|
1
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Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke.
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N Engl J Med
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2008
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28.42
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|
2
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Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study.
|
Lancet
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2007
|
10.74
|
|
3
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Thrombolysis in very elderly people: controlled comparison of SITS International Stroke Thrombolysis Registry and Virtual International Stroke Trials Archive.
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BMJ
|
2010
|
4.74
|
|
4
|
The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase.
|
Stroke
|
2004
|
4.39
|
|
5
|
Thrombolysis with alteplase 3-4.5 h after acute ischaemic stroke (SITS-ISTR): an observational study.
|
Lancet
|
2008
|
4.14
|
|
6
|
NXY-059 for the treatment of acute ischemic stroke.
|
N Engl J Med
|
2007
|
3.70
|
|
7
|
Statistical analysis of the primary outcome in acute stroke trials.
|
Stroke
|
2012
|
3.52
|
|
8
|
Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset.
|
Stroke
|
2006
|
3.03
|
|
9
|
Serum urate as an independent predictor of poor outcome and future vascular events after acute stroke.
|
Stroke
|
2003
|
2.96
|
|
10
|
Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial.
|
Circulation
|
2005
|
2.83
|
|
11
|
A simple, assumption-free, and clinically interpretable approach for analysis of modified Rankin outcomes.
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Stroke
|
2012
|
2.57
|
|
12
|
Acute Stroke Therapy by Inhibition of Neutrophils (ASTIN): an adaptive dose-response study of UK-279,276 in acute ischemic stroke.
|
Stroke
|
2003
|
2.42
|
|
13
|
NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials.
|
Stroke
|
2008
|
2.39
|
|
14
|
Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial.
|
Lancet
|
2014
|
2.31
|
|
15
|
Multivariable analysis of outcome predictors and adjustment of main outcome results to baseline data profile in randomized controlled trials: Safe Implementation of Thrombolysis in Stroke-MOnitoring STudy (SITS-MOST).
|
Stroke
|
2008
|
2.24
|
|
16
|
Comparison of stratification and adaptive methods for treatment allocation in an acute stroke clinical trial.
|
Stat Med
|
2003
|
2.21
|
|
17
|
Antiplatelet therapy and the effects of B vitamins in patients with previous stroke or transient ischaemic attack: a post-hoc subanalysis of VITATOPS, a randomised, placebo-controlled trial.
|
Lancet Neurol
|
2012
|
2.19
|
|
18
|
Effect of area-based deprivation on the severity, subtype, and outcome of ischemic stroke.
|
Stroke
|
2003
|
2.13
|
|
19
|
Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR.
|
Lancet Neurol
|
2010
|
2.12
|
|
20
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Design and analysis of phase III trials with ordered outcome scales: the concept of the sliding dichotomy.
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J Neurotrauma
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2005
|
2.06
|
|
21
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A multicentre observational study of presentation and early assessment of acute stroke.
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BMJ
|
2002
|
2.01
|
|
22
|
ABCD2 scores and prediction of noncerebrovascular diagnoses in an outpatient population: a case-control study.
|
Stroke
|
2009
|
1.84
|
|
23
|
Detection of atrial fibrillation after ischemic stroke or transient ischemic attack: a systematic review and meta-analysis.
|
Stroke
|
2014
|
1.77
|
|
24
|
Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial.
|
Stroke
|
2007
|
1.75
|
|
25
|
Predicting the risk of symptomatic intracerebral hemorrhage in ischemic stroke treated with intravenous alteplase: safe Implementation of Treatments in Stroke (SITS) symptomatic intracerebral hemorrhage risk score.
|
Stroke
|
2012
|
1.73
|
|
26
|
Acute stroke imaging research roadmap.
|
Stroke
|
2008
|
1.66
|
|
27
|
Noninvasive cardiac event monitoring to detect atrial fibrillation after ischemic stroke: a randomized, controlled trial.
|
Stroke
|
2013
|
1.66
|
|
28
|
Xanthine oxidase inhibition for the treatment of cardiovascular disease: a systematic review and meta-analysis.
|
Cardiovasc Ther
|
2011
|
1.58
|
|
29
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Frequent early cardiac complications contribute to worse stroke outcome in atrial fibrillation.
