Published in Pflugers Arch on February 04, 2010
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International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
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The TRPA1 channel in migraine mechanism and treatment. Br J Pharmacol (2014) 1.50
Progressive degeneration of dopaminergic neurons through TRP channel-induced cell death. J Neurosci (2014) 1.43
Pain as a channelopathy. J Clin Invest (2010) 1.33
From mechanosensitivity to inflammatory responses: new players in the pathology of glaucoma. Curr Eye Res (2013) 1.31
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Intracellular ATP supports TRPV6 activity via lipid kinases and the generation of PtdIns(4,5) P₂. FASEB J (2011) 1.02
Role of TRP channels in the regulation of the endosomal pathway. Physiology (Bethesda) (2011) 0.98
Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry (2012) 0.97
The history of TRP channels, a commentary and reflection. Pflugers Arch (2011) 0.96
cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. J Biol Chem (2011) 0.92
Cardiac-specific knockout of ET(A) receptor mitigates low ambient temperature-induced cardiac hypertrophy and contractile dysfunction. J Mol Cell Biol (2012) 0.91
Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel. Circ Res (2012) 0.90
TRIP Database: a manually curated database of protein-protein interactions for mammalian TRP channels. Nucleic Acids Res (2010) 0.88
Structural biology of TRP channels. Adv Exp Med Biol (2011) 0.87
Role of TRPM2 in cell proliferation and susceptibility to oxidative stress. Am J Physiol Cell Physiol (2013) 0.86
TRPA1 and other TRP channels in migraine. J Headache Pain (2013) 0.85
The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels. Channels (Austin) (2012) 0.84
Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons. J Neuroinflammation (2015) 0.83
A brief history of trp: commentary and personal perspective. Pflugers Arch (2011) 0.83
Mutation of the melastatin-related cation channel, TRPM3, underlies inherited cataract and glaucoma. PLoS One (2014) 0.83
TRPV1 and Endocannabinoids: Emerging Molecular Signals that Modulate Mammalian Vision. Cells (2014) 0.82
Discrete control of TRPV4 channel function in the distal nephron by protein kinases A and C. J Biol Chem (2013) 0.82
TRP channel cannabinoid receptors in skin sensation, homeostasis, and inflammation. ACS Chem Neurosci (2014) 0.82
A network perspective on unraveling the role of TRP channels in biology and disease. Pflugers Arch (2013) 0.81
TRIP database 2.0: a manually curated information hub for accessing TRP channel interaction network. PLoS One (2012) 0.81
Dietary Capsaicin Protects Cardiometabolic Organs from Dysfunction. Nutrients (2016) 0.79
TRP channels in the skin. Br J Pharmacol (2014) 0.79
Targeting Pain-evoking Transient Receptor Potential Channels for the Treatment of Pain. Curr Neuropharmacol (2013) 0.78
TRPM4 channels in smooth muscle function. Pflugers Arch (2013) 0.78
High-resolution views of TRPV1 and their implications for the TRP channel superfamily. Handb Exp Pharmacol (2014) 0.78
Insulin downregulates the expression of the Ca2+-activated nonselective cation channel TRPM5 in pancreatic islets from leptin-deficient mouse models. Pflugers Arch (2013) 0.77
Ocular transient receptor potential channel function in health and disease. BMC Ophthalmol (2015) 0.77
Discovery and pharmacological characterization of a novel potent inhibitor of diacylglycerol-sensitive TRPC cation channels. Br J Pharmacol (2015) 0.77
Effect of chirality and lipophilicity in the functional activity of evodiamine and its analogues at TRPV1 channels. Br J Pharmacol (2014) 0.77
The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin. J Biol Chem (2011) 0.77
Polymodal Sensory Integration in Retinal Ganglion Cells. Adv Exp Med Biol (2016) 0.77
Polymodal roles of transient receptor potential channels in the control of ocular function. Eye Vis (Lond) (2015) 0.77
Transient Receptor Potential (TRP) channels in T cells. Semin Immunopathol (2015) 0.75
An introduction to Bernd Nilius's Festschrift. J Physiol (2011) 0.75
New insights into TRP channels: Interaction with pattern recognition receptors. Channels (Austin) (2013) 0.75
Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium Induced Calcium Release Mechanism. J Pharmacol Exp Ther (2016) 0.75
Endocytic recycling. Nat Rev Mol Cell Biol (2004) 10.87
TRP channels. Annu Rev Biochem (2007) 8.09
An introduction to TRP channels. Annu Rev Physiol (2006) 7.52
