Pneumonia research to reduce childhood mortality in the developing world.

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Published in J Clin Invest on April 01, 2008

Authors

J Anthony G Scott1, W Abdullah Brooks, J S Malik Peiris, Douglas Holtzman, E Kim Mulholland

Author Affiliations

1: Wellcome Trust/KEMRI Research Programme, Kilifi, Kenya. ascott@ikikifi.net

Associated clinical trials:

Evaluating the Safety and Immune Response to Two Pneumococcal Vaccines in HIV-Infected Pregnant Women | NCT01443117

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Field evaluation of a respiratory syncytial virus vaccine and a trivalent parainfluenza virus vaccine in a pediatric population. Am J Epidemiol (1969) 4.93

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Aetiology, outcome, and risk factors for mortality among adults with acute pneumonia in Kenya. Lancet (2000) 2.74

The etiology of pneumonia in malnourished and well-nourished Gambian children. Pediatr Infect Dis J (1994) 2.73

Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol Rev (1985) 2.66

Diagnostic value of C reactive protein in infections of the lower respiratory tract: systematic review. BMJ (2005) 2.66

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Improved diagnosis of the etiology of community-acquired pneumonia with real-time polymerase chain reaction. Clin Infect Dis (2005) 2.54

Bacterial pneumonia during the Hong Kong influenza epidemic of 1968-1969. Arch Intern Med (1971) 2.52

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Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study. J Infect Dis (2005) 2.29

Granulocyte colony-stimulating factor as a marker for bacterial infection in neonates. J Pediatr (1996) 2.27

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Comparison of nasal prongs and nasopharyngeal catheter for the delivery of oxygen in children with hypoxemia because of a lower respiratory tract infection. J Pediatr (1995) 2.19

Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by capsulated pneumococci. Infect Immun (2001) 2.19

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IFNs activate toll-like receptor gene expression in viral infections. Genes Immun (2001) 1.90

A further attenuated derivative of a cold-passaged temperature-sensitive mutant of human respiratory syncytial virus retains immunogenicity and protective efficacy against wild-type challenge in seronegative chimpanzees. Vaccine (1994) 1.89

Severe pneumococcal pneumonia in previously healthy children: the role of preceding influenza infection. Clin Infect Dis (2000) 1.89

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Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infect Immun (2006) 1.80

Evasion of antibody neutralization in emerging severe acute respiratory syndrome coronaviruses. Proc Natl Acad Sci U S A (2005) 1.75

Zinc for severe pneumonia in very young children: double-blind placebo-controlled trial. Lancet (2004) 1.74

Lung puncture in the etiological diagnosis of pneumonia. A study of 543 infants and children. Am J Dis Child (1971) 1.68

Diagnosis of a critical respiratory illness caused by human metapneumovirus by use of a pan-virus microarray. J Clin Microbiol (2007) 1.67

Etiology of acute lower respiratory tract infections in Gambian children: I. Acute lower respiratory tract infections in infants presenting at the hospital. Pediatr Infect Dis J (1991) 1.66

Zinc deficiency, infectious disease and mortality in the developing world. J Nutr (2003) 1.64

Hypoxaemia in children with severe pneumonia in Papua New Guinea. Int J Tuberc Lung Dis (2001) 1.57

Haemophilus influenzae invasive disease in the United States, 1994-1995: near disappearance of a vaccine-preventable childhood disease. Emerg Infect Dis (1998) 1.57

Etiology of acute lower respiratory tract infections in Gambian children: II. Acute lower respiratory tract infection in children ages one to nine years presenting at the hospital. Pediatr Infect Dis J (1991) 1.57

A survey of human cases of H5N1 avian influenza reported by the WHO before June 2006 for infection control. Am J Infect Control (2007) 1.56

Emerging respiratory viruses: challenges and vaccine strategies. Clin Microbiol Rev (2006) 1.52

Immunopathology of RSV infection: prospects for developing vaccines without this complication. Rev Med Virol (2006) 1.48

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Validation of self-swab for virologic confirmation of influenza virus infections in a community setting. J Infect Dis (2011) 1.15

Immunogenicity and safety of intradermal influenza immunization at a reduced dose in healthy children. Pediatrics (2007) 1.15

Comparison of the NucliSens easyMAG and Qiagen BioRobot 9604 nucleic acid extraction systems for detection of RNA and DNA respiratory viruses in nasopharyngeal aspirate samples. J Clin Microbiol (2008) 1.13