Published in J Cell Biol on June 27, 2011
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Nonmuscle myosin-2: mix and match. Cell Mol Life Sci (2012) 1.30
Ubiquitylation of phosphatidylinositol 4-phosphate 5-kinase type I γ by HECTD1 regulates focal adhesion dynamics and cell migration. J Cell Sci (2013) 1.06
The late endosomal p14-MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration. J Cell Biol (2014) 0.96
Reactive oxygen species regulate protrusion efficiency by controlling actin dynamics. PLoS One (2012) 0.90
p21-Activated kinase (PAK) regulates cytoskeletal reorganization and directional migration in human neutrophils. PLoS One (2013) 0.89
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A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. Exp Hematol (2012) 0.83
Tyrosyl phosphorylated serine-threonine kinase PAK1 is a novel regulator of prolactin-dependent breast cancer cell motility and invasion. Adv Exp Med Biol (2015) 0.83
Inhibition of angiotensin II-induced cardiac hypertrophy and associated ventricular arrhythmias by a p21 activated kinase 1 bioactive peptide. PLoS One (2014) 0.83
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Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer. Oncotarget (2016) 0.82
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Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. J Biol Chem (2014) 0.76
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Pak-1 expression increases with progression of colorectal carcinomas to metastasis. Clin Cancer Res (2004) 1.65
Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem (2000) 1.64
A high-speed multispectral spinning-disk confocal microscope system for fluorescent speckle microscopy of living cells. Methods (2003) 1.59
Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II. J Cell Sci (2000) 1.48
Phosphorylation of myosin light chain kinase by p21-activated kinase PAK2. J Biol Chem (2000) 1.45
Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesis. J Biol Chem (2000) 1.18
Stochastic model of integrin-mediated signaling and adhesion dynamics at the leading edges of migrating cells. PLoS Comput Biol (2010) 1.10
Identification of MYO18A as a novel interacting partner of the PAK2/betaPIX/GIT1 complex and its potential function in modulating epithelial cell migration. Mol Biol Cell (2009) 1.07
Constitutive p21-activated kinase (PAK) activation in breast cancer cells as a result of mislocalization of PAK to focal adhesions. Mol Biol Cell (2004) 1.03
Why an A-loop phospho-mimetic fails to activate PAK1: understanding an inaccessible kinase state by molecular dynamics simulations. Structure (2010) 0.94
Rac-induced increase of phosphorylation of myosin regulatory light chain in HeLa cells. Cell Motil Cytoskeleton (2004) 0.94
Dissecting activation of the PAK1 kinase at protrusions in living cells. J Biol Chem (2009) 0.89
Activation of myosin in HeLa cells causes redistribution of focal adhesions and F-actin from cell center to cell periphery. Cell Motil Cytoskeleton (2006) 0.89
Signal analysis of total internal reflection fluorescent speckle microscopy (TIR-FSM) and wide-field epi-fluorescence FSM of the actin cytoskeleton and focal adhesions in living cells. J Microsc (2004) 0.87
Robust single-particle tracking in live-cell time-lapse sequences. Nat Methods (2008) 9.43
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Differential transmission of actin motion within focal adhesions. Science (2007) 5.36
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Mechanical integration of actin and adhesion dynamics in cell migration. Annu Rev Cell Dev Biol (2010) 4.06
An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol (2008) 3.94
High resolution traction force microscopy based on experimental and computational advances. Biophys J (2007) 3.89
FRET or no FRET: a quantitative comparison. Biophys J (2003) 3.88
Cargo and dynamin regulate clathrin-coated pit maturation. PLoS Biol (2009) 3.72
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol (2011) 3.72
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation. J Cell Biol (2010) 3.56
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Integrin-dependent actomyosin contraction regulates epithelial cell scattering. J Cell Biol (2005) 3.20
Chronophin, a novel HAD-type serine protein phosphatase, regulates cofilin-dependent actin dynamics. Nat Cell Biol (2004) 3.12
A tale of two Paks. Biol Cell (2008) 2.90
Cell migration without a lamellipodium: translation of actin dynamics into cell movement mediated by tropomyosin. J Cell Biol (2005) 2.89
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Analysis of microtubule dynamic instability using a plus-end growth marker. Nat Methods (2010) 2.67
Cofilin phosphatases and regulation of actin dynamics. Curr Opin Cell Biol (2005) 2.66
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Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Cell (2011) 2.57
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52
Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J Cell Biol (2003) 2.41
Architectural dynamics of the meiotic spindle revealed by single-fluorophore imaging. Nat Cell Biol (2007) 2.40
Myosin II contributes to cell-scale actin network treadmilling through network disassembly. Nature (2010) 2.37
Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase. Mol Cell (2004) 2.35
Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol (2012) 2.33
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Simultaneous mapping of filamentous actin flow and turnover in migrating cells by quantitative fluorescent speckle microscopy. Proc Natl Acad Sci U S A (2004) 2.25
GEF-H1 couples nocodazole-induced microtubule disassembly to cell contractility via RhoA. Mol Biol Cell (2008) 2.24
PAK signalling during the development and progression of cancer. Nat Rev Cancer (2014) 2.21
Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility. J Cell Biol (2007) 2.16
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Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J Biol Chem (2003) 1.99
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Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks. Dev Cell (2007) 1.96
GSK3beta phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment. J Cell Biol (2009) 1.95
Specificity profiling of Pak kinases allows identification of novel phosphorylation sites. J Biol Chem (2007) 1.92
Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy. Nat Biotechnol (2013) 1.92
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Epoxycyclopentenone-containing oxidized phospholipids restore endothelial barrier function via Cdc42 and Rac. Circ Res (2004) 1.88
Tracking retrograde flow in keratocytes: news from the front. Mol Biol Cell (2005) 1.88
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CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether. J Cell Biol (2008) 1.77
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New directions for fluorescent speckle microscopy. Curr Biol (2002) 1.71
Coordination of actin filament and microtubule dynamics during neurite outgrowth. Dev Cell (2008) 1.70
p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor. J Biol Chem (2004) 1.69
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Vinculin-actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth. J Cell Biol (2013) 1.63
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A zyxin-mediated mechanism for actin stress fiber maintenance and repair. Dev Cell (2010) 1.62
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol (2010) 1.60
Local clustering of transferrin receptors promotes clathrin-coated pit initiation. J Cell Biol (2010) 1.60
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p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol (2003) 1.57
Reactive oxygen species regulate a slingshot-cofilin activation pathway. Mol Biol Cell (2009) 1.56
Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol Biol Cell (2009) 1.55
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Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49
S. cerevisiae chromosomes biorient via gradual resolution of syntely between S phase and anaphase. Cell (2013) 1.49
Imaging the coordination of multiple signalling activities in living cells. Nat Rev Mol Cell Biol (2011) 1.47
PTP1B: a double agent in metabolism and oncogenesis. Trends Biochem Sci (2010) 1.44
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Vav1 transduces T cell receptor signals to the activation of the Ras/ERK pathway via LAT, Sos, and RasGRP1. J Biol Chem (2004) 1.42
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection. J Cell Physiol (2008) 1.42
Phosphatidylinositol-(4,5)-bisphosphate regulates clathrin-coated pit initiation, stabilization, and size. Mol Biol Cell (2011) 1.41
Regulation of protein tyrosine phosphatase 1B by sumoylation. Nat Cell Biol (2006) 1.40
A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases. J Mol Biol (2006) 1.39
Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol (2005) 1.38
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Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes. J Mol Cell Cardiol (2007) 1.38