Published in J Biol Chem on September 07, 2004
Selective autophagy mediated by autophagic adapter proteins. Autophagy (2011) 6.88
The molecular machinery of autophagy: unanswered questions. J Cell Sci (2005) 6.67
The autophagy machinery is required to initiate hepatitis C virus replication. Proc Natl Acad Sci U S A (2009) 2.91
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J (2009) 2.25
Atg8: an autophagy-related ubiquitin-like protein family. Genome Biol (2011) 2.04
Early autophagic response in a novel knock-in model of Huntington disease. Hum Mol Genet (2010) 1.99
p65/RelA modulates BECN1 transcription and autophagy. Mol Cell Biol (2009) 1.83
Modification of cellular autophagy protein LC3 by poliovirus. J Virol (2007) 1.71
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy. Nat Chem Biol (2012) 1.55
Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Hum Mol Genet (2008) 1.36
Dynamic regulation of macroautophagy by distinctive ubiquitin-like proteins. Nat Struct Mol Biol (2014) 1.31
Characterization of unusual families of ATG8-like proteins and ATG12 in the protozoan parasite Leishmania major. Autophagy (2009) 1.26
Quantitation of autophagy by luciferase release assay. Autophagy (2008) 1.22
Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells. J Cell Mol Med (2008) 1.18
After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy (2013) 1.17
Relationship between the proteasomal system and autophagy. Int J Biochem Mol Biol (2013) 1.16
Molecular mechanisms of autophagy in the cardiovascular system. Circ Res (2015) 1.10
The pathogenesis of Niemann-Pick type C disease: a role for autophagy? Expert Rev Mol Med (2008) 1.10
MIR181A regulates starvation- and rapamycin-induced autophagy through targeting of ATG5. Autophagy (2013) 1.10
Dasatinib induces autophagic cell death in human ovarian cancer. Cancer (2010) 1.07
Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy (2010) 1.03
Autophagy and polyglutamine diseases. Prog Neurobiol (2011) 1.02
Regulation of ATG4B stability by RNF5 limits basal levels of autophagy and influences susceptibility to bacterial infection. PLoS Genet (2012) 1.02
Steroid receptor coactivator 3 regulates autophagy in breast cancer cells through macrophage migration inhibitory factor. Cell Res (2012) 0.99
Vascular endothelial growth factor is important for brown adipose tissue development and maintenance. FASEB J (2013) 0.97
Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. Br J Cancer (2014) 0.96
The evolutionarily conserved interaction between LC3 and p62 selectively mediates autophagy-dependent degradation of mutant huntingtin. Cell Mol Neurobiol (2010) 0.93
Subcellular localization-dependent changes in EGFP fluorescence lifetime measured by time-resolved flow cytometry. Biomed Opt Express (2013) 0.92
Linkage of autophagy to fungal development, lipid storage and virulence in Metarhizium robertsii. Autophagy (2013) 0.91
Salinomycin activates AMP-activated protein kinase-dependent autophagy in cultured osteoblastoma cells: a negative regulator against cell apoptosis. PLoS One (2013) 0.91
Autophagosome Proteins LC3A, LC3B and LC3C Have Distinct Subcellular Distribution Kinetics and Expression in Cancer Cell Lines. PLoS One (2015) 0.91
Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy. PLoS One (2012) 0.89
Mir-24-3p downregulation contributes to VP16-DDP resistance in small-cell lung cancer by targeting ATG4A. Oncotarget (2015) 0.89
Lethal Cardiomyopathy in Mice Lacking Transferrin Receptor in the Heart. Cell Rep (2015) 0.88
Autophagy promotes oligodendrocyte survival and function following dysmyelination in a long-lived myelin mutant. J Neurosci (2013) 0.88
Development of fluorescent substrates and assays for the key autophagy-related cysteine protease enzyme, ATG4B. Assay Drug Dev Technol (2014) 0.88
GFP-LC3 labels organised smooth endoplasmic reticulum membranes independently of autophagy. J Cell Biochem (2009) 0.88
Receptor proteins in selective autophagy. Int J Cell Biol (2012) 0.87
MIR376A is a regulator of starvation-induced autophagy. PLoS One (2013) 0.85
ATG4B (Autophagin-1) Phosphorylation Modulates Autophagy. J Biol Chem (2015) 0.84
Ceramide induced mitophagy and tumor suppression. Biochim Biophys Acta (2015) 0.84
IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis. Autophagy (2014) 0.83
