Kieran Clarke

Author PubWeight™ 158.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Uncoupling proteins in human heart. Lancet 2004 2.85
2 In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Acad Sci U S A 2008 2.69
3 Beneficial cardiovascular effects of bariatric surgical and dietary weight loss in obesity. J Am Coll Cardiol 2009 2.57
4 The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging. Obesity (Silver Spring) 2010 2.43
5 Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imaging. J Mol Cell Cardiol 2003 2.24
6 Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment. Circulation 2005 2.23
7 Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB J 2009 2.05
8 Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol 2004 2.01
9 Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation 2003 2.01
10 Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system. J Magn Reson Imaging 2003 1.97
11 Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields. J Magn Reson Imaging 2004 1.92
12 The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. Circ Cardiovasc Imaging 2012 1.86
13 Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy. J Am Coll Cardiol 2003 1.84
14 Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart. Eur J Heart Fail 2012 1.82
15 Comprehensive cardiac magnetic resonance imaging and spectroscopy reveal a high burden of myocardial disease in HIV patients. Circulation 2013 1.71
16 Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity. Heart 2010 1.68
17 Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet 2004 1.61
18 Regulation of human metabolism by hypoxia-inducible factor. Proc Natl Acad Sci U S A 2010 1.56
19 NOS substrate during cardioplegic arrest and cold storage decreases stunning after heart transplantation in a rat model. J Heart Lung Transplant 2003 1.39
20 Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? J Heart Lung Transplant 2010 1.34
21 A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome. Physiol Genomics 2006 1.34
22 Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation 2005 1.33
23 Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Hum Mol Genet 2010 1.33
24 VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev 2008 1.32
25 A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging 2012 1.32
26 Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice. Circulation 2005 1.30
27 Cerebral venous system and anatomical predisposition to high-altitude headache. Ann Neurol 2013 1.29
28 High-resolution, high-throughput magnetic paragraph sign resonance imaging of mouse embryonic paragraph sign anatomy using a fast gradient-echo sequence. MAGMA 2003 1.28
29 High-resolution imaging of normal anatomy, and neural and adrenal malformations in mouse embryos using magnetic resonance microscopy. J Anat 2003 1.26
30 Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study. Circulation 2011 1.26
31 Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study. Cardiovasc Res 2009 1.24
32 Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease. Circulation 2011 1.24
33 Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study. Am J Physiol Heart Circ Physiol 2008 1.22
34 Determinants of left ventricular mass in obesity; a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson 2009 1.22
35 Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat. Stem Cells Dev 2012 1.20
36 Modification of myocardial substrate use as a therapy for heart failure. Nat Clin Pract Cardiovasc Med 2006 1.19
37 Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart. J Mol Cell Cardiol 2008 1.19
38 Diaphragm rescue alone prevents heart dysfunction in dystrophic mice. Hum Mol Genet 2010 1.19
39 A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart. Basic Res Cardiol 2011 1.19
40 Metabolomics of the interaction between PPAR-alpha and age in the PPAR-alpha-null mouse. Mol Syst Biol 2009 1.18
41 The effect of hyperpolarized tracer concentration on myocardial uptake and metabolism. Magn Reson Med 2009 1.18
42 Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart. NMR Biomed 2008 1.15
43 Deterioration of physical performance and cognitive function in rats with short-term high-fat feeding. FASEB J 2009 1.15
