Published in J Biol Chem on June 12, 2008
Structural basis of protein kinase C isoform function. Physiol Rev (2008) 4.00
Multiplex kinase signaling modifies cardiac function at the level of sarcomeric proteins. J Biol Chem (2008) 1.76
Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling. J Biol Chem (2009) 1.47
Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments. J Mol Cell Cardiol (2009) 1.46
Augmented phosphorylation of cardiac troponin I in hypertensive heart failure. J Biol Chem (2011) 1.38
Integration of troponin I phosphorylation with cardiac regulatory networks. Circ Res (2013) 1.38
Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I. Circ Res (2009) 1.33
Why does troponin I have so many phosphorylation sites? Fact and fancy. J Mol Cell Cardiol (2010) 1.25
Protein phosphorylation and signal transduction in cardiac thin filaments. J Biol Chem (2011) 1.23
Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice. J Mol Cell Cardiol (2009) 1.15
Oxidative stress and sarcomeric proteins. Circ Res (2013) 1.15
Cardiac actions of protein kinase C isoforms. Physiology (Bethesda) (2012) 1.08
Phosphorylation of cardiac troponin I at protein kinase C site threonine 144 depresses cooperative activation of thin filaments. J Biol Chem (2010) 1.08
Overview: the maturing of proteomics in cardiovascular research. Circ Res (2011) 0.95
Protein kinase D isoforms are activated in an agonist-specific manner in cardiomyocytes. J Biol Chem (2010) 0.92
H2O2 alters rat cardiac sarcomere function and protein phosphorylation through redox signaling. Am J Physiol Heart Circ Physiol (2010) 0.91
Regional variation in myofilament length-dependent activation. Pflugers Arch (2011) 0.89
Redox signaling and cardiac sarcomeres. J Biol Chem (2011) 0.88
Targeted activation of conventional and novel protein kinases C through differential translocation patterns. Mol Cell Biol (2014) 0.87
Interventricular differences in myofilament function in experimental congestive heart failure. Pflugers Arch (2011) 0.87
Cardiomyopathy-causing deletion K210 in cardiac troponin T alters phosphorylation propensity of sarcomeric proteins. J Mol Cell Cardiol (2010) 0.87
Regulatory autophosphorylation sites on protein kinase C-delta at threonine-141 and threonine-295. Biochemistry (2009) 0.86
Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction. J Biol Chem (2010) 0.86
Protein kinase C-{delta} regulates the subcellular localization of Shc in H2O2-treated cardiomyocytes. Am J Physiol Cell Physiol (2010) 0.84
Raf-1: a novel cardiac troponin T kinase. J Muscle Res Cell Motil (2009) 0.82
Serine-910 phosphorylation of focal adhesion kinase is critical for sarcomere reorganization in cardiomyocyte hypertrophy. Cardiovasc Res (2011) 0.82
Nuclear localization of a1A-adrenergic receptors is required for signaling in cardiac myocytes: an “inside-out” a1-AR signaling pathway. J Am Heart Assoc (2014) 0.81
Mechanisms for redox-regulation of protein kinase C. Front Pharmacol (2015) 0.81
The C2 Domain and Altered ATP-Binding Loop Phosphorylation at Ser³⁵⁹ Mediate the Redox-Dependent Increase in Protein Kinase C-δ Activity. Mol Cell Biol (2015) 0.81
Functionally conservative substitutions at cardiac troponin I S43/45. Arch Biochem Biophys (2016) 0.80
Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease. Pharmacol Ther (2016) 0.80
Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling. Mol Pharmacol (2014) 0.78
Molecular systems pharmacology: isoelectric focusing signature of protein kinase Cδ provides an integrated measure of its modulation in response to ligands. J Med Chem (2014) 0.77
A novel phosphorylation site at Ser130 adjacent to the pseudosubstrate domain contributes to the activation of protein kinase C-δ. Biochem J (2015) 0.76
Protein kinase C mechanisms that contribute to cardiac remodelling. Clin Sci (Lond) (2016) 0.76
Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling. J Proteome Res (2017) 0.75
The role of protein kinase C-mediated phosphorylation of sarcomeric proteins in the heart-detrimental or beneficial? Biophys Rev (2011) 0.75
LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils. J Leukoc Biol (2016) 0.75
CLEAVAGE ALTERS THE MOLECULAR DETERMINANTS OF PROTEIN KINASE C-δ CATALYTIC ACTIVITY. Mol Cell Biol (2017) 0.75
Functional communication between PKC-targeted cardiac troponin I phosphorylation sites. Arch Biochem Biophys (2017) 0.75
Protein kinase cascades in the regulation of cardiac hypertrophy. J Clin Invest (2005) 4.31
Calcium, thin filaments, and the integrative biology of cardiac contractility. Annu Rev Physiol (2005) 3.44
Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem J (2004) 2.70
Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol Cell Biol (2004) 2.51
Protein kinase C signaling and oxidative stress. Free Radic Biol Med (2000) 2.29
Cardiac troponin I gene knockout: a mouse model of myocardial troponin I deficiency. Circ Res (1999) 1.96
Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem (2003) 1.87
Loaded shortening, power output, and rate of force redevelopment are increased with knockout of cardiac myosin binding protein-C. Circ Res (2003) 1.81
Covalent and noncovalent modification of thin filament action: the essential role of troponin in cardiac muscle regulation. Circ Res (2004) 1.80
Protein kinase C and beyond. Nat Immunol (2004) 1.79
PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. J Mol Cell Cardiol (2006) 1.71
Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1. J Biol Chem (1995) 1.64
Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium. J Physiol (2003) 1.62
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin. J Mol Biol (2007) 1.60
Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes. J Biol Chem (2004) 1.43
Mechanism of diacylglycerol-induced membrane targeting and activation of protein kinase Cdelta. J Biol Chem (2004) 1.43
Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations. J Biol Chem (2003) 1.35
PKA accelerates rate of force development in murine skinned myocardium expressing alpha- or beta-tropomyosin. Am J Physiol Heart Circ Physiol (2001) 1.28
Molecular and integrated biology of thin filament protein phosphorylation in heart muscle. Ann N Y Acad Sci (2004) 1.22
Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene. Mol Cell Biochem (2004) 1.15
Protein kinase Cepsilon (PKCepsilon) and Src control PKCdelta activation loop phosphorylation in cardiomyocytes. J Biol Chem (2007) 1.07
Effects of the mutation R145G in human cardiac troponin I on the kinetics of the contraction-relaxation cycle in isolated cardiac myofibrils. J Physiol (2005) 1.07
Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response. J Biol Chem (2005) 1.07
Inorganic phosphate speeds loaded shortening in rat skinned cardiac myocytes. Am J Physiol Cell Physiol (2004) 1.06
Diacylglycerol's affair with protein kinase C turns 25. Trends Pharmacol Sci (2004) 1.05
CGP-48506 increases contractility of ventricular myocytes and myofilaments by effects on actin-myosin reaction. Am J Physiol (1996) 1.02
Independence of protein kinase C-delta activity from activation loop phosphorylation: structural basis and altered functions in cells. J Biol Chem (2006) 1.00
Myofilament remodeling during the progression of heart failure. J Card Fail (2002) 0.85
Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts. Heart Rhythm (2007) 5.25
Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell (2002) 4.35
Orphaned ryanodine receptors in the failing heart. Proc Natl Acad Sci U S A (2006) 3.99
Calcium, thin filaments, and the integrative biology of cardiac contractility. Annu Rev Physiol (2005) 3.44
Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res (2005) 2.79
At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function. Circ Res (2004) 2.06
Caveolar localization dictates physiologic signaling of beta 2-adrenoceptors in neonatal cardiac myocytes. J Biol Chem (2002) 2.06
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol (2006) 2.06
Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Circ Res (2007) 2.05
Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes. Biophys J (2006) 2.03
Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice. J Clin Invest (2008) 2.02
Identification of a functionally critical protein kinase C phosphorylation residue of cardiac troponin T. J Biol Chem (2003) 1.99
Functional consequences of caspase activation in cardiac myocytes. Proc Natl Acad Sci U S A (2002) 1.98
Increased Ca2+ affinity of cardiac thin filaments reconstituted with cardiomyopathy-related mutant cardiac troponin I. J Biol Chem (2006) 1.89
Interplay of ryanodine receptor distribution and calcium dynamics. Biophys J (2006) 1.87
Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem (2003) 1.87
Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing. J Physiol (2003) 1.85
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Am J Physiol Heart Circ Physiol (2007) 1.84
Biology of the troponin complex in cardiac myocytes. Prog Cardiovasc Dis (2005) 1.83
Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes. Circ Res (2003) 1.82
Repeated exposure to methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration. Neuron (2008) 1.81
Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases. Nat Med (2012) 1.79
The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation. Biochem Biophys Res Commun (2007) 1.77
Calcium handling in human embryonic stem cell-derived cardiomyocytes. Stem Cells (2008) 1.75
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem (2008) 1.75
The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circ Res (2007) 1.74
Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophys J (2007) 1.61
Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin. J Mol Biol (2007) 1.60
Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice. J Physiol (2005) 1.58
Enhanced G(i) signaling selectively negates beta2-adrenergic receptor (AR)--but not beta1-AR-mediated positive inotropic effect in myocytes from failing rat hearts. Circulation (2003) 1.55
Mechanisms and use of calcium-sensitizing agents in the failing heart. Circulation (2006) 1.53
Ser1928 is a common site for Cav1.2 phosphorylation by protein kinase C isoforms. J Biol Chem (2004) 1.51
p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. Circ Res (2007) 1.48
A dominant role of cardiac molecular motors in the intrinsic regulation of ventricular ejection and relaxation. Physiology (Bethesda) (2007) 1.48
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol (2004) 1.48
Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory. Heart Rhythm (2010) 1.47
Neuropeptide Y is an essential in vivo developmental regulator of cardiac ICa,L. Circ Res (2003) 1.47
