Published in BMC Dev Biol on December 10, 2009
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Generation of Nkx2.2:lacZ mice using recombination-mediated cassette exchange technology. Genesis (2012) 0.93
A small molecule differentiation inducer increases insulin production by pancreatic β cells. Proc Natl Acad Sci U S A (2011) 0.92
The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development (2011) 0.90
Pancreatic β cell identity requires continual repression of non-β cell programs. J Clin Invest (2016) 0.88
Systems biology approach to stage-wise characterization of epigenetic genes in lung adenocarcinoma. BMC Syst Biol (2013) 0.87
Generation of mice encoding a conditional allele of Nkx2.2. Transgenic Res (2013) 0.87
PAX6 maintains β cell identity by repressing genes of alternative islet cell types. J Clin Invest (2016) 0.86
Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. BMC Bioinformatics (2011) 0.86
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Identification and characterization of poorly differentiated invasive carcinomas in a mouse model of pancreatic neuroendocrine tumorigenesis. PLoS One (2013) 0.77
Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord. PLoS One (2014) 0.77
Organogenesis and functional genomics of the endocrine pancreas. Cell Mol Life Sci (2012) 0.77
EWS/FLI utilizes NKX2-2 to repress mesenchymal features of Ewing sarcoma. Genes Cancer (2015) 0.76
Genetic evidence that Nkx2.2 acts primarily downstream of Neurog3 in pancreatic endocrine lineage development. Elife (2017) 0.75
A regulatory network controls nephrocan expression and midgut patterning. Development (2014) 0.75
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In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21
Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (2002) 12.21
neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci U S A (2000) 8.34
The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nat Genet (2002) 8.28
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Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development (2000) 4.71
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Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells. Nature (1997) 4.01
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Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev (2002) 3.22
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Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A (2004) 2.91
MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol (2005) 2.85
An illustrated review of early pancreas development in the mouse. Endocr Rev (2007) 2.68
A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol (2006) 2.62
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Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mech Dev (2003) 2.58
Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development (2003) 2.39
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev (2008) 2.38
Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci U S A (2002) 2.20
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The MafA transcription factor appears to be responsible for tissue-specific expression of insulin. Proc Natl Acad Sci U S A (2004) 2.14
Pancreas and beta-cell development: from the actual to the possible. Development (2006) 2.13
MafB is required for islet beta cell maturation. Proc Natl Acad Sci U S A (2007) 2.13
Gene regulatory logic of dopamine neuron differentiation. Nature (2009) 2.04
NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Development (2005) 2.03
MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells. Diabetes (2006) 2.01
The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas. Development (2005) 1.98
Tmem27: a cleaved and shed plasma membrane protein that stimulates pancreatic beta cell proliferation. Cell Metab (2005) 1.92
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Dev Biol (2008) 1.79
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab (2005) 1.72
Foxa2 controls vesicle docking and insulin secretion in mature Beta cells. Cell Metab (2007) 1.66
Defining pancreatic endocrine precursors and their descendants. Diabetes (2007) 1.65
The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol (2004) 1.59
Gata6 is an important regulator of mouse pancreas development. Dev Biol (2006) 1.58
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol (2006) 1.58
Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. Proc Natl Acad Sci U S A (2004) 1.58
Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes (2005) 1.57
Foxa2 regulates multiple pathways of insulin secretion. J Clin Invest (2004) 1.57
Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation. Dev Biol (2008) 1.55
Genetic determinants of pancreatic epsilon-cell development. Dev Biol (2005) 1.54
Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2. Mol Cell Biol (2005) 1.45
Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins. Proc Natl Acad Sci U S A (2000) 1.42
Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology (2005) 1.38
Tetraspanin TM4SF5 mediates loss of contact inhibition through epithelial-mesenchymal transition in human hepatocarcinoma. J Clin Invest (2008) 1.35
Transcription factor occupancy of the insulin gene in vivo. Evidence for direct regulation by Nkx2.2. J Biol Chem (2002) 1.33