A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science (2005) 7.03
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature (1999) 6.85
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet (2005) 5.53
Polycystic kidney disease. Annu Rev Med (2009) 4.78
NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature (2009) 4.41
Polycystin-2 is an intracellular calcium release channel. Nat Cell Biol (2002) 4.37
TRP-PLIK, a bifunctional protein with kinase and ion channel activities. Science (2001) 4.33
Defective planar cell polarity in polycystic kidney disease. Nat Genet (2005) 4.31
Regulation of vertebrate cellular Mg2+ homeostasis by TRPM7. Cell (2003) 4.15
Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Nat Genet (2002) 3.90
Subunit composition of mammalian transient receptor potential channels in living cells. Proc Natl Acad Sci U S A (2002) 3.88
TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron (2001) 3.74
The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol (2002) 3.40
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept. Nat Rev Drug Discov (2007) 3.39
TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem (2003) 3.15
TRP channels: an overview. Cell Calcium (2005) 2.98
Permeation and selectivity of TRP channels. Annu Rev Physiol (2006) 2.96
TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol (2008) 2.88
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature (2008) 2.76
Mutation of TRPM6 causes familial hypomagnesemia with secondary hypocalcemia. Nat Genet (2002) 2.63
Calcium absorption across epithelia. Physiol Rev (2005) 2.57
Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. J Clin Invest (2009) 2.54
Sensing with TRP channels. Nat Chem Biol (2005) 2.51
Down-regulation of the novel gene melastatin correlates with potential for melanoma metastasis. Cancer Res (1998) 2.43
Mucolipidosis type IV is caused by mutations in a gene encoding a novel transient receptor potential channel. Hum Mol Genet (2000) 2.43
The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores. Pflugers Arch (2009) 2.35
Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nat Genet (2009) 2.32
Physiology and pathophysiology of canonical transient receptor potential channels. FASEB J (2008) 2.31
A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3. Nat Genet (1994) 2.30
Formation of novel TRPC channels by complex subunit interactions in embryonic brain. J Biol Chem (2003) 2.29
TRPM1 is required for the depolarizing light response in retinal ON-bipolar cells. Proc Natl Acad Sci U S A (2009) 2.27
Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem (2003) 2.26
Cardiac defects and renal failure in mice with targeted mutations in Pkd2. Nat Genet (2000) 2.24
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C. Nat Genet (2009) 2.22
Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4. Nat Genet (2009) 2.21
Abnormal transport along the lysosomal pathway in mucolipidosis, type IV disease. Proc Natl Acad Sci U S A (1998) 2.18
A functional single-nucleotide polymorphism in the TRPC6 gene promoter associated with idiopathic pulmonary arterial hypertension. Circulation (2009) 2.17
Upregulation of TRPC1 in the development of cardiac hypertrophy. J Mol Cell Cardiol (2006) 2.17
Differential gene expression of TRPM1, the potential cause of congenital stationary night blindness and coat spotting patterns (LP) in the Appaloosa horse (Equus caballus). Genetics (2008) 2.15
The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol (2009) 2.13
Cloning of the gene encoding a novel integral membrane protein, mucolipidin-and identification of the two major founder mutations causing mucolipidosis type IV. Am J Hum Genet (2000) 2.08
Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice. Proc Natl Acad Sci U S A (2002) 2.03
Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Am J Hum Genet (2009) 2.02
TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i. Proc Natl Acad Sci U S A (2003) 2.01
Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice. Proc Natl Acad Sci U S A (2007) 1.99
Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: Part 2. J Pharmacol Exp Ther (2008) 1.98
Selective association of TRPC channel subunits in rat brain synaptosomes. J Biol Chem (2002) 1.97
TRP-ML1 regulates lysosomal pH and acidic lysosomal lipid hydrolytic activity. J Biol Chem (2005) 1.96
TRPM1 is mutated in patients with autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet (2009) 1.93
Mutations in TRPM1 are a common cause of complete congenital stationary night blindness. Am J Hum Genet (2009) 1.92
