Structure and chemistry of cytochrome P450.

Thermochemistry of proton-coupled electron transfer reagents and its implications. Chem Rev (2010) 2.64

In crystallo posttranslational modification within a MauG/pre-methylamine dehydrogenase complex. Science (2010) 2.38

Hydrocarbon hydroxylation by cytochrome P450 enzymes. Chem Rev (2010) 2.34

SyrB2 in syringomycin E biosynthesis is a nonheme FeII alpha-ketoglutarate- and O2-dependent halogenase. Proc Natl Acad Sci U S A (2005) 2.12

Dioxygen activation in soluble methane monooxygenase. Acc Chem Res (2011) 2.07

Characterization of the arene-oxidizing intermediate in ToMOH as a diiron(III) species. J Am Chem Soc (2007) 1.60

Solid-state NMR reveals structural and dynamical properties of a membrane-anchored electron-carrier protein, cytochrome b5. J Am Chem Soc (2007) 1.53

Evolutionary history of a specialized p450 propane monooxygenase. J Mol Biol (2008) 1.40

Identification and structural basis of the reaction catalyzed by CYP121, an essential cytochrome P450 in Mycobacterium tuberculosis. Proc Natl Acad Sci U S A (2009) 1.38

The Structure of Mycobacterium tuberculosis CYP125: molecular basis for cholesterol binding in a P450 needed for host infection. J Biol Chem (2009) 1.38

Cytochrome p450 compound I. J Am Chem Soc (2006) 1.37

Redox potential control by drug binding to cytochrome P450 3A4. J Am Chem Soc (2007) 1.34

Cytochromes P450 in nanodiscs. Biochim Biophys Acta (2010) 1.31

Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450. J Phys Chem A (2008) 1.30

Revisiting the mechanism of dioxygen activation in soluble methane monooxygenase from M. capsulatus (Bath): evidence for a multi-step, proton-dependent reaction pathway. Biochemistry (2009) 1.26

Synthesis, characterization, and reactivities of manganese(V)-oxo porphyrin complexes. J Am Chem Soc (2007) 1.25

Unusual cytochrome p450 enzymes and reactions. J Biol Chem (2013) 1.24

Photochemical production of a highly reactive porphyrin-iron-oxo species. Inorg Chem (2007) 1.23

Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes. Free Radic Biol Med (2010) 1.19

Modulation of the cytochrome P450 reductase redox potential by the phospholipid bilayer. Biochemistry (2009) 1.19

Kinetics of two-electron oxidations by the compound I derivative of chloroperoxidase, a model for cytochrome P450 oxidants. Org Lett (2006) 1.18

Cytochrome P450–catalyzed L-tryptophan nitration in thaxtomin phytotoxin biosynthesis. Nat Chem Biol (2012) 1.17

The Mycobacterium tuberculosis cytochrome P450 system. Arch Biochem Biophys (2009) 1.16

Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation. J Am Chem Soc (2013) 1.15

tert-Butylphenylacetylene is a potent mechanism-based inactivator of cytochrome P450 2B4: inhibition of cytochrome P450 catalysis by steric hindrance. Mol Pharmacol (2009) 1.15

X-ray absorption spectroscopic characterization of a cytochrome P450 compound II derivative. Proc Natl Acad Sci U S A (2008) 1.13

Reactive intermediates in cytochrome p450 catalysis. J Biol Chem (2013) 1.13

Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium. Biochim Biophys Acta (2009) 1.12

Enzymatic functionalization of carbon-hydrogen bonds. Chem Soc Rev (2010) 1.11

Catalytic reduction of a tetrahydrobiopterin radical within nitric-oxide synthase. J Biol Chem (2008) 1.11

Structure and quantum chemical characterization of chloroperoxidase compound 0, a common reaction intermediate of diverse heme enzymes. Proc Natl Acad Sci U S A (2006) 1.11

Active intermediates in heme monooxygenase reactions as revealed by cryoreduction/annealing, EPR/ENDOR studies. Arch Biochem Biophys (2010) 1.10

Substrate binding to cytochromes P450. Anal Bioanal Chem (2008) 1.09

Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes. Phytochemistry (2009) 1.09

