Published in Physiol Rev on April 01, 2008
Linking actin dynamics and gene transcription to drive cellular motile functions. Nat Rev Mol Cell Biol (2010) 4.12
Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
Actin in dendritic spines: connecting dynamics to function. J Cell Biol (2010) 3.57
Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed. J Cell Biol (2008) 3.44
Cellular entry of ebola virus involves uptake by a macropinocytosis-like mechanism and subsequent trafficking through early and late endosomes. PLoS Pathog (2010) 2.60
Individual actin filaments in a microfluidic flow reveal the mechanism of ATP hydrolysis and give insight into the properties of profilin. PLoS Biol (2011) 2.59
Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension. Curr Biol (2010) 2.11
The ordered extension of pseudopodia by amoeboid cells in the absence of external cues. PLoS One (2009) 2.03
Electron tomography reveals unbranched networks of actin filaments in lamellipodia. Nat Cell Biol (2010) 2.02
Myosin II motors and F-actin dynamics drive the coordinated movement of the centrosome and soma during CNS glial-guided neuronal migration. Neuron (2009) 1.94
Mechanism of actin filament nucleation by the bacterial effector VopL. Nat Struct Mol Biol (2011) 1.80
Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. Tissue Eng Part A (2010) 1.77
Abl kinase inhibits the engulfment of apoptotic [corrected] cells in Caenorhabditis elegans. PLoS Biol (2009) 1.69
Actin filament nucleation and elongation factors--structure-function relationships. Crit Rev Biochem Mol Biol (2009) 1.61
Endocytosis and signaling: cell logistics shape the eukaryotic cell plan. Physiol Rev (2012) 1.61
Cystic fibrosis transmembrane conductance regulator is involved in airway epithelial wound repair. Am J Physiol Cell Physiol (2010) 1.58
Mechanics of the F-actin cytoskeleton. J Biomech (2009) 1.58
N-WASP and cortactin are involved in invadopodium-dependent chemotaxis to EGF in breast tumor cells. Cell Motil Cytoskeleton (2009) 1.54
Phylogenetic analysis identifies many uncharacterized actin-like proteins (Alps) in bacteria: regulated polymerization, dynamic instability and treadmilling in Alp7A. Mol Microbiol (2009) 1.52
New mechanisms and functions of actin nucleation. Curr Opin Cell Biol (2010) 1.45
F- and G-actin concentrations in lamellipodia of moving cells. PLoS One (2009) 1.41
Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion. PLoS One (2009) 1.41
Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron (2012) 1.37
RAGE and Alzheimer's disease: a progression factor for amyloid-beta-induced cellular perturbation? J Alzheimers Dis (2009) 1.31
Pak1 regulates focal adhesion strength, myosin IIA distribution, and actin dynamics to optimize cell migration. J Cell Biol (2011) 1.28
Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J Cell Biol (2010) 1.24
Filopodia initiation: focus on the Arp2/3 complex and formins. Cell Adh Migr (2011) 1.23
MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2. FASEB J (2010) 1.22
Investigating sub-spine actin dynamics in rat hippocampal neurons with super-resolution optical imaging. PLoS One (2009) 1.22
The role of actin filament dynamics in the myogenic response of cerebral resistance arteries. J Cereb Blood Flow Metab (2012) 1.21
Actin cross-link assembly and disassembly mechanics for alpha-Actinin and fascin. J Biol Chem (2010) 1.21
Exploring the roles of diaphanous and enabled activity in shaping the balance between filopodia and lamellipodia. Mol Biol Cell (2009) 1.20
14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assembly. J Cell Physiol (2009) 1.19
Review series: TOR kinase complexes and cell migration. J Cell Biol (2011) 1.19
Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension. J Cell Biol (2011) 1.17
Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence. PLoS One (2010) 1.17
The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration. Nucleic Acids Res (2010) 1.17
Srv2/cyclase-associated protein forms hexameric shurikens that directly catalyze actin filament severing by cofilin. Mol Biol Cell (2012) 1.14
P130Cas Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration. PLoS One (2010) 1.14
Quimp3, an automated pseudopod-tracking algorithm. Cell Adh Migr (2010) 1.12
Mammalian tropomodulins nucleate actin polymerization via their actin monomer binding and filament pointed end-capping activities. J Biol Chem (2010) 1.11
The microtubule-binding protein CLIP-170 coordinates mDia1 and actin reorganization during CR3-mediated phagocytosis. J Cell Biol (2008) 1.10
