Published in J Immunol on November 13, 2009
Metabolic regulation of T lymphocytes. Annu Rev Immunol (2013) 3.67
Macroautophagy regulates energy metabolism during effector T cell activation. J Immunol (2010) 1.71
Autophagy and adaptive immunity. Immunology (2010) 1.26
Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy (2011) 1.26
Autophagy in the regulation of pathogen replication and adaptive immunity. Trends Immunol (2012) 1.21
Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance. J Exp Med (2013) 1.09
Characterization of human thymic exosomes. PLoS One (2013) 1.05
Autophagy and autoimmunity crosstalks. Front Immunol (2013) 1.01
Antigen Processing for MHC Class II Presentation via Autophagy. Front Immunol (2012) 0.99
Pharmacological regulators of autophagy and their link with modulators of lupus disease. Br J Pharmacol (2014) 0.93
The Autoimmunity-Associated Gene CLEC16A Modulates Thymic Epithelial Cell Autophagy and Alters T Cell Selection. Immunity (2015) 0.93
Autophagic activity in thymus and liver during aging. Age (Dordr) (2011) 0.90
Autophagy in the thymic epithelium is dispensable for the development of self-tolerance in a novel mouse model. PLoS One (2012) 0.86
MHC presentation via autophagy and how viruses escape from it. Semin Immunopathol (2010) 0.86
Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules. Curr Opin Organ Transplant (2010) 0.82
Intersection of autophagy with pathways of antigen presentation. Protein Cell (2012) 0.81
Antigen processing by macroautophagy for MHC presentation. Front Immunol (2011) 0.79
Macroautophagy in Endogenous Processing of Self- and Pathogen-Derived Antigens for MHC Class II Presentation. Front Immunol (2015) 0.77
Autophagy in the pathogenesis of ankylosing spondylitis. Clin Rheumatol (2016) 0.75
Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy (2005) 7.33
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol (2004) 6.34
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab (2008) 5.55
Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci (2004) 5.19
Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem (2008) 4.20
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A (2007) 3.92
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
LC3 and Autophagy. Methods Mol Biol (2008) 3.59
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J Biol Chem (2002) 2.66
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem (2004) 2.58
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol (2008) 2.57
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem (2005) 2.44
Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res (2007) 2.39
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J Biol Chem (2003) 2.19
Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem (2005) 2.14
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem (2004) 2.10
Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes. J Biol Chem (2004) 2.01
A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J (2004) 1.99
Granular cell ameloblastoma: case report of a particular ameloblastoma histologically resembling oncocytoma. Pathol Int (2014) 1.97
Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci (2008) 1.87
Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy (2011) 1.81
The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun (2009) 1.77
Calpain is required for macroautophagy in mammalian cells. J Cell Biol (2006) 1.75
Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy (2008) 1.71
MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. FASEB J (2003) 1.64
Lysosomal turnover of GABARAP-phospholipid conjugate is activated during differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway. Autophagy (2006) 1.60
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles. Autophagy (2009) 1.60
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy (2011) 1.59
Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol (2003) 1.50
A novel type of E3 ligase for the Ufm1 conjugation system. J Biol Chem (2009) 1.47
Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls. Autophagy (2007) 1.45
Processing and activation of lysosomal proteinases. Biol Chem (2002) 1.44
The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. J Biol Chem (2003) 1.44
Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains. J Biol Chem (2005) 1.36
The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. J Mol Biol (2005) 1.34
Measurement of autophagy in cells and tissues. Methods Mol Biol (2010) 1.33
Multiple pathways of TWEAK-induced cell death. J Immunol (2002) 1.32
GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3. Biochem Biophys Res Commun (2003) 1.30
Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. Mol Cell Biol (2009) 1.27
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum Mol Genet (2002) 1.24
Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol (2011) 1.23
Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway. Biochem Biophys Res Commun (2010) 1.21
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci (2003) 1.21
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells (2002) 1.20
Increased RANKL expression is related to tumour migration and metastasis of renal cell carcinomas. J Pathol (2009) 1.20
Comprehensive proteomics analysis of autophagy-deficient mouse liver. Biochem Biophys Res Commun (2008) 1.18