Published in J Biol Chem on March 31, 2008
Integration of troponin I phosphorylation with cardiac regulatory networks. Circ Res (2013) 1.38
Why does troponin I have so many phosphorylation sites? Fact and fancy. J Mol Cell Cardiol (2010) 1.25
Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy. J Mol Cell Cardiol (2010) 1.17
Effect of troponin I Ser23/24 phosphorylation on Ca2+-sensitivity in human myocardium depends on the phosphorylation background. J Mol Cell Cardiol (2010) 1.14
Insights into the kinetics of Ca2+-regulated contraction and relaxation from myofibril studies. Pflugers Arch (2009) 1.14
Cardiac thin filament regulation. Pflugers Arch (2008) 1.13
The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments. Circ Res (2009) 1.11
Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice. J Biol Chem (2010) 1.07
Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. PLoS One (2012) 1.06
Diastolic myofilament dysfunction in the failing human heart. Pflugers Arch (2011) 1.05
Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circ Res (2012) 1.02
Combined troponin I Ser-150 and Ser-23/24 phosphorylation sustains thin filament Ca(2+) sensitivity and accelerates deactivation in an acidic environment. J Mol Cell Cardiol (2014) 0.96
Structural dynamics of C-domain of cardiac troponin I protein in reconstituted thin filament. J Biol Chem (2011) 0.94
Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity. J Biol Chem (2012) 0.93
Insights into restrictive cardiomyopathy from clinical and animal studies. J Geriatr Cardiol (2011) 0.93
N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle. J Physiol (2012) 0.92
Ala scanning of the inhibitory region of cardiac troponin I. J Biol Chem (2009) 0.92
Polyol pathway impairs the function of SERCA and RyR in ischemic-reperfused rat hearts by increasing oxidative modifications of these proteins. J Mol Cell Cardiol (2009) 0.87
Protein kinase C phosphomimetics alter thin filament Ca2+ binding properties. PLoS One (2014) 0.85
Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins. Proc Natl Acad Sci U S A (2016) 0.84
The functional significance of the last 5 residues of the C-terminus of cardiac troponin I. Arch Biochem Biophys (2016) 0.82
Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin I (K206I). Circ Cardiovasc Genet (2015) 0.81
Rapid large-scale purification of myofilament proteins using a cleavable His6-tag. Am J Physiol Heart Circ Physiol (2015) 0.77
Restrictive Cardiomyopathy Caused by Troponin Mutations: Application of Disease Animal Models in Translational Studies. Front Physiol (2016) 0.75
Differences between cardiac and skeletal troponin interaction with the thin filament probed by troponin exchange in skeletal myofibrils. Biophys J (2009) 0.75
Calcium, thin filaments, and the integrative biology of cardiac contractility. Annu Rev Physiol (2005) 3.44
The molecular mechanism of muscle contraction. Adv Protein Chem (2005) 3.30
Molecular and cellular mechanisms of myocardial stunning. Physiol Rev (1999) 3.16
Titin isoform switch in ischemic human heart disease. Circulation (2002) 3.05
Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics. Am J Physiol Regul Integr Comp Physiol (2006) 2.21
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T. J Biol Chem (2003) 1.99
Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I. J Biol Chem (2006) 1.89
Role of troponin I proteolysis in the pathogenesis of stunned myocardium. Circ Res (1997) 1.74
Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics. Am J Physiol Heart Circ Physiol (2004) 1.67
Calpain-I induced alterations in the cytoskeletal structure and impaired mechanical properties of single myocytes of rat heart. Cardiovasc Res (2000) 1.66
Stunned peri-infarct canine myocardium is characterized by degradation of troponin T, not troponin I. Cardiovasc Res (2004) 1.65
Transgenic mouse model of stunned myocardium. Science (2000) 1.62
Relaxation and diastole of the heart. Physiol Rev (1989) 1.61
Preload induces troponin I degradation independently of myocardial ischemia. Circulation (2001) 1.60
Absence of troponin I degradation or altered sarcoplasmic reticulum uptake protein expression after reversible ischemia in swine. Circ Res (1999) 1.57
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol (2004) 1.48
Force kinetics and individual sarcomere dynamics in cardiac myofibrils after rapid ca(2+) changes. Biophys J (2002) 1.41
Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T. Am J Physiol Heart Circ Physiol (2001) 1.36
The C terminus of cardiac troponin I is essential for full inhibitory activity and Ca2+ sensitivity of rat myofibrils. J Biol Chem (1997) 1.24
Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle. Circ Res (2006) 1.19
C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning. Circ Res (2003) 1.13
Cardiac troponin I is modified in the myocardium of bypass patients. Circulation (2001) 1.09
Proteomics of ischemia/reperfusion injury in rabbit myocardium reveals alterations to proteins of essential functional systems. Proteomics (2005) 1.04
Cardiac myofilaments: mechanics and regulation. J Biomech (2003) 1.04
The use of human cardiac tissue in biophysical research: the risks of translation. J Mol Cell Cardiol (2007) 0.99
Increased cross-bridge cycling rate in stunned myocardium. Am J Physiol Heart Circ Physiol (2005) 0.86
Calcium, thin filaments, and the integrative biology of cardiac contractility. Annu Rev Physiol (2005) 3.44
Titin isoform switch in ischemic human heart disease. Circulation (2002) 3.05
Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res (2005) 2.79
Ontology-based meta-analysis of global collections of high-throughput public data. PLoS One (2010) 2.67
Myofilament calcium sensitivity in skinned rat cardiac trabeculae: role of interfilament spacing. Circ Res (2002) 2.53
Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J (2008) 2.29
Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics. Am J Physiol Regul Integr Comp Physiol (2006) 2.21
At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ Res (2004) 2.06
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol (2006) 2.06
Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circ Res (2007) 2.05
Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. J Clin Invest (2008) 2.02
