PubRank

William H Gerwick

Author PubWeight™ 163.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem Biol 2004 4.58
2 Marine natural products as anticancer drugs. Mol Cancer Ther 2005 2.93
3 Single cell genome amplification accelerates identification of the apratoxin biosynthetic pathway from a complex microbial assemblage. PLoS One 2011 2.73
4 Biosynthetic pathway and gene cluster analysis of curacin A, an antitubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. J Nat Prod 2004 2.71
5 Metamorphic enzyme assembly in polyketide diversification. Nature 2009 2.64
6 The genomisotopic approach: a systematic method to isolate products of orphan biosynthetic gene clusters. Chem Biol 2007 2.32
7 Biosynthetic origin of natural products isolated from marine microorganism-invertebrate assemblages. Proc Natl Acad Sci U S A 2008 2.23
8 The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene 2002 2.09
9 Lyngbyatoxin biosynthesis: sequence of biosynthetic gene cluster and identification of a novel aromatic prenyltransferase. J Am Chem Soc 2004 1.73
10 Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites. Int J Syst Evol Microbiol 2011 1.71
11 Marine natural products as novel antioxidant prototypes. J Nat Prod 2003 1.70
12 The identification and characterization of the marine natural product scytonemin as a novel antiproliferative pharmacophore. J Pharmacol Exp Ther 2002 1.59
13 Molecular networking as a dereplication strategy. J Nat Prod 2013 1.57
14 Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. J Am Chem Soc 2006 1.55
15 Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth. Proc Natl Acad Sci U S A 2013 1.51
16 Visualizing the spatial distribution of secondary metabolites produced by marine cyanobacteria and sponges via MALDI-TOF imaging. Mol Biosyst 2008 1.47
17 Biologically active secondary metabolites from marine cyanobacteria. Curr Opin Biotechnol 2010 1.42
18 Dereplication and de novo sequencing of nonribosomal peptides. Nat Methods 2009 1.41
19 Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc Natl Acad Sci U S A 2011 1.40
20 Crystal structures of dehydratase domains from the curacin polyketide biosynthetic pathway. Structure 2010 1.39
21 Isolation of swinholide A and related glycosylated derivatives from two field collections of marine cyanobacteria. Org Lett 2005 1.39
22 Interpretation of tandem mass spectra obtained from cyclic nonribosomal peptides. Anal Chem 2009 1.37
23 GNAT-like strategy for polyketide chain initiation. Science 2007 1.36
24 Coibamide A, a potent antiproliferative cyclic depsipeptide from the Panamanian marine cyanobacterium Leptolyngbya sp. J Am Chem Soc 2008 1.36
25 Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc 2009 1.35
26 Synergistic allelochemicals from a freshwater cyanobacterium. Proc Natl Acad Sci U S A 2010 1.33
27 Apratoxin D, a potent cytotoxic cyclodepsipeptide from papua new guinea collections of the marine cyanobacteria Lyngbya majuscula and Lyngbya sordida. J Nat Prod 2008 1.29
28 Cloning and biochemical characterization of the hectochlorin biosynthetic gene cluster from the marine cyanobacterium Lyngbya majuscula. J Nat Prod 2007 1.28
29 Organization, evolution, and expression analysis of the biosynthetic gene cluster for scytonemin, a cyanobacterial UV-absorbing pigment. Appl Environ Microbiol 2009 1.28
30 Oxo-phytodienoic acid-containing galactolipids in Arabidopsis: jasmonate signaling dependence. Plant Physiol 2007 1.27
31 Venturamides A and B: antimalarial constituents of the panamanian marine Cyanobacterium Oscillatoria sp. J Nat Prod 2007 1.26
32 Characterization of the initial enzymatic steps of barbamide biosynthesis. J Nat Prod 2006 1.25
33 Antimalarial peptides from marine cyanobacteria: isolation and structural elucidation of gallinamide A. J Nat Prod 2009 1.25
