Published in EMBO Rep on May 02, 2008
Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev (2012) 1.64
Transient receptor potential channelopathies. Pflugers Arch (2010) 1.40
Regulation of voltage-gated sodium channel expression in cancer: hormones, growth factors and auto-regulation. Philos Trans R Soc Lond B Biol Sci (2014) 0.98
EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci (2015) 0.95
Identification of a clinically relevant androgen-dependent gene signature in prostate cancer. Cancer Res (2011) 0.94
Functional ion channels in stem cells. World J Stem Cells (2011) 0.91
Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells. J Biol Chem (2011) 0.91
Electrophysiological properties of human induced pluripotent stem cells. Am J Physiol Cell Physiol (2009) 0.90
A novel approach to identify driver genes involved in androgen-independent prostate cancer. Mol Cancer (2014) 0.89
TRPM8 ion channel is aberrantly expressed and required for preventing replicative senescence in pancreatic adenocarcinoma: potential role of TRPM8 as a biomarker and target. Cancer Biol Ther (2012) 0.87
hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer. Sci Rep (2013) 0.86
Ion transport and cancer: from initiation to metastasis. Philos Trans R Soc Lond B Biol Sci (2014) 0.84
Cellular physiological approach for treatment of gastric cancer. World J Gastroenterol (2014) 0.83
Altered expression of two-pore domain potassium (K2P) channels in cancer. PLoS One (2013) 0.82
Use of genetically encoded, light-gated ion translocators to control tumorigenesis. Oncotarget (2016) 0.80
TRP channels and STIM/ORAI proteins: sensors and effectors of cancer and stroma cell migration. Br J Pharmacol (2014) 0.80
The ClC-3 chloride channel associated with microtubules is a target of paclitaxel in its induced-apoptosis. Sci Rep (2013) 0.79
Long-term channel block is required to inhibit cellular transformation by human ether-à-go-go-related gene (hERG1) potassium channels. Mol Pharmacol (2014) 0.77
Ion transporters in brain tumors. Curr Med Chem (2015) 0.77
Efficacy of a hypotonic treatment for peritoneal dissemination from gastric cancer cells: an in vivo evaluation. Biomed Res Int (2014) 0.76
Altering bioelectricity on inhibition of human breast cancer cells. Cancer Cell Int (2016) 0.76
Na(+) Micro-Current Value Detection as a New Modality for Identification of Benign and Malignant Disease in Surgery. Sci Rep (2016) 0.75
Comparative study of the ion flux pathway in stator units of proton- and sodium-driven flagellar motors. Biophysics (Nagoya-shi) (2009) 0.75
Ion channels, transporters and cancer ("INCA2015"): an international meeting in honor of Prof. Dr. Walter Stühmer. Eur Biophys J (2016) 0.75
The hallmarks of cancer. Cell (2000) 113.05
Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer (2006) 5.06
Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? Nature (1984) 4.70
Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases. Proc Natl Acad Sci U S A (2006) 3.13
Oncogenic potential of EAG K(+) channels. EMBO J (1999) 2.74
BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat Cell Biol (2007) 2.18
Non-conducting functions of voltage-gated ion channels. Nat Rev Neurosci (2006) 2.02
The oxygen sensor factor-inhibiting hypoxia-inducible factor-1 controls expression of distinct genes through the bifunctional transcriptional character of hypoxia-inducible factor-1alpha. Cancer Res (2006) 1.75
Ion channels in cell proliferation and apoptotic cell death. J Membr Biol (2005) 1.69
Role of voltage-gated potassium channels in cancer. J Membr Biol (2005) 1.60
Prostate cell differentiation status determines transient receptor potential melastatin member 8 channel subcellular localization and function. J Clin Invest (2007) 1.49
Phase I single-dose study of intracavitary-administered iodine-131-TM-601 in adults with recurrent high-grade glioma. J Clin Oncol (2006) 1.37
Voltage-sensitive ion channels and cancer. Cancer Metastasis Rev (2006) 1.34
Clinical relevance of ion channels for diagnosis and therapy of cancer. J Membr Biol (2005) 1.26
TRP proteins and cancer. Cell Signal (2006) 1.25
Ion channels in death and differentiation of prostate cancer cells. Cell Death Differ (2007) 1.21
Expression of voltage-gated potassium channels in human and mouse colonic carcinoma. Clin Cancer Res (2007) 1.15
Voltage-gated Na+ channels: multiplicity of expression, plasticity, functional implications and pathophysiological aspects. Eur Biophys J (2004) 1.09
Functional expression of voltage-gated sodium channels in primary cultures of human cervical cancer. J Cell Physiol (2007) 1.05
Voltage-gated sodium channels: new targets in cancer therapy? Curr Pharm Des (2006) 1.02
Human neoplastic mesothelial cells express voltage-gated sodium channels involved in cell motility. Int J Biochem Cell Biol (2006) 0.97
