Published in HFSP J on October 15, 2008
Ubiquitin not only serves as a tag but also assists degradation by inducing protein unfolding. Proc Natl Acad Sci U S A (2010) 1.04
Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein. Nat Commun (2015) 0.88
Personalized biochemistry and biophysics. Biochemistry (2015) 0.88
Modulation of folding kinetics of repeat proteins: interplay between intra- and interdomain interactions. Biophys J (2012) 0.84
Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding. Biophys Chem (2015) 0.82
Nonspecific yet decisive: Ubiquitination can affect the native-state dynamics of the modified protein. Protein Sci (2015) 0.79
Natural diversity of cellulases, xylanases, and chitinases in bacteria. Biotechnol Biofuels (2016) 0.77
Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis. PLoS One (2013) 0.77
Two immunoglobulin tandem proteins with a linking β-strand reveal unexpected differences in cooperativity and folding pathways. J Mol Biol (2011) 0.76
Understanding pathogenic single-nucleotide polymorphisms in multidomain proteins--studies of isolated domains are not enough. FEBS J (2013) 0.76
Disorder drives cooperative folding in a multidomain protein. Proc Natl Acad Sci U S A (2016) 0.75
Molecular Properties of Globin Channels and Pores: Role of Cholesterol in Ligand Binding and Movement. Front Physiol (2016) 0.75
SCOP: a structural classification of proteins database for the investigation of sequences and structures. J Mol Biol (1995) 74.88
The Pfam protein families database. Nucleic Acids Res (2004) 56.46
Principles that govern the folding of protein chains. Science (1973) 23.40
Determination and analysis of urea and guanidine hydrochloride denaturation curves. Methods Enzymol (1986) 12.22
Theory of protein folding: the energy landscape perspective. Annu Rev Phys Chem (1997) 10.65
Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfolding. Protein Sci (1995) 9.23
Mechanical and chemical unfolding of a single protein: a comparison. Proc Natl Acad Sci U S A (1999) 7.74
Folding of newly translated proteins in vivo: the role of molecular chaperones. Annu Rev Biochem (2001) 5.74
Domain combinations in archaeal, eubacterial and eukaryotic proteomes. J Mol Biol (2001) 4.69
2.0 A crystal structure of a four-domain segment of human fibronectin encompassing the RGD loop and synergy region. Cell (1996) 4.05
Reverse engineering of the giant muscle protein titin. Nature (2002) 3.54
Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins. Proc Natl Acad Sci U S A (2007) 2.98
Structures of two repeats of spectrin suggest models of flexibility. Cell (1999) 2.30
Independent movement, dimerization and stability of tandem repeats of chicken brain alpha-spectrin. J Mol Biol (2004) 2.27
Assembly reflects evolution of protein complexes. Nature (2008) 2.27
Can non-mechanical proteins withstand force? Stretching barnase by atomic force microscopy and molecular dynamics simulation. Biophys J (2001) 2.25
Ribosome-mediated translational pause and protein domain organization. Protein Sci (1996) 2.20
The folding and evolution of multidomain proteins. Nat Rev Mol Cell Biol (2007) 2.16
Advances in structural genomics. Curr Opin Struct Biol (1999) 2.09
Multi-domain proteins in the three kingdoms of life: orphan domains and other unassigned regions. J Mol Biol (2005) 1.95
Role of linkers in communication between protein modules. Curr Opin Chem Biol (2000) 1.94
Domain interactions in the Fab fragment: a comparative evaluation of the single-chain Fv and Fab format engineered with variable domains of different stability. J Mol Biol (2005) 1.90
Co-translational folding of an alphavirus capsid protein in the cytosol of living cells. Nat Cell Biol (1999) 1.74
How representative are the known structures of the proteins in a complete genome? A comprehensive structural census. Fold Des (1998) 1.67
Unfolding of titin domains explains the viscoelastic behavior of skeletal myofibrils. Biophys J (2001) 1.67
A recurring theme in protein engineering: the design, stability and folding of repeat proteins. Curr Opin Struct Biol (2005) 1.58
Stability and folding of domain proteins. Prog Biophys Mol Biol (1999) 1.54
Module-module interactions in the cell binding region of fibronectin: stability, flexibility and specificity. J Mol Biol (1997) 1.52
Repeat-protein folding: new insights into origins of cooperativity, stability, and topology. Arch Biochem Biophys (2007) 1.51
The effect of boundary selection on the stability and folding of the third fibronectin type III domain from human tenascin. Biochemistry (1998) 1.49
Solution structure of the spectrin repeat: a left-handed antiparallel triple-helical coiled-coil. J Mol Biol (1997) 1.41