34 Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry. Biochemistry 2006 1.24
35 Relative stereochemistry determination and synthesis of the major chlorosulfolipid from Ochromonas danica. J Am Chem Soc 2009 1.23
36 Evolved diversification of a modular natural product pathway: apratoxins F and G, two cytotoxic cyclic depsipeptides from a Palmyra collection of Lyngbya bouillonii. Chembiochem 2010 1.22
37 New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol 2009 1.22
38 Imaging mass spectrometry of natural products. Nat Prod Rep 2009 1.20
39 The guineamides, novel cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 2003 1.20
40 The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Nat Prod Rep 2010 1.19
41 Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. J Nat Prod 2002 1.19
42 Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J Biol Chem 2007 1.18
43 Underestimated biodiversity as a major explanation for the perceived rich secondary metabolite capacity of the cyanobacterial genus Lyngbya. Environ Microbiol 2011 1.18
44 Antimalarial linear lipopeptides from a Panamanian strain of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 2007 1.17
45 Lyngbouilloside, a novel glycosidic macrolide from the marine cyanobacterium Lyngbya bouillonii. J Nat Prod 2002 1.17
46 Oxylipin profiling of the hypersensitive response in Arabidopsis thaliana. Formation of a novel oxo-phytodienoic acid-containing galactolipid, arabidopside E. J Biol Chem 2006 1.16
47 Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp. J Nat Prod 2008 1.16
48 Palmyramide A, a cyclic depsipeptide from a Palmyra Atoll collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 2010 1.16
49 Hoiamide a, a sodium channel activator of unusual architecture from a consortium of two papua new Guinea cyanobacteria. Chem Biol 2009 1.15
50 Significant natural product biosynthetic potential of actinorhizal symbionts of the genus frankia, as revealed by comparative genomic and proteomic analyses. Appl Environ Microbiol 2011 1.10
51 Influence of lipid-soluble gating modifier toxins on sodium influx in neocortical neurons. J Pharmacol Exp Ther 2008 1.10
52 A concise enantioselective synthesis of the chlorosulfolipid malhamensilipin A. J Am Chem Soc 2010 1.10
53 Structure and absolute stereochemistry of phormidolide, a new toxic metabolite from the marine cyanobacterium Phormidium sp. J Org Chem 2002 1.09
54 Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proc Natl Acad Sci U S A 2010 1.08
55 DNA methyl transferase inhibiting halogenated monoterpenes from the Madagascar red marine alga Portieria hornemannii. J Nat Prod 2006 1.06
56 Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp. J Nat Prod 2007 1.06
57 Palmyrolide A, an unusually stabilized neuroactive macrolide from Palmyra Atoll cyanobacteria. Org Lett 2010 1.06
58 The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A 2008 1.05
59 Cytotoxic veraguamides, alkynyl bromide-containing cyclic depsipeptides from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod 2011 1.05
60 Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. J Biol Chem 2011 1.03
61 Practical total syntheses of epiquinamide enantiomers. Org Lett 2006 1.02
62 Natural products chemistry and taxonomy of the marine cyanobacterium Blennothrix cantharidosmum. J Nat Prod 2008 1.02
63 Almiramides A-C: discovery and development of a new class of leishmaniasis lead compounds. J Med Chem 2010 1.01
64 Somocystinamide A, a novel cytotoxic disulfide dimer from a Fijian marine cyanobacterial mixed assemblage. Org Lett 2002 1.01
65 Viridamides A and B, lipodepsipeptides with antiprotozoal activity from the marine cyanobacterium Oscillatoria nigro-viridis. J Nat Prod 2008 1.01