Potential roles of large mafs in cell lineages and developing pancreas. Pancreas (2006) 1.27
The L6 membrane proteins--a new four-transmembrane superfamily. Protein Sci (2000) 1.24
Transcriptional program of the endocrine pancreas in mice and humans. Diabetes (2003) 1.23
Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion. Diabetes (2005) 1.20
Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev (2007) 1.20
The effect of neurogenin3 deficiency on pancreatic gene expression in embryonic mice. J Mol Endocrinol (2006) 1.20
Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet. Development (2007) 1.18
Cooperation between integrin alpha5 and tetraspan TM4SF5 regulates VEGF-mediated angiogenic activity. Blood (2008) 1.12
Mouse pancreatic endocrine cell transcriptome defined in the embryonic Ngn3-null mouse. Diabetes (2008) 1.09
Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. J Biol Chem (2009) 1.09
Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol (2007) 1.07
Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells. Dev Biol (2007) 1.06
Enhanced trypsin activity in pancreatic acinar cells deficient for serine protease inhibitor kazal type 3. Pancreas (2006) 1.03
Molecular characterization of the ets-related human transcription factor ER81. Oncogene (1995) 1.02
Nephrocan, a novel member of the small leucine-rich repeat protein family, is an inhibitor of transforming growth factor-beta signaling. J Biol Chem (2006) 1.01
ETS-family genes in pancreatic development. Dev Dyn (2007) 0.98
The tetraspanin Tm4sf3 is localized to the ventral pancreas and regulates fusion of the dorsal and ventral pancreatic buds. Development (2009) 0.97
A tetraspan membrane glycoprotein produced in the human intestinal epithelium and liver that can regulate cell density-dependent proliferation. J Biol Chem (1995) 0.97
Gene array identification of Ipf1/Pdx1-/- regulated genes in pancreatic progenitor cells. BMC Dev Biol (2007) 0.97
Nkx2.2 regulates beta-cell function in the mature islet. Diabetes (2007) 0.96
From endoderm to pancreas: a multistep journey. Cell Mol Life Sci (2007) 0.91
Transgenic mice overexpressing alpha2A-adrenoceptors in pancreatic beta-cells show altered regulation of glucose homeostasis. Diabetologia (2000) 0.91
Role of Sox-9, ER81 and VE-cadherin in retinoic acid-mediated trans-differentiation of breast cancer cells. PLoS One (2008) 0.91
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Er81 is a downstream target of Pax6 in cortical progenitors. BMC Dev Biol (2008) 0.89
Pharmacological characterization of alpha-2 adrenergic receptor subtype involved in the release of insulin from isolated rat pancreatic islets. J Pharmacol Exp Ther (1990) 0.89
Expression pattern of serine protease inhibitor kazal type 3 (Spink3) during mouse embryonic development. Histochem Cell Biol (2008) 0.88
Elastase and elastase-inhibitor. Nature (1949) 0.87
Differential expression of alpha 2-adrenoceptor subtypes in purified rat pancreatic islet A- and B-cells. Cell Signal (1997) 0.84
Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha. Mol Endocrinol (2009) 0.81
Tetraspanin in oncogenic epithelial-mesenchymal transition. J Clin Invest (2008) 0.80
Overexpression of the gene for transmembrane 4 superfamily member 4 accelerates liver damage in rats treated with CCl4. J Hepatol (2006) 0.80
The elastase and trypsin contents of the pancreatic secretion in dogs. Acta Physiol Hung (1951) 0.79
The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (2002) 5.09
Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure. Cell (2012) 4.88
Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nat Genet (2003) 3.91
The initiation of liver development is dependent on Foxa transcription factors. Nature (2005) 3.88
KLF family members regulate intrinsic axon regeneration ability. Science (2009) 3.80
Extracting transcription factor targets from ChIP-Seq data. Nucleic Acids Res (2009) 3.58
Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology (2002) 3.39
Control of pancreatic β cell regeneration by glucose metabolism. Cell Metab (2011) 3.35
Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature (2008) 3.23
Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev (2002) 3.22
The evolution of Fox genes and their role in development and disease. Nat Rev Genet (2009) 3.13
Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08
Revised national guidelines for analysis of cerebrospinal fluid for bilirubin in suspected subarachnoid haemorrhage. Ann Clin Biochem (2008) 3.07
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology (2011) 2.94
Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci U S A (2004) 2.91
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Dev Cell (2009) 2.55
Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology (2005) 2.53
Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes Dev (2011) 2.53
Cryoglobulin evaluation: best practice? Ann Clin Biochem (2010) 2.49
Epigenomic plasticity enables human pancreatic α to β cell reprogramming. J Clin Invest (2013) 2.38
Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes Dev (2008) 2.38
Expectancy and belief modulate the neuronal substrates of pain treated by acupuncture. Neuroimage (2005) 2.37
Foxa2 regulates alveolarization and goblet cell hyperplasia. Development (2004) 2.35
The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. EMBO J (2007) 2.34
Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circ Res (2008) 2.30
Use of prostate-specific antigen (PSA) isoforms for the detection of prostate cancer in men with a PSA level of 2-10 ng/ml: systematic review and meta-analysis. Eur Urol (2005) 2.26
Human β cell transcriptome analysis uncovers lncRNAs that are tissue-specific, dynamically regulated, and abnormally expressed in type 2 diabetes. Cell Metab (2012) 2.22
Glucocorticoid receptor-dependent gene regulatory networks. PLoS Genet (2005) 2.19
The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol (2004) 2.19
Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev (2011) 2.17
Foxa2 integrates the transcriptional response of the hepatocyte to fasting. Cell Metab (2005) 2.15
Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis. J Biol Chem (2005) 2.15
Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell (2009) 2.14
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol (2008) 2.14
Foxa2 is essential for mouse endometrial gland development and fertility. Biol Reprod (2010) 2.12
Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology (2009) 2.10
Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer. Cell (2012) 2.05
Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology (2006) 2.04
Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell (2012) 2.02
Effective treatment of injecting drug users with recently acquired hepatitis C virus infection. Gastroenterology (2009) 1.99
Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes Dev (2007) 1.97
MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function. Gastroenterology (2010) 1.95
An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge. Genome Biol (2014) 1.95
Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol (2005) 1.90
Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting. Diabetes (2013) 1.90
The transcriptional response of the islet to pregnancy in mice. Mol Endocrinol (2009) 1.89
Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metab (2010) 1.88
The Early Transmission Dynamics of H1N1pdm Influenza in the United Kingdom. PLoS Curr (2009) 1.87
FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (2010) 1.86
Foxl1 is a marker of bipotential hepatic progenitor cells in mice. Hepatology (2009) 1.82
Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab (2009) 1.81
A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo. Development (2006) 1.79
Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell (2013) 1.79
Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology (2007) 1.78
The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J Clin Invest (2005) 1.78
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Is there a better term than "medically unexplained symptoms"? J Psychosom Res (2010) 1.77
Imaging pancreatic beta-cells in the intact pancreas. Am J Physiol Endocrinol Metab (2005) 1.74
Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology (2008) 1.72
Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Res (2007) 1.71
The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse. BMC Dev Biol (2009) 1.66
FoxOs function synergistically to promote glucose production. J Biol Chem (2010) 1.66
Foxa2 controls vesicle docking and insulin secretion in mature Beta cells. Cell Metab (2007) 1.66
Defining pancreatic endocrine precursors and their descendants. Diabetes (2007) 1.65
Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Mol Cell Biol (2006) 1.63
Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes (2002) 1.60
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Dev Cell (2003) 1.60
Comparison of different labeling methods for two-channel high-density microarray experiments. Physiol Genomics (2002) 1.60
The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation. Dev Biol (2004) 1.59
Gata6 is an important regulator of mouse pancreas development. Dev Biol (2006) 1.58
Resetting the transcription factor network reverses terminal chronic hepatic failure. J Clin Invest (2015) 1.58
FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. Mol Cell Biol (2006) 1.58
Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci U S A (2004) 1.57
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nat Med (2008) 1.57
Foxa2 regulates multiple pathways of insulin secretion. J Clin Invest (2004) 1.57
Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metab (2011) 1.55
Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. J Clin Invest (2012) 1.55
CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metab (2009) 1.55
The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. J Clin Invest (2009) 1.54
Genome-wide analysis of histone modifications in human pancreatic islets. Genome Res (2010) 1.51
An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Dev Cell (2006) 1.50
Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. J Clin Invest (2009) 1.50
Nkx2.2 repressor complex regulates islet β-cell specification and prevents β-to-α-cell reprogramming. Genes Dev (2011) 1.48
The nucleosome map of the mammalian liver. Nat Struct Mol Biol (2011) 1.47
Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Mol Endocrinol (2010) 1.47
Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. J Clin Invest (2011) 1.46
Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation. Proc Natl Acad Sci U S A (2004) 1.46