In vivo imaging and quantitative monitoring of autophagic flux in tobacco BY-2 cells. Plant Signal Behav (2012) 0.81
Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. J Biol Chem (2014) 0.80
Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins. BMC Cell Biol (2013) 0.80
PSF knockdown enhances apoptosis via downregulation of LC3B in human colon cancer cells. Biomed Res Int (2013) 0.80
Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy. BMC Microbiol (2014) 0.80
Retigeric acid B-induced mitophagy by oxidative stress attenuates cell death against prostate cancer cells in vitro. Acta Pharmacol Sin (2013) 0.79
RNA-dependent protein kinase is essential for 2-methoxyestradiol-induced autophagy in osteosarcoma cells. PLoS One (2013) 0.79
Collapsin response mediator protein 5 (CRMP5) induces mitophagy, thereby regulating mitochondrion numbers in dendrites. J Biol Chem (2013) 0.79
Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1. PLoS One (2014) 0.79
Autophagy as a Survival Mechanism for Squamous Cell Carcinoma Cells in Endonuclease G-Mediated Apoptosis. PLoS One (2016) 0.78
MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro. Am J Physiol Lung Cell Mol Physiol (2015) 0.78
Docosahexaenoic acid prevents palmitate-induced activation of proteolytic systems in C2C12 myotubes. J Nutr Biochem (2014) 0.77
Size, stoichiometry, and organization of soluble LC3-associated complexes. Autophagy (2014) 0.77
Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma. Oncotarget (2016) 0.77
Coxsackievirus can exploit LC3 in both autophagy-dependent and -independent manners in vivo. Autophagy (2015) 0.77
c-Rel deficiency increases caspase-4 expression and leads to ER stress and necrosis in EBV-transformed cells. PLoS One (2011) 0.77
ATG4A promotes tumor metastasis by inducing the epithelial-mesenchymal transition and stem-like properties in gastric cells. Oncotarget (2016) 0.77
The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE. PLoS One (2013) 0.76
Alcohol modulates autophagy and apoptosis in pig liver tissue. J Surg Res (2016) 0.76
Inhibiting p21-Activated Kinase Induces Cell Death in Vestibular Schwannoma and Meningioma via Mitotic Catastrophe. Otol Neurotol (2017) 0.75
Sphingolipids in mitochondria. Biochim Biophys Acta (2016) 0.75
Nutrient availability alters the effect of autophagy on sulindac sulfide-induced colon cancer cell apoptosis. Gastroenterol Res Pract (2012) 0.75
Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential. Oncotarget (2016) 0.75
Differential regulation of muscle protein turnover in response to emphysema and acute pulmonary inflammation. Respir Res (2017) 0.75
Prognostic value of autophagy related proteins ULK1, Beclin 1, ATG3, ATG5, ATG7, ATG9, ATG10, ATG12, LC3B and p62/SQSTM1 in gastric cancer. Am J Transl Res (2016) 0.75
Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi. J Biol Chem (2015) 0.75
Cross-talk between apoptosis and autophagy in lung epithelial cell death. J Biochem Pharmacol Res (2014) 0.75
EWS-FLI1 positively regulates autophagy by increasing ATG4B expression in Ewing sarcoma cells. Int J Mol Med (2017) 0.75
GABARAPL1 tumor suppressive function is independent of its conjugation to autophagosomes in MCF-7 breast cancer cells. Oncotarget (2017) 0.75
Production of Human ATG Proteins for Lipidation Assays. Methods Enzymol (2016) 0.75
Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature (2006) 21.40
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol (2005) 18.60
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell (2007) 14.63
Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy (2005) 7.33
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
LC3 conjugation system in mammalian autophagy. Int J Biochem Cell Biol (2004) 6.34
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab (2008) 5.55
Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci (2004) 5.19
Structural basis for sorting mechanism of p62 in selective autophagy. J Biol Chem (2008) 4.20
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A (2007) 3.92
The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell (2008) 3.72
LC3 and Autophagy. Methods Mol Biol (2008) 3.59
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol (2009) 2.83
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p. J Biol Chem (2002) 2.66
HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem (2004) 2.58