Potassium channels are a new target field in anticancer drug design. Recent Pat Anticancer Drug Discov (2007) 0.96
Dynamics of single potassium channel proteins in the plasma membrane of migrating cells. Am J Physiol Cell Physiol (2008) 0.95
Growth factors differentially regulate neuronal Cav channels via ERK-dependent signalling. Cell Calcium (2007) 0.93
The pharmacology and regulation of T type calcium channels: new opportunities for unique therapeutics for cancer. Cell Calcium (2006) 0.92
Less REST, more vascular disease? Regulation of cell cycle and migration of vascular smooth muscle cells. Cell Cycle (2006) 0.86
Purging of the neuroblastoma stem cell compartment and tumor regression on exposure to hypoxia or cytotoxic treatment. Cancer Res (2007) 0.83
Neuro-bioenergetic concepts in cancer prevention and treatment. Med Hypotheses (2006) 0.81
Single plasma membrane K+ channel detection by using dual-color quantum dot labeling. Am J Physiol Cell Physiol (2006) 0.79
International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. Pharmacol Rev (2005) 3.50
Voltage-gated potassium channels as therapeutic targets. Nat Rev Drug Discov (2009) 3.12
Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer (2006) 1.78
Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity. Cancer Res (2007) 1.47
Silencing the activity and proliferative properties of the human EagI Potassium Channel by RNA Interference. J Biol Chem (2006) 1.43
Ether à go-go potassium channel expression in soft tissue sarcoma patients. Mol Cancer (2006) 1.42
Eag1 expression interferes with hypoxia homeostasis and induces angiogenesis in tumors. J Biol Chem (2008) 1.41
Ether a go-go potassium channels as human cervical cancer markers. Cancer Res (2004) 1.41
C-terminal domains implicated in the functional surface expression of potassium channels. EMBO J (2003) 1.32
Mechanism of block of hEag1 K+ channels by imipramine and astemizole. J Gen Physiol (2004) 1.31
Potassium channels in cell cycle and cell proliferation. Philos Trans R Soc Lond B Biol Sci (2014) 1.29
Pattern of axonal injury in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Neurobiol Dis (2008) 1.20
The potassium channel Ether à go-go is a novel prognostic factor with functional relevance in acute myeloid leukemia. Mol Cancer (2010) 1.13
Potassium channels as tumour markers. FEBS Lett (2006) 1.06
Functional K(v)10.1 channels localize to the inner nuclear membrane. PLoS One (2011) 1.06
Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots. PLoS One (2010) 1.03
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia. EMBO Mol Med (2011) 1.00
Glycosylation of Eag1 (Kv10.1) potassium channels: intracellular trafficking and functional consequences. J Biol Chem (2005) 0.99
TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. PLoS One (2012) 0.93
Frequent aberrant expression of the human ether à go-go (hEAG1) potassium channel in head and neck cancer: pathobiological mechanisms and clinical implications. J Mol Med (Berl) (2012) 0.91
KV 10.1 opposes activity-dependent increase in Ca2+ influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse. J Physiol (2014) 0.90
Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice. Hum Mol Genet (2013) 0.89
Tumor cell-selective apoptosis induction through targeting of K(V)10.1 via bifunctional TRAIL antibody. Mol Cancer (2011) 0.88
Human glioma-initiating cells show a distinct immature phenotype resembling but not identical to NG2 glia. J Neuropathol Exp Neurol (2013) 0.87
Cortactin controls surface expression of the voltage-gated potassium channel K(V)10.1. J Biol Chem (2012) 0.84
Rapid internalization of the oncogenic K+ channel K(V)10.1. PLoS One (2011) 0.84
Eag1 potassium channels as markers of cervical dysplasia. Oncol Rep (2011) 0.83
Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide. FEBS Lett (2006) 0.83
Nucleofection induces non-specific changes in the metabolic activity of transfected cells. Mol Biol Rep (2011) 0.82
Physical and functional interaction of KV10.1 with Rabaptin-5 impacts ion channel trafficking. FEBS Lett (2012) 0.82
PIST (GOPC) modulates the oncogenic voltage-gated potassium channel KV10.1. Front Physiol (2013) 0.81
K(+) channels as therapeutic targets in oncology. Future Med Chem (2010) 0.81
Re-expression of a developmentally restricted potassium channel in autoimmune demyelination: Kv1.4 is implicated in oligodendroglial proliferation. Am J Pathol (2007) 0.81
Concept of a selective tumour therapy and its evaluation by near-infrared fluorescence imaging and flat-panel volume computed tomography in mice. Eur J Radiol (2009) 0.80
The voltage dependence of hEag currents is not determined solely by membrane-spanning domains. Eur Biophys J (2008) 0.79