66 The hoiamides, structurally intriguing neurotoxic lipopeptides from Papua New Guinea marine cyanobacteria. J Nat Prod 2010 0.99
67 Probing marine natural product defenses with DESI-imaging mass spectrometry. Proc Natl Acad Sci U S A 2009 0.99
68 Temporal dynamics of natural product biosynthesis in marine cyanobacteria. Proc Natl Acad Sci U S A 2011 0.98
69 The chemical ecology of cyanobacteria. Nat Prod Rep 2012 0.98
70 Cyanolide A, a glycosidic macrolide with potent Molluscicidal activity from the Papua New Guinea cyanobacterium Lyngbya bouillonii. J Nat Prod 2010 0.97
71 Isolation of four new cyclic depsipeptides, antanapeptins A-D, and dolastatin 16 from a Madagascan collection of Lyngbya majuscula. J Nat Prod 2002 0.97
72 On the use of neuro-2a neuroblastoma cells versus intact neurons in primary culture for neurotoxicity studies. Crit Rev Neurobiol 2005 0.97
73 Hydroxyalkenylresorcinols from Stylogyne turbacensis. J Nat Prod 2007 0.97
74 Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angew Chem Int Ed Engl 2011 0.95
75 Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula. J Org Chem 2009 0.95
76 Diverse secondary metabolites from a Puerto Rican collection of Lyngbyamajuscula. J Nat Prod 2003 0.95
77 The carmaphycins: new proteasome inhibitors exhibiting an α,β-epoxyketone warhead from a marine cyanobacterium. Chembiochem 2012 0.95
78 Chemical constituents of the new endophytic fungus Mycosphaerella sp. nov. and their anti-parasitic activity. Nat Prod Commun 2011 0.94
79 Structure revision and absolute configuration of malhamensilipin A from the freshwater chrysophyte Poterioochromonas malhamensis. J Nat Prod 2010 0.94
80 Phylogenetic inferences reveal a large extent of novel biodiversity in chemically rich tropical marine cyanobacteria. Appl Environ Microbiol 2013 0.94
81 Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. J Org Chem 2012 0.94
82 Honaucins A-C, potent inhibitors of inflammation and bacterial quorum sensing: synthetic derivatives and structure-activity relationships. Chem Biol 2012 0.93
83 Cyanobacterial polyketide synthase docking domains: a tool for engineering natural product biosynthesis. Chem Biol 2013 0.93
84 Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction. PLoS One 2012 0.92
85 Polyenoic fatty acid isomerase from the marine alga Ptilota filicina: protein characterization and functional expression of the cloned cDNA. Arch Biochem Biophys 2002 0.92
86 Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. ACS Chem Biol 2012 0.92
87 Survey of marine natural product structure revisions: a synergy of spectroscopy and chemical synthesis. Bioorg Med Chem 2011 0.92
88 Alotamide A, a novel neuropharmacological agent from the marine cyanobacterium Lyngbya bouillonii. Org Lett 2009 0.92
89 Neurotoxic meroditerpenoids from the tropical marine brown alga Stypopodium flabelliforme. J Nat Prod 2005 0.91
90 Aurilides B and C, cancer cell toxins from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 2006 0.91
91 Desmethoxymajusculamide C, a cyanobacterial depsipeptide with potent cytotoxicity in both cyclic and ring-opened forms. J Nat Prod 2009 0.91
92 Crossbyanols A-D, toxic brominated polyphenyl ethers from the Hawai'ian bloom-forming Cyanobacterium Leptolyngbya crossbyana. J Nat Prod 2010 0.91
93 Semiplenamides A-G, fatty acid amides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. J Nat Prod 2003 0.91
94 Combining Mass Spectrometric Metabolic Profiling with Genomic Analysis: A Powerful Approach for Discovering Natural Products from Cyanobacteria. J Nat Prod 2015 0.91
95 The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. J Nat Prod 2013 0.91
96 Dragonamide E, a modified linear lipopeptide from Lyngbya majuscula with antileishmanial activity. J Nat Prod 2010 0.90
