Published in ChemMedChem on July 05, 2010
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One (2013) 1.31
The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb) (2011) 1.03
Targeting iron assimilation to develop new antibacterials. Expert Opin Drug Discov (2012) 0.97
Inhibitors of the salicylate synthase (MbtI) from Mycobacterium tuberculosis discovered by high-throughput screening. ChemMedChem (2010) 0.89
Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy. Biochim Biophys Acta (2015) 0.88
Synthesis and Pharmacokinetic Evaluation of Siderophore Biosynthesis Inhibitors for Mycobacterium tuberculosis. J Med Chem (2015) 0.82
Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism. Bioorg Med Chem (2014) 0.77
Stereocontrolled Synthesis of a Potential Transition-State Inhibitor of the Salicylate Synthase MbtI from Mycobacterium tuberculosis. J Org Chem (2015) 0.76
When Does Chemical Elaboration Induce a Ligand To Change Its Binding Mode? J Med Chem (2016) 0.76
An Open and Shut Case: The Interaction of Magnesium with MST Enzymes. J Am Chem Soc (2016) 0.75
Stabilizing isopeptide bonds revealed in gram-positive bacterial pilus structure. Science (2007) 4.10
A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis. Mol Microbiol (2007) 2.13
The Corynebacterium diphtheriae shaft pilin SpaA is built of tandem Ig-like modules with stabilizing isopeptide and disulfide bonds. Proc Natl Acad Sci U S A (2009) 1.79
Distant structural homology leads to the functional characterization of an archaeal PIN domain as an exonuclease. J Biol Chem (2004) 1.74
A flexible and economical medium-throughput strategy for protein production and crystallization. Acta Crystallogr D Biol Crystallogr (2005) 1.67
The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance. J Mol Biol (2003) 1.65
Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1. Structure (2014) 1.58
Intramolecular isopeptide bonds give thermodynamic and proteolytic stability to the major pilin protein of Streptococcus pyogenes. J Biol Chem (2009) 1.45
Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis. Proc Natl Acad Sci U S A (2004) 1.44
Dealing with iron: common structural principles in proteins that transport iron and heme. Proc Natl Acad Sci U S A (2003) 1.44
Early prediction of hypocalcemia after thyroidectomy using parathyroid hormone: an analysis of pooled individual patient data from nine observational studies. J Am Coll Surg (2007) 1.41
Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2. Microbiology (2010) 1.36
Intramolecular isopeptide bonds: protein crosslinks built for stress? Trends Biochem Sci (2010) 1.31
The TB structural genomics consortium: providing a structural foundation for drug discovery. Curr Drug Targets Infect Disord (2002) 1.28
Identification of histone demethylases in Saccharomyces cerevisiae. J Biol Chem (2007) 1.28
The Three-dimensional structure of a superantigen-like protein, SET3, from a pathogenicity island of the Staphylococcus aureus genome. J Biol Chem (2002) 1.28
The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily. J Bacteriol (2009) 1.27
Crystal structure of a substrate complex of myo-inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism. Proc Natl Acad Sci U S A (2006) 1.27
Structure and assembly of Gram-positive bacterial pili: unique covalent polymers. Curr Opin Struct Biol (2012) 1.21
Aminoglycoside antibiotic resistance by enzymatic deactivation. Curr Drug Targets Infect Disord (2002) 1.17
Crystal structure of the minor pilin FctB reveals determinants of Group A streptococcal pilus anchoring. J Biol Chem (2010) 1.16
A new Gateway vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis. Protein Expr Purif (2007) 1.14
Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation. Structure (2005) 1.13
Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding. J Biol Chem (2008) 1.12
Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin. J Mol Biol (2005) 1.11
The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase. J Bacteriol (2006) 1.11
Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system. Protein Expr Purif (2007) 1.10
The crystal structure of Rv1347c, a putative antibiotic resistance protein from Mycobacterium tuberculosis, reveals a GCN5-related fold and suggests an alternative function in siderophore biosynthesis. J Biol Chem (2005) 1.08
The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition. Mol Microbiol (2007) 1.07
Crystal structure of PAE0151 from Pyrobaculum aerophilum, a PIN-domain (VapC) protein from a toxin-antitoxin operon. Proteins (2008) 1.07
The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. J Mol Biol (2005) 1.04
Crystal structure of MshB from Mycobacterium tuberculosis, a deacetylase involved in mycothiol biosynthesis. J Mol Biol (2004) 1.04
Lactoferrin is a potent regulator of bone cell activity and increases bone formation in vivo. Endocrinology (2004) 1.04
The TB Structural Genomics Consortium: a decade of progress. Tuberculosis (Edinb) (2011) 1.03
Lactoferrin and iron: structural and dynamic aspects of binding and release. Biometals (2004) 1.03
Total synthesis of homogeneous antifreeze glycopeptides and glycoproteins. Angew Chem Int Ed Engl (2012) 1.03
Identification of a catalytic exosite for complement component C4 on the serine protease domain of C1s. J Immunol (2012) 1.03
Roles of minor pilin subunits Spy0125 and Spy0130 in the serotype M1 Streptococcus pyogenes strain SF370. J Bacteriol (2010) 1.03
Self-adjuvanting multicomponent cancer vaccine candidates combining per-glycosylated MUC1 glycopeptides and the Toll-like receptor 2 agonist Pam3CysSer. Angew Chem Int Ed Engl (2011) 1.02
Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins. J Mol Biol (2007) 1.02