A helix-breaking mutation in TRPML3 leads to constitutive activity underlying deafness in the varitint-waddler mouse. Proc Natl Acad Sci U S A (2007) 1.91
Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1. J Biol Chem (2006) 1.90
Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol (2005) 1.88
TRP channels in disease. Biochim Biophys Acta (2007) 1.84
Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model. Am J Physiol Renal Physiol (2007) 1.83
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. Proc Natl Acad Sci U S A (2007) 1.75
Melastatin expression and prognosis in cutaneous malignant melanoma. J Clin Oncol (2001) 1.75
TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J Biol Chem (2005) 1.75
Recent developments in vascular endothelial cell transient receptor potential channels. Circ Res (2005) 1.73
TRPV4 channel is involved in the coupling of fluid viscosity changes to epithelial ciliary activity. J Cell Biol (2005) 1.68
Recessive mutations of the gene TRPM1 abrogate ON bipolar cell function and cause complete congenital stationary night blindness in humans. Am J Hum Genet (2009) 1.68
A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci U S A (2009) 1.66
Transcriptional regulation of the melanoma prognostic marker melastatin (TRPM1) by MITF in melanocytes and melanoma. Cancer Res (2004) 1.64
The TRPM ion channel subfamily: molecular, biophysical and functional features. Trends Pharmacol Sci (2004) 1.60
Mucolipidosis type IV. Mol Genet Metab (2001) 1.56
Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype. J Biol Chem (2007) 1.56
Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology. J Lab Clin Med (2003) 1.56
TRP channels: a TR(I)P through a world of multifunctional cation channels. Pflugers Arch (2005) 1.54
Novel TRPM6 mutations in 21 families with primary hypomagnesemia and secondary hypocalcemia. J Am Soc Nephrol (2005) 1.52
The varitint-waddler (Va) deafness mutation in TRPML3 generates constitutive, inward rectifying currents and causes cell degeneration. Proc Natl Acad Sci U S A (2007) 1.51
A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype. EMBO J (2008) 1.47
A novel TRPC6 mutation that causes childhood FSGS. PLoS One (2009) 1.47
Ion channels: functional expression and therapeutic potential in cancer. Colloquium on Ion Channels and Cancer. EMBO Rep (2008) 1.46
Alpha-kinases: analysis of the family and comparison with conventional protein kinases. Prog Biophys Mol Biol (2004) 1.46
The Ca(2+) channel TRPML3 regulates membrane trafficking and autophagy. Traffic (2009) 1.44
Isoform-specific inhibition of TRPC4 channel by phosphatidylinositol 4,5-bisphosphate. J Biol Chem (2008) 1.44
Insights into the molecular nature of magnesium homeostasis. Am J Physiol Renal Physiol (2004) 1.43
Cation channels of the transient receptor potential superfamily: their role in physiological and pathophysiological processes of smooth muscle cells. Pharmacol Ther (2006) 1.41
Membrane dynamics and the biogenesis of lysosomes. Mol Membr Biol (2003) 1.40
Vanilloid transient receptor potential cation channels: an overview. Curr Pharm Des (2008) 1.40
A TRPM7 variant shows altered sensitivity to magnesium that may contribute to the pathogenesis of two Guamanian neurodegenerative disorders. Proc Natl Acad Sci U S A (2005) 1.37
Molecular pathophysiology of mucolipidosis type IV: pH dysregulation of the mucolipin-1 cation channel. Hum Mol Genet (2004) 1.37
Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels. Am J Physiol Renal Physiol (2007) 1.37
Polycystins: polymodal receptor/ion-channel cellular sensors. Pflugers Arch (2005) 1.37
Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem (2007) 1.36
Structure-function relationship of the TRP channel superfamily. Rev Physiol Biochem Pharmacol (2006) 1.35
Role of polycystins in renal tubulogenesis. Trends Cell Biol (2003) 1.35
Activating mutations of the TRPML1 channel revealed by proline-scanning mutagenesis. J Biol Chem (2009) 1.32
The mammalian melastatin-related transient receptor potential cation channels: an overview. Pflugers Arch (2005) 1.28
TRP-ML1 functions as a lysosomal NAADP-sensitive Ca2+ release channel in coronary arterial myocytes. J Cell Mol Med (2008) 1.28
TRP channels entering the structural era. J Physiol (2008) 1.28
TRPP2 and autosomal dominant polycystic kidney disease. Biochim Biophys Acta (2007) 1.27
TRPML and lysosomal function. Biochim Biophys Acta (2007) 1.27