97 Lophocladines, bioactive alkaloids from the red alga Lophocladia sp. J Nat Prod 2006 0.89
98 Heterologous production of 4-O-demethylbarbamide, a marine cyanobacterial natural product. Org Lett 2012 0.89
99 Credneramides A and B: neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov. J Nat Prod 2011 0.88
100 Observing the invisible through imaging mass spectrometry, a window into the metabolic exchange patterns of microbes. J Proteomics 2012 0.88
101 The wewakpeptins, cyclic depsipeptides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya semiplena. J Org Chem 2005 0.88
102 Coibacins A-D, antileishmanial marine cyanobacterial polyketides with intriguing biosynthetic origins. Org Lett 2012 0.88
103 Three new malyngamides from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula. J Nat Prod 2003 0.87
104 Enantioselective divergent syntheses of several polyhalogenated Plocamium monoterpenes and evaluation of their selectivity for solid tumors. Angew Chem Int Ed Engl 2014 0.87
105 Secondary metabolites from marine cyanobacteria and algae inhibit LFA-1/ICAM-1 mediated cell adhesion. Planta Med 2004 0.86
106 Wewakazole, a novel cyclic dodecapeptide from a Papua New Guinea Lyngbya majuscula. Org Lett 2003 0.86
107 Cannabinomimetic lipid from a marine cyanobacterium. J Nat Prod 2011 0.86
108 Microbiota of healthy corals are active against fungi in a light-dependent manner. ACS Chem Biol 2014 0.85
109 Peyssonenynes a and B, novel enediyne oxylipins with DNA methyl transferase inhibitory activity from the red marine alga peyssonneliacaulifera. J Nat Prod 2004 0.85
110 Malyngolide dimer, a bioactive symmetric cyclodepside from the panamanian marine cyanobacterium Lyngbya majuscula. J Nat Prod 2010 0.85
111 High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium. ACS Chem Biol 2013 0.85
112 Two cytotoxic stereoisomers of malyngamide C, 8-epi-malyngamide C and 8-O-acetyl-8-epi-malyngamide C, from the marine cyanobacterium Lyngbya majuscula. Phytochemistry 2010 0.84
113 Transcriptional analysis of the jamaicamide gene cluster from the marine cyanobacterium Lyngbya majuscula and identification of possible regulatory proteins. BMC Microbiol 2009 0.84
114 New steroids with a rearranged skeleton as (h)P300 inhibitors from the sponge Theonella swinhoei. Org Lett 2014 0.83
115 Evaluation of Streptomyces coelicolor A3(2) as a heterologous expression host for the cyanobacterial protein kinase C activator lyngbyatoxin A. FEBS J 2012 0.82
116 Hoiamide D, a marine cyanobacteria-derived inhibitor of p53/MDM2 interaction. Bioorg Med Chem Lett 2011 0.82
117 Malyngamide 2, an oxidized lipopeptide with nitric oxide inhibiting activity from a Papua New Guinea marine cyanobacterium. J Nat Prod 2010 0.82
118 Weakly antimalarial flavonol arabinofuranosides from Calycolpus warszewiczianus. J Nat Prod 2006 0.81
119 Phylogeny-guided isolation of ethyl tumonoate A from the marine cyanobacterium cf. Oscillatoria margaritifera. J Nat Prod 2011 0.81
120 Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 α subunits. BMC Neurosci 2010 0.81
121 Ichthyotoxic brominated diphenyl ethers from a mixed assemblage of a red alga and cyanobacterium: structure clarification and biological properties. Toxicon 2009 0.81
122 Expedient synthesis of α,α-dimethyl-β-hydroxy carbonyl scaffolds via Evans' aldol reaction with a tertiary enolate. Tetrahedron Lett 2011 0.81
123 Molluscicidal metabolites from an assemblage of Palmyra Atoll cyanobacteria. J Nat Prod 2011 0.80
124 Stereospecific total synthesis of somocystinamide A. Org Lett 2008 0.80
125 Chemoecological screening reveals high bioactivity in diverse culturable Portuguese marine cyanobacteria. Mar Drugs 2013 0.80
