Published in Mutat Res on February 23, 2008
Premature aging in mice deficient in DNA repair and transcription. Science (2002) 3.82
Aging and genome maintenance: lessons from the mouse? Science (2003) 3.72
Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome. PLoS Biol (2007) 2.21
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging. J Exp Med (2010) 1.86
High incidence of protein-truncating TP53 mutations in BRCA1-related breast cancer. Cancer Res (2009) 1.82
Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet (2008) 1.76
Hazardous compounds in tobacco smoke. Int J Environ Res Public Health (2011) 1.75
Truncated ETV1, fused to novel tissue-specific genes, and full-length ETV1 in prostate cancer. Cancer Res (2008) 1.68
Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol (2006) 1.63
Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer. Oncogene (2004) 1.61
Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity. Nat Cell Biol (2009) 1.55
Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice. DNA Repair (Amst) (2003) 1.53
Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair. Nat Cell Biol (2002) 1.48
Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010. Arch Toxicol (2011) 1.46
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol (2004) 1.44
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res (2006) 1.43
Toxicogenomics directory of chemically exposed human hepatocytes. Arch Toxicol (2014) 1.43
Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med (2005) 1.39
Powerful skin cancer protection by a CPD-photolyase transgene. Curr Biol (2005) 1.39
Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction. DNA Repair (Amst) (2005) 1.38
Early events in the mammalian response to DNA double-strand breaks. Mutagenesis (2008) 1.33
Green tea polyphenols prevent UV-induced immunosuppression by rapid repair of DNA damage and enhancement of nucleotide excision repair genes. Cancer Prev Res (Phila) (2010) 1.29
New and emerging technologies for genetic toxicity testing. Environ Mol Mutagen (2010) 1.28
Mice expressing a mammary gland-specific R270H mutation in the p53 tumor suppressor gene mimic human breast cancer development. Cancer Res (2005) 1.26
How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop. Mutat Res (2007) 1.22
An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria. Cancer Cell (2006) 1.21
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach. Mutat Res (2009) 1.17
Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage. Mol Cell Biol (2004) 1.17
Broad segmental progeroid changes in short-lived Ercc1(-/Δ7) mice. Pathobiol Aging Age Relat Dis (2011) 1.17
Mouse models for xeroderma pigmentosum group A and group C show divergent cancer phenotypes. Cancer Res (2008) 1.15
Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res (2010) 1.10
Polypodium leucotomos extract decreases UV-induced Cox-2 expression and inflammation, enhances DNA repair, and decreases mutagenesis in hairless mice. Am J Pathol (2009) 1.07
Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome. Mol Cell Biol (2006) 1.07
Tissue specific mutagenic and carcinogenic responses in NER defective mouse models. Mutat Res (2007) 1.05
In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma. Blood (2007) 1.04
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice. Proc Natl Acad Sci U S A (2004) 1.04
Dominant-negative but not gain-of-function effects of a p53.R270H mutation in mouse epithelium tissue after DNA damage. Cancer Res (2007) 1.01
Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay. Mutat Res (2007) 1.00
Oxidative DNA damage and nucleotide excision repair. Antioxid Redox Signal (2012) 0.99
An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair. Mol Cell Biol (2008) 0.99
Association of transcription-coupled repair but not global genome repair with ultraviolet-B-induced Langerhans cell depletion and local immunosuppression. J Invest Dermatol (2003) 0.99
The absence of Ser389 phosphorylation in p53 affects the basal gene expression level of many p53-dependent genes and alters the biphasic response to UV exposure in mouse embryonic fibroblasts. Mol Cell Biol (2008) 0.98
Identification of TDRD1 as a direct target gene of ERG in primary prostate cancer. Int J Cancer (2013) 0.95
Interlaboratory validation of a CD71-based flow cytometric method (Microflow) for the scoring of micronucleated reticulocytes in mouse peripheral blood. Environ Mol Mutagen (2005) 0.95
Discovery of novel serum biomarkers for prenatal Down syndrome screening by integrative data mining. PLoS One (2009) 0.94
