Published in J Clin Invest on April 01, 2008
Epithelial-mesenchymal transition in hepatocellular carcinoma. Future Oncol (2009) 1.85
Epithelial to mesenchymal transition of a primary prostate cell line with switches of cell adhesion modules but without malignant transformation. PLoS One (2008) 1.27
Epithelial-mesenchymal transitions and hepatocarcinogenesis. J Clin Invest (2010) 1.20
A novel protein associated with membrane-type 1 matrix metalloproteinase binds p27(kip1) and regulates RhoA activation, actin remodeling, and matrigel invasion. J Biol Chem (2009) 1.13
Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. BMC Dev Biol (2009) 1.02
Tetraspanins and tumor progression. Clin Exp Metastasis (2010) 0.98
Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells. J Cell Sci (2012) 0.96
Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein. Cancer Res (2012) 0.96
Production of antibodies with peptide-CpG-DNA-liposome complex without carriers. BMC Immunol (2011) 0.95
Prevention and therapy of hepatocellular carcinoma by vaccination with TM4SF5 epitope-CpG-DNA-liposome complex without carriers. PLoS One (2012) 0.94
The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development (2011) 0.90
Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5. Genomics Inform (2014) 0.85
Loss of E-cadherin expression is not a prerequisite for c-erbB2-induced epithelial-mesenchymal transition. Int J Oncol (2014) 0.85
Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells. Mol Cell Biol (2014) 0.85
Biomarkers for hepatocellular carcinoma: diagnostic and therapeutic utility. Hepat Med (2015) 0.84
Correlations between transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities. PLoS One (2014) 0.82
Glucosamine treatment-mediated O-GlcNAc modification of paxillin depends on adhesion state of rat insulinoma INS-1 cells. J Biol Chem (2010) 0.82
TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1. Oncotarget (2014) 0.82
Tetraspanin in oncogenic epithelial-mesenchymal transition. J Clin Invest (2008) 0.80
A high level of TM4SF5 is associated with human esophageal cancer progression and poor patient survival. Dig Dis Sci (2013) 0.80
TM4SF1 Promotes Proliferation, Invasion, and Metastasis in Human Liver Cancer Cells. Int J Mol Sci (2016) 0.80
Therapeutic effect of a TM4SF5-specific peptide vaccine against colon cancer in a mouse model. BMB Rep (2014) 0.79
TM4SF1 Promotes Gemcitabine Resistance of Pancreatic Cancer In Vitro and In Vivo. PLoS One (2015) 0.78
Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model. Oncotarget (2014) 0.78
Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment. Oncotarget (2017) 0.78
TM4SF5-mediated protein-protein networks and tumorigenic roles. BMB Rep (2014) 0.77
Production of epitope-specific antibodies using peptide-CpG-ODN-liposome complex without carriers and their application as a cancer vaccine in mice. Oncoimmunology (2012) 0.77
Pancreatic cancer stem cell markers and exosomes - the incentive push. World J Gastroenterol (2016) 0.76
Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model. Oncotarget (2016) 0.75
A HLA-A2-restricted CTL epitope induces anti-tumor effects against human lung cancer in mouse xenograft model. Oncotarget (2016) 0.75
TM4SF5-Mediated Roles in the Development of Fibrotic Phenotypes. Mediators Inflamm (2017) 0.75
Anti-cancer Activity of Novel TM4SF5-Targeting Antibodies through TM4SF5 Neutralization and Immune Cell-Mediated Cytotoxicity. Theranostics (2017) 0.75
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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med (2002) 5.79
Rho GTPases and the control of cell behaviour. Biochem Soc Trans (2005) 5.38
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E-cadherin suppresses cellular transformation by inhibiting beta-catenin signaling in an adhesion-independent manner. J Cell Biol (2001) 4.04
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Complexes of tetraspanins with integrins: more than meets the eye. J Cell Sci (2001) 3.20
p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev (2004) 3.16
Rho GTPases: signaling, migration, and invasion. Exp Cell Res (2000) 2.82
Functional domains in tetraspanin proteins. Trends Biochem Sci (2003) 2.71