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Cerebrovasc Dis
|
2011
|
1.53
|
|
30
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Influence of age on outcome from thrombolysis in acute stroke: a controlled comparison in patients from the Virtual International Stroke Trials Archive (VISTA).
|
Stroke
|
2010
|
1.53
|
|
31
|
Pre-stroke CHADS2 and CHA2DS2-VASc scores are useful in stratifying three-month outcomes in patients with and without atrial fibrillation.
|
Cerebrovasc Dis
|
2013
|
1.52
|
|
32
|
Elevated pulse pressure during the acute period of ischemic stroke is associated with poor stroke outcome.
|
Stroke
|
2004
|
1.48
|
|
33
|
Acute Stroke Imaging Research Roadmap II.
|
Stroke
|
2013
|
1.47
|
|
34
|
Mismatch-based delayed thrombolysis: a meta-analysis.
|
Stroke
|
2009
|
1.41
|
|
35
|
Acute stroke imaging research roadmap.
|
AJNR Am J Neuroradiol
|
2008
|
1.41
|
|
36
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Thrombolysis in stroke despite contraindications or warnings?
|
Stroke
|
2013
|
1.40
|
|
37
|
The effect of losartan on global and focal cerebral perfusion and on renal function in hypertensives in mild early ischaemic stroke.
|
J Hypertens
|
2004
|
1.40
|
|
38
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The Virtual International Stroke Trials Archive.
|
Stroke
|
2007
|
1.34
|
|
39
|
Predictors of early cardiac morbidity and mortality after ischemic stroke.
|
Stroke
|
2007
|
1.26
|
|
40
|
Evidence-based stroke r-ehabilitation: an expanded guidance document from the european stroke organisation (ESO) guidelines for management of ischaemic stroke and transient ischaemic attack 2008.
|
J Rehabil Med
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2009
|
1.25
|
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41
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Relationship of blood pressure, antihypertensive therapy, and outcome in ischemic stroke treated with intravenous thrombolysis: retrospective analysis from Safe Implementation of Thrombolysis in Stroke-International Stroke Thrombolysis Register (SITS-ISTR).
|
Stroke
|
2009
|
1.18
|
|
42
|
Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy.
|
Cerebrovasc Dis
|
2005
|
1.16
|
|
43
|
Neuroprotection is unlikely to be effective in humans using current trial designs: an opposing view.
|
Stroke
|
2002
|
1.15
|
|
44
|
Effect of hyperthermia on prognosis after acute ischemic stroke.
|
Stroke
|
2009
|
1.14
|
|
45
|
EuroHYP-1: European multicenter, randomized, phase III clinical trial of therapeutic hypothermia plus best medical treatment vs. best medical treatment alone for acute ischemic stroke.
|
Int J Stroke
|
2014
|
1.13
|
|
46
|
Reliability of the modified Rankin Scale: a systematic review.
|
Stroke
|
2009
|
1.13
|
|
47
|
Comparison of the National Institutes of Health Stroke Scale with disability outcome measures in acute stroke trials.
|
Stroke
|
2005
|
1.09
|
|
48
|
The effect of time to treatment on outcome in very elderly thrombolysed stroke patients.
|
Int J Stroke
|
2014
|
1.09
|
|
49
|
Allopurinol use yields potentially beneficial effects on inflammatory indices in those with recent ischemic stroke: a randomized, double-blind, placebo-controlled trial.
|
Stroke
|
2008
|
1.08
|
|
50
|
Variability in modified Rankin scoring across a large cohort of international observers.
|
Stroke
|
2008
|
1.08
|
|
51
|
Exploring the reliability of the modified rankin scale.
|
Stroke
|
2009
|
1.08
|
|
52
|
Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke: pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II Trials.
|
Stroke
|
2009
|
1.07
|
|
53
|
Effect of blood pressure during the acute period of ischemic stroke on stroke outcome: a tertiary analysis of the GAIN International Trial.