44 Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart. Cardiovasc Res 2004 1.15
45 Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest. FASEB J 2011 1.15
46 Determination of cardiac volumes and mass with FLASH and SSFP cine sequences at 1.5 vs. 3 Tesla: a validation study. J Magn Reson Imaging 2006 1.14
47 CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system. J Cardiovasc Magn Reson 2006 1.13
48 Metabolism, hypoxia and the diabetic heart. J Mol Cell Cardiol 2011 1.13
49 Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice. Circ Res 2013 1.13
50 Novel MRI method to detect altered left ventricular ejection and filling patterns in rodent models of disease. Magn Reson Med 2008 1.12
51 Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart. Cardiovasc Res 2006 1.11
52 Investigation of a transgenic mouse model of familial dilated cardiomyopathy. J Mol Cell Cardiol 2010 1.10
53 Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors. Mol Biol Rep 2011 1.10
54 PPAR-alpha activation required for decreased glucose uptake and increased susceptibility to injury during ischemia. Am J Physiol Heart Circ Physiol 2005 1.10
55 Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp. FASEB J 2010 1.09
56 Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels. Diabetes 2005 1.08
57 Dystrophin- and MLP-deficient mouse hearts: marked differences in morphology and function, but similar accumulation of cytoskeletal proteins. FASEB J 2004 1.07
58 A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects. Am J Clin Nutr 2011 1.07
59 Increasing plasma free fatty acids in healthy subjects induces aortic distensibility changes seen in obesity. Circ Cardiovasc Imaging 2012 1.06
60 The PPARgamma-activator rosiglitazone does not alter remodeling but increases mortality in rats post-myocardial infarction. Cardiovasc Res 2003 1.05
61 Quantification and 3D reconstruction of atherosclerotic plaque components in apolipoprotein E knockout mice using ex vivo high-resolution MRI. Arterioscler Thromb Vasc Biol 2004 1.05
62 Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the zucker Fatty rat heart. Diabetes 2002 1.05
63 A functional analysis of mouse models of cardiac disease through metabolic profiling. J Biol Chem 2004 1.04
64 microMRI-HREM pipeline for high-throughput, high-resolution phenotyping of murine embryos. J Anat 2007 1.04
65 A ketone ester diet increases brain malonyl-CoA and Uncoupling proteins 4 and 5 while decreasing food intake in the normal Wistar Rat. J Biol Chem 2010 1.04
66 Insulin resistance, abnormal energy metabolism and increased ischemic damage in the chronically infarcted rat heart. Cardiovasc Res 2006 1.03
67 Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity. J Mol Cell Cardiol 2009 1.02
68 Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study. PLoS One 2011 1.02
69 In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart. Cardiovasc Res 2012 1.01
70 The effect of high-altitude on human skeletal muscle energetics: P-MRS results from the Caudwell Xtreme Everest expedition. PLoS One 2010 1.00
71 Abnormal cardiac morphology, function and energy metabolism in the dystrophic mdx mouse: an MRI and MRS study. J Mol Cell Cardiol 2008 1.00
72 Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin. Cardiovasc Diabetol 2013 1.00
73 A comparison of cardiac (31)P MRS at 1.5 and 3 T. NMR Biomed 2008 1.00
74 Critical role of complex III in the early metabolic changes following myocardial infarction. Cardiovasc Res 2010 0.99
75 Metabolic adaptation to chronic hypoxia in cardiac mitochondria. Basic Res Cardiol 2012 0.99
76 Effects of catecholamine stress on diastolic function and myocardial energetics in obesity. Circulation 2012 0.99
77 Short-term consumption of a high-fat diet impairs whole-body efficiency and cognitive function in sedentary men. FASEB J 2010 0.99
78 Assessment of left atrial volumes at 1.5 Tesla and 3 Tesla using FLASH and SSFP cine imaging. J Cardiovasc Magn Reson 2007 0.99
79 Longitudinally and circumferentially directed movements of the left ventricle studied by cardiovascular magnetic resonance phase contrast velocity mapping. J Cardiovasc Magn Reson 2010 0.98