p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J (2001) 2.45
N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts. J Cell Biol (2002) 2.29
The integrin-actin connection, an eternal love affair. EMBO J (2003) 2.26
Cell adhesion system and human cancer morphogenesis. Cancer Sci (2003) 2.18
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem (2002) 2.17
An inhibitory role for FAK in regulating proliferation: a link between limited adhesion and RhoA-ROCK signaling. J Cell Biol (2006) 2.08
A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression. Genes Dev (2006) 2.05
Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors? Nat Rev Cancer (2004) 1.99
A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression. EMBO J (2002) 1.99
Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma. Cancer Res (1998) 1.92
Palmitoylation supports assembly and function of integrin-tetraspanin complexes. J Cell Biol (2004) 1.89
Integrin regulation of growth factor receptors. Nat Cell Biol (2002) 1.80
14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1). EMBO J (2004) 1.75
Integrin regulation of cell signalling and motility. Biochem Soc Trans (2004) 1.53
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways. Mol Cells (2004) 1.46
Localization and expression of p27KIP1 in multistage colorectal carcinogenesis. Cancer Res (1998) 1.40
Multiple levels of interactions within the tetraspanin web. Biochem Biophys Res Commun (2003) 1.34
Overexpressed cyclin D3 contributes to retaining the growth inhibitor p27 in the cytoplasm of thyroid tumor cells. J Clin Invest (1999) 1.30
The L6 membrane proteins--a new four-transmembrane superfamily. Protein Sci (2000) 1.24
Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism. J Biol Chem (2005) 1.23
Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. J Biol Chem (2002) 1.10
Identification of a new tumour-associated antigen TM4SF5 and its expression in human cancer. Gene (1998) 1.02
The signaling network of transforming growth factor beta1, protein kinase Cdelta, and integrin underlies the spreading and invasiveness of gastric carcinoma cells. Mol Cell Biol (2005) 0.96
Cell adhesion status-dependent histone acetylation is regulated through intracellular contractility-related signaling activities. J Biol Chem (2005) 0.93
Focal adhesion and actin organization by a cross-talk of TM4SF5 with integrin alpha2 are regulated by serum treatment. Exp Cell Res (2006) 0.93
TGF-beta1-mediated activations of c-Src and Rac1 modulate levels of cyclins and p27(Kip1) CDK inhibitor in hepatoma cells replated on fibronectin. Biochim Biophys Acta (2005) 0.90
PKCdelta and cofilin activation affects peripheral actin reorganization and cell-cell contact in cells expressing integrin alpha5 but not its tailless mutant. J Cell Sci (2007) 0.89
Epigenetic regulation of integrin-linked kinase expression depending on adhesion of gastric carcinoma cells. Am J Physiol Cell Physiol (2006) 0.83
Identification of genes associated with the corticotroph phenotype in bronchial carcinoid tumors. J Clin Endocrinol Metab (2002) 0.78
STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J (2005) 2.60
Sulfonate chalcone as new class voltage-dependent K+ channel blocker. Bioorg Med Chem Lett (2007) 2.26
Elevated levels of cholesterol-rich lipid rafts in cancer cells are correlated with apoptosis sensitivity induced by cholesterol-depleting agents. Am J Pathol (2006) 2.21
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther (2010) 2.10
Simvastatin suppresses RANTES-mediated neutrophilia in polyinosinic-polycytidylic acid-induced pneumonia. Eur Respir J (2012) 2.10
A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivity. J Biol Chem (2007) 2.05
Proteolytic activation of the 1918 influenza virus hemagglutinin. J Virol (2009) 2.05
The 5p15.33 locus is associated with risk of lung adenocarcinoma in never-smoking females in Asia. PLoS Genet (2010) 1.90
VEGF-induced vascular permeability is mediated by FAK. Dev Cell (2012) 1.85
Critical role of cyclin D1 nuclear import in cardiomyocyte proliferation. Circ Res (2003) 1.70
Nitric oxide inhibits ischemia/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity. Cardiovasc Res (2003) 1.60
Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload. Proc Natl Acad Sci U S A (2008) 1.58
Cardiomyocyte proliferation and protection against post-myocardial infarction heart failure by cyclin D1 and Skp2 ubiquitin ligase. Cardiovasc Res (2008) 1.57
Trithorax-group protein ASH1 methylates histone H3 lysine 36. Gene (2007) 1.56
Identification of motifs in the fasciclin domains of the transforming growth factor-beta-induced matrix protein betaig-h3 that interact with the alphavbeta5 integrin. J Biol Chem (2002) 1.53
TGFBIp/betaig-h3 protein: a versatile matrix molecule induced by TGF-beta. Int J Biochem Cell Biol (2007) 1.51
Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. J Control Release (2008) 1.44
Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury. Pain (2006) 1.42
Transforming growth factor-beta-induced protein (TGFBIp/beta ig-h3) activates platelets and promotes thrombogenesis. Blood (2009) 1.42
Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models. Cancer Biol Ther (2010) 1.41
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. EMBO J (2005) 1.41
Targeting prion-like protein doppel selectively suppresses tumor angiogenesis. J Clin Invest (2016) 1.39
Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells. Oncogene (2003) 1.38
Betaig-h3 supports keratinocyte adhesion, migration, and proliferation through alpha3beta1 integrin. Biochem Biophys Res Commun (2002) 1.38
Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy. J Control Release (2008) 1.38
Tumor-homing multifunctional nanoparticles for cancer theragnosis: Simultaneous diagnosis, drug delivery, and therapeutic monitoring. J Control Release (2010) 1.37
DNMT3B polymorphisms and risk of primary lung cancer. Carcinogenesis (2004) 1.37
Phosphoinositide signaling regulates the exocyst complex and polarized integrin trafficking in directionally migrating cells. Dev Cell (2012) 1.35
Biodistribution and anti-tumor efficacy of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect. J Control Release (2003) 1.34
Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell (2010) 1.33
Cell-permeable and biocompatible polymeric nanoparticles for apoptosis imaging. J Am Chem Soc (2006) 1.33
Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: in vivo biodistribution and anti-tumor activity. Biomaterials (2006) 1.32
Identification of the alphavbeta3 integrin-interacting motif of betaig-h3 and its anti-angiogenic effect. J Biol Chem (2003) 1.31
TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways. Carcinogenesis (2010) 1.30
Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev (2005) 1.29
Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice. J Control Release (2007) 1.29
Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway. Cancer Res (2006) 1.27
A case of recurrent superficial acral fibromyxoma. Ann Dermatol (2010) 1.24
Transcriptional repressor activating transcription factor 3 protects human umbilical vein endothelial cells from tumor necrosis factor-alpha-induced apoptosis through down-regulation of p53 transcription. J Biol Chem (2002) 1.24
ATF3 inhibits doxorubicin-induced apoptosis in cardiac myocytes: a novel cardioprotective role of ATF3. J Mol Cell Cardiol (2002) 1.24
Beta ig-h3 promotes renal proximal tubular epithelial cell adhesion, migration and proliferation through the interaction with alpha3beta1 integrin. Exp Mol Med (2004) 1.23
Role of cyclin D1 cytoplasmic sequestration in the survival of postmitotic neurons. Oncogene (2003) 1.22
Polymorphisms in the survivin gene and the risk of lung cancer. Lung Cancer (2007) 1.19
RGD peptides released from beta ig-h3, a TGF-beta-induced cell-adhesive molecule, mediate apoptosis. Oncogene (2003) 1.19
Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1. J Biol Chem (2002) 1.19
Pyk2 inhibition of p53 as an adaptive and intrinsic mechanism facilitating cell proliferation and survival. J Biol Chem (2009) 1.18
Comparative assessment of laparoscopic single-site surgery instruments to conventional laparoscopic in laboratory setting. J Endourol (2010) 1.18
Effect of polymer molecular weight on the tumor targeting characteristics of self-assembled glycol chitosan nanoparticles. J Control Release (2007) 1.18