Use of virtual cell in studies of cellular dynamics. Int Rev Cell Mol Biol (2010) 1.09
Kindlin-1 Is required for RhoGTPase-mediated lamellipodia formation in keratinocytes. Am J Pathol (2009) 1.09
Traction forces during collective cell motion. HFSP J (2009) 1.08
The role of vimentin intermediate filaments in the progression of lung cancer. Am J Respir Cell Mol Biol (2014) 1.08
Does size matter in platelet production? Blood (2012) 1.07
Distinct roles for CARMIL isoforms in cell migration. Mol Biol Cell (2009) 1.06
Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PLoS One (2011) 1.06
Functional comparison of chronological and in vitro aging: differential role of the cytoskeleton and mitochondria in mesenchymal stromal cells. PLoS One (2012) 1.05
Role of anoctamins in cancer and apoptosis. Philos Trans R Soc Lond B Biol Sci (2014) 1.04
Vinculin is a dually regulated actin filament barbed end-capping and side-binding protein. J Biol Chem (2010) 1.03
Murid herpesvirus-4 exploits dendritic cells to infect B cells. PLoS Pathog (2011) 1.00
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. EMBO J (2011) 1.00
A unique role for heat shock protein 70 and its binding partner tissue transglutaminase in cancer cell migration. J Biol Chem (2011) 0.99
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol Neurobiol (2009) 0.99
Theoretical model for cellular shapes driven by protrusive and adhesive forces. PLoS Comput Biol (2011) 0.98
How a cell crawls and the role of cortical myosin II. Eukaryot Cell (2009) 0.98
Vinculin activation is necessary for complete talin binding. Biophys J (2011) 0.97
The p38/MK2/Hsp25 pathway is required for BMP-2-induced cell migration. PLoS One (2011) 0.97
Downregulation of connective tissue growth factor by three-dimensional matrix enhances ovarian carcinoma cell invasion. Int J Cancer (2009) 0.95
Characterization of the biochemical properties and biological function of the formin homology domains of Drosophila DAAM. J Biol Chem (2010) 0.95
Human cytomegalovirus-regulated paxillin in monocytes links cellular pathogenic motility to the process of viral entry. J Virol (2010) 0.95
Assembling neurospheres: dynamics of neural progenitor/stem cell aggregation probed using an optical trap. PLoS One (2012) 0.95
Capping protein is essential for cell migration in vivo and for filopodial morphology and dynamics. Mol Biol Cell (2014) 0.94
Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML. BMC Res Notes (2012) 0.94
In vivo role of focal adhesion kinase in regulating pancreatic β-cell mass and function through insulin signaling, actin dynamics, and granule trafficking. Diabetes (2012) 0.94
Role of c-Met/phosphatidylinositol 3-kinase (PI3k)/Akt signaling in hepatocyte growth factor (HGF)-mediated lamellipodia formation, reactive oxygen species (ROS) generation, and motility of lung endothelial cells. J Biol Chem (2014) 0.94
Quantitative kinetic study of the actin-bundling protein L-plastin and of its impact on actin turn-over. PLoS One (2010) 0.93
Interferon regulatory factor 6 regulates keratinocyte migration. J Cell Sci (2014) 0.93
In vivo roles for Arp2/3 in cortical actin organization during C. elegans gastrulation. J Cell Sci (2009) 0.93
A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis. Breast Cancer Res (2013) 0.93
The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes. Br J Pharmacol (2011) 0.93
Impact of branching on the elasticity of actin networks. Proc Natl Acad Sci U S A (2012) 0.93
Heterogeneous nuclear ribonucleoprotein k interacts with Abi-1 at postsynaptic sites and modulates dendritic spine morphology. PLoS One (2011) 0.92
A myosin IK-Abp1-PakB circuit acts as a switch to regulate phagocytosis efficiency. Mol Biol Cell (2010) 0.92
Glia maturation factor-γ mediates neutrophil chemotaxis. J Leukoc Biol (2011) 0.92
Geometric constrains for detecting short actin filaments by cryogenic electron tomography. PMC Biophys (2010) 0.92
The key feature for early migratory processes: Dependence of adhesion, actin bundles, force generation and transmission on filopodia. Cell Adh Migr (2010) 0.92
Emergent complexity of the cytoskeleton: from single filaments to tissue. Adv Phys (2013) 0.92
Transducer of Cdc42-dependent actin assembly promotes epidermal growth factor-induced cell motility and invasiveness. J Biol Chem (2010) 0.91
The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. Mol Cancer (2010) 0.91
Mechanism for CARMIL protein inhibition of heterodimeric actin-capping protein. J Biol Chem (2012) 0.91
Dissecting regulatory networks of filopodia formation in a Drosophila growth cone model. PLoS One (2011) 0.91
