Published in Biochemistry on March 21, 2008
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
Probing protein structure by amino acid-specific covalent labeling and mass spectrometry. Mass Spectrom Rev (2009) 1.86
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair (Amst) (2010) 1.71
Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58
Molecular analysis of Ku redox regulation. BMC Mol Biol (2009) 0.84
Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80. Int J Biochem Mol Biol (2012) 0.81
An Intrinsically Disordered APLF Links Ku, DNA-PKcs and XRCC4-DNA Ligase IV in an Extended Flexible Non-Homologous End Joining Complex. J Biol Chem (2016) 0.78
Drosophila SAF-B links the nuclear matrix, chromosomes, and transcriptional activity. PLoS One (2010) 0.77
The role of ubiquitin-dependent segregase p97 (VCP or Cdc48) in chromatin dynamics after DNA double strand breaks. Philos Trans R Soc Lond B Biol Sci (2017) 0.77
C-terminal region of bacterial Ku controls DNA bridging, DNA threading and recruitment of DNA ligase D for double strand breaks repair. Nucleic Acids Res (2016) 0.76
Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis. Int J Mol Sci (2012) 0.76
Recognition of DNA Termini by the C-Terminal Region of the Ku80 and the DNA-Dependent Protein Kinase Catalytic Subunit. PLoS One (2015) 0.76
Reversion of the ErbB malignant phenotype and the DNA damage response. Exp Mol Pathol (2012) 0.76
A moonlighting function of Mycobacterium smegmatis Ku in zinc homeostasis? Protein Sci (2014) 0.75
Mapping protein surface accessibility via an electron transfer dissociation selectively cleavable hydrazone probe. Mol Cell Proteomics (2012) 0.75
Protection of Arabidopsis blunt-ended telomeres is mediated by a physical association with the Ku heterodimer. Plant Cell (2017) 0.75
Computational studies on full-length Ku70 with DNA duplexes: base interactions and a helical path. J Mol Model (2011) 0.75
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem (1987) 59.79
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature (2001) 6.29
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell (2006) 5.33
Protein identification at the low femtomole level from silver-stained gels using a new fritless electrospray interface for liquid chromatography-microspray and nanospray mass spectrometry. Anal Biochem (1998) 3.76
A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol Cell (2005) 3.68
DNA end-joining catalyzed by human cell-free extracts. Proc Natl Acad Sci U S A (1998) 3.11
Ku recruits the XRCC4-ligase IV complex to DNA ends. Mol Cell Biol (2000) 2.93
Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) (2006) 2.67
DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J (2006) 2.48
Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system. Genome Res (2001) 2.19
Solution structure of the C-terminal domain of Ku80 suggests important sites for protein-protein interactions. Structure (2004) 1.78
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex. Nucleic Acids Res (1999) 1.72
Photocross-linking of an oriented DNA repair complex. Ku bound at a single DNA end. J Biol Chem (1999) 1.65
Single-stranded DNA ligation and XLF-stimulated incompatible DNA end ligation by the XRCC4-DNA ligase IV complex: influence of terminal DNA sequence. Nucleic Acids Res (2007) 1.56
Distinct faces of the Ku heterodimer mediate DNA repair and telomeric functions. Nat Struct Mol Biol (2007) 1.55
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs. EMBO Rep (2006) 1.50
The C terminus of Ku80 activates the DNA-dependent protein kinase catalytic subunit. Mol Cell Biol (1999) 1.46
DNA-PKcs dependence of Artemis endonucleolytic activity, differences between hairpins and 5' or 3' overhangs. J Biol Chem (2006) 1.28
Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent. Proc Natl Acad Sci U S A (2002) 1.26
Specific interaction of IP6 with human Ku70/80, the DNA-binding subunit of DNA-PK. EMBO J (2002) 1.19
Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK. Nucleic Acids Res (2000) 1.17
The 3D solution structure of the C-terminal region of Ku86 (Ku86CTR). J Mol Biol (2004) 1.14
Mass spectrometric identification of lysines involved in the interaction of human replication protein a with single-stranded DNA. Biochemistry (2005) 1.14
Differential activation of DNA-PK based on DNA strand orientation and sequence bias. Nucleic Acids Res (2005) 1.12
The three-dimensional structure of the C-terminal DNA-binding domain of human Ku70. J Biol Chem (2001) 1.08
Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex. J Biol Chem (2006) 1.07
Reduced sulphydryl groups are required for DNA binding of Ku protein. Biochem J (1993) 0.88
Eukaryotic nucleotide excision repair: from understanding mechanisms to influencing biology. Cell Res (2008) 3.06
RPA phosphorylation in mitosis alters DNA binding and protein-protein interactions. Biochemistry (2003) 1.63
Novel function of the flap endonuclease 1 complex in processing stalled DNA replication forks. EMBO Rep (2005) 1.56
Association and regulation of the BLM helicase by the telomere proteins TRF1 and TRF2. Hum Mol Genet (2004) 1.47
Behavior of T7 RNA polymerase and mammalian RNA polymerase II at site-specific cisplatin adducts in the template DNA. J Biol Chem (2003) 1.34
DNA damage-induced phosphorylation of the human telomere-associated protein TRF2. Proc Natl Acad Sci U S A (2005) 1.24
