Published in Proteins on July 01, 2008
The exosome contains domains with specific endoribonuclease, exoribonuclease and cytoplasmic mRNA decay activities. Nat Struct Mol Biol (2008) 2.81
Nob1 binds the single-stranded cleavage site D at the 3'-end of 18S rRNA with its PIN domain. Proc Natl Acad Sci U S A (2009) 1.53
VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. PLoS One (2011) 1.13
Bacterial toxin-antitoxin systems: Translation inhibitors everywhere. Mob Genet Elements (2011) 1.11
The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. Protein Sci (2012) 1.05
Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry. RNA (2012) 1.02
Crystal structure of the VapBC toxin-antitoxin complex from Shigella flexneri reveals a hetero-octameric DNA-binding assembly. J Mol Biol (2011) 1.01
Growth and translation inhibition through sequence-specific RNA binding by Mycobacterium tuberculosis VapC toxin. J Biol Chem (2012) 0.97
VapC6, a ribonucleolytic toxin regulates thermophilicity in the crenarchaeote Sulfolobus solfataricus. RNA (2011) 0.96
Growth-regulating Mycobacterium tuberculosis VapC-mt4 toxin is an isoacceptor-specific tRNase. Nat Commun (2015) 0.94
Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides. Nucleic Acids Res (2015) 0.86
Solution structure and membrane binding of the toxin fst of the par addiction module. Biochemistry (2010) 0.86
VapC from the leptospiral VapBC toxin-antitoxin module displays ribonuclease activity on the initiator tRNA. PLoS One (2014) 0.86
Protein expression, crystallization and preliminary X-ray crystallographic analysis of the isolated Shigella flexneri VapC toxin. Acta Crystallogr Sect F Struct Biol Cryst Commun (2013) 0.82
Analysis of non-typeable Haemophilous influenzae VapC1 mutations reveals structural features required for toxicity and flexibility in the active site. PLoS One (2014) 0.77
Toxin-antitoxin systems in the mobile genome of Acidithiobacillus ferrooxidans. PLoS One (2014) 0.77
Crystal structure of toxin HP0892 from Helicobacter pylori with two Zn(II) at 1.8 Å resolution. Protein Sci (2014) 0.76
A PilT N-terminus domain protein SSO1118 from hyperthemophilic archaeon Sulfolobus solfataricus P2. J Biomol NMR (2013) 0.76
Comprehensive classification of the PIN domain-like superfamily. Nucleic Acids Res (2017) 0.75
Structural conservation of the PIN domain active site across all domains of life. Protein Sci (2017) 0.75
Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure. Science (2007) 4.10
The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. Proc Natl Acad Sci U S A (2009) 1.79
Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease. J Biol Chem (2004) 1.74
A flexible and economical medium-throughput strategy for protein production and crystallization. Acta Crystallogr D Biol Crystallogr (2005) 1.67
The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance. J Mol Biol (2003) 1.65
Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes. J Biol Chem (2009) 1.45
Dealing with iron: common structural principles in proteins that transport iron and heme. Proc Natl Acad Sci U S A (2003) 1.44
Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis. Proc Natl Acad Sci U S A (2004) 1.44
The PIN-domain ribonucleases and the prokaryotic VapBC toxin-antitoxin array. Protein Eng Des Sel (2010) 1.43
Intramolecular isopeptide bonds: protein crosslinks built for stress? Trends Biochem Sci (2010) 1.31
The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord (2002) 1.28
The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome. J Biol Chem (2002) 1.28
The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily. J Bacteriol (2009) 1.27
Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism. Proc Natl Acad Sci U S A (2006) 1.27
The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. J Mol Biol (2009) 1.22
Structure and assembly of Gram-positive bacterial pili: unique covalent polymers. Curr Opin Struct Biol (2012) 1.21
Aminoglycoside antibiotic resistance by enzymatic deactivation. Curr Drug Targets Infect Disord (2002) 1.17
Crystal structure of the minor pilin FctB reveals determinants of Group A streptococcal pilus anchoring. J Biol Chem (2010) 1.16
A new Gateway vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis. Protein Expr Purif (2007) 1.14
VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. PLoS One (2011) 1.13
Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure (2005) 1.13
Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding. J Biol Chem (2008) 1.12
Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin. J Mol Biol (2005) 1.11
The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase. J Bacteriol (2006) 1.11
Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system. Protein Expr Purif (2007) 1.10
The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis. J Biol Chem (2005) 1.08
The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition. Mol Microbiol (2007) 1.07
Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology (2004) 1.04
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. J Mol Biol (2005) 1.04
Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. J Mol Biol (2004) 1.04
A VapBC toxin-antitoxin module is a posttranscriptional regulator of metabolic flux in mycobacteria. J Bacteriol (2012) 1.04
The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb) (2011) 1.03
Lactoferrin and iron: structural and dynamic aspects of binding and release. Biometals (2004) 1.03
Roles of minor pilin subunits Spy0125 and Spy0130 in the serotype M1 Streptococcus pyogenes strain SF370. J Bacteriol (2010) 1.03
Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry. RNA (2012) 1.02
Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins. J Mol Biol (2007) 1.02
Crystal structure of Epiphyas postvittana takeout 1 with bound ubiquinone supports a role as ligand carriers for takeout proteins in insects. J Biol Chem (2008) 1.02
Metabolic engineering of cofactor F420 production in Mycobacterium smegmatis. PLoS One (2010) 1.01