Senescence in Human Mesenchymal Stem Cells: Functional Changes and Implications in Stem Cell-Based Therapy. Int J Mol Sci (2016) 0.91
Inositol 1,4,5-trisphosphate 3-kinase-A is a new cell motility-promoting protein that increases the metastatic potential of tumor cells by two functional activities. J Biol Chem (2009) 0.90
Housekeeping genes in prostate tumorigenesis. Int J Cancer (2009) 0.90
Local ATP generation by brain-type creatine kinase (CK-B) facilitates cell motility. PLoS One (2009) 0.90
SRF in angiogenesis: branching the vascular system. Cell Adh Migr (2009) 0.89
Synthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization. J Biol Chem (2010) 0.89
Essential and nonredundant roles for Diaphanous formins in cortical microtubule capture and directed cell migration. Mol Biol Cell (2014) 0.89
Seven kinds of intermediate filament networks in the cytoplasm of polarized cells: structure and function. Acta Histochem Cytochem (2010) 0.89
PI3K p110α isoform-dependent Rho GTPase Rac1 activation mediates H2S-promoted endothelial cell migration via actin cytoskeleton reorganization. PLoS One (2012) 0.89
Exo70 stimulates the Arp2/3 complex for lamellipodia formation and directional cell migration. Curr Biol (2012) 0.89
Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture. Front Neural Circuits (2009) 0.89
Regulation of the actin cytoskeleton in Helicobacter pylori-induced migration and invasive growth of gastric epithelial cells. Cell Commun Signal (2011) 0.88
Survival motor neuron protein deficiency impairs myotube formation by altering myogenic gene expression and focal adhesion dynamics. Hum Mol Genet (2014) 0.88
Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels. J Biol Chem (2015) 0.88
Bone morphogenetic protein- and mating-dependent secretory cell growth and migration in the Drosophila accessory gland. Proc Natl Acad Sci U S A (2012) 0.87
Expression and Y435-phosphorylation of Abelson interactor 1 (Abi1) promotes tumour cell adhesion, extracellular matrix degradation and invasion by colorectal carcinoma cells. Mol Cancer (2014) 0.87
Abi1 is essential for the formation and activation of a WAVE2 signalling complex. Nat Cell Biol (2004) 4.04
Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis. Cell (2004) 4.01
TccP is an enterohaemorrhagic Escherichia coli O157:H7 type III effector protein that couples Tir to the actin-cytoskeleton. Cell Microbiol (2004) 2.91
Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response. Cell Host Microbe (2008) 2.80
The dynamics of actin-based motility depend on surface parameters. Nature (2002) 2.78
Forces generated during actin-based propulsion: a direct measurement by micromanipulation. Proc Natl Acad Sci U S A (2004) 2.73
A biomimetic motility assay provides insight into the mechanism of actin-based motility. J Cell Biol (2003) 2.67
Individual actin filaments in a microfluidic flow reveal the mechanism of ATP hydrolysis and give insight into the properties of profilin. PLoS Biol (2011) 2.59
Eps8 controls actin-based motility by capping the barbed ends of actin filaments. Nat Cell Biol (2004) 2.40
The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly. Cell (2004) 2.35
Abi1 regulates the activity of N-WASP and WAVE in distinct actin-based processes. Nat Cell Biol (2005) 2.16
Control of actin filament treadmilling in cell motility. Annu Rev Biophys (2010) 2.15
How VASP enhances actin-based motility. J Cell Biol (2003) 1.97
A novel actin barbed-end-capping activity in EPS-8 regulates apical morphogenesis in intestinal cells of Caenorhabditis elegans. Nat Cell Biol (2004) 1.82
IQGAP1 stimulates actin assembly through the N-WASP-Arp2/3 pathway. J Biol Chem (2006) 1.57
Analysis of the function of Spire in actin assembly and its synergy with formin and profilin. Mol Cell (2007) 1.57
An electrostatic steering mechanism of Cdc42 recognition by Wiskott-Aldrich syndrome proteins. Mol Cell (2005) 1.33
ATP hydrolysis on actin-related protein 2/3 complex causes debranching of dendritic actin arrays. Proc Natl Acad Sci U S A (2003) 1.33
Mammalian twinfilin sequesters ADP-G-actin and caps filament barbed ends: implications in motility. EMBO J (2006) 1.31
Coupling of folding and binding of thymosin beta4 upon interaction with monomeric actin monitored by nuclear magnetic resonance. J Biol Chem (2004) 1.28
How ATP hydrolysis controls filament assembly from profilin-actin: implication for formin processivity. J Biol Chem (2007) 1.26
Characterization of TccP-mediated N-WASP activation during enterohaemorrhagic Escherichia coli infection. Cell Microbiol (2006) 1.25