126 Ion mobility mass spectrometry enables the efficient detection and identification of halogenated natural products from cyanobacteria with minimal sample preparation. Bioorg Med Chem 2011 0.80
127 Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J Nat Prod 2013 0.80
128 Minor alkaloids from Guatteria dumetorum with antileishmanial activity. Planta Med 2006 0.79
129 Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Sci 2012 0.79
130 Antitumor activity of hierridin B, a cyanobacterial secondary metabolite found in both filamentous and unicellular marine strains. PLoS One 2013 0.79
131 Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi. Int Microbiol 2011 0.79
132 Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544. Nat Prod Commun 2012 0.79
133 Lipopeptides from the tropical marine cyanobacterium Symploca sp. J Nat Prod 2014 0.78
134 Enzymatic production of (-)-indolactam V by LtxB, a cytochrome P450 monooxygenase. J Nat Prod 2010 0.78
135 Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194. J Nat Prod 2013 0.78
136 Probing the in vivo biosynthesis of scytonemin, a cyanobacterial ultraviolet radiation sunscreen, through small scale stable isotope incubation studies and MALDI-TOF mass spectrometry. Bioorg Med Chem 2011 0.77
137 Vidalenolone, a novel phenolic metabolite from the tropical red alga Vidalia sp. J Nat Prod 2002 0.77
138 Evaluation of the efficiency of three different solvent systems to extract triterpene saponins from roots of Panax quinquefolius using high-performance liquid chromatography. J Agric Food Chem 2004 0.77
139 Viequeamide A, a cytotoxic member of the kulolide superfamily of cyclic depsipeptides from a marine button cyanobacterium. J Nat Prod 2012 0.77
140 Wewakamide A and guineamide G, cyclic depsipeptides from the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula. J Microbiol Biotechnol 2011 0.77
141 Mooreamide A: a cannabinomimetic lipid from the marine cyanobacterium Moorea bouillonii. Lipids 2014 0.76
142 Cymatherelactone and cymatherols A-C, polycyclic oxylipins from the marine brown alga Cymathere triplicata. Phytochemistry 2011 0.76
143 Antifungal Depsidone Metabolites from Cordyceps dipterigena, an Endophytic Fungus Antagonistic to the Phytopathogen Gibberella fujikuroi. Tetrahedron Lett 2012 0.76
144 Bidirectional influence of sodium channel activation on NMDA receptor-dependent cerebrocortical neuron structural plasticity. Proc Natl Acad Sci U S A 2012 0.76
145 Bouillonamide: a mixed polyketide-peptide cytotoxin from the marine cyanobacterium Moorea bouillonii. Mar Drugs 2013 0.75
146 Elegant metabolite biosynthesis. Chem Biol 2011 0.75
147 Detailed analysis of (-)-palmyrolide a and some synthetic derivatives as voltage-gated sodium channel antagonists. J Nat Prod 2014 0.75
148 Parguerene and precarriebowmide, two classes of lipopeptides from the marine cyanobacterium Moorea producens. J Nat Prod 2013 0.75
149 Coibacins A and B: total synthesis and stereochemical revision. J Org Chem 2014 0.75
150 A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit. ACS Chem Biol 2017 0.75
151 The structure elucidation of isomalyngamide K from the marine cyanobacterium Lyngbya majuscula by experimental and DFT computational methods. J Mol Struct 2011 0.75
152 A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens. J Nat Prod 2017 0.75
153 Corrigendum: Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria. Angew Chem Int Ed Engl 2016 0.75
154 Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway. J Nat Prod 2017 0.75
155 Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium. J Nat Prod 2017 0.75
156 Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens. J Nat Prod 2017 0.75
157 Polyhydroxy cyclohexanols from a Dendrodochium sp. fungus associated with the sea cucumber Holothuria nobilis Selenka. J Nat Prod 2014 0.75