Single-molecule studies of protein folding.

Fluorescent analogs of biomolecular building blocks: design, properties, and applications. Chem Rev (2010) 2.16

Single-molecule junctions beyond electronic transport. Nat Nanotechnol (2013) 2.08

Single-molecule protein unfolding in solid state nanopores. J Am Chem Soc (2009) 1.84

The folding cooperativity of a protein is controlled by its chain topology. Nature (2010) 1.76

Single-molecule studies of the neuronal SNARE fusion machinery. Annu Rev Biochem (2009) 1.55

Hidden dynamics in the unfolding of individual bacteriorhodopsin proteins. Science (2017) 1.39

Ratcheting up protein translocation with anthrax toxin. Protein Sci (2012) 1.38

Single-molecule spectroscopy of protein folding in a chaperonin cage. Proc Natl Acad Sci U S A (2010) 1.37

Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins. Nature (2011) 1.37

Mechanochemistry: one bond at a time. ACS Nano (2009) 1.26

Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates. Proc Natl Acad Sci U S A (2012) 1.24

Single Molecule Analysis Research Tool (SMART): an integrated approach for analyzing single molecule data. PLoS One (2012) 1.17

Collapse dynamics of single proteins extended by force. Biophys J (2010) 1.16

Direct observation of multiple misfolding pathways in a single prion protein molecule. Proc Natl Acad Sci U S A (2012) 1.08

Structure, folding dynamics, and amyloidogenesis of D76N β2-microglobulin: roles of shear flow, hydrophobic surfaces, and α-crystallin. J Biol Chem (2013) 1.04

Empirical Bayes methods enable advanced population-level analyses of single-molecule FRET experiments. Biophys J (2014) 1.02

Reshaping of the conformational search of a protein by the chaperone trigger factor. Nature (2013) 1.01

Collapse kinetics and chevron plots from simulations of denaturant-dependent folding of globular proteins. Proc Natl Acad Sci U S A (2011) 0.96

Understanding biology by stretching proteins: recent progress. Curr Opin Struct Biol (2010) 0.96

Observing single protein binding by optical transmission through a double nanohole aperture in a metal film. Biomed Opt Express (2013) 0.95

Fast and forceful refolding of stretched alpha-helical solenoid proteins. Biophys J (2010) 0.95

Denaturant-dependent folding of GFP. Proc Natl Acad Sci U S A (2012) 0.92

Forcing a connection: impacts of single-molecule force spectroscopy on in vivo tension sensing. Biopolymers (2011) 0.92

How force unfolding differs from chemical denaturation. Proc Natl Acad Sci U S A (2014) 0.91

Ligand-modulated parallel mechanical unfolding pathways of maltose-binding proteins. J Biol Chem (2011) 0.90

Multicolor single-molecule FRET to explore protein folding and binding. Mol Biosyst (2010) 0.90

DNA energy landscapes via calorimetric detection of microstate ensembles of metastable macrostates and triplet repeat diseases. Proc Natl Acad Sci U S A (2008) 0.88

Measuring the folding landscape of a harmonically constrained biopolymer. Biophys J (2011) 0.87

Geometrical membrane curvature as an allosteric regulator of membrane protein structure and function. Biophys J (2014) 0.86

Protein folding at single-molecule resolution. Biochim Biophys Acta (2011) 0.86

A microfluidic approach for investigating the temperature dependence of biomolecular activity with single-molecule resolution. Lab Chip (2010) 0.86

Mechanically untying a protein slipknot: multiple pathways revealed by force spectroscopy and steered molecular dynamics simulations. J Am Chem Soc (2012) 0.86

Multiple barriers in forced rupture of protein complexes. J Chem Phys (2012) 0.86

Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations. J Biol Chem (2010) 0.86

Contrasting the individual reactive pathways in protein unfolding and disulfide bond reduction observed within a single protein. J Am Chem Soc (2011) 0.86

Lab-on-a-chip technologies for single-molecule studies. Lab Chip (2013) 0.85

Single-molecule FRET of protein structure and dynamics - a primer. J Nanobiotechnology (2013) 0.85