Resonance Raman detection of the hydroperoxo intermediate in the cytochrome P450 enzymatic cycle. J Am Chem Soc (2007) 1.08

Characterization of a high-spin non-heme Fe(III)-OOH intermediate and its quantitative conversion to an Fe(IV)═O complex. J Am Chem Soc (2011) 1.08

Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate. J Biol Chem (2009) 1.06

Efficient incorporation of protein flexibility and dynamics into molecular docking simulations. Biochemistry (2011) 1.06

The effects of acute hydrogen sulfide poisoning on cytochrome P450 isoforms activity in rats. Biomed Res Int (2014) 1.05

Three clusters of conformational states in p450cam reveal a multistep pathway for closing of the substrate access channel. Biochemistry (2011) 1.05

Photooxidation of cytochrome P450-BM3. Proc Natl Acad Sci U S A (2010) 1.05

Improved ligand-protein binding affinity predictions using multiple binding modes. Biophys J (2010) 1.04

Structural differences between soluble and membrane bound cytochrome P450s. J Inorg Biochem (2011) 1.04

A suite of activity-based probes for human cytochrome P450 enzymes. J Am Chem Soc (2009) 1.03

Chemical proteomic probes for profiling cytochrome p450 activities and drug interactions in vivo. Chem Biol (2007) 1.03

Understanding how the thiolate sulfur contributes to the function of the non-heme iron enzyme superoxide reductase. Acc Chem Res (2007) 1.03

Dioxygen activation at non-heme diiron centers: oxidation of a proximal residue in the I100W variant of toluene/o-xylene monooxygenase hydroxylase. Biochemistry (2007) 1.03

Manganese catalysts for C-H activation: an experimental/theoretical study identifies the stereoelectronic factor that controls the switch between hydroxylation and desaturation pathways. J Am Chem Soc (2010) 1.01

Probing the role of the proximal heme ligand in cytochrome P450cam by recombinant incorporation of selenocysteine. Proc Natl Acad Sci U S A (2009) 1.01

Regio- and stereoselectivity of P450-catalysed hydroxylation of steroids controlled by laboratory evolution. Nat Chem (2011) 1.00

Comparison of the complexes formed by cytochrome P450cam with cytochrome b5 and putidaredoxin, two effectors of camphor hydroxylase activity. Biochemistry (2006) 1.00

Rational tuning of the thiolate donor in model complexes of superoxide reductase: direct evidence for a trans influence in Fe(III)-OOR complexes. J Am Chem Soc (2008) 0.99

Prediction of high-valent iron K-edge absorption spectra by time-dependent density functional theory. Dalton Trans (2011) 0.99

Spectroscopic features of cytochrome P450 reaction intermediates. Arch Biochem Biophys (2010) 0.98

Influence of the nitrogen donors on nonheme iron models of superoxide reductase: high-spin Fe(III)-OOR complexes. J Am Chem Soc (2010) 0.98

The ferrous-oxy complex of human aromatase. Biochem Biophys Res Commun (2008) 0.98

Elucidating the role of the proximal cysteine hydrogen-bonding network in ferric cytochrome P450cam and corresponding mutants using magnetic circular dichroism spectroscopy. Biochemistry (2011) 0.97

Correlated single-crystal electronic absorption spectroscopy and X-ray crystallography at NSLS beamline X26-C. J Synchrotron Radiat (2011) 0.97

Development of nitric oxide synthase inhibitors for neurodegeneration and neuropathic pain. Chem Soc Rev (2014) 0.97

Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones. ACS Catal (2015) 0.97

Structure and reaction mechanism in the heme dioxygenases. Biochemistry (2011) 0.96

An efficient light-driven P450 BM3 biocatalyst. J Am Chem Soc (2013) 0.96

Laser flash photolysis generation of high-valent transition metal-oxo species: insights from kinetic studies in real time. Acc Chem Res (2008) 0.95

Solution NMR structure of putidaredoxin-cytochrome P450cam complex via a combined residual dipolar coupling-spin labeling approach suggests a role for Trp106 of putidaredoxin in complex formation. J Mol Biol (2008) 0.95