The folding of spectrin domains I: wild-type domains have the same stability but very different kinetic properties. J Mol Biol (2004) 1.40
Titin; a multidomain protein that behaves as the sum of its parts. J Mol Biol (2002) 1.30
The folding of spectrin domains II: phi-value analysis of R16. J Mol Biol (2004) 1.29
Free energies of urea and of thermal unfolding show that two tandem repeats of spectrin are thermodynamically more stable than a single repeat. Biochemistry (2001) 1.24
The molecular basis of cooperativity in protein folding. Thermodynamic dissection of interdomain interactions in phosphoglycerate kinase. Biochemistry (1992) 1.23
Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding. Blood (2006) 1.22
Modular structure of the trigger factor required for high activity in protein folding. J Mol Biol (1997) 1.21
Cooperative folding in a multi-domain protein. J Mol Biol (2005) 1.20
Spectrin R16: broad energy barrier or sequential transition states? Protein Sci (2005) 1.16
Spectrin oligomerization is cooperatively coupled to membrane assembly: a linkage targeted by many hereditary hemolytic anemias? Exp Mol Pathol (2001) 1.16
The assembly of immunoglobulin-like modules in titin: implications for muscle elasticity. J Mol Biol (1998) 1.15
Sequence conservation in Ig-like domains: the role of highly conserved proline residues in the fibronectin type III superfamily. J Mol Biol (2002) 1.13
Biophysical investigations of engineered polyproteins: implications for force data. Biophys J (2004) 1.04
Complex folding kinetics of a multidomain protein. Biophys J (2005) 1.02
CHOP: parsing proteins into structural domains. Nucleic Acids Res (2004) 0.98
Invariant tryptophan at a shielded site promotes folding of the conformational unit of spectrin. Proc Natl Acad Sci U S A (1994) 0.97
Apparent cooperativity in the folding of multidomain proteins depends on the relative rates of folding of the constituent domains. Proc Natl Acad Sci U S A (2006) 0.97
Asymmetric effect of domain interactions on the kinetics of folding in yeast phosphoglycerate kinase. Protein Sci (2005) 0.95
Domain behavior during the folding of a thermostable phosphoglycerate kinase. Biochemistry (1996) 0.94
When a module is also a domain: the rôle of the N terminus in the stability and the dynamics of immunoglobulin domains from titin. J Mol Biol (1997) 0.86
Distinguishing specific and nonspecific interdomain interactions in multidomain proteins. Biophys J (2007) 0.86
Fast folding of the two-domain semliki forest virus capsid protein explains co-translational proteolytic activity. J Mol Biol (2004) 0.85
Folding mechanism of a multiple independently-folding domain protein: double B domain of protein A. Biochemistry (2006) 0.84
The folding pathway of a single domain in a multidomain protein is not affected by its neighbouring domain. J Mol Biol (2008) 0.81
The importance of sequence diversity in the aggregation and evolution of proteins. Nature (2005) 2.70
Hidden complexity in the mechanical properties of titin. Nature (2003) 2.51
Single-molecule studies of protein folding. Annu Rev Biochem (2008) 2.22
The folding and evolution of multidomain proteins. Nat Rev Mol Cell Biol (2007) 2.16
Mechanical unfolding of a titin Ig domain: structure of unfolding intermediate revealed by combining AFM, molecular dynamics simulations, NMR and protein engineering. J Mol Biol (2002) 2.00
Parallel protein-unfolding pathways revealed and mapped. Nat Struct Biol (2003) 1.67
Versatile cloning system for construction of multimeric proteins for use in atomic force microscopy. Protein Sci (2002) 1.67
Experimental evidence for a frustrated energy landscape in a three-helix-bundle protein family. Nature (2010) 1.61
Mechanical unfolding of a titin Ig domain: structure of transition state revealed by combining atomic force microscopy, protein engineering and molecular dynamics simulations. J Mol Biol (2003) 1.53
Mechanical unfolding of proteins: insights into biology, structure and folding. Curr Opin Struct Biol (2007) 1.43
The folding of spectrin domains I: wild-type domains have the same stability but very different kinetic properties. J Mol Biol (2004) 1.40
What contributions to protein side-chain dynamics are probed by NMR experiments? A molecular dynamics simulation analysis. J Mol Biol (2005) 1.40
A simple method for probing the mechanical unfolding pathway of proteins in detail. Proc Natl Acad Sci U S A (2002) 1.39
Mechanical unfolding of TNfn3: the unfolding pathway of a fnIII domain probed by protein engineering, AFM and MD simulation. J Mol Biol (2005) 1.37
Single-molecule fluorescence reveals sequence-specific misfolding in multidomain proteins. Nature (2011) 1.37
The remarkable mechanical strength of polycystin-1 supports a direct role in mechanotransduction. J Mol Biol (2005) 1.34
