PubRank

Klaus Schulze-Osthoff

Author PubWeight™ 141.87‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 T-helper-1-cell cytokines drive cancer into senescence. Nature 2013 4.47
2 Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 2003 3.68
3 Regulation of apoptosis by alternative pre-mRNA splicing. Mol Cell 2005 2.89
4 Prospective biopsy-controlled evaluation of cell death biomarkers for prediction of liver fibrosis and nonalcoholic steatohepatitis. Hepatology 2011 2.49
5 Detection of apoptotic caspase activation in sera from patients with chronic HCV infection is associated with fibrotic liver injury. Hepatology 2004 2.41
6 MicroRNAs play a role in spontaneous recovery from acute liver failure. Hepatology 2014 2.23
7 Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell 2002 2.05
8 Increased hepatotoxicity of tumor necrosis factor-related apoptosis-inducing ligand in diseased human liver. Hepatology 2007 1.97
9 Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells. J Exp Med 2011 1.81
10 Migration to apoptotic "find-me" signals is mediated via the phagocyte receptor G2A. J Biol Chem 2007 1.75
11 Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment. Gut 2011 1.75
12 Cancer stem cell markers in common cancers - therapeutic implications. Trends Mol Med 2008 1.75
13 Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J 2003 1.60
14 Functional characterization of p53beta and p53gamma, two isoforms of the tumor suppressor p53. Cell Cycle 2009 1.59
15 Thioredoxin in human and experimental sepsis. Crit Care Med 2009 1.51
16 Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity. Mol Cell Biol 2008 1.44
17 IκBζ is a transcriptional key regulator of CCL2/MCP-1. J Immunol 2013 1.41
18 MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program. Blood 2006 1.40
19 Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop. Oncogene 2003 1.40
20 New approaches and therapeutics targeting apoptosis in disease. Pharmacol Rev 2005 1.40
21 Apoptin, a tumor-selective killer. Biochim Biophys Acta 2009 1.39
22 Multiple virulence factors are required for Staphylococcus aureus-induced apoptosis in endothelial cells. Cell Microbiol 2005 1.35
23 SOX2 expression associates with stem cell state in human ovarian carcinoma. Cancer Res 2013 1.34
24 Apoptosis resistance of MCF-7 breast carcinoma cells to ionizing radiation is independent of p53 and cell cycle control but caused by the lack of caspase-3 and a caffeine-inhibitable event. Cancer Res 2004 1.30
25 Guardians of cell death: the Bcl-2 family proteins. Essays Biochem 2003 1.28
26 Non-apoptotic functions of caspases in cellular proliferation and differentiation. Biochem Pharmacol 2003 1.27
27 Staphylococcus aureus alpha-toxin induces apoptosis in peripheral blood mononuclear cells: role of endogenous tumour necrosis factor-alpha and the mitochondrial death pathway. Cell Microbiol 2003 1.26
28 p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Res 2006 1.26
29 The multiple battles fought by anti-apoptotic p21. Cell Cycle 2007 1.25
30 Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness. FASEB J 2002 1.24
31 A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding. J Biol Chem 2006 1.22
32 Lidocaine induces apoptosis via the mitochondrial pathway independently of death receptor signaling. Anesthesiology 2007 1.21
33 Caspase activation is associated with spontaneous recovery from acute liver failure. Hepatology 2008 1.20
34 S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta 2007 1.19
35 The transforming acidic coiled coil 3 protein is essential for spindle-dependent chromosome alignment and mitotic survival. J Biol Chem 2007 1.18
36 Caspase-8 can be activated by interchain proteolysis without receptor-triggered dimerization during drug-induced apoptosis. J Biol Chem 2004 1.16
37 Agonists of proteinase-activated receptor-2 stimulate upregulation of intercellular cell adhesion molecule-1 in primary human keratinocytes via activation of NF-kappa B. J Invest Dermatol 2005 1.16
38 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene 2005 1.15
39 Triggering of a novel intrinsic apoptosis pathway by the kinase inhibitor staurosporine: activation of caspase-9 in the absence of Apaf-1. FASEB J 2011 1.14
40 Adult stem cells and their trans-differentiation potential--perspectives and therapeutic applications. J Mol Med (Berl) 2008 1.12
41 Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells. J Invest Dermatol 2002 1.12
42 RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. J Biol Chem 2010 1.12
43 CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3 kinase function. J Exp Med 2004 1.12
44 Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. Blood 2007 1.12
