The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury.

PubWeight™: 1.71‹?› | Rank: Top 3%

🔗 View Article (PMC 3000830)

Published in J Immunol on December 09, 2009

Authors

Hiroyuki Seki1, Koichi Fukunaga, Makoto Arita, Hiroyuki Arai, Hiroki Nakanishi, Ryo Taguchi, Taku Miyasho, Rina Takamiya, Koichiro Asano, Akitoshi Ishizaka, Junzo Takeda, Bruce D Levy

Author Affiliations

1: Department of Anesthesiology, Keio University School of Medicine, Tokyo, Japan.

Articles citing this

Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature (2012) 4.04

Resolvins and protectins in inflammation resolution. Chem Rev (2011) 3.09

Novel lipid mediators and resolution mechanisms in acute inflammation: to resolve or not? Am J Pathol (2010) 2.16

Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins. Circ Res (2010) 1.89

Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity (2014) 1.85

Specialized pro-resolving lipid mediators in the inflammatory response: An update. Biochim Biophys Acta (2010) 1.72

Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol (2012) 1.67

Emerging roles of resolvins in the resolution of inflammation and pain. Trends Neurosci (2011) 1.60

The resolution of inflammation. Nat Rev Immunol (2012) 1.58

Emerging targets in neuroinflammation-driven chronic pain. Nat Rev Drug Discov (2014) 1.57

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation. Proc Natl Acad Sci U S A (2012) 1.49

Controlling herpes simplex virus-induced ocular inflammatory lesions with the lipid-derived mediator resolvin E1. J Immunol (2010) 1.38

Acute lung injury: how macrophages orchestrate resolution of inflammation and tissue repair. Front Immunol (2011) 1.34

Impaired phagocytosis in localized aggressive periodontitis: rescue by Resolvin E1. PLoS One (2011) 1.29

A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. PLoS One (2013) 1.28

Lipid mediators in immune dysfunction after severe inflammation. Trends Immunol (2013) 1.24

Resolvins: natural agonists for resolution of pulmonary inflammation. Prog Lipid Res (2010) 1.08

Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol (2014) 1.04

Respiratory infection and the impact of pulmonary immunity on lung health and disease. Am J Respir Crit Care Med (2012) 1.04

Maresin-1 reduces the pro-inflammatory response of bronchial epithelial cells to organic dust. Respir Res (2013) 1.00

Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. Free Radic Biol Med (2012) 1.00

Wound repair: role of immune-epithelial interactions. Mucosal Immunol (2015) 1.00

Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. Proc Natl Acad Sci U S A (2014) 0.99

Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol (2015) 0.99

Regulation of neutrophil survival/apoptosis by Mcl-1. ScientificWorldJournal (2011) 0.99

The role of pro-resolution lipid mediators in infectious disease. Immunology (2014) 0.98

Update in acute lung injury and critical care 2010. Am J Respir Crit Care Med (2011) 0.98

Bioactive products formed in humans from fish oils. J Lipid Res (2015) 0.95

17(R)-Resolvin D1 differentially regulates TLR4-mediated responses of primary human macrophages to purified LPS and live E. coli. J Leukoc Biol (2011) 0.94

Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol (2015) 0.93

Maresin 1 mitigates LPS-induced acute lung injury in mice. Br J Pharmacol (2014) 0.93

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway. FASEB J (2012) 0.93

Enhanced Resolution of Hyperoxic Acute Lung Injury as a result of Aspirin Triggered Resolvin D1 Treatment. Am J Respir Cell Mol Biol (2015) 0.90

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins. Front Immunol (2013) 0.89

The endogenous pro-resolving mediators lipoxin A4 and resolvin E1 preserve organ function in allograft rejection. Prostaglandins Leukot Essent Fatty Acids (2010) 0.84

Resolvin D1 and Resolvin E1 Promote the Resolution of Allergic Airway Inflammation via Shared and Distinct Molecular Counter-Regulatory Pathways. Front Immunol (2012) 0.84

Understanding resolvin signaling pathways to improve oral health. Int J Mol Sci (2013) 0.82

Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation. Mucosal Immunol (2015) 0.81

Omega-3 polyunsaturated Fatty acids suppress the cystic lesion formation of peritoneal endometriosis in transgenic mouse models. PLoS One (2013) 0.81

Maresin-1 reduces airway inflammation associated with acute and repetitive exposures to organic dust. Transl Res (2015) 0.81

Resolution of inflammation: targeting GPCRs that interact with lipids and peptides. Drug Discov Today (2014) 0.81

DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation. Eur J Pharmacol (2015) 0.80

Molecular circuits of resolution in airway inflammation. ScientificWorldJournal (2010) 0.80

Targeting neutrophil apoptosis for enhancing the resolution of inflammation. Cells (2013) 0.80