Titin; a multidomain protein that behaves as the sum of its parts. J Mol Biol (2002) 1.30
The folding of spectrin domains II: phi-value analysis of R16. J Mol Biol (2004) 1.29
Surgery or embolisation for varicoceles in subfertile men. Cochrane Database Syst Rev (2009) 1.28
The origin of protein sidechain order parameter distributions. J Am Chem Soc (2004) 1.25
The folding pathway of spectrin R17 from experiment and simulation: using experimentally validated MD simulations to characterize States hinted at by experiment. J Mol Biol (2006) 1.21
Robotic surgery for benign gynaecological disease. Cochrane Database Syst Rev (2012) 1.21
Atomic force microscopy: mechanical unfolding of proteins. Methods (2004) 1.21
Cooperative folding in a multi-domain protein. J Mol Biol (2005) 1.20
Designing an extracellular matrix protein with enhanced mechanical stability. Proc Natl Acad Sci U S A (2007) 1.19
Spectrin R16: broad energy barrier or sequential transition states? Protein Sci (2005) 1.16
BPPred: a Web-based computational tool for predicting biophysical parameters of proteins. Protein Sci (2006) 1.14
Sequence conservation in Ig-like domains: the role of highly conserved proline residues in the fibronectin type III superfamily. J Mol Biol (2002) 1.13
Localizing internal friction along the reaction coordinate of protein folding by combining ensemble and single-molecule fluorescence spectroscopy. Nat Commun (2012) 1.13
Folding and binding of an intrinsically disordered protein: fast, but not 'diffusion-limited'. J Am Chem Soc (2013) 1.11
Hydrophobic core fluidity of homologous protein domains: relation of side-chain dynamics to core composition and packing. Biochemistry (2004) 1.08
Spectrin domains lose cooperativity in forced unfolding. Biophys J (2006) 1.08
Comparison of the transition states for folding of two Ig-like proteins from different superfamilies. J Mol Biol (2004) 1.05
Biophysical investigations of engineered polyproteins: implications for force data. Biophys J (2004) 1.04
Staphylococcal biofilm-forming protein has a contiguous rod-like structure. Proc Natl Acad Sci U S A (2012) 1.04
Fusion of contrast-enhanced breast MR and mammographic imaging data. Med Image Anal (2003) 1.03
Complex folding kinetics of a multidomain protein. Biophys J (2005) 1.02
What can atomic force microscopy tell us about protein folding? Chem Commun (Camb) (2002) 1.00
Different members of a simple three-helix bundle protein family have very different folding rate constants and fold by different mechanisms. J Mol Biol (2009) 1.00
Folding of a LysM domain: entropy-enthalpy compensation in the transition state of an ideal two-state folder. J Mol Biol (2008) 1.00
Coupled folding and binding of the disordered protein PUMA does not require particular residual structure. J Am Chem Soc (2014) 1.00
Thermodynamic characterisation of two transition states along parallel protein folding pathways. J Mol Biol (2004) 0.99
Plasticity within the obligatory folding nucleus of an immunoglobulin-like domain. J Mol Biol (2007) 0.99
Quantifying heterogeneity and conformational dynamics from single molecule FRET of diffusing molecules: recurrence analysis of single particles (RASP). Phys Chem Chem Phys (2011) 0.98
What lessons can be learned from studying the folding of homologous proteins? Methods (2010) 0.97
Remarkably fast coupled folding and binding of the intrinsically disordered transactivation domain of cMyb to CBP KIX. J Phys Chem B (2013) 0.97
Apparent cooperativity in the folding of multidomain proteins depends on the relative rates of folding of the constituent domains. Proc Natl Acad Sci U S A (2006) 0.97
Acupuncture for uterine fibroids. Cochrane Database Syst Rev (2010) 0.97
An effective strategy for the design of proteins with enhanced mechanical stability. Angew Chem Int Ed Engl (2008) 0.96
Self-consistent determination of the transition state for protein folding: application to a fibronectin type III domain. Proc Natl Acad Sci U S A (2003) 0.95
Cost-effectiveness analysis of screening for risk of in-hospital falls using physiotherapist clinical judgement. Med Care (2009) 0.94
Using model proteins to quantify the effects of pathogenic mutations in Ig-like proteins. J Biol Chem (2006) 0.93
Naturally occurring mutations alter the stability of polycystin-1 polycystic kidney disease (PKD) domains. J Biol Chem (2009) 0.93
Multicentre study of delirium in ICU patients using a simple screening tool. Aust Crit Care (2005) 0.93
Structural comparison of the two alternative transition states for folding of TI I27. Biophys J (2006) 0.92
Separating the effects of internal friction and transition state energy to explain the slow, frustrated folding of spectrin domains. Proc Natl Acad Sci U S A (2012) 0.92
