The Streptococcus pneumoniae competence regulatory system influences respiratory tract colonization.

PubWeight™: 0.98‹?› | Rank: Top 15%

🔗 View Article (PMC 2446691)

Published in Infect Immun on April 28, 2008

Authors

J E Kowalko1, M E Sebert

Author Affiliations

1: Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

Articles citing this

Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev (2013) 1.64

Control of virulence by small RNAs in Streptococcus pneumoniae. PLoS Pathog (2012) 1.46

Peptide pheromone signaling in Streptococcus and Enterococcus. FEMS Microbiol Rev (2013) 1.25

Identification and characterization of noncoding small RNAs in Streptococcus pneumoniae serotype 2 strain D39. J Bacteriol (2010) 1.19

Increased chain length promotes pneumococcal adherence and colonization. Infect Immun (2012) 0.99

Identification of 88 regulatory small RNAs in the TIGR4 strain of the human pathogen Streptococcus pneumoniae. RNA (2012) 0.99

The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide. J Biol Chem (2012) 0.98

Streptococcus pneumoniae nasopharyngeal colonization induces type I interferons and interferon-induced gene expression. BMC Genomics (2009) 0.98

Inhibition of competence development, horizontal gene transfer and virulence in Streptococcus pneumoniae by a modified competence stimulating peptide. PLoS Pathog (2011) 0.87

Coordinated Bacteriocin Expression and Competence in Streptococcus pneumoniae Contributes to Genetic Adaptation through Neighbor Predation. PLoS Pathog (2016) 0.81

Structural insights into the dimerization of the response regulator ComE from Streptococcus pneumoniae. Nucleic Acids Res (2014) 0.81

Small regulatory RNAs in Streptococcus pneumoniae: discovery and biological functions. Front Genet (2015) 0.80

The Streptococcus sanguinis competence regulon is not required for infective endocarditis virulence in a rabbit model. PLoS One (2011) 0.78

Saturated alanine scanning mutagenesis of the pneumococcus competence stimulating peptide identifies analogs that inhibit genetic transformation. PLoS One (2012) 0.76

Mutation of the Streptococcus gordonii Thiol-Disulfide Oxidoreductase SdbA Leads to Enhanced Biofilm Formation Mediated by the CiaRH Two-Component Signaling System. PLoS One (2016) 0.75

ComE, an Essential Response Regulator, Negatively Regulates the Expression of the Capsular Polysaccharide Locus and Attenuates the Bacterial Virulence in Streptococcus pneumoniae. Front Microbiol (2017) 0.75

The Mechanisms of Virulence Regulation by Small Noncoding RNAs in Low GC Gram-Positive Pathogens. Int J Mol Sci (2015) 0.75

Articles cited by this

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES : INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III. J Exp Med (1944) 24.08

Two-component signal transduction. Annu Rev Biochem (2000) 19.12

A study of the genetic material determining an enzyme in Pneumococcus. Biochim Biophys Acta (1960) 16.02

The acetate switch. Microbiol Mol Biol Rev (2005) 6.10

Protein kinase and phosphoprotein phosphatase activities of nitrogen regulatory proteins NTRB and NTRC of enteric bacteria: roles of the conserved amino-terminal domain of NTRC. Proc Natl Acad Sci U S A (1988) 5.62

Phase variation in pneumococcal opacity: relationship between colonial morphology and nasopharyngeal colonization. Infect Immun (1994) 4.90

An rpsL cassette, janus, for gene replacement through negative selection in Streptococcus pneumoniae. Appl Environ Microbiol (2001) 4.59

Virulence of antibiotic-resistant Salmonella typhimurium. Proc Natl Acad Sci U S A (1998) 4.28

Regulation of competence for genetic transformation in Streptococcus pneumoniae by an auto-induced peptide pheromone and a two-component regulatory system. Mol Microbiol (1996) 4.19

Identification of a new regulator in Streptococcus pneumoniae linking quorum sensing to competence for genetic transformation. J Bacteriol (1999) 4.07

A family of bacteriocin ABC transporters carry out proteolytic processing of their substrates concomitant with export. Mol Microbiol (1995) 4.07

PCR ligation mutagenesis in transformable streptococci: application and efficiency. J Microbiol Methods (2002) 3.78

A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Mol Microbiol (2001) 3.53

A genomic analysis of two-component signal transduction in Streptococcus pneumoniae. Mol Microbiol (2000) 3.50

Identification of competence pheromone responsive genes in Streptococcus pneumoniae by use of DNA microarrays. Mol Microbiol (2004) 3.29

Cross-regulation of competence pheromone production and export in the early control of transformation in Streptococcus pneumoniae. Mol Microbiol (2000) 2.52

DNA as a nutrient: novel role for bacterial competence gene homologs. J Bacteriol (2001) 2.33

A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae. Mol Microbiol (1994) 2.22

Identification of DNA binding sites for ComE, a key regulator of natural competence in Streptococcus pneumoniae. Mol Microbiol (1999) 2.18

Switch from planktonic to sessile life: a major event in pneumococcal pathogenesis. Mol Microbiol (2006) 2.17

A novel type of conserved DNA-binding domain in the transcriptional regulators of the AlgR/AgrA/LytR family. Nucleic Acids Res (2002) 2.10

Competence for genetic transformation in Streptococcus pneumoniae: organization of a regulatory locus with homology to two lactococcin A secretion genes. Gene (1995) 1.94

Microarray-based identification of htrA, a Streptococcus pneumoniae gene that is regulated by the CiaRH two-component system and contributes to nasopharyngeal colonization. Infect Immun (2002) 1.87

The com locus controls genetic transformation in Streptococcus pneumoniae. Mol Microbiol (1997) 1.80

Competence regulation by oxygen in Streptococcus pneumoniae: involvement of ciaRH and comCDE. Mol Microbiol (2000) 1.79

Extracellular-peptide control of competence for genetic transformation in Streptococcus pneumoniae. Front Biosci (2002) 1.70

Differential fluorescence induction reveals Streptococcus pneumoniae loci regulated by competence stimulatory peptide. Mol Microbiol (2001) 1.70

Transient association of an alternative sigma factor, ComX, with RNA polymerase during the period of competence for genetic transformation in Streptococcus pneumoniae. J Bacteriol (2003) 1.68

Genes for breakfast: the have-your-cake-and-eat-it-too of bacterial transformation. J Hered (1993) 1.60

Competence-induced fratricide in streptococci. Mol Microbiol (2007) 1.60

Autophosphorylation and phosphatase activities of the oxygen-sensing protein FixL of Rhizobium meliloti are coordinately regulated by oxygen. J Biol Chem (1993) 1.56

ComX is a unique link between multiple quorum sensing outputs and competence in Streptococcus pneumoniae. Mol Microbiol (2003) 1.41

ppearance of a protein "agglutinin" on the spheroplast membrane of pneumococci during induction of competence. J Bacteriol (1971) 1.25

Antibacterial activity of a competence-stimulating peptide in experimental sepsis caused by Streptococcus pneumoniae. Antimicrob Agents Chemother (2004) 1.23

Pneumococcal HtrA protease mediates inhibition of competence by the CiaRH two-component signaling system. J Bacteriol (2005) 1.15

Competence modulation by the NADH oxidase of Streptococcus pneumoniae involves signal transduction. J Bacteriol (2001) 1.05

Constitutive competence for genetic transformation in Streptococcus pneumoniae caused by mutation of a transmembrane histidine kinase. Mol Microbiol (2001) 0.91