Resolvin D1 Reduces Emphysema and Chronic Inflammation. Am J Pathol (2015) 0.80

Resolvins: Endogenously-Generated Potent Painkilling Substances and their Therapeutic Perspectives. Curr Neuropharmacol (2013) 0.79

The omega-3 fatty acid docosahexaenoic acid attenuates organic dust-induced airway inflammation. Nutrients (2014) 0.78

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia. Am J Pathol (2016) 0.77

Biological Roles of Resolvins and Related Substances in the Resolution of Pain. Biomed Res Int (2015) 0.77

Alpha-1 antitrypsin reduces severity of pseudomonas pneumonia in mice and inhibits epithelial barrier disruption and pseudomonas invasion of respiratory epithelial cells. Front Public Health (2013) 0.77

Resolvin E1 maintains macrophage function under cigarette smoke-induced oxidative stress. FEBS Open Bio (2012) 0.77

Differences between basal lung levels of select eicosanoids in rat and mouse. Pulm Circ (2013) 0.77

Discovery of specialized pro-resolving mediators marks the dawn of resolution physiology and pharmacology. Mol Aspects Med (2017) 0.77

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors. Mol Aspects Med (2017) 0.76

Advanced Age Alters Monocyte and Macrophage Responses. Antioxid Redox Signal (2016) 0.75

Pretreatment with Fish Oil-Based Lipid Emulsion Modulates Muscle Leukocyte Chemotaxis in Murine Model of Sublethal Lower Limb Ischemia. Mediators Inflamm (2017) 0.75

Omega-3 Polyunsaturated Fatty Acids and Oxylipins in Neuroinflammation and Management of Alzheimer Disease. Adv Nutr (2016) 0.75

The use of fish oil lipid emulsion in the treatment of intestinal failure associated liver disease (IFALD). Nutrients (2012) 0.75

ResolvinD1 reduces apoptosis and inflammation in primary human alveolar epithelial type 2 cells. Lab Invest (2016) 0.75

Lipoxin Signaling in Murine Lung Host Responses to Cryptococcus neoformans Infection. Am J Respir Cell Mol Biol (2016) 0.75

Pro-Resolving Molecules-New Approaches to Treat Sepsis? Int J Mol Sci (2017) 0.75

Resolvin D1 prevents smoking-induced emphysema and promotes lung tissue regeneration. Int J Chron Obstruct Pulmon Dis (2016) 0.75

Nutrition: A Primary Therapy in Pediatric Acute Respiratory Distress Syndrome. Front Pediatr (2016) 0.75

Specialized Pro-resolving Mediators (SPM) Rescue Infant Mice from Lethal Citrobacter rodentium Infection and Promote Immunity against Re-infection. Infect Immun (2017) 0.75

Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation. Mol Aspects Med (2017) 0.75

Artesunate Protects LPS-Induced Acute Lung Injury by Inhibiting TLR4 Expression and Inducing Nrf2 Activation. Inflammation (2017) 0.75

Articles cited by this

The acute respiratory distress syndrome. N Engl J Med (2000) 25.38

Tissue destruction by neutrophils. N Engl J Med (1989) 13.81

Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature (2007) 6.53

Aspiration pneumonitis and aspiration pneumonia. N Engl J Med (2001) 6.51

Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groups. Lancet (1993) 6.39

Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell (2008) 6.37

Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing. J Exp Med (2000) 5.59

Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med (2005) 5.00

Trends in infectious disease mortality in the United States during the 20th century. JAMA (1999) 4.97

Neutrophils and acute lung injury. Crit Care Med (2003) 4.56

Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med (2007) 4.36

Acute lower respiratory tract infection. N Engl J Med (2008) 3.70

Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids. Nature (2004) 3.65

Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol (2004) 3.65

Effects of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in mechanically ventilated patients with severe sepsis and septic shock. Crit Care Med (2006) 3.35

Lung infection--a public health priority. PLoS Med (2006) 3.34

Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis. Proc Natl Acad Sci U S A (2005) 3.32

Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group. Crit Care Med (1999) 3.27

Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol (2008) 3.15

Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol (2007) 2.83

Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am J Respir Crit Care Med (1996) 2.81

Resolvin E1 regulates inflammation at the cellular and tissue level and restores tissue homeostasis in vivo. J Immunol (2007) 2.66

Synthetic chemerin-derived peptides suppress inflammation through ChemR23. J Exp Med (2008) 2.54

Contributions of high mobility group box protein in experimental and clinical acute lung injury. Am J Respir Crit Care Med (2004) 2.50

Inflammatory cytokines in the BAL of patients with ARDS. Persistent elevation over time predicts poor outcome. Chest (1995) 2.38

