Published in Cancer Sci on April 29, 2008
Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer (2010) 8.55
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci U S A (2011) 4.15
Exploring mechanisms of FGF signalling through the lens of structural biology. Nat Rev Mol Cell Biol (2013) 1.90
The Fibroblast Growth Factor signaling pathway. Wiley Interdiscip Rev Dev Biol (2015) 1.82
Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy. Expert Rev Anticancer Ther (2009) 1.73
Prostate cancer cell-stromal cell crosstalk via FGFR1 mediates antitumor activity of dovitinib in bone metastases. Sci Transl Med (2014) 1.71
Positive selection for new disease mutations in the human germline: evidence from the heritable cancer syndrome multiple endocrine neoplasia type 2B. PLoS Genet (2012) 1.55
Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. Mol Biol Cell (2009) 1.22
Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances. Front Endocrinol (Lausanne) (2012) 1.17
Deletion of Frs2alpha from the ureteric epithelium causes renal hypoplasia. Am J Physiol Renal Physiol (2009) 1.12
Independent roles of Fgfr2 and Frs2alpha in ureteric epithelium. Development (2011) 1.11
Network-guided analysis of genes with altered somatic copy number and gene expression reveals pathways commonly perturbed in metastatic melanoma. PLoS One (2011) 1.09
Flotillins in receptor tyrosine kinase signaling and cancer. Cells (2014) 1.08
Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts. J Biol Chem (2010) 1.03
Noonan syndrome is associated with enhanced pERK activity, the repression of which can prevent craniofacial malformations. Proc Natl Acad Sci U S A (2009) 1.01
Chlamydia trachomatis co-opts the FGF2 signaling pathway to enhance infection. PLoS Pathog (2011) 0.99
An integrated understanding of the physiological response to elevated extracellular phosphate. J Cell Physiol (2013) 0.98
Interaction of connexin43 and protein kinase C-delta during FGF2 signaling. BMC Biochem (2010) 0.98
Reversible modulation of myofibroblast differentiation in adipose-derived mesenchymal stem cells. PLoS One (2014) 0.98
Targeting fibroblast growth factor pathways in prostate cancer. Clin Cancer Res (2013) 0.98
Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events. J Proteome Res (2010) 0.97
Novel phosphotyrosine targets of FGFR2IIIb signaling. Cell Signal (2009) 0.97
Grb2, a double-edged sword of receptor tyrosine kinase signaling. Sci Signal (2012) 0.96
The Role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymis. Biol Reprod (2013) 0.91
Molecular networks in FGF signaling: flotillin-1 and cbl-associated protein compete for the binding to fibroblast growth factor receptor substrate 2. PLoS One (2012) 0.90
Regulation of medullary thymic epithelial cell differentiation and function by the signaling protein Sin. J Exp Med (2010) 0.89
Enhancing the therapeutic efficacy of adenovirus in combination with biomaterials. Biomaterials (2011) 0.87
Deficient FGF signaling causes optic nerve dysgenesis and ocular coloboma. Development (2013) 0.87
Frs2α enhances fibroblast growth factor-mediated survival and differentiation in lens development. Development (2012) 0.86
Ataxin-2 modulates the levels of Grb2 and SRC but not ras signaling. J Mol Neurosci (2013) 0.84
Identification of critical residues within the conserved and specificity patches of nerve growth factor leading to survival or differentiation. J Biol Chem (2009) 0.84
FGFR1-Frs2/3 signalling maintains sensory progenitors during inner ear hair cell formation. PLoS Genet (2014) 0.83
Integrative analysis of cancer-related signaling pathways. Front Physiol (2013) 0.83
The receptor tyrosine kinase FGFR2b/KGFR controls early differentiation of human keratinocytes. PLoS One (2011) 0.83
G(i)α proteins exhibit functional differences in the activation of ERK1/2, Akt and mTORC1 by growth factors in normal and breast cancer cells. Cell Commun Signal (2014) 0.83
FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells. Stem Cells (2010) 0.83
Multiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis. BMC Genomics (2011) 0.82
Renin-angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms. Pediatr Nephrol (2011) 0.82
Self-organization and regulation of intrinsically disordered proteins with folded N-termini. PLoS Biol (2011) 0.82
Frs2α and Shp2 signal independently of Gab to mediate FGF signaling in lens development. J Cell Sci (2013) 0.81
Mosaic Activating Mutations in FGFR1 Cause Encephalocraniocutaneous Lipomatosis. Am J Hum Genet (2016) 0.80
Fibroblast Growth Factor Signaling in Metabolic Regulation. Front Endocrinol (Lausanne) (2016) 0.80
Allostery mediates ligand binding to Grb2 adaptor in a mutually exclusive manner. J Mol Recognit (2013) 0.79
Chronic Exposure to Bisphenol A Affects Uterine Function During Early Pregnancy in Mice. Endocrinology (2016) 0.78
Choindroitinase ABC I-mediated enhancement of oncolytic virus spread and anti tumor efficacy: a mathematical model. PLoS One (2014) 0.77
Palifermin for the protection and regeneration of epithelial tissues following injury: new findings in basic research and pre-clinical models. J Cell Mol Med (2013) 0.77
A novel conserved phosphotyrosine motif in the Drosophila fibroblast growth factor signaling adaptor Dof with a redundant role in signal transmission. Mol Cell Biol (2010) 0.77
Smooth muscle FGF/TGFβ cross talk regulates atherosclerosis progression. EMBO Mol Med (2016) 0.77
The Hydra FGFR, Kringelchen, partially replaces the Drosophila Heartless FGFR. Dev Genes Evol (2012) 0.77
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. PLoS One (2010) 0.76
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling. PLoS One (2014) 0.76
Compartmentalizing proximal FGFR1 signaling in ovine placental artery endothelial cell caveolae. Biol Reprod (2012) 0.76
FGF8 activates proliferation and migration in mouse post-natal oligodendrocyte progenitor cells. PLoS One (2014) 0.76
Oncogenic Signaling Adaptor Proteins. J Genet Genomics (2015) 0.75
MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor positive breast cancer patients receiving tamoxifen as adjuvant endocrine therapy. Oncotarget (2016) 0.75
The docking protein FRS2α is a critical regulator of VEGF receptors signaling. Proc Natl Acad Sci U S A (2014) 0.75
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor. Proc Natl Acad Sci U S A (2016) 0.75
Trans-Activation between EphA and FGFR Regulates Self-Renewal and Differentiation of Mouse Embryonic Neural Stem/Progenitor Cells via Differential Activation of FRS2α. PLoS One (2015) 0.75
Biochemical and Functional Insights into the Integrated Regulation of Innate Immune Cell Responses by Teleost Leukocyte Immune-Type Receptors. Biology (Basel) (2016) 0.75
A place for precision medicine in bladder cancer: targeting the FGFRs. Future Oncol (2016) 0.75
Structural insights into FRS2α PTB domain recognition by neurotrophin receptor TrkB. Proteins (2014) 0.75
Androgen suppresses protein kinase D1 expression through fibroblast growth factor receptor substrate 2 in prostate cancer cells. Oncotarget (2017) 0.75
FGF-dependent, context-driven role for FRS adapters in the early telencephalon. J Neurosci (2017) 0.75
FGF2 cooperates with IL-17 to promote autoimmune inflammation. Sci Rep (2017) 0.75