45 The extent of liver steatosis in chronic hepatitis C virus infection is mirrored by caspase activity in serum. Hepatology 2005 1.10
46 Impaired adrenal stress response in Toll-like receptor 2-deficient mice. Proc Natl Acad Sci U S A 2004 1.09
47 Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Natl Acad Sci U S A 2006 1.08
48 Loss of Acinus inhibits oligonucleosomal DNA fragmentation but not chromatin condensation during apoptosis. J Biol Chem 2006 1.08
49 Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell 2006 1.07
50 Translational approaches targeting the p53 pathway for anti-cancer therapy. Br J Pharmacol 2012 1.04
51 Switching Akt: from survival signaling to deadly response. Bioessays 2009 1.03
52 MiRNA expression patterns predict survival in glioblastoma. Radiat Oncol 2011 1.01
53 Zinc oxide nanoparticles induce necrosis and apoptosis in macrophages in a p47phox- and Nrf2-independent manner. PLoS One 2013 0.99
54 Caspase activation is required for antiviral treatment response in chronic hepatitis C virus infection. Hepatology 2006 0.98
55 Inhibition of the ER Ca2+ pump forces multidrug-resistant cells deficient in Bak and Bax into necrosis. J Cell Sci 2009 0.98
56 The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. J Biol Chem 2006 0.98
57 Toxoplasma gondii inhibits Fas/CD95-triggered cell death by inducing aberrant processing and degradation of caspase 8. Cell Microbiol 2007 0.97
58 Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis. J Biol Chem 2006 0.97
59 The role of caspases in cryoinjury: caspase inhibition strongly improves the recovery of cryopreserved hematopoietic and other cells. FASEB J 2002 0.96
60 Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells. Antimicrob Agents Chemother 2003 0.95
61 Up-regulation of c-FLIP short by NFAT contributes to apoptosis resistance of short-term activated T cells. Blood 2008 0.95
62 Cancer stem cells as targets for cancer therapy: selected cancers as examples. Arch Immunol Ther Exp (Warsz) 2008 0.95
63 Myrtucommulone from Myrtus communis induces apoptosis in cancer cells via the mitochondrial pathway involving caspase-9. Apoptosis 2008 0.94
64 Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas. Eur J Cancer 2010 0.94
65 IkappaBzeta expression is regulated by miR-124a. Cell Cycle 2009 0.93
66 Irradiation-induced translocation of p53 to mitochondria in the absence of apoptosis. J Biol Chem 2005 0.93
67 Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway. Oncogene 2005 0.92
68 Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells. J Biol Chem 2002 0.92
69 Caspase-10 sensitizes breast carcinoma cells to TRAIL-induced but not tumor necrosis factor-induced apoptosis in a caspase-3-dependent manner. Mol Cell Biol 2005 0.92
70 New insights into the molecular pathology of radiation-induced pneumopathy. Radiother Oncol 2011 0.91
71 Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells. Mol Cancer Ther 2013 0.91
72 Cell surface externalization of annexin A1 as a failsafe mechanism preventing inflammatory responses during secondary necrosis. J Immunol 2009 0.91
73 Human SAP18 mediates assembly of a splicing regulatory multiprotein complex via its ubiquitin-like fold. RNA 2010 0.91
74 Death receptor-induced signaling pathways are differentially regulated by gamma interferon upstream of caspase 8 processing. Mol Cell Biol 2005 0.91
75 The proteasome is required for rapid initiation of death receptor-induced apoptosis. Mol Cell Biol 2006 0.91
76 Adaptation of topoisomerase I paralogs to nuclear and mitochondrial DNA. Nucleic Acids Res 2009 0.90
77 IκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 2012 0.89
78 Redox events in HTLV-1 Tax-induced apoptotic T-cell death. Antioxid Redox Signal 2002 0.89
79 Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway. Oncogene 2004 0.89
80 Potentials and pitfalls of DNA array analysis of the endothelial stress response. Biochim Biophys Acta 2005 0.89
81 Cyclooxygenase-2 (COX-2) inhibitors sensitize tumor cells specifically to death receptor-induced apoptosis independently of COX-2 inhibition. Oncogene 2003 0.89
82 The centrosome and mitotic spindle apparatus in cancer and senescence. Cell Cycle 2010 0.89
83 Caspase-10 in mouse or not? Science 2006 0.88
84 Tumor necrosis factor alpha sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-kappaB. Oncogene 2004 0.88
85 Sulforaphane protects from T cell-mediated autoimmune disease by inhibition of IL-23 and IL-12 in dendritic cells. J Immunol 2014 0.87
86 A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein. Blood 2009 0.87
87 Thalidomide induces limb anomalies by PTEN stabilization, Akt suppression, and stimulation of caspase-dependent cell death. Mol Cell Biol 2008 0.86