Molecular probes of the mechanism of cytochrome P450. Oxygen traps a substrate radical intermediate. Arch Biochem Biophys (2010) 0.95

Microsomal monooxygenase as a multienzyme system: the role of P450-P450 interactions. Expert Opin Drug Metab Toxicol (2011) 0.94

Enhanced electron-transfer reactivity of nonheme manganese(IV)-oxo complexes by binding scandium ions. J Am Chem Soc (2013) 0.94

Periodic trends within a series of five-coordinate thiolate-ligated [MII(SMe2N4(tren))]+ (M = Mn, Fe, Co, Ni, Cu, Zn) complexes, including a rare example of a stable CuII-thiolate. Inorg Chem (2007) 0.94

The conformation of P450cam in complex with putidaredoxin is dependent on oxidation state. J Am Chem Soc (2013) 0.94

Crystal structure of H2O2-dependent cytochrome P450SPalpha with its bound fatty acid substrate: insight into the regioselective hydroxylation of fatty acids at the alpha position. J Biol Chem (2011) 0.93

Kinetics and mechanism of oxidation reactions of porphyrin-iron(IV)-oxo intermediates. Inorg Chem (2007) 0.93

Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules. Mol Inform (2012) 0.93

Dramatic influence of an anionic donor on the oxygen-atom transfer reactivity of a Mn(V) -oxo complex. Chemistry (2014) 0.92

Binding of a cyano- and fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response. J Biol Chem (2013) 0.92

S K-edge XAS and DFT calculations on cytochrome P450: covalent and ionic contributions to the cysteine-Fe bond and their contribution to reactivity. J Am Chem Soc (2009) 0.92

Activation of a high-valent manganese-oxo complex by a nonmetallic Lewis acid. Inorg Chem (2014) 0.92

Kinetic solvent isotope effect in human P450 CYP17A1-mediated androgen formation: evidence for a reactive peroxoanion intermediate. J Am Chem Soc (2013) 0.92

Overview of extracellular microvesicles in drug metabolism. Expert Opin Drug Metab Toxicol (2010) 0.91

Differential hydrogen bonding in human CYP17 dictates hydroxylation versus lyase chemistry. Angew Chem Int Ed Engl (2013) 0.91

Lessons on O2 and NO bonding to heme from ab initio multireference/multiconfiguration and DFT calculations. J Biol Inorg Chem (2011) 0.90

Genome mining in streptomyces. Discovery of an unprecedented P450-catalyzed oxidative rearrangement that is the final step in the biosynthesis of pentalenolactone. J Am Chem Soc (2011) 0.90

Structure and biochemical properties of the alkene producing cytochrome P450 OleTJE (CYP152L1) from the Jeotgalicoccus sp. 8456 bacterium. J Biol Chem (2014) 0.89

Cryoradiolytic reduction of heme proteins: Maximizing dose dependent yield. Radiat Phys Chem Oxf Engl 1993 (2007) 0.89

Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W. Arch Biochem Biophys (2007) 0.89

Oxygen activation by cytochrome P450 monooxygenase. Photosynth Res (2008) 0.89

Oxygen-atom transfer reactivity of axially ligated Mn(V)-oxo complexes: evidence for enhanced electrophilic and nucleophilic pathways. J Am Chem Soc (2014) 0.89

Light-initiated hydroxylation of lauric acid using hybrid P450 BM3 enzymes. Chem Commun (Camb) (2011) 0.89

Light-driven, proton-controlled, catalytic aerobic C-H oxidation mediated by a Mn(III) porphyrinoid complex. J Am Chem Soc (2015) 0.89

Spin-state-dependent oxygen sensitivity of iron dithiolates: sulfur oxygenation or disulfide formation. J Biol Inorg Chem (2008) 0.88

Coupled electron transfer and proton hopping in the final step of CYP19-catalyzed androgen aromatization. Biochemistry (2012) 0.88

A ligand field chemistry of oxygen generation by the oxygen-evolving complex and synthetic active sites. Philos Trans R Soc Lond B Biol Sci (2008) 0.88