Erythropoietin decreases renal fibrosis in mice with ureteral obstruction: role of inhibiting TGF-beta-induced epithelial-to-mesenchymal transition. J Am Soc Nephrol (2007) 1.18
Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy. ACS Nano (2011) 1.18
Developmental pluripotency-associated 4 (DPPA4) localized in active chromatin inhibits mouse embryonic stem cell differentiation into a primitive ectoderm lineage. J Biol Chem (2007) 1.17
Four novel RUNX2 mutations including a splice donor site result in the cleidocranial dysplasia phenotype. J Cell Physiol (2006) 1.16
AMP-activated protein kinase inhibits TGF-β-induced fibrogenic responses of hepatic stellate cells by targeting transcriptional coactivator p300. J Cell Physiol (2012) 1.16
DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma. Biochem Biophys Res Commun (2007) 1.16
Tumor-targeting peptide conjugated pH-responsive micelles as a potential drug carrier for cancer therapy. Bioconjug Chem (2010) 1.16
Morphological adjustment of senescent cells by modulating caveolin-1 status. J Biol Chem (2004) 1.14
Class I histone deacetylase-selective novel synthetic inhibitors potently inhibit human tumor proliferation. Clin Cancer Res (2004) 1.14
Molecular properties of wild-type and mutant betaIG-H3 proteins. Invest Ophthalmol Vis Sci (2002) 1.14
AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity. Oncogene (2004) 1.14
Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver. Blood (2011) 1.13
Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53. Biochem Biophys Res Commun (2002) 1.12
Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy. Biomaterials (2008) 1.12
Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. Blood (2008) 1.12
Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Proteomics (2011) 1.11
Transforming growth factor-beta-inducible gene-h3 (beta(ig)-h3) promotes cell adhesion of human astrocytoma cells in vitro: implication of alpha6beta4 integrin. Neurosci Lett (2003) 1.11
Targeting bladder tumor cells in vivo and in the urine with a peptide identified by phage display. Mol Cancer Res (2007) 1.10
Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages. J Cell Sci (2009) 1.10
Ras-dependent induction of HIF-1alpha785 via the Raf/MEK/ERK pathway: a novel mechanism of Ras-mediated tumor promotion. Oncogene (2004) 1.10
The bone-related Zn finger transcription factor Osterix promotes proliferation of mesenchymal cells. Gene (2005) 1.08
A splice variant of stress response gene ATF3 counteracts NF-kappaB-dependent anti-apoptosis through inhibiting recruitment of CREB-binding protein/p300 coactivator. J Biol Chem (2005) 1.08
Beta ig-h3 mediates osteoblast adhesion and inhibits differentiation. Bone (2005) 1.07
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol (2014) 1.07
Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev (2002) 1.07
O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Exp Cell Res (2008) 1.07
Caffeic acid and its synthetic derivative CADPE suppress tumor angiogenesis by blocking STAT3-mediated VEGF expression in human renal carcinoma cells. Carcinogenesis (2007) 1.06
Differential usage of alternate promoters of the human stress response gene ATF3 in stress response and cancer cells. Nucleic Acids Res (2009) 1.06
Requirement of adaptor protein GULP during stabilin-2-mediated cell corpse engulfment. J Biol Chem (2008) 1.05
Polymorphisms in TGF-beta1 gene and the risk of lung cancer. Lung Cancer (2006) 1.05
Cholesterol depletion induces anoikis-like apoptosis via FAK down-regulation and caveolae internalization. J Pathol (2009) 1.05
Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells. Food Chem Toxicol (2011) 1.05
Tumor specificity and therapeutic efficacy of photosensitizer-encapsulated glycol chitosan-based nanoparticles in tumor-bearing mice. Biomaterials (2009) 1.05
Self-assembled nanoparticles based on glycol chitosan bearing 5beta-cholanic acid for RGD peptide delivery. J Control Release (2004) 1.05
Plasminogen activator inhibitor-1 and -3 increase cell adhesion and motility of MDA-MB-435 breast cancer cells. J Biol Chem (2002) 1.04
Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy. J Control Release (2007) 1.03