|
Stroke
|
2003
|
1.07
|
|
54
|
Association of admission blood glucose and outcome in patients treated with intravenous thrombolysis: results from the Safe Implementation of Treatments in Stroke International Stroke Thrombolysis Register (SITS-ISTR).
|
Arch Neurol
|
2010
|
1.07
|
|
55
|
Thrombolysis is associated with consistent functional improvement across baseline stroke severity: a comparison of outcomes in patients from the Virtual International Stroke Trials Archive (VISTA).
|
Stroke
|
2010
|
1.06
|
|
56
|
Initial experience of a digital training resource for modified Rankin scale assessment in clinical trials.
|
Stroke
|
2007
|
1.05
|
|
57
|
Robotic measurement of arm movements after stroke establishes biomarkers of motor recovery.
|
Stroke
|
2013
|
1.05
|
|
58
|
Results of intravenous thrombolysis within 4.5 to 6 hours and updated results within 3 to 4.5 hours of onset of acute ischemic stroke recorded in the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis Register (SITS-ISTR): an observational study.
|
JAMA Neurol
|
2013
|
1.05
|
|
59
|
Development, expansion, and use of a stroke clinical trials resource for novel exploratory analyses.
|
Int J Stroke
|
2012
|
1.02
|
|
60
|
Safety of intravenous thrombolysis for ischemic stroke in patients treated with warfarin.
|
Ann Neurol
|
2013
|
1.00
|
|
61
|
Stroke outcome in clinical trial patients deriving from different countries.
|
Stroke
|
2008
|
0.99
|
|
62
|
Targeting neuroprotection clinical trials to ischemic stroke patients with potential to benefit from therapy.
|
Stroke
|
2004
|
0.99
|
|
63
|
Association between disability measures and healthcare costs after initial treatment for acute stroke.
|
Stroke
|
2007
|
0.97
|
|
64
|
Safety of intravenous thrombolysis for acute ischemic stroke in patients receiving antiplatelet therapy at stroke onset.
|
Stroke
|
2010
|
0.96
|
|
65
|
The Modified Graeb Score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome.
|
Stroke
|
2013
|
0.95
|
|
66
|
Seven-day NIHSS is a sensitive outcome measure for exploratory clinical trials in acute stroke: evidence from the Virtual International Stroke Trials Archive.
|
Stroke
|
2012
|
0.95
|
|
67
|
Gavestinel does not improve outcome after acute intracerebral hemorrhage: an analysis from the GAIN International and GAIN Americas studies.
|
Stroke
|
2005
|
0.95
|
|
68
|
The past is the future: innovative designs in acute stroke therapy trials.
|
Stroke
|
2005
|
0.93
|
|
69
|
Prehospital stroke care: new prospects for treatment and clinical research.
|
Neurology
|
2013
|
0.92
|
|
70
|
Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes.
|
Diabetes Metab Res Rev
|
2005
|
0.91
|
|
71
|
Assessment of additional endpoints for trials in acute stroke - what, when, where, in who?
|
Int J Stroke
|
2012
|
0.90
|
|
72
|
Time spent at home poststroke: "home-time" a meaningful and robust outcome measure for stroke trials.
|
Stroke
|
2007
|
0.90
|
|
73
|
Strengthening acute stroke trials through optimal use of disability end points.
|
Stroke
|
2003
|
0.89
|
|
74
|
Effects of magnesium treatment in a model of internal capsule lesion in spontaneously hypertensive rats.
|
Stroke
|
2008
|
0.89
|
|
75
|
Reliability of structured modified rankin scale assessment.
|
Stroke
|
2010
|
0.89
|
|
76
|
Will delays in treatment jeopardize the population benefit from extending the time window for stroke thrombolysis?
|
Stroke
|
2012
|
0.89
|
|
77
|
Improving trial power through use of prognosis-adjusted end points.
|
Stroke
|
2005
|
0.88
|
|
78
|
Prior events predict cerebrovascular and coronary outcomes in the PROGRESS trial.