Active site proton delivery and the lyase activity of human CYP17A1. Biochem Biophys Res Commun (2013) 0.87

One-electron oxidation of an oxoiron(IV) complex to form an [O═FeV═NR]+ center. Proc Natl Acad Sci U S A (2012) 0.87

Mn(V)(O) versus Cr(V)(O) Porphyrinoid Complexes: Structural Characterization and Implications for Basicity Controlling H-Atom Abstraction. J Am Chem Soc (2015) 0.87

The lung cancer breath signature: a comparative analysis of exhaled breath and air sampled from inside the lungs. Sci Rep (2015) 0.87

A single-site mutation (F429H) converts the enzyme CYP 2B4 into a heme oxygenase: a QM/MM study. J Am Chem Soc (2012) 0.87

Breakdown of Chlorophyll in Higher Plants-Phyllobilins as Abundant, Yet Hardly Visible Signs of Ripening, Senescence, and Cell Death. Angew Chem Int Ed Engl (2016) 0.87

Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactions. Biochemistry (2011) 0.87

Compound I is the reactive intermediate in the first monooxygenation step during conversion of cholesterol to pregnenolone by cytochrome P450scc: EPR/ENDOR/cryoreduction/annealing studies. J Am Chem Soc (2012) 0.86

Bioinorganic chemistry: Model offers intermediate insight. Nature (2010) 0.86

Femtosecond X-ray protein nanocrystallography. Nature (2011) 14.34

A genetically encoded photoactivatable Rac controls the motility of living cells. Nature (2009) 7.25

High-resolution protein structure determination by serial femtosecond crystallography. Science (2012) 6.90

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature (2010) 6.25

Single mimivirus particles intercepted and imaged with an X-ray laser. Nature (2011) 4.63

Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements. Nat Photonics (2012) 3.68

Membrane protein assembly into Nanodiscs. FEBS Lett (2009) 3.58

Applications of phospholipid bilayer nanodiscs in the study of membranes and membrane proteins. Biochemistry (2007) 3.21

Transducin activation by nanoscale lipid bilayers containing one and two rhodopsins. J Biol Chem (2007) 3.07

Lipidic phase membrane protein serial femtosecond crystallography. Nat Methods (2012) 2.76

In vivo protein crystallization opens new routes in structural biology. Nat Methods (2012) 2.69

Self-assembly of single integral membrane proteins into soluble nanoscale phospholipid bilayers. Protein Sci (2003) 2.62

Nanodiscs separate chemoreceptor oligomeric states and reveal their signaling properties. Proc Natl Acad Sci U S A (2006) 2.52

Recreation of the terminal events in physiological integrin activation. J Cell Biol (2010) 2.48

Time-resolved protein nanocrystallography using an X-ray free-electron laser. Opt Express (2012) 2.38

Functional reconstitution of Beta2-adrenergic receptors utilizing self-assembling Nanodisc technology. Biotechniques (2006) 2.22

Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase. Nature (2009) 2.15

Homotropic cooperativity of monomeric cytochrome P450 3A4 in a nanoscale native bilayer environment. Arch Biochem Biophys (2004) 2.11

Cooperativity in cytochrome P450 3A4: linkages in substrate binding, spin state, uncoupling, and product formation. J Biol Chem (2007) 2.11

Crystal structures and molecular mechanism of a light-induced signaling switch: The Phot-LOV1 domain from Chlamydomonas reinhardtii. Biophys J (2003) 2.08

Radiation damage in protein serial femtosecond crystallography using an x-ray free-electron laser. Phys Rev B Condens Matter Mater Phys (2011) 2.05

Single-molecule height measurements on microsomal cytochrome P450 in nanometer-scale phospholipid bilayer disks. Proc Natl Acad Sci U S A (2002) 1.98

The local phospholipid environment modulates the activation of blood clotting. J Biol Chem (2007) 1.91

Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA. EMBO J (2007) 1.81

Crystal structure and mechanism of a DNA (6-4) photolyase. Angew Chem Int Ed Engl (2008) 1.76

Assembly of single bacteriorhodopsin trimers in bilayer nanodiscs. Arch Biochem Biophys (2006) 1.68

