site ligands. Biochemistry (2007) 0.98
Allostery and substrate channeling in the tryptophan synthase bienzyme complex: evidence for two subunit conformations and four quaternary states. Biochemistry (2013) 0.98
Sensing the wavefront of x-ray free-electron lasers using aerosol spheres. Opt Express (2013) 0.97
Synthesis and characterization of allosteric probes of substrate channeling in the tryptophan synthase bienzyme complex. Biochemistry (2007) 0.96
Production and X-ray crystallographic analysis of fully deuterated cytochrome P450cam. Acta Crystallogr D Biol Crystallogr (2005) 0.96
Proteome analysis of aerobic and fermentative metabolism in Rhizobium etli CE3. Proteomics (2003) 0.95
The Rhizobium etli bioMNY operon is involved in biotin transport. FEMS Microbiol Lett (2005) 0.94
Crystal structures of chloroperoxidase with its bound substrates and complexed with formate, acetate, and nitrate. J Biol Chem (2006) 0.94
Quantum mechanical/molecular mechanical study on the mechanisms of compound I formation in the catalytic cycle of chloroperoxidase: an overview on heme enzymes. J Phys Chem B (2008) 0.94
Primary reactions of the LOV2 domain of phototropin studied with ultrafast mid-infrared spectroscopy and quantum chemistry. Biophys J (2009) 0.94
Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. J Med Chem (2005) 0.93
Tryptophan synthase, an allosteric molecular factory. Curr Opin Chem Biol (2008) 0.93
The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes. Proc Natl Acad Sci U S A (2009) 0.92
AniA regulates reserve polymer accumulation and global protein expression in Rhizobium etli. J Bacteriol (2002) 0.92
Coherent infrared emission from myoglobin crystals: an electric field measurement. Proc Natl Acad Sci U S A (2002) 0.91
On the role of alphaThr183 in the allosteric regulation and catalytic mechanism of tryptophan synthase. J Mol Biol (2002) 0.91
Participation of glutamate-354 of the CP43 polypeptide in the ligation of manganese and the binding of substrate water in photosystem II. Biochemistry (2010) 0.90
Structure of the molybdenum site in YedY, a sulfite oxidase homologue from Escherichia coli. Inorg Chem (2010) 0.90
Structural and biochemical characterization of the cytochrome P450 CypX (CYP134A1) from Bacillus subtilis: a cyclo-L-leucyl-L-leucyl dipeptide oxidase. Biochemistry (2010) 0.89
Crystal structures of substrate-free and retinoic acid-bound cyanobacterial cytochrome P450 CYP120A1. Biochemistry (2008) 0.89
Production of prodigiosin and chitinases by tropical Serratia marcescens strains with potential to control plant pathogens. World J Microbiol Biotechnol (2011) 0.89
Glutamine rotamers in BLUF photoreceptors: a mechanistic reappraisal. J Phys Chem B (2013) 0.89
Evolution of a new enzyme for carbon disulphide conversion by an acidothermophilic archaeon. Nature (2011) 0.89
Proton transfers in the beta-reaction catalyzed by tryptophan synthase. Biochemistry (2002) 0.88
Inactivation and activation of Ras by the neurotrophin receptor p75. Eur J Neurosci (2004) 0.88
Protonation states of the tryptophan synthase internal aldimine active site from solid-state NMR spectroscopy: direct observation of the protonated Schiff base linkage to pyridoxal-5'-phosphate. J Am Chem Soc (2014) 0.88
Combining crystallography and EPR: crystal and solution structures of the multidomain cochaperone DnaJ. Acta Crystallogr D Biol Crystallogr (2013) 0.88
Photoreaction in BLUF receptors: proton-coupled electron transfer in the flavin-Gln-Tyr system. Photochem Photobiol (2011) 0.88
Electronic structure of (6-4) DNA photoproduct repair involving a non-oxetane pathway. J Am Chem Soc (2009) 0.87
Irreversible photoreduction of flavin in a mutated Phot-LOV1 domain. Biochemistry (2003) 0.87
Intermediate trapping via a conformational switch in the Na(+)-activated tryptophan synthase bienzyme complex. Biochemistry (2002) 0.87