Crystal structure of Epiphyas postvittana takeout 1 with bound ubiquinone supports a role as ligand carriers for takeout proteins in insects. J Biol Chem (2008) 1.02
Metabolic engineering of cofactor F420 production in Mycobacterium smegmatis. PLoS One (2010) 1.01
Body mass index in the evaluation of thyroid cancer risk. Thyroid (2009) 1.01
Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Biol Chem (2010) 1.00
Citations in supplementary material. Acta Crystallogr D Biol Crystallogr (2010) 1.00
The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device. Nature (2013) 1.00
Structure and function of GlmU from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr (2009) 0.99
Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin. Proc Natl Acad Sci U S A (2013) 0.98
Thyroid gland management in total laryngectomy: meta-analysis and surgical recommendations. Otolaryngol Head Neck Surg (2009) 0.98
Crystal structure of Spy0129, a Streptococcus pyogenes class B sortase involved in pilus assembly. PLoS One (2011) 0.98
3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity. Proc Natl Acad Sci U S A (2011) 0.97
Incidence and histopathological behavior of papillary microcarcinomas: study of 429 cases. Otolaryngol Head Neck Surg (2008) 0.96
Solid-phase synthesis of peptide and glycopeptide thioesters through side-chain-anchoring strategies. Chemistry (2008) 0.96
Isopeptide bonds in bacterial pili and their characterization by X-ray crystallography and mass spectrometry. Biopolymers (2009) 0.95
The laminin-binding protein Lbp from Streptococcus pyogenes is a zinc receptor. J Bacteriol (2009) 0.95
Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Mol Microbiol (2014) 0.95
Structural model for covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond. J Biol Chem (2013) 0.95
Prediction of hypocalcemia after using 1- to 6-hour postoperative parathyroid hormone and calcium levels: an analysis of pooled individual patient data from 3 observational studies. Head Neck (2010) 0.94
Structure of the full-length major pilin from Streptococcus pneumoniae: implications for isopeptide bond formation in gram-positive bacterial pili. PLoS One (2011) 0.93
Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga. J Mol Biol (2011) 0.93
Cost savings associated with post-thyroidectomy parathyroid hormone levels. Otolaryngol Head Neck Surg (2008) 0.92
Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1). J Biol Chem (2013) 0.92
Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1). J Biol Chem (2012) 0.92
Three sites and you are out: ternary synergistic allostery controls aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Mol Biol (2012) 0.92
Tyrosine sulfation influences the chemokine binding selectivity of peptides derived from chemokine receptor CCR3. Biochemistry (2011) 0.92
Fluorosurfactants for microdroplets: interfacial tension analysis. J Colloid Interface Sci (2010) 0.92
Fine-needle aspiration biopsies in the management of indeterminate follicular and Hurthle cell thyroid lesions. Otolaryngol Head Neck Surg (2009) 0.92
Crystal structure and metal binding properties of the lipoprotein MtsA, responsible for iron transport in Streptococcus pyogenes. Biochemistry (2009) 0.92
Defining the potassium binding region in an apple terpene synthase. J Biol Chem (2009) 0.92
Crystal structure of a putative methyltransferase from Mycobacterium tuberculosis: misannotation of a genome clarified by protein structural analysis. J Bacteriol (2003) 0.91
High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon. Biochemistry (2007) 0.91
Histidine phosphorylation in biological systems. Biochim Biophys Acta (2007) 0.91
A structural perspective on lactoferrin function. Biochem Cell Biol (2012) 0.91
Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms. Acta Crystallogr D Biol Crystallogr (2005) 0.91
Extrathyroidal extension in well-differentiated thyroid cancer: macroscopic vs microscopic as a predictor of outcome. Arch Otolaryngol Head Neck Surg (2007) 0.91
Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif. Biochim Biophys Acta (2013) 0.90
McGill Thyroid Nodule Score (MTNS): "rating the risk," a novel predictive scheme for cancer risk determination. J Otolaryngol Head Neck Surg (2011) 0.90
Inhibitors of an essential mycobacterial cell wall lipase (Rv3802c) as tuberculosis drug leads. Chem Commun (Camb) (2011) 0.89
Structures of Mycobacterium tuberculosis folylpolyglutamate synthase complexed with ADP and AMPPCP. Acta Crystallogr D Biol Crystallogr (2008) 0.89
Structural and functional characterization of an RNase HI domain from the bifunctional protein Rv2228c from Mycobacterium tuberculosis. J Bacteriol (2010) 0.89
Structural and functional analysis of Rv3214 from Mycobacterium tuberculosis, a protein with conflicting functional annotations, leads to its characterization as a phosphatase. J Bacteriol (2006) 0.88
Investigating the oxidation of alkenes by non-heme iron enzyme mimics. Org Biomol Chem (2012) 0.88
Pneumomediastinum and cervicofacial emphysema following a nasally obstructed sneeze. J Otolaryngol (2006) 0.88
A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations. Retrovirology (2013) 0.88
Isopenicillin N synthase mediates thiolate oxidation to sulfenate in a depsipeptide substrate analogue: implications for oxygen binding and a link to nitrile hydratase? J Am Chem Soc (2008) 0.87
Chemical sensors that incorporate click-derived triazoles. Chem Soc Rev (2011) 0.87
Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis. J Biol Chem (2009) 0.87
The potential impact of structural genomics on tuberculosis drug discovery. Drug Discov Today (2006) 0.87
Unambiguous determination of isobaric histone modifications by reversed-phase retention time and high-mass accuracy. Anal Biochem (2009) 0.87