Ribonucleases in bacterial toxin-antitoxin systems. Biochim Biophys Acta (2013) 1.00
Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Biol Chem (2010) 1.00
Citations in supplementary material. Acta Crystallogr D Biol Crystallogr (2010) 1.00
Structure and function of GlmU from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr (2009) 0.99
Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin. Proc Natl Acad Sci U S A (2013) 0.98
Crystal structure of Spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly. PLoS One (2011) 0.98
On the origin and evolution of thermophily: reconstruction of functional precambrian enzymes from ancestors of Bacillus. Mol Biol Evol (2011) 0.98
Thermodynamic theory explains the temperature optima of soil microbial processes and high Q10 values at low temperatures. Glob Chang Biol (2014) 0.98
Structural and functional characterization of a promiscuous feruloyl esterase (Est1E) from the rumen bacterium Butyrivibrio proteoclasticus. Proteins (2010) 0.98
Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Mol Microbiol (2014) 0.95
Isopeptide bonds in bacterial pili and their characterization by X-ray crystallography and mass spectrometry. Biopolymers (2009) 0.95
The laminin-binding protein Lbp from Streptococcus pyogenes is a zinc receptor. J Bacteriol (2009) 0.95
Structural model for covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond. J Biol Chem (2013) 0.95
Toxin-antitoxin systems of Mycobacterium smegmatis are essential for cell survival. J Biol Chem (2011) 0.95
Structure of the full-length major pilin from Streptococcus pneumoniae: implications for isopeptide bond formation in gram-positive bacterial pili. PLoS One (2011) 0.93
Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Biochemistry (2009) 0.92
Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Mol Biol (2012) 0.92
Defining the potassium binding region in an apple terpene synthase. J Biol Chem (2009) 0.92
Change in heat capacity for enzyme catalysis determines temperature dependence of enzyme catalyzed rates. ACS Chem Biol (2013) 0.92
Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis. J Bacteriol (2003) 0.91
A structural perspective on lactoferrin function. Biochem Cell Biol (2012) 0.91
Histidine phosphorylation in biological systems. Biochim Biophys Acta (2007) 0.91
Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms. Acta Crystallogr D Biol Crystallogr (2005) 0.91
High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon. Biochemistry (2007) 0.91
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP. Acta Crystallogr D Biol Crystallogr (2008) 0.89
Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. J Bacteriol (2010) 0.89
Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase. J Bacteriol (2006) 0.88
Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI). ChemMedChem (2010) 0.88
Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis. J Biol Chem (2009) 0.87
The potential impact of structural genomics on tuberculosis drug discovery. Drug Discov Today (2006) 0.87
The structure of the oligomerization domain of Lsr2 from Mycobacterium tuberculosis reveals a mechanism for chromosome organization and protection. PLoS One (2012) 0.86
Structure and function of human xylulokinase, an enzyme with important roles in carbohydrate metabolism. J Biol Chem (2012) 0.86
In defence of our science - validation now! Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.86
Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis. Biochemistry (2009) 0.85
Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.85
The extracellular protein factor Epf from Streptococcus pyogenes is a cell surface adhesin that binds to cells through an N-terminal domain containing a carbohydrate-binding module. J Biol Chem (2012) 0.85
Protein structure prediction and analysis as a tool for functional genomics. Appl Bioinformatics (2003) 0.85
Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery. J Mol Biol (2009) 0.85
Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis. Acta Crystallogr D Biol Crystallogr (2010) 0.84
Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases. Eur J Med Chem (2007) 0.84
Crystallization and preliminary X-ray analysis of a conserved hypothetical protein PAE2754 from Pyrobaculum aerophilum and of a double Leu-->Met mutant engineered for MAD phasing. Acta Crystallogr D Biol Crystallogr (2004) 0.84
Structural and functional consequences of binding site mutations in transferrin: crystal structures of the Asp63Glu and Arg124Ala mutants of the N-lobe of human transferrin. Biochemistry (2003) 0.84
Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site. Org Biomol Chem (2012) 0.84
Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2004) 0.84
Tat-dependent translocation of an F420-binding protein of Mycobacterium tuberculosis. PLoS One (2012) 0.84
The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis. J Mol Biol (2008) 0.83
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry (2012) 0.82
Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr (2004) 0.82
Expression, purification, crystallization and preliminary crystallographic analysis of SpaA, a major pilin from Corynebacterium diphtheriae. Acta Crystallogr Sect F Struct Biol Cryst Commun (2009) 0.82
Purification, crystallization and preliminary crystallographic analysis of mouse myo-inositol oxygenase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.82
Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC). Acta Crystallogr D Biol Crystallogr (2006) 0.81
The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate. J Mol Biol (2005) 0.81
Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design. J Biol Chem (2011) 0.81
Purification, crystallization and preliminary crystallographic analysis of human dihydrodipicolinate synthase-like protein (DHDPSL). Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.81
Three-dimensional structure and ligand binding properties of trichosurin, a metatherian lipocalin from the milk whey of the common brushtail possum Trichosurus vulpecula. Biochem J (2007) 0.80