80 Gender differences in hypertrophy, insulin resistance and ischemic injury in the aging type 2 diabetic rat heart. J Mol Cell Cardiol 2004 0.98
81 Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine. Am J Physiol Endocrinol Metab 2003 0.98
82 In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy. PLoS One 2012 0.98
83 Magnetic resonance imaging evaluation of remodeling by cardiac elastomeric tissue scaffold biomaterials in a rat model of myocardial infarction. Tissue Eng Part A 2010 0.97
84 Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction. Cardiovasc Res 2012 0.97
85 Mechanisms of creatine depletion in chronically failing rat heart. J Mol Cell Cardiol 2005 0.97
86 Mitochondria and heart failure. Curr Opin Clin Nutr Metab Care 2007 0.95
87 Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet. FASEB J 2012 0.94
88 In vivo cardiac 1H-MRS in the mouse. Magn Reson Med 2004 0.94
89 Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss. Cardiovasc Res 2009 0.93
90 Exercise training in dilated cardiomyopathy improves rest and stress cardiac function without changes in cardiac high energy phosphate metabolism. Heart 2012 0.93
91 Simultaneous determination of low free Mg2+ and pH in human sickle cells using 31P NMR spectroscopy. J Biol Chem 2002 0.92
92 Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics. Proc Natl Acad Sci U S A 2013 0.92
93 Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse. J Biol Chem 2011 0.91
94 Serial high resolution 3D-MRI after aortic banding in mice: band internalization is a source of variability in the hypertrophic response. Basic Res Cardiol 2005 0.91
95 Cardiac cine MR-imaging at 3T: FLASH vs SSFP. J Cardiovasc Magn Reson 2006 0.91
96 The energetics of ion distribution: the origin of the resting electric potential of cells. IUBMB Life 2002 0.90
97 Details of left ventricular remodeling and the mechanism of paradoxical ventricular septal motion after coronary artery bypass graft surgery. J Invasive Cardiol 2011 0.89
98 Hyperpolarized butyrate: a metabolic probe of short chain fatty acid metabolism in the heart. Magn Reson Med 2013 0.89
99 Stem cell-based therapy for ischemic heart disease. Cell Transplant 2012 0.89
100 Human hippocampal energy metabolism is impaired during cognitive activity in a lipid infusion model of insulin resistance. Brain Behav 2013 0.88
101 Normobaric hypoxia impairs human cardiac energetics. FASEB J 2011 0.88
102 A combined metabolomic and proteomic investigation of the effects of a failure to express dystrophin in the mouse heart. J Proteome Res 2008 0.88
103 High-resolution, multicontrast three-dimensional-MRI characterizes atherosclerotic plaque composition in ApoE-/- mice ex vivo. J Magn Reson Imaging 2004 0.87
104 Abnormal function and glucose metabolism in the type-2 diabetic db/db mouse heart. Can J Physiol Pharmacol 2007 0.87
105 Upregulation of eNOS and unchanged energy metabolism in increased susceptibility of the aging type 2 diabetic GK rat heart to ischemic injury. Am J Physiol Heart Circ Physiol 2010 0.87
106 The reproducibility of 31-phosphorus MRS measures of muscle energetics at 3 Tesla in trained men. PLoS One 2012 0.87
107 Adenosine monophosphate-activated protein kinase activation, substrate transporter translocation, and metabolism in the contracting hyperthyroid rat heart. Endocrinology 2009 0.86
108 Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study. J Cardiovasc Magn Reson 2008 0.86
109 Long-term stability of cardiac function in normal and chronically failing mouse hearts in a vertical-bore MR system. MAGMA 2004 0.84
110 Dietary long-chain, but not medium-chain, triglycerides impair exercise performance and uncouple cardiac mitochondria in rats. Nutr Metab (Lond) 2011 0.83
111 Normal values of regional and global myocardial wall motion in young and elderly individuals using navigator gated tissue phase mapping. Age (Dordr) 2013 0.83
112 Concentric left ventricular remodeling and aortic stiffness: a comparison of obesity and hypertension. Int J Cardiol 2012 0.83
113 Chasing the reflected wave back into the heart: a new hypothesis while the jury is still out. Vasc Health Risk Manag 2011 0.83
