Published in EMBO J on July 27, 2006
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem (2010) 9.80
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2. EMBO J (2009) 2.94
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks. J Cell Biol (2007) 2.92
Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J (2009) 2.68
Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Proc Natl Acad Sci U S A (2007) 2.09
Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination. Mol Cell (2008) 1.91
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. J Clin Invest (2008) 1.82
KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat Struct Mol Biol (2011) 1.77
Replication protein A: directing traffic at the intersection of replication and repair. Front Biosci (Landmark Ed) (2010) 1.77
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair (Amst) (2010) 1.71
Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates. Mol Cell (2009) 1.70
The response to and repair of RAG-mediated DNA double-strand breaks. Annu Rev Immunol (2012) 1.64
Repair of double-strand breaks by end joining. Cold Spring Harb Perspect Biol (2013) 1.58
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XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Res (2008) 1.44
DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination. J Exp Med (2008) 1.44
Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4. Mol Cell Biol (2009) 1.43
Coordinate 5' and 3' endonucleolytic trimming of terminally blocked blunt DNA double-strand break ends by Artemis nuclease and DNA-dependent protein kinase. Nucleic Acids Res (2008) 1.36
The role of DNA-PKcs and artemis in opening viral DNA hairpin termini in various tissues in mice. J Virol (2007) 1.35
Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation. Mol Cell Biol (2011) 1.32
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) (2014) 1.31
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Choosing the right path: does DNA-PK help make the decision? Mutat Res (2011) 1.18
Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining. Proc Natl Acad Sci U S A (2011) 1.18
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A human XRCC4-XLF complex bridges DNA. Nucleic Acids Res (2012) 1.15
Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans. Subcell Biochem (2010) 1.13
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TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J (2010) 1.11
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. Biochem Cell Biol (2013) 1.09
APLF promotes the assembly and activity of non-homologous end joining protein complexes. EMBO J (2012) 1.09
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DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis. DNA Repair (Amst) (2010) 1.07
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XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic Acids Res (2012) 1.01
PTIP associates with Artemis to dictate DNA repair pathway choice. Genes Dev (2014) 1.01
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Orchestrating the nucleases involved in DNA interstrand cross-link (ICL) repair. Cell Cycle (2011) 1.00
DNA-dependent conformational changes in the Ku heterodimer. Biochemistry (2008) 1.00
Serine/threonine protein phosphatase 6 modulates the radiation sensitivity of glioblastoma. Cell Death Dis (2011) 0.98
A noncatalytic function of the ligation complex during nonhomologous end joining. J Cell Biol (2013) 0.96
Differential phosphorylation of DNA-PKcs regulates the interplay between end-processing and end-ligation during nonhomologous end-joining. Mol Cell (2015) 0.96
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog Biophys Mol Biol (2014) 0.96
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. J Exp Med (2012) 0.95
Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination. Cell Cycle (2011) 0.95
The human telomerase RNA component, hTR, activates the DNA-dependent protein kinase to phosphorylate heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Res (2009) 0.94
The catalytic subunit of DNA-protein kinase (DNA-PKcs) is not required for Ig class-switch recombination. Proc Natl Acad Sci U S A (2007) 0.94
Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining. J Immunol (2008) 0.94
The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining. Mol Cell Biol (2011) 0.93
Extent to which hairpin opening by the Artemis:DNA-PKcs complex can contribute to junctional diversity in V(D)J recombination. Nucleic Acids Res (2007) 0.93
Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites. J Immunol (2011) 0.92
Artemis and nonhomologous end joining-independent influence of DNA-dependent protein kinase catalytic subunit on chromosome stability. Mol Cell Biol (2008) 0.92
The multifunctional SNM1 gene family: not just nucleases. Future Oncol (2010) 0.91
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxid Redox Signal (2010) 0.90
Purification and characterization of exonuclease-free Artemis: Implications for DNA-PK-dependent processing of DNA termini in NHEJ-catalyzed DSB repair. DNA Repair (Amst) (2010) 0.88
Structure of the catalytic region of DNA ligase IV in complex with an Artemis fragment sheds light on double-strand break repair. Structure (2013) 0.88
Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Mol Cell Biol (2013) 0.88
Phosphorylation: the molecular switch of double-strand break repair. Int J Proteomics (2011) 0.87
Lymphocyte development: integration of DNA damage response signaling. Adv Immunol (2012) 0.87
Unraveling the complexities of DNA-dependent protein kinase autophosphorylation. Mol Cell Biol (2014) 0.87
Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining. Cell Rep (2012) 0.86
Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Res (2011) 0.85
