Published in Methods Mol Biol on January 01, 2008
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival. Cell Death Differ (2009) 2.30
HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis. Cell Cycle (2010) 1.89
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy (2011) 1.81
Phosphorylated Ribosomal Protein S6 Is Required for Akt-Driven Hyperplasia and Malignant Transformation, but Not for Hypertrophy, Aneuploidy and Hyperfunction of Pancreatic β-Cells. PLoS One (2016) 1.38
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Cancer Res (2012) 1.38
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A (2013) 1.29
Nucleocytoplasmic distribution and dynamics of the autophagosome marker EGFP-LC3. PLoS One (2010) 1.28
Apoptotic and autophagic responses to photodynamic therapy in 1c1c7 murine hepatoma cells. Autophagy (2011) 1.28
BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response. EMBO J (2011) 1.21
Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. Autophagy (2014) 1.11
Autophagy in tumor suppression and cancer therapy. Crit Rev Eukaryot Gene Expr (2011) 1.08
Macroautophagy is defective in mucolipin-1-deficient mouse neurons. Neurobiol Dis (2010) 1.07
Epidermal growth factor reduces autophagy in intestinal epithelium and in the rat model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol (2010) 1.06
Sonic hedgehog promotes autophagy of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol (2012) 1.03
A screen of Coxiella burnetii mutants reveals important roles for Dot/Icm effectors and host autophagy in vacuole biogenesis. PLoS Pathog (2014) 1.03
Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy. Cardiovasc Res (2011) 1.03
Variants of mitochondrial autophagy: Types 1 and 2 mitophagy and micromitophagy (Type 3). Redox Biol (2014) 1.03
Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria. Eur J Histochem (2011) 1.01
Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal (2014) 1.01
SB202190-induced cell type-specific vacuole formation and defective autophagy do not depend on p38 MAP kinase inhibition. PLoS One (2011) 1.00
Autophagy in oncogenic K-Ras promotes basal extrusion of epithelial cells by degrading S1P. Curr Biol (2013) 0.99
mVps34 deletion in podocytes causes glomerulosclerosis by disrupting intracellular vesicle trafficking. J Am Soc Nephrol (2013) 0.98
Persistent hepatitis C virus infection impairs ribavirin antiviral activity through clathrin-mediated trafficking of equilibrative nucleoside transporter 1. J Virol (2014) 0.98
Novel PI3K and mTOR Inhibitor NVP-BEZ235 Radiosensitizes Breast Cancer Cell Lines under Normoxic and Hypoxic Conditions. Breast Cancer (Auckl) (2014) 0.98
Impaired autophagy in neurons after disinhibition of mammalian target of rapamycin and its contribution to epileptogenesis. J Neurosci (2012) 0.97
Autophagy is active in normal colon mucosa. Autophagy (2012) 0.96
Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts. Autophagy (2012) 0.95
Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization. Oncotarget (2015) 0.95
Cellular targets and mechanisms in the cytotoxic action of non-biodegradable engineered nanoparticles. Curr Drug Metab (2013) 0.95
Using LC3 to monitor autophagy flux in the retinal pigment epithelium. Autophagy (2009) 0.95
Chronic mTOR activation promotes cell survival in Merkel cell carcinoma. Cancer Lett (2013) 0.94
Regulation of EGFR protein stability by the HECT-type ubiquitin ligase SMURF2. Neoplasia (2011) 0.94
A cytotoxic type III secretion effector of Vibrio parahaemolyticus targets vacuolar H+-ATPase subunit c and ruptures host cell lysosomes. PLoS Pathog (2012) 0.93
Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells. Int J Physiol Pathophysiol Pharmacol (2011) 0.93
Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells. Int J Mol Sci (2013) 0.92
Aqueous Extract of Solanum nigrum Leaves Induces Autophagy and Enhances Cytotoxicity of Cisplatin, Doxorubicin, Docetaxel, and 5-Fluorouracil in Human Colorectal Carcinoma Cells. Evid Based Complement Alternat Med (2013) 0.91
Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis. Autophagy (2015) 0.90
Survival by self-destruction: a role for autophagy in the placenta? Placenta (2012) 0.90
Autophagy in retinal ganglion cells in a rhesus monkey chronic hypertensive glaucoma model. PLoS One (2013) 0.90
Autophagy and apoptosis are differentially induced in neurons and astrocytes treated with an in vitro mimic of the ischemic penumbra. PLoS One (2012) 0.89
Tamoxifen reduces fat mass by boosting reactive oxygen species. Cell Death Dis (2015) 0.89
Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells. Toxicol Appl Pharmacol (2011) 0.89
Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders. Autophagy (2016) 0.88
p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration. Cell Death Differ (2016) 0.88
Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. Mol Cancer Ther (2012) 0.88
Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells. J Virol (2013) 0.88