|
Stroke
|
2006
|
0.88
|
|
79
|
Long-term outcome following attendance at a transient ischemic attack clinic.
|
Int J Stroke
|
2011
|
0.88
|
|
80
|
Low triglyceride, not low cholesterol concentration, independently predicts poor outcome following acute stroke.
|
Cerebrovasc Dis
|
2003
|
0.87
|
|
81
|
Independent preoperative predictors of outcomes in orthopedic and vascular surgery: the influence of time interval between an acute coronary syndrome or stroke and the operation.
|
Ann Surg
|
2012
|
0.87
|
|
82
|
Deriving modified Rankin scores from medical case-records.
|
Stroke
|
2008
|
0.87
|
|
83
|
Baseline serum urate and 90-day functional outcomes following acute ischemic stroke.
|
Cerebrovasc Dis
|
2009
|
0.87
|
|
84
|
Effect of smoking status on outcome after acute ischemic stroke.
|
Cerebrovasc Dis
|
2006
|
0.87
|
|
85
|
Effect size measures and their relationships in stroke studies.
|
Stroke
|
2013
|
0.87
|
|
86
|
Magnesium for treatment of acute lacunar stroke syndromes: further analysis of the IMAGES trial.
|
Stroke
|
2007
|
0.86
|
|
87
|
Informal carers' experience of caring for stroke survivors.
|
J Adv Nurs
|
2004
|
0.86
|
|
88
|
Delayed detection of atrial fibrillation after ischemic stroke.
|
J Stroke Cerebrovasc Dis
|
2009
|
0.86
|
|
89
|
Does hemispheric lateralization influence functional and cardiovascular outcomes after stroke?: an analysis of placebo-treated patients from prospective acute stroke trials.
|
Stroke
|
2008
|
0.85
|
|
90
|
Alteplase for acute stroke revisited: the first 10 years.
|
Lancet Neurol
|
2006
|
0.85
|
|
91
|
AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels.
|
Stroke
|
2002
|
0.85
|
|
92
|
Reliability of the modified Rankin Scale.
|
Stroke
|
2007
|
0.84
|
|
93
|
Does the cognitive measure Cog-4 show improvement among patients treated with thrombolysis after acute stroke?
|
Int J Stroke
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2012
|
0.84
|
|
94
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Thrombolysis for acute ischemic stroke.
|
J Vasc Surg
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2011
|
0.83
|
|
95
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Home time is extended in patients with ischemic stroke who receive thrombolytic therapy: a validation study of home time as an outcome measure.
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Stroke
|
2011
|
0.82
|
|
96
|
Aspirin resistance and compliance with therapy.
|
Cardiovasc Ther
|
2010
|
0.81
|
|
97
|
Allopurinol and nitric oxide activity in the cerebral circulation of those with diabetes: a randomized trial.
|
Diabetes Care
|
2008
|
0.80
|
|
98
|
Comparison of outcomes following thrombolytic therapy among patients with prior stroke and diabetes in the Virtual International Stroke Trials Archive (VISTA).
|
Diabetes Care
|
2010
|
0.80
|
|
99
|
Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke.
|
Int J Stroke
|
2013
|
0.80
|
|
100
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Regulation and governance of multinational drug trials in stroke: barriers and possibilities.
|
Int J Stroke
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2015
|
0.79
|
|
101
|
The effect of allopurinol on the cerebral vasculature of patients with subcortical stroke; a randomized trial.
|
Br J Clin Pharmacol
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2009
|
0.79
|
|
102
|
VISTA-Rehab: a resource for stroke rehabilitation trials.
|
Int J Stroke
|
2010
|
0.79
|
|
103
|
Past, present and future of alteplase for acute ischemic stroke.
|
Expert Rev Neurother
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2008
|
0.79
|
|
104
|
Impact and influences on caregiver outcomes at one year post-stroke.
|
Cerebrovasc Dis
|
2004
|
0.79
|
|
105
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Impact of atrial fibrillation on outcome in thrombolyzed patients with stroke: evidence from the Virtual International Stroke Trials Archive (VISTA).