Differential effects of phosphorylation of regions of troponin I in modifying cooperative activation of cardiac thin filaments. J Mol Cell Cardiol (2009) 1.46
Role of the transverse-axial tubule system in generating calcium sparks and calcium transients in rat atrial myocytes. J Physiol (2003) 1.45
Stimulus-specific differences in protein kinase C delta localization and activation mechanisms in cardiomyocytes. J Biol Chem (2004) 1.43
Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res (2012) 1.39
Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats. Am J Respir Crit Care Med (2005) 1.39
Accessory subunit KChIP2 modulates the cardiac L-type calcium current. Circ Res (2009) 1.39
Augmented phosphorylation of cardiac troponin I in hypertensive heart failure. J Biol Chem (2011) 1.38
Protection against endotoxemia-induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J (2005) 1.38
Integration of troponin I phosphorylation with cardiac regulatory networks. Circ Res (2013) 1.38
Funding opportunities for investigators in the early stages of career development. Circulation (2009) 1.38
Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circ Res (2011) 1.37
Phosphoinositide 3-kinase gamma-deficient mice are protected from isoproterenol-induced heart failure. Circulation (2003) 1.36
Cross-regulation of novel protein kinase C (PKC) isoform function in cardiomyocytes. Role of PKC epsilon in activation loop phosphorylations and PKC delta in hydrophobic motif phosphorylations. J Biol Chem (2003) 1.35
Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I. Circ Res (2009) 1.33
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res (2004) 1.32
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res (2007) 1.29
Protein kinase D links Gq-coupled receptors to cAMP response element-binding protein (CREB)-Ser133 phosphorylation in the heart. J Biol Chem (2008) 1.29
Hypertension-induced remodeling of cardiac excitation-contraction coupling in ventricular myocytes occurs prior to hypertrophy development. Am J Physiol Heart Circ Physiol (2007) 1.29
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol (2009) 1.29
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation (2010) 1.29
The significance of regulatory light chain phosphorylation in cardiac physiology. Arch Biochem Biophys (2011) 1.27
Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. J Biol Chem (2004) 1.27
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function. J Biol Chem (2012) 1.27
Regulation of L-type calcium channel and delayed rectifier potassium channel activity by p21-activated kinase-1 in guinea pig sinoatrial node pacemaker cells. Circ Res (2007) 1.26
Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. J Neurosci (2007) 1.26
Transformation of adult rat cardiac myocytes in primary culture. Exp Physiol (2007) 1.25
Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. Am J Physiol Heart Circ Physiol (2006) 1.25
Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916. J Biol Chem (2008) 1.24
Protein phosphorylation and signal transduction in cardiac thin filaments. J Biol Chem (2011) 1.23
Molecular and integrated biology of thin filament protein phosphorylation in heart muscle. Ann N Y Acad Sci (2004) 1.22
PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation. Basic Res Cardiol (2010) 1.21
Protein kinase C isoform-selective signals that lead to cardiac hypertrophy and the progression of heart failure. Mol Cell Biochem (2003) 1.20
Quantitative comparison of sarcomeric phosphoproteomes of neonatal and adult rat hearts. Am J Physiol Heart Circ Physiol (2008) 1.20
Multiple defects in intracellular calcium cycling in whole failing rat heart. Circ Heart Fail (2009) 1.20
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation (2011) 1.18
Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation (2010) 1.18
Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation (2008) 1.17
Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure. Am J Physiol Heart Circ Physiol (2007) 1.17
Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway. J Clin Invest (2004) 1.17
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. Am J Physiol Cell Physiol (2008) 1.16
Increased cross-bridge cycling kinetics after exchange of C-terminal truncated troponin I in skinned rat cardiac muscle. J Biol Chem (2008) 1.15
Protein kinase C zeta. A novel regulator of both phosphorylation and de-phosphorylation of cardiac sarcomeric proteins. J Biol Chem (2007) 1.14
Functional effects of rho-kinase-dependent phosphorylation of specific sites on cardiac troponin. Circ Res (2005) 1.14
Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties. J Mol Cell Cardiol (2012) 1.14
TREK-1 is a novel molecular target in prostate cancer. Cancer Res (2008) 1.12
A novel cardiomyocyte-enriched microRNA, miR-378, targets insulin-like growth factor 1 receptor: implications in postnatal cardiac remodeling and cell survival. J Biol Chem (2012) 1.12
p66Shc links alpha1-adrenergic receptors to a reactive oxygen species-dependent AKT-FOXO3A phosphorylation pathway in cardiomyocytes. Circ Res (2009) 1.12
Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function. Cardiovasc Res (2008) 1.12
Role of L-type calcium channels in pacing-induced short-term and long-term cardiac memory in canine heart. Circulation (2003) 1.12