Acetonic extract of Buxus sempervirens induces cell cycle arrest, apoptosis and autophagy in breast cancer cells. PLoS One (2011) 0.88
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration. Proc Natl Acad Sci U S A (2015) 0.87
Meloxicam executes its antitumor effects against hepatocellular carcinoma in COX-2- dependent and -independent pathways. PLoS One (2014) 0.87
Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a. J Neurosci (2015) 0.87
Raf/MEK/ERK can regulate cellular levels of LC3B and SQSTM1/p62 at expression levels. Exp Cell Res (2014) 0.87
Genetic and phenotypic characterization of complex hereditary spastic paraplegia. Brain (2016) 0.87
Resveratrol ameliorates hepatic steatosis and inflammation in methionine/choline-deficient diet-induced steatohepatitis through regulating autophagy. Lipids Health Dis (2015) 0.86
Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling. Mol Cell Biol (2012) 0.86
Proteomic analysis of the action of the Mycobacterium ulcerans toxin mycolactone: targeting host cells cytoskeleton and collagen. PLoS Negl Trop Dis (2014) 0.86
Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. Oncotarget (2014) 0.86
Autophagy-based survival prognosis in human colorectal carcinoma. Oncotarget (2015) 0.86
Molecular insights into the premature aging disease progeria. Histochem Cell Biol (2016) 0.86
Rapamycin Inhibits Cardiac Hypertrophy by Promoting Autophagy via the MEK/ERK/Beclin-1 Pathway. Front Physiol (2016) 0.85
Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta (2015) 0.84
Docetaxel-carboxymethylcellulose nanoparticles target cells via a SPARC and albumin dependent mechanism. Biomaterials (2015) 0.83
Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells. Oncotarget (2016) 0.83
Time-dependent dual effects of high levels of unconjugated bilirubin on the human blood-brain barrier lining. Front Cell Neurosci (2012) 0.83
Human T-cell leukemia virus type 1 Tax-deregulated autophagy pathway and c-FLIP expression contribute to resistance against death receptor-mediated apoptosis. J Virol (2013) 0.83
Autophagy in myocardium of murine hearts subjected to ischemia followed by reperfusion. Histochem Cell Biol (2010) 0.83
Autophagy: an emerging therapeutic target in vascular diseases. Br J Pharmacol (2015) 0.82
FRS2α is essential for the fibroblast growth factor to regulate the mTOR pathway and autophagy in mouse embryonic fibroblasts. Int J Biol Sci (2011) 0.82
Down-regulation of the autophagy gene, ATG7, protects bone marrow-derived mesenchymal stem cells from stressful conditions. Blood Res (2015) 0.82
The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase. Biochem J (2015) 0.82
Proteasome inhibitor-induced autophagy in PC12 cells overexpressing A53T mutant α-synuclein. Mol Med Rep (2014) 0.82
Autophagy in hepatic fibrosis. Biomed Res Int (2014) 0.81
Delayed inhaled carbon monoxide mediates the regression of established neointimal lesions. J Vasc Surg (2014) 0.81
Ovothiol isolated from sea urchin oocytes induces autophagy in the Hep-G2 cell line. Mar Drugs (2014) 0.81
Brief Report: Oxidative Stress Mediates Cardiomyocyte Apoptosis in a Human Model of Danon Disease and Heart Failure. Stem Cells (2015) 0.81
Mitigation of autophagy ameliorates hepatocellular damage following ischemia-reperfusion injury in murine steatotic liver. Am J Physiol Gastrointest Liver Physiol (2014) 0.81
Chlamydia trachomatis vacuole maturation in infected macrophages. J Leukoc Biol (2012) 0.81
Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo. Sci Rep (2016) 0.80
The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core. PLoS One (2015) 0.80
Intracellular localization of GASP/ECOP/VOPP1. J Mol Histol (2010) 0.80
Rapamycin Inhibition of mTOR Reduces Levels of the Na+/H+ Exchanger 3 in Intestines of Mice and Humans, Leading to Diarrhea. Gastroenterology (2015) 0.80
The role of autophagy during group B Streptococcus infection of blood-brain barrier endothelium. J Biol Chem (2014) 0.80
Links of Autophagy Dysfunction to Inflammatory Bowel Disease Onset. Dig Dis (2016) 0.80
Gingival fibroblasts resist apoptosis in response to oxidative stress in a model of periodontal diseases. Cell Death Discov (2015) 0.80
Autophagy enhancement contributes to the synergistic effect of vitamin D in temozolomide-based glioblastoma chemotherapy. Exp Ther Med (2016) 0.79
Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons. Oxid Med Cell Longev (2014) 0.79
Silica Nanoparticles Induce Oxidative Stress and Autophagy but Not Apoptosis in the MRC-5 Cell Line. Int J Mol Sci (2015) 0.79
Mammalian ER mannosidase I resides in quality control vesicles, where it encounters its glycoprotein substrates. Mol Biol Cell (2014) 0.79
A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages. J Immunol (2011) 0.79
Smac mimetic LCL161 overcomes protective ER stress induced by obatoclax, synergistically causing cell death in multiple myeloma. Oncotarget (2016) 0.78
Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways. Front Microbiol (2015) 0.78
Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade. Proc Natl Acad Sci U S A (2016) 0.78
Acute Endurance Exercise Induces Nuclear p53 Abundance in Human Skeletal Muscle. Front Physiol (2016) 0.78
Herpes Simplex Virus-1 Fine-Tunes Host's Autophagic Response to Infection: A Comprehensive Analysis in Productive Infection Models. PLoS One (2015) 0.78
Autophagy sensitivity of neuroendocrine lung tumor cells. Int J Oncol (2013) 0.78
Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells. Sci Rep (2016) 0.78
Glioblastoma, hypoxia and autophagy: a survival-prone 'ménage-à-trois'. Cell Death Dis (2016) 0.77
Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy (2005) 7.33
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol (2004) 6.34
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab (2008) 5.55
Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci (2004) 5.19
Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem (2008) 4.20
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A (2007) 3.92
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J Biol Chem (2002) 2.66
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem (2004) 2.58
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol (2008) 2.57
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem (2005) 2.44
Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res (2007) 2.39
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J Biol Chem (2003) 2.19
Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem (2005) 2.14
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem (2004) 2.10
Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. J Biol Chem (2004) 2.01
A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J (2004) 1.99
Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci (2008) 1.87
The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun (2009) 1.77
Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy (2008) 1.71
MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. FASEB J (2003) 1.64
Lysosomal turnover of GABARAP-phospholipid conjugate is activated during differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway. Autophagy (2006) 1.60
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles. Autophagy (2009) 1.60
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy (2011) 1.59
Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol (2003) 1.50
A novel type of E3 ligase for the Ufm1 conjugation system. J Biol Chem (2009) 1.47
Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls. Autophagy (2007) 1.45
Processing and activation of lysosomal proteinases. Biol Chem (2002) 1.44
The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. J Biol Chem (2003) 1.44
Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains. J Biol Chem (2005) 1.36
The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. J Mol Biol (2005) 1.34
Multiple pathways of TWEAK-induced cell death. J Immunol (2002) 1.32
GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3. Biochem Biophys Res Commun (2003) 1.30
Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. Mol Cell Biol (2009) 1.27
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum Mol Genet (2002) 1.24
Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol (2011) 1.23
Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway. Biochem Biophys Res Commun (2010) 1.21
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci (2003) 1.21
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells (2002) 1.20
Comprehensive proteomics analysis of autophagy-deficient mouse liver. Biochem Biophys Res Commun (2008) 1.18
LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation. Biochem Biophys Res Commun (2010) 1.18
Skeletal muscle gene expression in space-flown rats. FASEB J (2004) 1.18
Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus (2003) 1.15
Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3. FEBS J (2006) 1.12
Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation. Autophagy (2008) 1.11
Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy. J Gastroenterol (2009) 1.08
Inflammatory response and cathepsins in silica-exposed Hermansky-Pudlak syndrome model pale ear mice. Pathol Int (2004) 1.07
Autophagic compartments gain access to the MHC class II compartments in thymic epithelium. J Immunol (2009) 1.03
Autophagy and neurodegeneration. Autophagy (2006) 1.03
Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. Biochem Biophys Res Commun (2006) 1.01
Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes. Kidney Int (2002) 0.99
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. J Neurosci (2007) 0.99
Neuronal ceroid lipofuscinosis: a common pathway? Pediatr Res (2007) 0.96
Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing. Biochem Biophys Res Commun (2002) 0.96
The intracellular location and function of proteins of neuronal ceroid lipofuscinoses. Brain Pathol (2004) 0.95