Formin mDia1 senses and generates mechanical forces on actin filaments. Nat Commun (2013) 1.23
Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol (2010) 1.15
Structural basis and evolutionary origin of actin filament capping by twinfilin. Proc Natl Acad Sci U S A (2007) 1.14
Cordon-Bleu uses WH2 domains as multifunctional dynamizers of actin filament assembly. Mol Cell (2011) 1.12
Spire and Cordon-bleu: multifunctional regulators of actin dynamics. Trends Cell Biol (2008) 1.12
Control of actin dynamics by proteins made of beta-thymosin repeats: the actobindin family. J Biol Chem (2002) 1.11
Concerted action of two formins in gliding motility and host cell invasion by Toxoplasma gondii. PLoS Pathog (2010) 1.07
Intermittent depolymerization of actin filaments is caused by photo-induced dimerization of actin protomers. Proc Natl Acad Sci U S A (2012) 1.07
Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation. J Clin Invest (2013) 1.04
Vinculin is a dually regulated actin filament barbed end-capping and side-binding protein. J Biol Chem (2010) 1.03
Dimeric WH2 domains in Vibrio VopF promote actin filament barbed-end uncapping and assisted elongation. Nat Struct Mol Biol (2013) 1.03
The pleckstrin homology domain of the Arf6-specific exchange factor EFA6 localizes to the plasma membrane by interacting with phosphatidylinositol 4,5-bisphosphate and F-actin. J Biol Chem (2008) 1.01
Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain. FEBS Lett (2007) 0.98
Arp2/3 controls the motile behavior of N-WASP-functionalized GUVs and modulates N-WASP surface distribution by mediating transient links with actin filaments. Biophys J (2008) 0.98
The effect of stathmin phosphorylation on microtubule assembly depends on tubulin critical concentration. J Biol Chem (2002) 0.97
Mutant alpha-actinin-4 promotes tumorigenicity and regulates cell motility of a human lung carcinoma. Oncogene (2004) 0.96
Characterization of the biochemical properties and biological function of the formin homology domains of Drosophila DAAM. J Biol Chem (2010) 0.95
CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. EMBO J (2013) 0.93
How a single residue in individual β-thymosin/WH2 domains controls their functions in actin assembly. EMBO J (2011) 0.93
Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. J Biol Chem (2012) 0.92
The IQGAP1 protein is a calmodulin-regulated barbed end capper of actin filaments: possible implications in its function in cell migration. J Biol Chem (2011) 0.91
Multifunctionality of the beta-thymosin/WH2 module: G-actin sequestration, actin filament growth, nucleation, and severing. Ann N Y Acad Sci (2010) 0.91
On phosphate release in actin filaments. Biophys J (2013) 0.90
How tropomyosin regulates lamellipodial actin-based motility: a combined biochemical and reconstituted motility approach. EMBO J (2009) 0.89
Force-velocity measurements of a few growing actin filaments. PLoS Biol (2011) 0.88
Microfluidics pushes forward microscopy analysis of actin dynamics. Bioarchitecture (2011) 0.86
Synthetic polyamines promote rapid lamellipodial growth by regulating actin dynamics. Nat Commun (2013) 0.85
Molecular characterization of Toxoplasma gondii formin 3, an actin nucleator dispensable for tachyzoite growth and motility. Eukaryot Cell (2011) 0.84
How do in vitro reconstituted actin-based motility assays provide insight into in vivo behavior? FEBS Lett (2008) 0.83
Mutagenetic and electron microscopy analysis of actin filament severing by Cordon-Bleu, a WH2 domain protein. Cytoskeleton (Hoboken) (2014) 0.82
Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion. Infect Immun (2007) 0.81
Analysis of tetramethylrhodamine-labeled actin polymerization and interaction with actin regulatory proteins. J Biol Chem (2006) 0.81
Actin-based motility assay. Curr Protoc Cell Biol (2004) 0.80
Fluorescence correlation spectroscopy analysis of the dynamics of tubulin interaction with RB3, a stathmin family protein. FEBS Lett (2003) 0.79
The interplay between viscoelastic and thermodynamic properties determines the birefringence of F-actin gels. Biophys J (2005) 0.78
Functional characterization of proteins regulating actin assembly. Curr Protoc Cell Biol (2005) 0.78
A new twist in actin filament nucleation. Nat Struct Mol Biol (2011) 0.78
Force generation of curved actin gels characterized by combined AFM-epifluorescence measurements. Biophys J (2010) 0.78
Synthetic polyamines: new compounds specific to actin dynamics for mammalian cell and fission yeast. Bioarchitecture (2015) 0.75