Low folding cooperativity of HP35 revealed by single-molecule force spectroscopy and molecular dynamics simulation. Biophys J (2012) 0.84

Altered mechanical properties of titin immunoglobulin domain 27 in the presence of calcium. Eur Biophys J (2012) 0.84

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis. EMBO Mol Med (2015) 0.84

Dynamics of protein folding and cofactor binding monitored by single-molecule force spectroscopy. Biophys J (2011) 0.84

Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly. Proc Natl Acad Sci U S A (2012) 0.83

Effects of pH on proteins: predictions for ensemble and single-molecule pulling experiments. J Am Chem Soc (2011) 0.83

Escherichia coli-derived von Willebrand factor-A2 domain fluorescence/Förster resonance energy transfer proteins that quantify ADAMTS13 activity. Anal Biochem (2010) 0.82

Insights into chromatin fibre structure by in vitro and in silico single-molecule stretching experiments. Biochem Soc Trans (2013) 0.81

Extracting Kinetic and Stationary Distribution Information from Short MD Trajectories via a Collection of Surrogate Diffusion Models. J Chem Theory Comput (2009) 0.81

Diverse metastable structures formed by small oligomers of α-synuclein probed by force spectroscopy. PLoS One (2014) 0.81

Single molecule force spectroscopy on G-quadruplex DNA. Chemistry (2009) 0.81

Mechanisms of cellular proteostasis: insights from single-molecule approaches. Annu Rev Biophys (2014) 0.81

Elucidating the exact role of engineered CRABPII residues for the formation of a retinal protonated Schiff base. Proteins (2009) 0.80

Single-molecule approaches to prion protein misfolding. Prion (2013) 0.80

Single-molecule Force Spectroscopy Predicts a Misfolded, Domain-swapped Conformation in human γD-Crystallin Protein. J Biol Chem (2015) 0.80

Minimum energy compact structures in force-quench polyubiquitin folding are domain swapped. Proc Natl Acad Sci U S A (2011) 0.79

Optimizing 1-μs-Resolution Single-Molecule Force Spectroscopy on a Commercial Atomic Force Microscope. Nano Lett (2015) 0.79

Single-molecule experiments reveal the flexibility of a Per-ARNT-Sim domain and the kinetic partitioning in the unfolding pathway under force. Biophys J (2012) 0.79

Modification of a single-molecule AFM probe with highly defined surface functionality. Beilstein J Nanotechnol (2014) 0.78

Correction of the viscous drag induced errors in macromolecular manipulation experiments using atomic force microscope. Rev Sci Instrum (2010) 0.78

Nanomechanics of full-length nebulin: an elastic strain gauge in the skeletal muscle sarcomere. Langmuir (2009) 0.78

Mechanical Folding and Unfolding of Protein Barnase at the Single-Molecule Level. Biophys J (2016) 0.78

Locked nucleic acid oligomers as handles for single molecule manipulation. Nucleic Acids Res (2014) 0.77

Hierarchically-coupled hidden Markov models for learning kinetic rates from single-molecule data. JMLR Workshop Conf Proc (2013) 0.77

UV resonance Raman studies of the NaClO4 dependence of poly-L-lysine conformation and hydrogen exchange kinetics. J Phys Chem B (2012) 0.77

Experimental and computational characterization of biological liquid crystals: a review of single-molecule bioassays. Int J Mol Sci (2009) 0.76

Reconciling Intermediates in Mechanical Unfolding Experiments with Two-State Protein Folding in Bulk. J Phys Chem Lett (2016) 0.76

Engineered bi-histidine metal chelation sites map the structure of the mechanical unfolding transition state of an elastomeric protein domain GB1. Biophys J (2012) 0.76

Competing Pathways and Multiple Folding Nuclei in a Large Multidomain Protein, Luciferase. Biophys J (2017) 0.75

Detection of atomic force microscopy cantilever displacement with a transmitted electron beam. Appl Phys Lett (2016) 0.75

Single-Molecule Analysis of Cytochrome c Folding by Monitoring the Lifetime of an Attached Fluorescent Probe. J Phys Chem Lett (2013) 0.75