The role of XPC: implications in cancer and oxidative DNA damage. Mutat Res (2011) 0.94
Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop. Mutat Res (2009) 0.94
International Pig-a gene mutation assay trial: evaluation of transferability across 14 laboratories. Environ Mol Mutagen (2011) 0.93
Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation. EMBO Rep (2002) 0.93
Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology. PLoS Genet (2011) 0.93
A bead-based multiplexed immunoassay to evaluate breast cancer biomarkers for early detection in pre-diagnostic serum. Int J Mol Sci (2012) 0.92
Use of an open access spirometry service by general practitioners. Prim Care Respir J (2006) 0.91
Gene expression profiling in a mouse model identifies fetal liver- and placenta-derived potential biomarkers for Down Syndrome screening. PLoS One (2011) 0.91
Genotoxicity evaluation of amorphous silica nanoparticles of different sizes using the micronucleus and the plasmid lacZ gene mutation assay. Nanotoxicology (2010) 0.91
Contribution of the ADP-ribosylating and receptor-binding properties of cholera-like enterotoxins in modulating cytokine secretion by human intestinal epithelial cells. Microbiology (2002) 0.90
IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression. J Immunol (2006) 0.90
Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Oncogene (2004) 0.89
lacZ mouse embryonic fibroblasts detect both clastogens and mutagens. Mutat Res (2009) 0.89
Lack of p53 Ser389 phosphorylation predisposes mice to develop 2-acetylaminofluorene-induced bladder tumors but not ionizing radiation-induced lymphomas. Cancer Res (2005) 0.89
Nucleotide excision repair- and p53-deficient mouse models in cancer research. Mutat Res (2005) 0.88
DNA adduct kinetics in reproductive tissues of DNA repair proficient and deficient male mice after oral exposure to benzo(a)pyrene. Environ Mol Mutagen (2010) 0.88
Mice with the CHEK2*1100delC SNP are predisposed to cancer with a strong gender bias. Proc Natl Acad Sci U S A (2009) 0.87
Extended longevity mechanisms in short-lived progeroid mice: identification of a preservative stress response associated with successful aging. Mech Ageing Dev (2006) 0.87
MPHASYS: a mouse phenotype analysis system. BMC Bioinformatics (2007) 0.87
Slow accumulation of mutations in Xpc-/- mice upon induction of oxidative stress. DNA Repair (Amst) (2013) 0.86
Evaluation of benzo(a)pyrene-induced gene mutations in male germ cells. Toxicol Sci (2010) 0.86
Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes. Arch Toxicol (2012) 0.86
Delayed expression of apoptotic and cell-cycle control genes in carcinogen-exposed bladders of mice lacking p53.S389 phosphorylation. Carcinogenesis (2007) 0.86
DNA damage in normally and prematurely aged mice. Aging Cell (2013) 0.85
ECVAM retrospective validation of in vitro micronucleus test (MNT). Mutagenesis (2008) 0.85
Inactivation of RAD52 aggravates RAD54 defects in mice but not in Schizosaccharomyces pombe. DNA Repair (Amst) (2005) 0.85
Can carcinogenic potency be predicted from in vivo genotoxicity data?: a meta-analysis of historical data. Environ Mol Mutagen (2011) 0.84
Serious complications in gene-expression studies with stress perturbation: An example of UV-exposed p53-mutant mouse embryonic fibroblasts. Transcription (2010) 0.84
Analysis of 75 marketed pharmaceuticals using the GADD45a-GFP 'GreenScreen HC' genotoxicity assay. Mutagenesis (2009) 0.84
An evaluation of chemical photoreactivity and the relationship to phototoxicity. Regul Toxicol Pharmacol (2010) 0.84
Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice. Mutat Res (2002) 0.84
RNA isolation for transcriptomics of human and mouse small skin biopsies. BMC Res Notes (2011) 0.84
Analysis of osteoarthritis in a mouse model of the progeroid human DNA repair syndrome trichothiodystrophy. Age (Dordr) (2010) 0.84
Mammary gland tumor promotion by chronic administration of IGF1 and the insulin analogue AspB10 in the p53R270H/⁺WAPCre mouse model. Breast Cancer Res (2015) 0.83
Homeostatic imbalance between apoptosis and cell renewal in the liver of premature aging Xpd mice. PLoS One (2008) 0.83
Identification of interleukin-1 beta, but no other inflammatory proteins, as an early onset pre-eclampsia biomarker in first trimester serum by bead-based multiplexed immunoassays. Prenat Diagn (2013) 0.83
Transgenic and knockout mice for DNA repair functions in carcinogenesis and mutagenesis. Toxicology (2003) 0.83
p53 heterozygosity results in an increased 2-acetylaminofluorene-induced urinary bladder but not liver tumor response in DNA repair-deficient Xpa mice. Cancer Res (2004) 0.83