88 α-Fucosidase as a novel convenient biomarker for cellular senescence. Cell Cycle 2013 0.86
89 Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death. Oncogene 2005 0.86
90 Cutting-edge apoptosis-based therapeutics: a panacea for cancer? BioDrugs 2007 0.86
91 Cell death in sepsis: a matter of how, when, and where. Crit Care 2009 0.85
92 Release of lysophospholipid 'find-me' signals during apoptosis requires the ATP-binding cassette transporter A1. Autoimmunity 2012 0.85
93 LORD-Q: a long-run real-time PCR-based DNA-damage quantification method for nuclear and mitochondrial genome analysis. Nucleic Acids Res 2013 0.85
94 Mechanisms of cell death in acute liver failure. Front Physiol 2012 0.85
95 Increased apoptosis induction in hepatocellular carcinoma by a novel tumor-targeted TRAIL fusion protein combined with bortezomib. Hepatology 2013 0.85
96 Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR). Cell Cycle 2013 0.84
97 Serum-derived plasminogen is activated by apoptotic cells and promotes their phagocytic clearance. J Immunol 2012 0.84
98 Evaluation of apoptosis induced by nanoparticles and fine particles in RAW 264.7 macrophages: facts and artefacts. Toxicol In Vitro 2011 0.84
99 Caspase activation is involved in chronic periodontitis. FEBS Lett 2005 0.83
100 Mitochondria are not required for death receptor-mediated cytosolic acidification during apoptosis. Apoptosis 2006 0.83
101 Specific inhibition of transcription factor NF-kappaB through intracellular protein delivery of I kappaBalpha by the Herpes virus protein VP22. Oncogene 2003 0.83
102 The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. Int J Cancer 2011 0.83
103 IκBζ is a regulator of the senescence-associated secretory phenotype in DNA damage- and oncogene-induced senescence. J Cell Sci 2013 0.82
104 Biopsy-controlled liver fibrosis staging using the enhanced liver fibrosis (ELF) score compared to transient elastography. PLoS One 2012 0.82
105 A novel intronic promoter of the Crem gene induces small ICER (smICER) isoforms. FASEB J 2013 0.82
106 Protein kinase C delta (PKCδ) affects proliferation of insulin-secreting cells by promoting nuclear extrusion of the cell cycle inhibitor p21Cip1/WAF1. PLoS One 2011 0.82
107 Friend or foe? The proteasome in combined cancer therapy. Cell Cycle 2006 0.81
108 Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway. Oncogene 2005 0.81
109 Inhibition of JNK signaling diminishes early but not late cellular stress-induced apoptosis. Int J Cancer 2003 0.80
110 Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses. Int J Cancer 2013 0.80
111 Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity. Hepatology 2010 0.80
112 Stimulation of serum- and glucocorticoid-regulated kinase-1 gene expression by endothelin-1. Biochem Pharmacol 2006 0.80
113 Demonstration of PDC-E1 subunits as major antigens in the complement-fixing fraction M4 and re-evaluation of PDC-E1-specific antibodies in PBC patients. Liver Int 2006 0.79
114 TNF Antagonists in IBD: Novel Antiinflammatory Mechanisms Beyond Cytokine Inhibition. Inflamm Bowel Dis 2013 0.78
115 Up-regulation of c-FLIPS+R upon CD40 stimulation is associated with inhibition of CD95-induced apoptosis in primary precursor B-ALL. Blood 2007 0.78
116 Does caspase inhibition promote clonogenic tumor growth? Cell Cycle 2007 0.78
117 A rapid nonradioactive peptide phosphorylation assay. J Exp Ther Oncol 2003 0.77
118 Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis. Arterioscler Thromb Vasc Biol 2008 0.76
119 Ordering of ceramide formation and caspase-9 activation in CD95L-induced Jurkat leukemia T cell apoptosis. Biochim Biophys Acta 2012 0.76
120 An apoptosis biomarker for prediction of nonalcoholic steatohepatitis. Hepatology 2009 0.76
121 Tributyltin (TBT) induces ultra-rapid caspase activation independent of apoptosome formation in human platelets. Oncogene 2003 0.76
122 Decrease of Store-Operated Ca2+ Entry and Increase of Na+/Ca2+ Exchange by Pharmacological JAK2 Inhibition. Cell Physiol Biochem 2016 0.76
123 Can cell death biomarkers predict the outcome of acute liver failure? Liver Int 2011 0.76
124 Transforming growth factor-beta1 enhances the antifibrinolytic and prothrombotic state of growing endothelial cells in a cell cycle-specific manner. FASEB J 2006 0.76
125 Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak. J Cell Sci 2016 0.75
126 Catching chromatin relaxation in act by flow cytometry. Cell Cycle 2009 0.75
127 Reply: To PMID 24913549. Hepatology 2015 0.75
128 Modulation of the beta-adrenergic receptor system of vascular smooth muscle cells in vitro and in vivo by chronically elevated endothelin-1 levels. Biochem Pharmacol 2002 0.75