Single-molecule fluorescence resonance energy transfer in molecular biology. Nanoscale (2016) 0.75

Folding and binding: when the force is against you. Biophys J (2013) 0.75

Exact solution of the Zwanzig-Lauritzen model of polymer crystallization under tension. J Chem Phys (2013) 0.75

Single-molecule Force Spectroscopy Reveals the Calcium Dependence of the Alternative Conformations in the Native State of a βγ-Crystallin Protein. J Biol Chem (2016) 0.75

A simple DNA handle attachment method for single molecule mechanical manipulation experiments. Protein Sci (2016) 0.75

Accurate label-free reaction kinetics determination using initial rate heat measurements. Sci Rep (2015) 0.75

DNA-Endonuclease Complex Dynamics by Simultaneous FRET and Fluorophore Intensity in Evanescent Field. Biophys J (2017) 0.75

Changes of protein stiffness during folding detect protein folding intermediates. J Biol Phys (2013) 0.75

The importance of sequence diversity in the aggregation and evolution of proteins. Nature (2005) 2.70

Hidden complexity in the mechanical properties of titin. Nature (2003) 2.51

The folding and evolution of multidomain proteins. Nat Rev Mol Cell Biol (2007) 2.16

Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering. J Mol Biol (2002) 2.00

Parallel protein-unfolding pathways revealed and mapped. Nat Struct Biol (2003) 1.67

Versatile cloning system for construction of multimeric proteins for use in atomic force microscopy. Protein Sci (2002) 1.67

Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family. Nature (2010) 1.61

Mechanical unfolding of a titin Ig domain: structure of transition state revealed by combining atomic force microscopy, protein engineering and molecular dynamics simulations. J Mol Biol (2003) 1.53

Mechanical unfolding of proteins: insights into biology, structure and folding. Curr Opin Struct Biol (2007) 1.43

The folding of spectrin domains I: wild-type domains have the same stability but very different kinetic properties. J Mol Biol (2004) 1.40

What contributions to protein side-chain dynamics are probed by NMR experiments? A molecular dynamics simulation analysis. J Mol Biol (2005) 1.40

A simple method for probing the mechanical unfolding pathway of proteins in detail. Proc Natl Acad Sci U S A (2002) 1.39

Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins. Nature (2011) 1.37

Mechanical unfolding of TNfn3: the unfolding pathway of a fnIII domain probed by protein engineering, AFM and MD simulation. J Mol Biol (2005) 1.37

The remarkable mechanical strength of polycystin-1 supports a direct role in mechanotransduction. J Mol Biol (2005) 1.34

Titin; a multidomain protein that behaves as the sum of its parts. J Mol Biol (2002) 1.30

The folding of spectrin domains II: phi-value analysis of R16. J Mol Biol (2004) 1.29

Surgery or embolisation for varicoceles in subfertile men. Cochrane Database Syst Rev (2009) 1.28

The origin of protein sidechain order parameter distributions. J Am Chem Soc (2004) 1.25

The folding pathway of spectrin R17 from experiment and simulation: using experimentally validated MD simulations to characterize States hinted at by experiment. J Mol Biol (2006) 1.21

Robotic surgery for benign gynaecological disease. Cochrane Database Syst Rev (2012) 1.21

Atomic force microscopy: mechanical unfolding of proteins. Methods (2004) 1.21

Cooperative folding in a multi-domain protein. J Mol Biol (2005) 1.20

Designing an extracellular matrix protein with enhanced mechanical stability. Proc Natl Acad Sci U S A (2007) 1.19

Spectrin R16: broad energy barrier or sequential transition states? Protein Sci (2005) 1.16

BPPred: a Web-based computational tool for predicting biophysical parameters of proteins. Protein Sci (2006) 1.14

Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy. Nat Commun (2012) 1.13

Sequence conservation in Ig-like domains: the role of highly conserved proline residues in the fibronectin type III superfamily. J Mol Biol (2002) 1.13

Folding and binding of an intrinsically disordered protein: fast, but not 'diffusion-limited'. J Am Chem Soc (2013) 1.11