Enhancement of growth of virulent strains of Escherichia coli by interleukin-1. Science (1991) 2.37

Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest (1995) 2.36

Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis. Proc Natl Acad Sci U S A (2006) 2.31

Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. J Immunol (2005) 2.11

Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol (2007) 2.11

Effects of leukotriene B4 in the human lung. Recruitment of neutrophils into the alveolar spaces without a change in protein permeability. J Clin Invest (1989) 2.09

Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J (1996) 2.09

Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med (2006) 2.04

Pneumonia research to reduce childhood mortality in the developing world. J Clin Invest (2008) 2.01

Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J (2007) 1.67

The aspiration of stomach contents into the lungs during obstetric anesthesia. Am J Obstet Gynecol (1946) 1.67

Intake of n-6 and n-3 fatty acids and fish and risk of community-acquired pneumonia in US men. Am J Clin Nutr (2005) 1.57

Aspiration pneumonitis primes the host for an exaggerated inflammatory response during pneumonia. Crit Care Med (2005) 1.46

Metabolic inactivation of resolvin E1 and stabilization of its anti-inflammatory actions. J Biol Chem (2006) 1.45

Enteral nutrition with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants reduces alveolar inflammatory mediators and protein influx in patients with acute respiratory distress syndrome. Crit Care Med (2003) 1.43

Omega-3 polyunsaturated fatty acids and human health outcomes. Biofactors (2009) 1.43

Aspiration of gastric contents in the operative period. N Engl J Med (1965) 1.42

Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma. Biochem Biophys Res Commun (2008) 1.33

The role of neutrophils, oxidants, and proteases in the pathogenesis of acid pulmonary injury. Anesthesiology (1992) 1.24

Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria. Am J Respir Crit Care Med (1999) 1.13

Acute lung injury is reduced in fat-1 mice endogenously synthesizing n-3 fatty acids. Am J Respir Crit Care Med (2009) 1.01

Acid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expression. Am J Respir Cell Mol Biol (2001) 0.98

Monocyte chemoattractant protein-1 influences trauma-hemorrhage-induced distal organ damage via regulation of keratinocyte-derived chemokine production. Am J Physiol Regul Integr Comp Physiol (2006) 0.92

Gastric acid and particulate aspiration injury inhibits pulmonary bacterial clearance. Crit Care Med (2004) 0.91

Dietary (n-3) polyunsaturated fatty acids affect the kinetics of pro- and antiinflammatory responses in mice with Pseudomonas aeruginosa lung infection. J Nutr (2008) 0.86

Omega-3 polyunsaturated fatty acids improve host response in chronic Pseudomonas aeruginosa lung infection in mice. Am J Physiol Lung Cell Mol Physiol (2007) 0.82

Acid aspiration induces bacterial pneumonia by enhanced bacterial adherence in mice. Microb Pathog (2002) 0.82

Articles by these authors

Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem (2003) 8.34

Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature (2007) 6.53

Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33

MassBank: a public repository for sharing mass spectral data for life sciences. J Mass Spectrom (2010) 6.16

Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol (2010) 5.55

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol (2002) 5.52

High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol (2005) 5.04

Evaluation of a redesign initiative in an internal-medicine residency. N Engl J Med (2010) 4.85

Molecular circuits of resolution: formation and actions of resolvins and protectins. J Immunol (2005) 4.30

Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization. Nat Med (2005) 4.02

Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Arch Neurol (2003) 3.75

LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature (2005) 3.35

Modified double-K method for intraocular lens power calculation after excimer laser corneal refractive surgery. J Cataract Refract Surg (2013) 3.29

The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition. J Biol Chem (2002) 3.24

The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell (2013) 3.19

Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol (2008) 3.15

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc Natl Acad Sci U S A (2002) 3.01

Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report. J Allergy Clin Immunol (2010) 2.98

Reversal with sugammadex in the absence of monitoring did not preclude residual neuromuscular block. Anesth Analg (2013) 2.97

Role of prostanoid DP receptor variants in susceptibility to asthma. N Engl J Med (2004) 2.86

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid. J Biol Chem (2006) 2.79

Contributions of high mobility group box protein in experimental and clinical acute lung injury. Am J Respir Crit Care Med (2004) 2.50

Serum lysophosphatidic acid is produced through diverse phospholipase pathways. J Biol Chem (2002) 2.42

Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. Chem Biol (2006) 2.36

Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome. Am J Pathol (2002) 2.30

Reevaluation of the efficacy and safety of the neutrophil elastase inhibitor, Sivelestat, for the treatment of acute lung injury associated with systemic inflammatory response syndrome; a phase IV study. Pulm Pharmacol Ther (2011) 2.29

No forward shifting of posterior corneal surface in eyes undergoing LASIK. Ophthalmology (2007) 2.21

HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol (2005) 2.21

Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production. J Biol Chem (2006) 2.18

Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. J Biol Chem (2004) 2.17

Incidence and prognostic significance of myocardial late gadolinium enhancement in patients with sarcoidosis without cardiac manifestation. Chest (2014) 2.15

Impaired α-TTP-PIPs interaction underlies familial vitamin E deficiency. Science (2013) 2.15

Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. J Immunol (2005) 2.11

Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum. Cell (2010) 2.09

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation. Nat Methods (2012) 2.04

Vitamin E decreases bone mass by stimulating osteoclast fusion. Nat Med (2012) 2.04

Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2010) 2.03

Fall prevention using olfactory stimulation with lavender odor in elderly nursing home residents: a randomized controlled trial. J Am Geriatr Soc (2012) 2.03

Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med (2013) 2.01

Subcortical hematoma caused by cerebral amyloid angiopathy: does the first evidence of hemorrhage occur in the subarachnoid space? Neuropathology (2003) 1.99

The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement (2011) 1.87

Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity. Proc Natl Acad Sci U S A (2008) 1.86

Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol (2003) 1.82

Evaluation of pathogen detection from clinical samples by real-time polymerase chain reaction using a sepsis pathogen DNA detection kit. Crit Care (2010) 1.81

A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase. J Biol Chem (2006) 1.80

Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metab (2012) 1.77

The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun (2009) 1.77

Severe asthma: lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med (2011) 1.76

Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their aspirin-triggered endogenous epimers: an overview of their protective roles in catabasis. Prostaglandins Other Lipid Mediat (2004) 1.75

Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med (2005) 1.73

Serum indicators for the diagnosis of pneumocystis pneumonia. Chest (2007) 1.73

Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J (2007) 1.67

Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets. Blood (2008) 1.66

Physiological and biochemical markers of alveolar epithelial barrier dysfunction in perfused human lungs. Am J Physiol Lung Cell Mol Physiol (2007) 1.63

Bronchoscopic microsampling method for measuring drug concentration in epithelial lining fluid. Am J Respir Crit Care Med (2003) 1.62

Elucidating the relationship between DISC1, NDEL1 and NDE1 and the risk for schizophrenia: evidence of epistasis and competitive binding. Hum Mol Genet (2008) 1.60

Beta-1 blocker improves survival of septic rats through preservation of gut barrier function. Intensive Care Med (2011) 1.60

Exhaled breath condensate eicosanoid levels associate with asthma and its severity. J Allergy Clin Immunol (2013) 1.59

Novel 18F-labeled arylquinoline derivatives for noninvasive imaging of tau pathology in Alzheimer disease. J Nucl Med (2013) 1.58

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1. Hum Mol Genet (2006) 1.58

Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids (2004) 1.57

Tumor necrosis factor-alpha mediates hyperglycemia-augmented gut barrier dysfunction in endotoxemia. Crit Care Med (2009) 1.57

Lipoxin A(4) regulates bronchial epithelial cell responses to acid injury. Am J Pathol (2006) 1.56

Predictors of osteoporosis and vertebral fractures in patients presenting with moderate-to-severe chronic obstructive lung disease. COPD (2012) 1.55

Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid. J Biol Chem (2006) 1.55

Role of high mobility group box chromosomal protein 1 in ischemia-reperfusion injury in the rat small intestine. J Surg Res (2012) 1.54

ABCA3 as a lipid transporter in pulmonary surfactant biogenesis. J Biol Chem (2007) 1.54

Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6. J Biol Chem (2009) 1.53

Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-alpha secretion from human T cells. J Immunol (2003) 1.52

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1. J Lipid Res (2006) 1.52

Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry. J Lipid Res (2009) 1.52

A shotgun tandem mass spectrometric analysis of phospholipids with normal-phase and/or reverse-phase liquid chromatography/electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom (2005) 1.52

A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatry (2005) 1.51

Resolvin E1 receptor activation signals phosphorylation and phagocytosis. J Biol Chem (2009) 1.50

A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid. J Biol Chem (2002) 1.49

Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer. Lab Invest (2004) 1.49

Decrease in membrane phospholipid unsaturation induces unfolded protein response. J Biol Chem (2010) 1.48

Resolvin D1 and aspirin-triggered resolvin D1 promote resolution of allergic airways responses. J Immunol (2012) 1.48

Cerebrospinal fluid tau protein and periventricular white matter lesions in patients with mild cognitive impairment: implications for 2 major pathways. Arch Neurol (2004) 1.48

LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling. EMBO J (2011) 1.48

The arachidonic acid metabolome serves as a conserved regulator of cholesterol metabolism. Cell Metab (2014) 1.47

Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury. Am J Respir Crit Care Med (2008) 1.47

Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med (2008) 1.45