Published in Proteins on July 01, 2014
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
NMRPipe: a multidimensional spectral processing system based on UNIX pipes. J Biomol NMR (1995) 93.94
AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR. J Biomol NMR (1996) 29.55
Protein backbone angle restraints from searching a database for chemical shift and sequence homology. J Biomol NMR (1999) 26.99
NMR View: A computer program for the visualization and analysis of NMR data. J Biomol NMR (1994) 22.42
Cell signaling by receptor tyrosine kinases. Cell (2000) 18.16
TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts. J Biomol NMR (2009) 16.09
Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev (2005) 9.62
The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov (2009) 6.23
A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. Cell (1997) 4.43
ARIA2: automated NOE assignment and data integration in NMR structure calculation. Bioinformatics (2006) 3.70
Fibroblast growth factors and their receptors in cancer. Biochem J (2011) 2.66
Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature (1995) 2.59
Functional evolutionary history of the mouse Fgf gene family. Dev Dyn (2008) 2.43
FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol (2000) 2.11
A pulsed field gradient isotope-filtered 3D 13C HMQC-NOESY experiment for extracting intermolecular NOE contacts in molecular complexes. FEBS Lett (1994) 1.84
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins. Cancer Sci (2008) 1.77
The signaling adapter FRS-2 competes with Shc for binding to the nerve growth factor receptor TrkA. A model for discriminating proliferation and differentiation. J Biol Chem (1999) 1.56
Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat Struct Biol (1996) 1.25
Molecular mechanisms of insulin receptor substrate protein-mediated modulation of insulin signalling. FEBS Lett (2003) 1.19
FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts. FEBS Lett (2004) 1.10
Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors. Mol Cell (2000) 1.10
The RET proto-oncogene: a molecular therapeutic target in thyroid cancer. Cancer Sci (2005) 1.04
Trk kinase inhibitors as new treatments for cancer and pain. Expert Opin Ther Pat (2009) 1.02
PTB or not PTB -- that is the question. FEBS Lett (2002) 0.99
Another version of the human insulin receptor kinase domain: expression, purification, and characterization. Proc Natl Acad Sci U S A (1989) 0.99
Identification of SNT/FRS2 docking site on RET receptor tyrosine kinase and its role for signal transduction. Oncogene (2001) 0.98
Differential phosphoproteomics of fibroblast growth factor signaling: identification of Src family kinase-mediated phosphorylation events. J Proteome Res (2010) 0.97
Structural and functional diversity of adaptor proteins involved in tyrosine kinase signalling. Bioessays (2006) 0.91
The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment. Expert Opin Ther Targets (2009) 0.91
Role and expression of FRS2 and FRS3 in prostate cancer. BMC Cancer (2011) 0.89
ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. FEBS Lett (2007) 0.86
The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins. Endocrinology (2003) 0.85
FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors. J Biol Chem (2002) 0.80
Chiral kinase inhibitors. Curr Top Med Chem (2011) 0.77
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a. Mol Cell (2010) 6.94
Structure and conserved RNA binding of the PAZ domain. Nature (2003) 5.28
Reading protein modifications with interaction domains. Nat Rev Mol Cell Biol (2006) 4.55
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol (2008) 3.74
Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell (2007) 3.51
Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev (2009) 2.98
PHD domain-mediated E3 ligase activity directs intramolecular sumoylation of an adjacent bromodomain required for gene silencing. Mol Cell (2007) 2.77
The MMSET protein is a histone methyltransferase with characteristics of a transcriptional corepressor. Blood (2007) 2.58
Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell (2004) 2.43
Structure and regulation of MAPK phosphatases. Cell Signal (2004) 2.42
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell (2002) 2.20
Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b. Nature (2010) 2.02
The role of human bromodomains in chromatin biology and gene transcription. Curr Opin Drug Discov Devel (2009) 1.99
BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism. Cell Cycle (2012) 1.88
Structural basis of site-specific histone recognition by the bromodomains of human coactivators PCAF and CBP/p300. Structure (2008) 1.86
The PHD finger: a versatile epigenome reader. Trends Biochem Sci (2011) 1.81
A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3. Nat Struct Biol (2003) 1.67
Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition. J Biol Chem (2012) 1.66
Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP. Structure (2003) 1.54
Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J (2002) 1.49
BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy. Cancer Res (2013) 1.43
Two-pronged binding with bromodomain-containing protein 4 liberates positive transcription elongation factor b from inactive ribonucleoprotein complexes. J Biol Chem (2011) 1.43
A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem Biol (2011) 1.35
Structure and site-specific recognition of histone H3 by the PHD finger of human autoimmune regulator. Structure (2009) 1.35
Epigenetic transcriptional repression of cellular genes by a viral SET protein. Nat Cell Biol (2008) 1.34
Structural insights into human KAP1 PHD finger-bromodomain and its role in gene silencing. Nat Struct Mol Biol (2008) 1.32
Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression. Cancer Res (2011) 1.31
Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase. J Mol Biol (2006) 1.30
Keeping it in the family: diverse histone recognition by conserved structural folds. Crit Rev Biochem Mol Biol (2010) 1.29
Structure and hemimethylated CpG binding of the SRA domain from human UHRF1. J Biol Chem (2008) 1.26