|
Stroke
|
2012
|
0.79
|
|
106
|
Advances in emerging therapies.
|
Stroke
|
2009
|
0.79
|
|
107
|
Poststroke neurological improvement within 7 days is associated with subsequent deterioration.
|
Stroke
|
2004
|
0.79
|
|
108
|
Testing devices for the prevention and treatment of stroke and its complications.
|
Int J Stroke
|
2014
|
0.79
|
|
109
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Stroke treatment academic industry roundtable: research priorities in the assessment of neurothrombectomy devices.
|
Stroke
|
2013
|
0.78
|
|
110
|
Population pharmacokinetic modelling and estimation of dosing strategy for NXY-059, a nitrone being developed for stroke.
|
Clin Pharmacokinet
|
2005
|
0.78
|
|
111
|
Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis.
|
Stroke
|
2013
|
0.78
|
|
112
|
Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: results of a randomized placebo-controlled trial.
|
Stroke
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2012
|
0.78
|
|
113
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Effect of perindopril on cerebral and renal perfusion on normotensives in mild early ischaemic stroke: a randomized controlled trial.
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Cerebrovasc Dis
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2004
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0.77
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114
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Turbulence and circulating cerebral emboli detectable at Doppler ultrasonography: a differentiation study in a stenotic middle cerebral artery model.
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AJNR Am J Neuroradiol
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2002
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0.77
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|
115
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Acute stroke: we have the treatments and we have the evidence--we need to use them.
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Crit Care
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2007
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0.77
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116
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Advances in emerging therapies 2007.
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Stroke
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2008
|
0.76
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117
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Advances in emerging therapies 2009.
|
Stroke
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2010
|
0.76
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|
118
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Results of the MRI substudy of the intravenous magnesium efficacy in stroke trial.
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Stroke
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2009
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0.76
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119
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Improving the efficiency of stroke trials: feasibility and efficacy of group adjudication of functional end points.
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Stroke
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2013
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0.76
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120
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Training and consistency in stroke assessments.
|
Stroke
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2009
|
0.75
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121
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Letter by Kerr and Lees regarding article, "country comparisons of human stroke research since 2001: a bibliometric study".
|
Stroke
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2012
|
0.75
|
|
122
|
Preoperative stroke and outcomes after coronary artery bypass graft surgery.
|
Anesthesiology
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2013
|
0.75
|
|
123
|
Intracluster correlation coefficients and reliability of randomized multicenter stroke trials within VISTA.
|
Int J Stroke
|
2013
|
0.75
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|
124
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Should thrombolysis be recommended for diabetic stroke patients?
|
Expert Rev Cardiovasc Ther
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2011
|
0.75
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|
125
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Postthrombolysis outcomes in acute ischemic stroke patients of Asian race-ethnicity.
|
Int J Stroke
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2013
|
0.75
|
|
126
|
Impact of benzodiazepines on functional outcome and occurrence of pneumonia in stroke: evidence from VISTA.
|
Int J Stroke
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2013
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0.75
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|
127
|
Improving mortality from stroke disease: putting the evidence into practice.
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Br J Hosp Med (Lond)
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2008
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0.75
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128
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Exploration of time-course combinations of outcome scales for use in a global test of stroke recovery.
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Int J Stroke
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2013
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0.75
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129
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Paroxysmal atrial fibrillation after ischemic stroke: how should we hunt for it?
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Expert Rev Cardiovasc Ther
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2013
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0.75
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130
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Response of blood pressure and blood glucose to treatment with recombinant tissue-type plasminogen activator in acute ischemic stroke: evidence from the virtual international stroke trials archive.
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Stroke
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2011
|
0.75
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131
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How a sequential design would have affected the GAIN International Study of gavestinel in stroke.
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Cerebrovasc Dis
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2003
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0.75
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132
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Selection for delayed intravenous alteplase treatment based on a prognostic score.
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Int J Stroke
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2013
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0.75
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133
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Microembolic signals and aspirin resistance in patients with carotid stenosis.
|
Cardiovasc Ther
|
2011
|
0.75
|