Antioxidants for female subfertility. Cochrane Database Syst Rev (2013) 0.91
Dose-response relationship between physiotherapy resource provision with function and balance improvements in patients following stroke: a multi-centre observational study. J Eval Clin Pract (2010) 0.88
Take home lessons from studies of related proteins. Curr Opin Struct Biol (2012) 0.87
Development and validation of the balance outcome measure for elder rehabilitation. Arch Phys Med Rehabil (2007) 0.87
Mouse lymphoma thymidine kinase gene mutation assay: follow-up meeting of the International Workshop on Genotoxicity Testing--Aberdeen, Scotland, 2003--Assay acceptance criteria, positive controls, and data evaluation. Environ Mol Mutagen (2006) 0.86
Single molecule studies of protein folding using atomic force microscopy. Methods Mol Biol (2007) 0.86
Topology is the principal determinant in the folding of a complex all-alpha Greek key death domain from human FADD. J Mol Biol (2009) 0.86
Characterisation of transition state structures for protein folding using 'high', 'medium' and 'low' {Phi}-values. Protein Eng Des Sel (2008) 0.86
Distinguishing specific and nonspecific interdomain interactions in multidomain proteins. Biophys J (2007) 0.86
Changes in falls risk factors for geriatric diagnostic groups across inpatient, outpatient and domiciliary rehabilitation settings. Disabil Rehabil (2011) 0.85
Crosstalk between the protein surface and hydrophobic core in a core-swapped fibronectin type III domain. J Mol Biol (2007) 0.84
Experiments suggest that simulations may overestimate electrostatic contributions to the mechanical stability of a fibronectin type III domain. J Mol Biol (2007) 0.84
Membrane protein folding makes the transition. Proc Natl Acad Sci U S A (2010) 0.83
The importance of loop length in the folding of an immunoglobulin domain. Protein Eng Des Sel (2004) 0.82
Balance impairment not predictive of falls in geriatric rehabilitation wards. J Gerontol A Biol Sci Med Sci (2008) 0.82
A mechanistic model for amorphous protein aggregation of immunoglobulin-like domains. J Am Chem Soc (2013) 0.81
The folding pathway of a single domain in a multidomain protein is not affected by its neighbouring domain. J Mol Biol (2008) 0.81
Biophysics: Rough passage across a barrier. Nature (2013) 0.81
Protein folding: adding a nucleus to guide helix docking reduces landscape roughness. J Mol Biol (2012) 0.81
Treatment of heavy menstrual bleeding. BMJ (2010) 0.81
Insulin-like growth factor binding protein-5 (IGFBP-5) interacts with thrombospondin-1 to induce negative regulatory effects on IGF-I actions. J Cell Physiol (2005) 0.80
Pentoxifylline for endometriosis. Cochrane Database Syst Rev (2012) 0.80
Surgery or embolisation for varicoceles in subfertile men. Cochrane Database Syst Rev (2008) 0.80
Hysterectomy versus hysterectomy plus oophorectomy for premenopausal women. Cochrane Database Syst Rev (2008) 0.79
The morphology of decorated amyloid fibers is controlled by the conformation and position of the displayed protein. ACS Nano (2012) 0.78
Further validation of the Balance Outcome Measure for Elder Rehabilitation. Arch Phys Med Rehabil (2011) 0.78
Manipulating the stability of fibronectin type III domains by protein engineering. Nanotechnology (2008) 0.77
Affinity maturation of phage display antibody populations using ribosome display. Methods Mol Biol (2012) 0.77
FnIII domains: predicting mechanical stability. Structure (2004) 0.77
Mouse lymphoma thymidine kinase gene mutation assay: meeting of the International Workshop on Genotoxicity Testing, San Francisco, 2005, recommendations for 24-h treatment. Mutat Res (2006) 0.77
Two immunoglobulin tandem proteins with a linking β-strand reveal unexpected differences in cooperativity and folding pathways. J Mol Biol (2011) 0.76
Understanding pathogenic single-nucleotide polymorphisms in multidomain proteins--studies of isolated domains are not enough. FEBS J (2013) 0.76
Paediatric thoracic tumours presenting as empyema. Pediatr Surg Int (2006) 0.75
Football for life versus antidoping for the masses: ethical antidoping issues and solutions based on the extenuating experiences of an elite footballer competing while undergoing treatment for metastatic testicular cancer. Br J Sports Med (2014) 0.75
Protein engineering and design: from first principles to new technologies. Curr Opin Struct Biol (2010) 0.75
Pentoxifylline versus medical therapies for subfertile women with endometriosis. Cochrane Database Syst Rev (2009) 0.75
What is a systematic review? Evid Based Nurs (2011) 0.75
Pauline Drewitt 1923-2014. Nurs Stand (2014) 0.75
Learning from Nature to design new biomolecules. Curr Opin Struct Biol (2012) 0.75