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol (2006) 1.25
Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc (2005) 1.18
p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase. PLoS One (2010) 1.18
Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription. Biochemistry (2011) 1.10
Structure and chromosomal DNA binding of the SWIRM domain. Nat Struct Mol Biol (2005) 1.06
T cell–derived inducible nitric oxide synthase switches off Th17 cell differentiation. J Exp Med (2013) 1.03
Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2. Cell Res (2010) 1.02
Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found Symp (2004) 1.01
A 14-amino acid sequence with a beta-turn structure is required for apical membrane sorting of the rat ileal bile acid transporter. J Biol Chem (2002) 1.01
Structure of the neural (N-) cadherin prodomain reveals a cadherin extracellular domain-like fold without adhesive characteristics. Structure (2004) 1.01
PTB or not PTB -- that is the question. FEBS Lett (2002) 0.99
The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis. PLoS Genet (2011) 0.95
Biochemical profiling of histone binding selectivity of the yeast bromodomain family. PLoS One (2010) 0.93
Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains. J Med Chem (2013) 0.93
Computer aided identification of small molecules disrupting uPAR/alpha5beta1--integrin interaction: a new paradigm for metastasis prevention. PLoS One (2009) 0.93
Viral-encoded enzymes that target host chromatin functions. Biochim Biophys Acta (2009) 0.93
Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding protein-associated factor. J Med Chem (2007) 0.92
Molecular basis of distinct interactions between Dok1 PTB domain and tyrosine-phosphorylated EGF receptor. J Mol Biol (2004) 0.91
Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2. J Med Chem (2008) 0.90
An archaeal SET domain protein exhibits distinct lysine methyltransferase activity towards DNA-associated protein MC1-alpha. FEBS Lett (2005) 0.90
Dockres: a computer program that analyzes the output of virtual screening of small molecules. Source Code Biol Med (2010) 0.89
Dimerization of a viral SET protein endows its function. Proc Natl Acad Sci U S A (2010) 0.89
Coupling of folding and binding in the PTB domain of the signaling protein Shc. Structure (2003) 0.88
Human uroporphyrinogen III synthase: NMR-based mapping of the active site. Proteins (2008) 0.88
Structural basis for substrate specificity and catalysis of human histone acetyltransferase 1. Proc Natl Acad Sci U S A (2012) 0.88
Rational design of cyclic peptide modulators of the transcriptional coactivator CBP: a new class of p53 inhibitors. J Am Chem Soc (2011) 0.87
The biology of lysine acetylation integrates transcriptional programming and metabolism. Nutr Metab (Lond) (2011) 0.87
Structure and function of protein modules in chromatin biology. Results Probl Cell Differ (2006) 0.85
Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity. J Med Chem (2011) 0.85
New insights into the catalytic activation of the MAPK phosphatase PAC-1 induced by its substrate MAPK ERK2 binding. J Mol Biol (2005) 0.85
Prevalence of plasmid-mediated quinolone resistance in Escherichia coli isolates in Wenzhou, Southern China, 2002-2008. Jpn J Infect Dis (2011) 0.85
γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers. PLoS One (2012) 0.83
PTB or not to be: promiscuous, tolerant and Bizarro domains come of age. IUBMB Life (2004) 0.83
Integration of small-molecule discovery in academic biomedical research. Mt Sinai J Med (2010) 0.83
Coactivator MYST1 regulates nuclear factor-κB and androgen receptor functions during proliferation of prostate cancer cells. Mol Endocrinol (2014) 0.83
Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype. Cancer Res (2006) 0.82
Modulating molecular functions of p53 with small molecules. Cell Cycle (2006) 0.81
Structure of the adaptor protein p14 reveals a profilin-like fold with distinct function. J Mol Biol (2005) 0.81
Structural insights into piRNA recognition by the human PIWI-like 1 PAZ domain. Proteins (2011) 0.80
FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors. J Biol Chem (2002) 0.80
Scaling the druggability landscape of human bromodomains, a new class of drug targets. J Med Chem (2012) 0.80
Optimization of ultrasonic-assisted enzymatic hydrolysis for the extraction of luteolin and apigenin from celery. J Food Sci (2011) 0.80
ChEpiMod: a knowledgebase for chemical modulators of epigenome reader domains. Bioinformatics (2014) 0.80
Catalysis and regioselectivity of the aqueous Heck reaction by Pd(0) nanoparticles under ultrasonic irradiation. J Org Chem (2006) 0.79
Anti-viral opportunities during transcriptional activation of latent HIV in the host chromatin. Methods (2010) 0.79
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci (2002) 0.78
Use of nuclear magnetic resonance spectroscopy to study structure-function of bromodomains. Methods Enzymol (2004) 0.77
The arabidopsis histone methyltransferase SUVR4 binds ubiquitin via a domain with a four-helix bundle structure. Biochemistry (2014) 0.76
Pspace: a program that assesses protein space. Source Code Biol Med (2007) 0.75
Paramecium bursaria chlorella virus 1 encodes a polyamine acetyltransferase. J Biol Chem (2012) 0.75
TAGging the target for damage control. Nat Struct Biol (2002) 0.75
Examining both sides of a Janus PTB domain. Structure (2003) 0.75
1H, 13C and 15N resonance assignments for the N-cadherin prodomain. J Biomol NMR (2004) 0.75
Regulation of Raf activity by dimerization. Pigment Cell Melanoma Res (2010) 0.75
[Molecular evidence for origin of plastid-like organelle apicoplast: a review]. Yi Chuan (2005) 0.75
1H, 13C and 15N resonance assignments of a viral SET domain histone lysine methyltransferase. J Biomol NMR (2003) 0.75
Structure-based functional design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci (2004) 0.75
Structure-based rational design of chemical ligands for AMPA-subtype glutamate receptors. J Mol Neurosci (2003) 0.75
Resonance assignments for the endosomal adaptor protein p14. J Biomol NMR (2004) 0.75