Hydrophobic core fluidity of homologous protein domains: relation of side-chain dynamics to core composition and packing. Biochemistry (2004) 1.08

Spectrin domains lose cooperativity in forced unfolding. Biophys J (2006) 1.08

Comparison of the transition states for folding of two Ig-like proteins from different superfamilies. J Mol Biol (2004) 1.05

Biophysical investigations of engineered polyproteins: implications for force data. Biophys J (2004) 1.04

Staphylococcal biofilm-forming protein has a contiguous rod-like structure. Proc Natl Acad Sci U S A (2012) 1.04

Fusion of contrast-enhanced breast MR and mammographic imaging data. Med Image Anal (2003) 1.03

Complex folding kinetics of a multidomain protein. Biophys J (2005) 1.02

Different members of a simple three-helix bundle protein family have very different folding rate constants and fold by different mechanisms. J Mol Biol (2009) 1.00

What can atomic force microscopy tell us about protein folding? Chem Commun (Camb) (2002) 1.00

Folding of a LysM domain: entropy-enthalpy compensation in the transition state of an ideal two-state folder. J Mol Biol (2008) 1.00

Coupled folding and binding of the disordered protein PUMA does not require particular residual structure. J Am Chem Soc (2014) 1.00

Thermodynamic characterisation of two transition states along parallel protein folding pathways. J Mol Biol (2004) 0.99

Plasticity within the obligatory folding nucleus of an immunoglobulin-like domain. J Mol Biol (2007) 0.99

Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP). Phys Chem Chem Phys (2011) 0.98

What lessons can be learned from studying the folding of homologous proteins? Methods (2010) 0.97

Influence of architecture on the kinetic stability of molecular assemblies. J Am Chem Soc (2004) 0.97

Acupuncture for uterine fibroids. Cochrane Database Syst Rev (2010) 0.97

Apparent cooperativity in the folding of multidomain proteins depends on the relative rates of folding of the constituent domains. Proc Natl Acad Sci U S A (2006) 0.97

Remarkably fast coupled folding and binding of the intrinsically disordered transactivation domain of cMyb to CBP KIX. J Phys Chem B (2013) 0.97

Studying the folding of multidomain proteins. HFSP J (2008) 0.96

An effective strategy for the design of proteins with enhanced mechanical stability. Angew Chem Int Ed Engl (2008) 0.96

Self-consistent determination of the transition state for protein folding: application to a fibronectin type III domain. Proc Natl Acad Sci U S A (2003) 0.95

The effect of poly(ethylene glycol) molecular architecture on cellular interaction and uptake of DNA complexes. J Control Release (2004) 0.94

Cost-effectiveness analysis of screening for risk of in-hospital falls using physiotherapist clinical judgement. Med Care (2009) 0.94

Naturally occurring mutations alter the stability of polycystin-1 polycystic kidney disease (PKD) domains. J Biol Chem (2009) 0.93

Multicentre study of delirium in ICU patients using a simple screening tool. Aust Crit Care (2005) 0.93

Using model proteins to quantify the effects of pathogenic mutations in Ig-like proteins. J Biol Chem (2006) 0.93

Structural comparison of the two alternative transition states for folding of TI I27. Biophys J (2006) 0.92

Separating the effects of internal friction and transition state energy to explain the slow, frustrated folding of spectrin domains. Proc Natl Acad Sci U S A (2012) 0.92

Direct real-time molecular scale visualisation of the degradation of condensed DNA complexes exposed to DNase I. Nucleic Acids Res (2003) 0.92

Antioxidants for female subfertility. Cochrane Database Syst Rev (2013) 0.91

Dose-response relationship between physiotherapy resource provision with function and balance improvements in patients following stroke: a multi-centre observational study. J Eval Clin Pract (2010) 0.88

Take home lessons from studies of related proteins. Curr Opin Struct Biol (2012) 0.87

Development and validation of the balance outcome measure for elder rehabilitation. Arch Phys Med Rehabil (2007) 0.87

pH-dependent behavior of surface-immobilized artificial leucine zipper proteins. Langmuir (2004) 0.86