Restoration of G1 chemo/radioresistance and double-strand-break repair proficiency by wild-type but not endonuclease-deficient Artemis. Nucleic Acids Res (2011) 0.85
A hypomorphic Artemis human disease allele causes aberrant chromosomal rearrangements and tumorigenesis. Hum Mol Genet (2010) 0.85
Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. PLoS One (2014) 0.85
Non-homologous DNA end joining and alternative pathways to double-strand break repair. Nat Rev Mol Cell Biol (2017) 0.85
Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance. Mol Cancer Res (2012) 0.84
N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Res (2011) 0.84
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Defective Artemis causes mild telomere dysfunction. Genome Integr (2010) 0.83
Mechanisms of human lymphoid chromosomal translocations. Nat Rev Cancer (2016) 0.81
DNA-dependent protein kinase and DNA repair: relevance to Alzheimer's disease. Alzheimers Res Ther (2013) 0.80
Unifying the DNA End-processing Roles of the Artemis Nuclease: KU-DEPENDENT ARTEMIS RESECTION AT BLUNT DNA ENDS. J Biol Chem (2015) 0.80
An autonomous chromatin/DNA-PK mechanism for localized DNA damage signaling in mammalian cells. Nucleic Acids Res (2013) 0.78
Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases. Genome Integr (2010) 0.78
Replication stress induced site-specific phosphorylation targets WRN to the ubiquitin-proteasome pathway. Oncotarget (2016) 0.78
Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining. J Nucleic Acids (2010) 0.78
Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex. Nucleic Acids Res (2016) 0.77
Integrated signaling in developing lymphocytes: the role of DNA damage responses. Cell Cycle (2012) 0.77
Increased Artemis levels confer radioresistance to both high and low LET radiation exposures. Radiat Oncol (2012) 0.77
Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications. Curr Genomics (2010) 0.77
Reversion of the ErbB malignant phenotype and the DNA damage response. Exp Mol Pathol (2012) 0.76
Resolution of complex ends by Nonhomologous end joining - better to be lucky than good? Genome Integr (2012) 0.76
Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining. J Immunol (2016) 0.76
Autoinhibition of the Nuclease ARTEMIS is Mediated by a Physical Interaction between Its Catalytic and C-terminal Domains. J Biol Chem (2017) 0.75
Artemis is required to improve the accuracy of repair of double-strand breaks with 5'-blocked termini generated from non-DSB-clustered lesions. Mutagenesis (2013) 0.75
A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis. Trends Biochem Sci (2017) 0.75
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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination. Cell (2002) 6.34
Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23
XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining. Cell (2006) 5.62
Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly. Cell (2006) 5.33
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Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol (2003) 2.63
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Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Mol Cell Biol (2005) 2.37
Identification of a DNA nonhomologous end-joining complex in bacteria. Science (2002) 2.27
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Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nat Cell Biol (2006) 2.20
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The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1. Immunity (2005) 1.85
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Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J (2002) 1.80
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Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. J Biol Chem (2004) 1.76
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A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation. DNA Repair (Amst) (2010) 1.71
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ATM deficiency sensitizes mantle cell lymphoma cells to poly(ADP-ribose) polymerase-1 inhibitors. Mol Cancer Ther (2010) 1.67
The impact of heterochromatin on DSB repair. Biochem Soc Trans (2009) 1.65
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM. Cancer Res (2005) 1.65
Healing the wounds inflicted by sleeping beauty transposition by double-strand break repair in mammalian somatic cells. Mol Cell (2004) 1.64
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Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining. Int J Radiat Oncol Biol Phys (2013) 1.57
ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation. J Biol Chem (2002) 1.56
Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21. Nucleic Acids Res (2004) 1.56
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DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. DNA Repair (Amst) (2003) 1.55
Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res (2003) 1.52
A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin. Mol Cell (2007) 1.52
XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair. J Biol Chem (2011) 1.48
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53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J (2009) 1.47
An Artemis polymorphic variant reduces Artemis activity and confers cellular radiosensitivity. DNA Repair (Amst) (2010) 1.46
Ipl1p-dependent phosphorylation of Mad3p is required for the spindle checkpoint response to lack of tension at kinetochores. Genes Dev (2007) 1.45
XLF-Cernunnos promotes DNA ligase IV-XRCC4 re-adenylation following ligation. Nucleic Acids Res (2008) 1.44
Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53. EMBO Mol Med (2012) 1.44