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T. J Biol Chem (2003) 1.99
Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci U S A (2002) 1.98
Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I. J Biol Chem (2006) 1.89
Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem (2003) 1.87
Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing. J Physiol (2003) 1.85
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Am J Physiol Heart Circ Physiol (2007) 1.84
Biology of the troponin complex in cardiac myocytes. Prog Cardiovasc Dis (2005) 1.83
Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Circ Res (2003) 1.82
The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation. Biochem Biophys Res Commun (2007) 1.77
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem (2008) 1.75
The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circ Res (2007) 1.74
Impact of beta-myosin heavy chain isoform expression on cross-bridge cycling kinetics. Am J Physiol Heart Circ Physiol (2004) 1.67
Cooperative activation in cardiac muscle: impact of sarcomere length. Am J Physiol Heart Circ Physiol (2002) 1.61
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophys J (2007) 1.61
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin. J Mol Biol (2007) 1.60
Mechanisms and use of calcium-sensitizing agents in the failing heart. Circulation (2006) 1.53
Blebbistatin: use as inhibitor of muscle contraction. Pflugers Arch (2007) 1.52
p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. Circ Res (2007) 1.48
A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation. Physiology (Bethesda) (2007) 1.48
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol (2004) 1.48
Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I. J Biol Chem (2008) 1.46
Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments. J Mol Cell Cardiol (2009) 1.46
Medical literature searches: a comparison of PubMed and Google Scholar. Health Info Libr J (2012) 1.43
Beneficial effects of SR33805 in failing myocardium. Cardiovasc Res (2011) 1.43
Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res (2012) 1.39
Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J (2005) 1.38
Integration of troponin I phosphorylation with cardiac regulatory networks. Circ Res (2013) 1.38
Length-dependent activation in three striated muscle types of the rat. J Physiol (2002) 1.37
Frank-Starling law of the heart and the cellular mechanisms of length-dependent activation. Pflugers Arch (2002) 1.34
Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I. Circ Res (2009) 1.33
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res (2004) 1.32
Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: increased or decreased? J Mol Cell Cardiol (2008) 1.31
Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium. Am J Physiol Heart Circ Physiol (2006) 1.30
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res (2007) 1.29
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol (2009) 1.29
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation (2010) 1.29
The significance of regulatory light chain phosphorylation in cardiac physiology. Arch Biochem Biophys (2011) 1.27
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function. J Biol Chem (2012) 1.27
Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. J Biol Chem (2004) 1.27
Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells. Circ Res (2007) 1.26
Selective deletion of the NH2-terminal variable region of cardiac troponin T in ischemia reperfusion by myofibril-associated mu-calpain cleavage. Biochemistry (2006) 1.25
Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. Am J Physiol Heart Circ Physiol (2006) 1.25
Restoration of resting sarcomere length after uniaxial static strain is regulated by protein kinase Cepsilon and focal adhesion kinase. Circ Res (2004) 1.24
Restricted N-terminal truncation of cardiac troponin T: a novel mechanism for functional adaptation to energetic crisis. J Physiol (2008) 1.24
Protein phosphorylation and signal transduction in cardiac thin filaments. J Biol Chem (2011) 1.23
Molecular and integrated biology of thin filament protein phosphorylation in heart muscle. Ann N Y Acad Sci (2004) 1.22
PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation. Basic Res Cardiol (2010) 1.21
Myosin head orientation: a structural determinant for the Frank-Starling relationship. Am J Physiol Heart Circ Physiol (2011) 1.21
Coupled expression of troponin T and troponin I isoforms in single skeletal muscle fibers correlates with contractility. Am J Physiol Cell Physiol (2005) 1.20
Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts. Am J Physiol Heart Circ Physiol (2008) 1.20
Approaches to modeling crossbridges and calcium-dependent activation in cardiac muscle. Prog Biophys Mol Biol (2004) 1.19
Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. J Physiol (2007) 1.18
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation (2011) 1.18
Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation (2010) 1.18
Cardiac troponin I threonine 144: role in myofilament length dependent activation. Circ Res (2007) 1.18
Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation (2008) 1.17
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. Am J Physiol Cell Physiol (2008) 1.16
Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure. J Card Fail (2002) 1.16
Cardiac myosin binding protein-C: redefining its structure and function. Biophys Rev (2012) 1.15
Increased phosphorylation of tropomyosin, troponin I, and myosin light chain-2 after stretch in rabbit ventricular myocardium under physiological conditions. J Mol Cell Cardiol (2010) 1.15
Cardiac dysfunction and heart failure are associated with abnormalities in the subcellular distribution and amounts of oligomeric muscle LIM protein. Am J Physiol Heart Circ Physiol (2006) 1.15
The role of thin filament cooperativity in cardiac length-dependent calcium activation. Biophys J (2010) 1.15
Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. J Biol Chem (2007) 1.14
Pathogenic properties of the N-terminal region of cardiac myosin binding protein-C in vitro. J Muscle Res Cell Motil (2012) 1.14
Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin. Circ Res (2005) 1.14
Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties. J Mol Cell Cardiol (2012) 1.14