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol (2008) 2.57
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease). Am J Pathol (2005) 2.56
Excess peroxisomes are degraded by autophagic machinery in mammals. J Biol Chem (2005) 2.44
Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation. Cancer Res (2007) 2.39
The ALG-2-interacting protein Alix associates with CHMP4b, a human homologue of yeast Snf7 that is involved in multivesicular body sorting. J Biol Chem (2003) 2.19
Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16. J Biol Chem (2005) 2.14
Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem (2004) 2.10
A novel protein-conjugating system for Ufm1, a ubiquitin-fold modifier. EMBO J (2004) 1.99
Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci (2008) 1.87
The MAP1-LC3 conjugation system is involved in lipid droplet formation. Biochem Biophys Res Commun (2009) 1.77
Selective turnover of p62/A170/SQSTM1 by autophagy. Autophagy (2008) 1.71
MAP-LC3, a promising autophagosomal marker, is processed during the differentiation and recovery of podocytes from PAN nephrosis. FASEB J (2003) 1.64
Lysosomal turnover of GABARAP-phospholipid conjugate is activated during differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway. Autophagy (2006) 1.60
Knockdown of autophagy-related gene decreases the production of infectious hepatitis C virus particles. Autophagy (2009) 1.60
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy (2011) 1.59
Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol (2003) 1.50
A novel type of E3 ligase for the Ufm1 conjugation system. J Biol Chem (2009) 1.47
Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls. Autophagy (2007) 1.45
Processing and activation of lysosomal proteinases. Biol Chem (2002) 1.44
The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. J Biol Chem (2003) 1.44
Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains. J Biol Chem (2005) 1.36
The crystal structure of human Atg4b, a processing and de-conjugating enzyme for autophagosome-forming modifiers. J Mol Biol (2005) 1.34
Multiple pathways of TWEAK-induced cell death. J Immunol (2002) 1.32
GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3. Biochem Biophys Res Commun (2003) 1.30
Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. Mol Cell Biol (2009) 1.27
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum Mol Genet (2002) 1.24
Crucial role for autophagy in degranulation of mast cells. J Allergy Clin Immunol (2011) 1.23
Free fatty acids stimulate autophagy in pancreatic β-cells via JNK pathway. Biochem Biophys Res Commun (2010) 1.21
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci (2003) 1.21
CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis. Genes Cells (2002) 1.20
Comprehensive proteomics analysis of autophagy-deficient mouse liver. Biochem Biophys Res Commun (2008) 1.18
LC3, a microtubule-associated protein1A/B light chain3, is involved in cytoplasmic lipid droplet formation. Biochem Biophys Res Commun (2010) 1.18
Skeletal muscle gene expression in space-flown rats. FASEB J (2004) 1.18
Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus (2003) 1.15
Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3. FEBS J (2006) 1.12
Loss of Pten, a tumor suppressor, causes the strong inhibition of autophagy without affecting LC3 lipidation. Autophagy (2008) 1.11
Inhibition of hepatitis C virus replication by chloroquine targeting virus-associated autophagy. J Gastroenterol (2009) 1.08
Inflammatory response and cathepsins in silica-exposed Hermansky-Pudlak syndrome model pale ear mice. Pathol Int (2004) 1.07
Autophagic compartments gain access to the MHC class II compartments in thymic epithelium. J Immunol (2009) 1.03
Autophagy and neurodegeneration. Autophagy (2006) 1.03
Monoubiquitylation of GGA3 by hVPS18 regulates its ubiquitin-binding ability. Biochem Biophys Res Commun (2006) 1.01
Selective modulation of the secretion of proteinases and their inhibitors by growth factors in cultured differentiated podocytes. Kidney Int (2002) 0.99
Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface. J Neurosci (2007) 0.99
Neuronal ceroid lipofuscinosis: a common pathway? Pediatr Res (2007) 0.96
Mammalian Apg12p, but not the Apg12p.Apg5p conjugate, facilitates LC3 processing. Biochem Biophys Res Commun (2002) 0.96