Cryoradiolytic reduction of crystalline heme proteins: analysis by UV-Vis spectroscopy and X-ray crystallography. J Synchrotron Radiat (2006) 1.67

Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding. J Biol Chem (2010) 1.66

Thermotropic phase transition in soluble nanoscale lipid bilayers. J Phys Chem B (2005) 1.61

The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proc Natl Acad Sci U S A (2004) 1.57

Kinetic characterization of compound I formation in the thermostable cytochrome P450 CYP119. J Biol Chem (2002) 1.54

Molecular dynamics simulations of discoidal bilayers assembled from truncated human lipoproteins. Biophys J (2004) 1.53

Direct solubilization of heterologously expressed membrane proteins by incorporation into nanoscale lipid bilayers. Biotechniques (2003) 1.48

Phospholipid phase transitions in homogeneous nanometer scale bilayer discs. FEBS Lett (2004) 1.44

Magic-angle spinning solid-state NMR spectroscopy of nanodisc-embedded human CYP3A4. Biochemistry (2007) 1.44

Structure of a bacterial BLUF photoreceptor: insights into blue light-mediated signal transduction. Proc Natl Acad Sci U S A (2005) 1.43

Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs: the effect of model membranes. J Biol Chem (2007) 1.42

Anomalous signal from S atoms in protein crystallographic data from an X-ray free-electron laser. Acta Crystallogr D Biol Crystallogr (2013) 1.42

The ferrous-dioxygen intermediate in human cytochrome P450 3A4. Substrate dependence of formation and decay kinetics. J Biol Chem (2006) 1.38

Thermophilic cytochrome P450 (CYP119) from Sulfolobus solfataricus: high resolution structure and functional properties. J Inorg Biochem (2002) 1.37

Cytochrome p450 compound I. J Am Chem Soc (2006) 1.37

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Mol Cell (2003) 1.37

Redox potential control by drug binding to cytochrome P450 3A4. J Am Chem Soc (2007) 1.34

A survey of active site access channels in cytochromes P450. J Inorg Biochem (2004) 1.32

Cytochromes P450 in nanodiscs. Biochim Biophys Acta (2010) 1.31

Tryptophan synthase: the workings of a channeling nanomachine. Trends Biochem Sci (2008) 1.31

Kinetics of dithionite-dependent reduction of cytochrome P450 3A4: heterogeneity of the enzyme caused by its oligomerization. Biochemistry (2005) 1.30

Resonance Raman characterization of the peroxo and hydroperoxo intermediates in cytochrome P450. J Phys Chem A (2008) 1.30

Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450(BioI) ACP complex. Proc Natl Acad Sci U S A (2008) 1.29

Screening of type I and II drug binding to human cytochrome P450-3A4 in nanodiscs by localized surface plasmon resonance spectroscopy. Anal Chem (2009) 1.28

Unsupervised classification of single-particle X-ray diffraction snapshots by spectral clustering. Opt Express (2011) 1.27

Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment. Proc Natl Acad Sci U S A (2006) 1.26

The one-electron autoxidation of human cytochrome P450 3A4. J Biol Chem (2007) 1.25

Crystal structures of the AppA BLUF domain photoreceptor provide insights into blue light-mediated signal transduction. J Mol Biol (2006) 1.24

Co-incorporation of heterologously expressed Arabidopsis cytochrome P450 and P450 reductase into soluble nanoscale lipid bilayers. Arch Biochem Biophys (2004) 1.24

The status of high-valent metal oxo complexes in the P450 cytochromes. J Inorg Biochem (2006) 1.22

Structural analysis of nanoscale self-assembled discoidal lipid bilayers by solid-state NMR spectroscopy. Biophys J (2006) 1.20

Assembly of lipids and proteins into lipoprotein particles. J Phys Chem B (2007) 1.20

Nanodiscs for immobilization of lipid bilayers and membrane receptors: kinetic analysis of cholera toxin binding to a glycolipid receptor. Anal Chem (2008) 1.19

Modulation of the cytochrome P450 reductase redox potential by the phospholipid bilayer. Biochemistry (2009) 1.19