Neuropathology of the Mcoln1(-/-) knockout mouse model of mucolipidosis type IV. J Neuropathol Exp Neurol (2009) 1.26
Transient receptor potential cation channels in disease. Physiol Rev (2007) 6.91
TRP channels: an overview. Cell Calcium (2005) 2.98
Sensing with TRP channels. Nat Chem Biol (2005) 2.51
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol (2007) 2.48
TRPM3 is a nociceptor channel involved in the detection of noxious heat. Neuron (2011) 2.31
Gating of TRP channels: a voltage connection? J Physiol (2005) 2.30
Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet (2008) 2.24
The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J (2006) 2.22
Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. J Clin Invest (2007) 2.19
The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol (2009) 2.13
The transient receptor potential family of ion channels. Genome Biol (2011) 2.08
Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci U S A (2010) 1.96
Transient receptor potential channels meet phosphoinositides. EMBO J (2008) 1.89
Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem (2004) 1.82
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. Cell Metab (2008) 1.79
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
The loss and progressive recovery of voiding after spinal cord interruption in rats is associated with simultaneous changes in autonomous contractile bladder activity. Eur Urol (2008) 1.48
Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice. Proc Natl Acad Sci U S A (2010) 1.46
Vanilloid transient receptor potential cation channels: an overview. Curr Pharm Des (2008) 1.40
Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol Renal Physiol (2009) 1.39
Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem (2007) 1.36
Irritating channels: the case of TRPA1. J Physiol (2010) 1.32
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31
Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J Biol Chem (2008) 1.26
The selectivity filter of the cation channel TRPM4. J Biol Chem (2005) 1.24
TRPV3: time to decipher a poorly understood family member! J Physiol (2013) 1.18
TRP channels. Compr Physiol (2012) 1.17
TRPM8-independent menthol-induced Ca2+ release from endoplasmic reticulum and Golgi. J Biol Chem (2006) 1.09
TRP channels in neurogastroenterology: opportunities for therapeutic intervention. Br J Pharmacol (2011) 1.07
Channelopathies converge on TRPV4. Nat Genet (2010) 1.06
Transcriptional activation of metalloid tolerance genes in Saccharomyces cerevisiae requires the AP-1-like proteins Yap1p and Yap8p. Mol Biol Cell (2004) 1.06
Systematic and quantitative mRNA expression analysis of TRP channel genes at the single trigeminal and dorsal root ganglion level in mouse. BMC Neurosci (2013) 1.05
Invertebrate TRP proteins as functional models for mammalian channels. Pflugers Arch (2004) 1.05
Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase? Pflugers Arch (2013) 1.02
HGF/SF and menthol increase human glioblastoma cell calcium and migration. Biochem Biophys Res Commun (2008) 1.00
TRPP2 and TRPV4 form an EGF-activated calcium permeable channel at the apical membrane of renal collecting duct cells. PLoS One (2013) 0.94
TRPM4 regulates migration of mast cells in mice. Cell Calcium (2008) 0.93
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study. J Med Chem (2009) 0.91
Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate. Mol Pharmacol (2013) 0.91
TRPC channels are involved in calcium-dependent migration and proliferation in immortalized GnRH neurons. Cell Calcium (2011) 0.87
Functional analysis of CFTR chloride channel activity in cells with elevated MDR1 expression. Biochem Biophys Res Commun (2003) 0.84
Interaction of the protein phosphatase 2A with the regulatory domain of the cystic fibrosis transmembrane conductance regulator channel. FEBS Lett (2005) 0.81
Chronic exposure to EGF affects trafficking and function of ENaC channel in cystic fibrosis cells. Biochem Biophys Res Commun (2005) 0.80
Activation of TRPV4 channels reduces migration of immortalized neuroendocrine cells. J Neurochem (2011) 0.79
Insulin downregulates the expression of the Ca2+-activated nonselective cation channel TRPM5 in pancreatic islets from leptin-deficient mouse models. Pflugers Arch (2013) 0.77
Silencing SERCA1b in a few fibers stimulates growth in the entire regenerating soleus muscle. Histochem Cell Biol (2010) 0.76
Maturation of stretch-induced contractile activity and its muscarinic regulation in isolated whole bladder strips from rat. Neurourol Urodyn (2010) 0.75