114 In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy. J Cardiovasc Magn Reson 2013 0.83
115 MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas. Cancer Res 2012 0.83
116 Uncomplicated obesity is associated with abnormal aortic function assessed by cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2008 0.83
117 First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart. J Cardiovasc Magn Reson 2011 0.82
118 Changes in cardiac substrate transporters and metabolic proteins mirror the metabolic shift in patients with aortic stenosis. PLoS One 2011 0.82
119 Haemoglobin and flow-mediated vasodilation. Clin Sci (Lond) 2006 0.82
120 Differential translocation of the fatty acid transporter, FAT/CD36, and the glucose transporter, GLUT4, coordinates changes in cardiac substrate metabolism during ischemia and reperfusion. Circ Heart Fail 2013 0.82
121 MR spectroscopy in heart failure. Front Biosci (Schol Ed) 2011 0.82
122 Efficient pro-survival/angiogenic miRNA delivery by an MRI-detectable nanomaterial. ACS Nano 2013 0.81
123 Murine cardiosphere-derived cells are impaired by age but not by cardiac dystrophic dysfunction. Stem Cells Dev 2014 0.81
124 A comparison of visual and quantitative assessment of left ventricular ejection fraction by cardiac magnetic resonance. Int J Cardiovasc Imaging 2010 0.81
125 Endurance exercise training blunts the deleterious effect of high-fat feeding on whole body efficiency. Am J Physiol Regul Integr Comp Physiol 2011 0.79
126 (31)P cardiac magnetic resonance spectroscopy during leg exercise at 3 Tesla. Int J Cardiovasc Imaging 2009 0.79
127 Human cardiosphere-derived cells from patients with chronic ischaemic heart disease can be routinely expanded from atrial but not epicardial ventricular biopsies. J Cardiovasc Transl Res 2012 0.79
128 Functional and morphological maturation of implanted neonatal cardiomyocytes as a comparator for cell therapy. Stem Cells Dev 2010 0.79
129 Changes in creatine transporter function during cardiac maturation in the rat. BMC Dev Biol 2010 0.79
130 Metabolic imaging of acute and chronic infarction in the perfused rat heart using hyperpolarised [1-13C]pyruvate. NMR Biomed 2013 0.79
131 Effect of isoproterenol on myocardial perfusion, function, energy metabolism and nitric oxide pathway in the rat heart - a longitudinal MR study. NMR Biomed 2014 0.79
132 Chronic oral ascorbic acid therapy worsens skeletal muscle metabolism in patients with chronic heart failure. Eur J Heart Fail 2006 0.79
133 Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism. Cell Transplant 2015 0.78
134 Ongoing dual-angle measurements for the correction of partial saturation in 31P MR spectroscopy. Magn Reson Med 2010 0.77
135 Oral Coenzyme Q10 supplementation does not prevent cardiac alterations during a high altitude trek to everest base cAMP. High Alt Med Biol 2014 0.77
136 The mechanism underlying the positive inotropic effect of angiotensin II in the isolated perfused rabbit heart: a 31P NMR study. Int J Biochem Cell Biol 2003 0.76
137 MLP accumulation and remodelling in the infarcted rat heart. Eur J Heart Fail 2005 0.76
138 Myocardial substrate metabolism in heart disease. Front Biosci (Schol Ed) 2012 0.76
139 Accumulation of 2-deoxy-D-glucose-6-phosphate as a measure of glucose uptake in the isolated perfused heart: a 31P NMR study. Metab Eng 2004 0.76
140 Response to "Weight loss, blood pressure reduction, and aortic stiffness: an old dilemma revisited". Obesity (Silver Spring) 2011 0.75
141 A Ketone Ester Drink Increases Postexercise Muscle Glycogen Synthesis in Humans. Med Sci Sports Exerc 2017 0.75
142 The Effects Of Oral Ketones On Human Muscle Recovery Following Exercise: 630 Board #2 June 1, 1: 00 PM - 3: 00 PM. Med Sci Sports Exerc 2016 0.75
143 Abnormal cardiac high-energy phosphate metabolism in a patient with type 2 diabetes mellitus. J Cardiometab Syndr 2006 0.75
144 Investigation of muscle bioenergetics in the Marfan syndrome indicates reduced metabolic efficiency. J Cardiovasc Magn Reson 2007 0.75
145 Is MR spectroscopy of the heart ready for humans? Heart Lung Circ 2010 0.75