Disassembly of nanodiscs with cholate. Nano Lett (2007) 1.18

Crystallography on a chip. Acta Crystallogr D Biol Crystallogr (2012) 1.17

Crystal structure of OxyB, a cytochrome P450 implicated in an oxidative phenol coupling reaction during vancomycin biosynthesis. J Biol Chem (2002) 1.16

Characterizing the membrane-bound state of cytochrome P450 3A4: structure, depth of insertion, and orientation. J Am Chem Soc (2013) 1.15

Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. Structure (2006) 1.15

Epoxidation of olefins by hydroperoxo-ferric cytochrome P450. J Am Chem Soc (2003) 1.14

Thirty years of microbial P450 monooxygenase research: peroxo-heme intermediates--the central bus station in heme oxygenase catalysis. Biochem Biophys Res Commun (2005) 1.14

X-ray absorption spectroscopic characterization of a cytochrome P450 compound II derivative. Proc Natl Acad Sci U S A (2008) 1.13

Functional assays of membrane-bound proteins with SAMDI-TOF mass spectrometry. Angew Chem Int Ed Engl (2007) 1.13

Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium. Biochim Biophys Acta (2009) 1.12

Blood clotting reactions on nanoscale phospholipid bilayers. Thromb Res (2008) 1.12

Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design. Proc Natl Acad Sci U S A (2004) 1.11

Structure and quantum chemical characterization of chloroperoxidase compound 0, a common reaction intermediate of diverse heme enzymes. Proc Natl Acad Sci U S A (2006) 1.11

Biomimetic chemical sensors using nanoelectronic readout of olfactory receptor proteins. ACS Nano (2011) 1.11

Nanodiscs as a new tool to examine lipid-protein interactions. Methods Mol Biol (2013) 1.10

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5). J Biol Chem (2012) 1.10

Structural aspects of ligand binding to and electron transfer in bacterial and fungal P450s. Annu Rev Biochem (2004) 1.09

Cooperative properties of cytochromes P450. Pharmacol Ther (2009) 1.09

Mechanistic enzymology of oxygen activation by the cytochromes P450. Drug Metab Rev (2002) 1.08

Resonance Raman detection of the hydroperoxo intermediate in the cytochrome P450 enzymatic cycle. J Am Chem Soc (2007) 1.08

Femtosecond free-electron laser x-ray diffraction data sets for algorithm development. Opt Express (2012) 1.07

Native mass spectrometry characterization of intact nanodisc lipoprotein complexes. Anal Chem (2012) 1.06

Molecular models predict light-induced glutamine tautomerization in BLUF photoreceptors. Biophys J (2008) 1.05

Crystal structure of OxyC, a cytochrome P450 implicated in an oxidative C-C coupling reaction during vancomycin biosynthesis. J Biol Chem (2003) 1.05

X-ray and NMR crystallography in an enzyme active site: the indoline quinonoid intermediate in tryptophan synthase. J Am Chem Soc (2010) 1.05

Cryoradiolysis for the study of P450 reaction intermediates. Methods Enzymol (2002) 1.04

Toward unsupervised single-shot diffractive imaging of heterogeneous particles using X-ray free-electron lasers. Opt Express (2013) 1.04

Serial femtosecond X-ray diffraction of 30S ribosomal subunit microcrystals in liquid suspension at ambient temperature using an X-ray free-electron laser. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 1.04

Tyrosine radical formation in the reaction of wild type and mutant cytochrome P450cam with peroxy acids: a multifrequency EPR study of intermediates on the millisecond time scale. J Biol Chem (2003) 1.03

Optimal mapping of x-ray laser diffraction patterns into three dimensions using routing algorithms. Phys Rev E Stat Nonlin Soft Matter Phys (2013) 1.03

Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry. Biochemistry (2007) 1.02

Crystal structures of cyanide complexes of P450cam and the oxygenase domain of inducible nitric oxide synthase-structural models of the short-lived oxygen complexes. Arch Biochem Biophys (2003) 1.02

Two copies of the SecY channel and acidic lipids are necessary to activate the SecA translocation ATPase. Proc Natl Acad Sci U S A (2012) 1.02