Development of a high-throughput screen for inhibitors of replication protein A and its role in nucleotide excision repair. Mol Cancer Ther (2004) 1.20
Xeroderma pigmentosum complementation group A protein (XPA) modulates RPA-DNA interactions via enhanced complex stability and inhibition of strand separation activity. J Biol Chem (2002) 1.18
Partial reconstitution of human DNA mismatch repair in vitro: characterization of the role of human replication protein A. Mol Cell Biol (2002) 1.18
Chemotherapy induced DNA damage response: convergence of drugs and pathways. Cancer Biol Ther (2013) 1.16
DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage. Biochemistry (2005) 1.16
Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining. Mol Cancer Res (2005) 1.16
Strand-specific binding of RPA and XPA to damaged duplex DNA. Biochemistry (2002) 1.12
Differential activation of DNA-PK based on DNA strand orientation and sequence bias. Nucleic Acids Res (2005) 1.12
Pre-steady-state binding of damaged DNA by XPC-hHR23B reveals a kinetic mechanism for damage discrimination. Biochemistry (2006) 1.07
Kinetic analysis of the Ku-DNA binding activity reveals a redox-dependent alteration in protein structure that stimulates dissociation of the Ku-DNA complex. J Biol Chem (2006) 1.07
Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function. Cancer Res (2010) 1.04
Telomerase-associated protein 1, HSP90, and topoisomerase IIalpha associate directly with the BLM helicase in immortalized cells using ALT and modulate its helicase activity using telomeric DNA substrates. J Biol Chem (2009) 1.00
DNA repair: from genome maintenance to biomarker and therapeutic target. Clin Cancer Res (2011) 0.99
A mechanism for DNA-PK activation requiring unique contributions from each strand of a DNA terminus and implications for microhomology-mediated nonhomologous DNA end joining. Nucleic Acids Res (2008) 0.98
Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation. Biochemistry (2003) 0.92
Interrogation of nucleotide excision repair capacity: impact on platinum-based cancer therapy. Antioxid Redox Signal (2011) 0.91
Identification of novel small molecule inhibitors of the XPA protein using in silico based screening. ACS Chem Biol (2010) 0.91
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxid Redox Signal (2010) 0.90
Targeting ovarian tumor cell adhesion mediated by tissue transglutaminase. Mol Cancer Ther (2011) 0.89
Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair. DNA Repair (Amst) (2010) 0.88
Extracellular tissue transglutaminase activates noncanonical NF-κB signaling and promotes metastasis in ovarian cancer. Neoplasia (2013) 0.88
Targeting the OB-Folds of Replication Protein A with Small Molecules. J Nucleic Acids (2010) 0.88
Novel irreversible small molecule inhibitors of replication protein A display single-agent activity and synergize with cisplatin. Mol Cancer Ther (2011) 0.88
Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma. Biochem Biophys Res Commun (2013) 0.88
Three-dimensional neuroblastoma cell culture: proteomic analysis between monolayer and multicellular tumor spheroids. Pediatr Surg Int (2008) 0.88
Complex cisplatin-double strand break (DSB) lesions directly impair cellular non-homologous end-joining (NHEJ) independent of downstream damage response (DDR) pathways. J Biol Chem (2012) 0.88
Novel peptides secreted from human neuroblastoma: useful clinical tools? J Pediatr Surg (2006) 0.86
Serum protein profiling to identify high-risk neuroblastoma: preclinical relevance of blood-based biomarkers. J Surg Res (2007) 0.86
Photo-cross-linking of XPC-Rad23B to cisplatin-damaged DNA reveals contacts with both strands of the DNA duplex and spans the DNA adduct. Biochemistry (2010) 0.86
ATM mediates repression of DNA end-degradation in an ATP-dependent manner. DNA Repair (Amst) (2008) 0.85
Molecular analysis of Ku redox regulation. BMC Mol Biol (2009) 0.84
Multiple protein-protein interactions within the DNA-PK complex are mediated by the C-terminus of Ku 80. Int J Biochem Mol Biol (2012) 0.81
Bin1 is linked to metastatic potential and chemosensitivity in neuroblastoma. Pediatr Blood Cancer (2009) 0.81
Profiling of nuclear extract proteins from human neuroblastoma cell lines: the search for fingerprints. J Pediatr Surg (2005) 0.79
Exploring a structural protein-drug interactome for new therapeutics in lung cancer. Mol Biosyst (2014) 0.79
Proteomic analysis of neuroblastoma subtypes in response to mitogen-activated protein kinase inhibition: profiling multiple targets of cancer kinase signaling. J Surg Res (2006) 0.79
Serum proteome profiles identifies parathyroid hormone physiologic response. Proteomics (2006) 0.78
Identification of Mre11 as a target for heat radiosensitization. Radiat Res (2011) 0.77
Current advances in DNA repair: regulation of enzymes and pathways involved in maintaining genomic stability. Antioxid Redox Signal (2011) 0.76
Intrinsic hTRF1 fluorescence quenching reveals details of telomere DNA binding activity: impact of DNA length, structure and position of telomeric repeats. Arch Biochem Biophys (2009) 0.75
Proteomic analysis of neuroblastoma microenvironment: effect of the host-tumor interaction on disease progression. J Surg Res (2009) 0.75
Modulating DNA repair pathways to improve precision genome engineering. ACS Chem Biol (2017) 0.75