Single molecule studies of protein folding using atomic force microscopy. Methods Mol Biol (2007) 0.86

Mouse lymphoma thymidine kinase gene mutation assay: follow-up meeting of the International Workshop on Genotoxicity Testing--Aberdeen, Scotland, 2003--Assay acceptance criteria, positive controls, and data evaluation. Environ Mol Mutagen (2006) 0.86

Topology is the principal determinant in the folding of a complex all-alpha Greek key death domain from human FADD. J Mol Biol (2009) 0.86

Characterisation of transition state structures for protein folding using 'high', 'medium' and 'low' {Phi}-values. Protein Eng Des Sel (2008) 0.86

Distinguishing specific and nonspecific interdomain interactions in multidomain proteins. Biophys J (2007) 0.86

Changes in falls risk factors for geriatric diagnostic groups across inpatient, outpatient and domiciliary rehabilitation settings. Disabil Rehabil (2011) 0.85

An assessment of beclomethasone dipropionate clathrate formation in a model suspension metered dose inhaler. Int J Pharm (2010) 0.84

Molecular level investigations of the inter- and intramolecular interactions of pH-responsive artificial triblock proteins. Biomacromolecules (2005) 0.84

Crosstalk between the protein surface and hydrophobic core in a core-swapped fibronectin type III domain. J Mol Biol (2007) 0.84

Experiments suggest that simulations may overestimate electrostatic contributions to the mechanical stability of a fibronectin type III domain. J Mol Biol (2007) 0.84

Dendron arrays for the force-based detection of DNA hybridization events. J Am Chem Soc (2007) 0.83

Membrane protein folding makes the transition. Proc Natl Acad Sci U S A (2010) 0.83

The importance of loop length in the folding of an immunoglobulin domain. Protein Eng Des Sel (2004) 0.82

Balance impairment not predictive of falls in geriatric rehabilitation wards. J Gerontol A Biol Sci Med Sci (2008) 0.82

A mechanistic model for amorphous protein aggregation of immunoglobulin-like domains. J Am Chem Soc (2013) 0.81

Bacterial attachment to polymeric materials correlates with molecular flexibility and hydrophilicity. Adv Healthc Mater (2014) 0.81

Protein folding: adding a nucleus to guide helix docking reduces landscape roughness. J Mol Biol (2012) 0.81

Treatment of heavy menstrual bleeding. BMJ (2010) 0.81

The folding pathway of a single domain in a multidomain protein is not affected by its neighbouring domain. J Mol Biol (2008) 0.81

Biophysics: Rough passage across a barrier. Nature (2013) 0.81

Single-molecule investigations of RNA dissociation. Biophys J (2004) 0.80

Pentoxifylline for endometriosis. Cochrane Database Syst Rev (2012) 0.80

Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions. J Cell Physiol (2005) 0.80

Surgery or embolisation for varicoceles in subfertile men. Cochrane Database Syst Rev (2008) 0.80

An atomic force microscopy study of the effect of nanoscale contact geometry and surface chemistry on the adhesion of pharmaceutical particles. Pharm Res (2004) 0.80

Spatial confinement of neurite regrowth from dorsal root ganglia within nonporous microconduits. Tissue Eng (2003) 0.79

Hysterectomy versus hysterectomy plus oophorectomy for premenopausal women. Cochrane Database Syst Rev (2008) 0.79

Ultra-resolution imaging of a self-assembling biomolecular system using robust carbon nanotube AFM probes. Langmuir (2007) 0.79

Strategies for MCR image analysis of large hyperspectral data-sets. Surf Interface Anal (2012) 0.78

Further validation of the Balance Outcome Measure for Elder Rehabilitation. Arch Phys Med Rehabil (2011) 0.78

Manipulating the stability of fibronectin type III domains by protein engineering. Nanotechnology (2008) 0.77

FnIII domains: predicting mechanical stability. Structure (2004) 0.77

Interactions between signal-transducing proteins measured by atomic force microscopy. Anal Chem (2009) 0.77

Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment. Mutat Res (2006) 0.77

Protein unfolding under force: crack propagation in a network. Biophys J (2011) 0.77