Published in BMC Biochem on March 25, 2010
ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. Am J Physiol Cell Physiol (2012) 1.05
The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade. J Bone Miner Res (2013) 1.04
The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter. Bone (2011) 1.02
Connexin 43 deficiency attenuates loss of trabecular bone and prevents suppression of cortical bone formation during unloading. J Bone Miner Res (2012) 0.98
An intact connexin43 is required to enhance signaling and gene expression in osteoblast-like cells. J Cell Biochem (2013) 0.93
Gap junctional regulation of signal transduction in bone cells. FEBS Lett (2014) 0.93
Molecular mechanisms of osteoblast/osteocyte regulation by connexin43. Calcif Tissue Int (2013) 0.91
Regulation of cellular communication by signaling microdomains in the blood vessel wall. Pharmacol Rev (2014) 0.90
Protein kinase Cδ-mediated phosphorylation of Connexin43 gap junction channels causes movement within gap junctions followed by vesicle internalization and protein degradation. J Biol Chem (2014) 0.85
Determining how defects in connexin43 cause skeletal disease. Genesis (2012) 0.85
CONNEXIN 43 AND BONE: NOT JUST A GAP JUNCTION PROTEIN. Actual osteol (2011) 0.84
Connexins and pannexins in the skeleton: gap junctions, hemichannels and more. Cell Mol Life Sci (2015) 0.81
Low Level Pro-inflammatory Cytokines Decrease Connexin36 Gap Junction Coupling in Mouse and Human Islets through Nitric Oxide-mediated Protein Kinase Cδ. J Biol Chem (2015) 0.81
Communication of cAMP by connexin43 gap junctions regulates osteoblast signaling and gene expression. Cell Signal (2016) 0.80
Reduced connexin 43 immunolabeling in the orbitofrontal cortex in alcohol dependence and depression. J Psychiatr Res (2014) 0.80
Up-regulation of BMP2/4 signaling increases both osteoblast-specific marker expression and bone marrow adipogenesis in Gja1Jrt/+ stromal cell cultures. Mol Biol Cell (2015) 0.80
Defective signaling, osteoblastogenesis, and bone remodeling in a mouse model of connexin43 C-terminal truncation. J Cell Sci (2017) 0.77
Role of connexins and pannexins during ontogeny, regeneration, and pathologies of bone. BMC Cell Biol (2016) 0.75
Novel multi-functional fluid flow device for studying cellular mechanotransduction. J Biomech (2016) 0.75
Connexin43 and Runx2 Interact to Affect Cortical Bone Geometry, Skeletal Development, and Osteoblast and Osteoclast Function. J Bone Miner Res (2017) 0.75
Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J (2000) 22.23
Plasma membrane channels formed by connexins: their regulation and functions. Physiol Rev (2003) 4.87
Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol (2003) 3.75
Life cycle of connexins in health and disease. Biochem J (2006) 3.44
Connexin 43 (GJA1) mutations cause the pleiotropic phenotype of oculodentodigital dysplasia. Am J Hum Genet (2002) 3.43
Differential phosphorylation of the gap junction protein connexin43 in junctional communication-competent and -deficient cell lines. J Cell Biol (1990) 3.32
Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev (2005) 3.28
Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol (2000) 3.13
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol (1991) 3.13
Phosphorylation of connexin43 on serine368 by protein kinase C regulates gap junctional communication. J Cell Biol (2000) 2.78
Connexin43 phosphorylation: structural changes and biological effects. Biochem J (2009) 2.75
Distinctive activation mechanisms and functions for protein kinase Cdelta. Biochem J (2004) 2.70
Gap junctions and connexin-interacting proteins. Cardiovasc Res (2004) 2.56
Connexin43 deficiency causes delayed ossification, craniofacial abnormalities, and osteoblast dysfunction. J Cell Biol (2000) 2.55
Inositol hexaphosphate (IP6) blocks proliferation of human breast cancer cells through a PKCdelta-dependent increase in p27Kip1 and decrease in retinoblastoma protein (pRb) phosphorylation. Breast Cancer Res Treat (2005) 2.25
Connexins and cell signaling in development and disease. Annu Rev Cell Dev Biol (2004) 2.25
Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. J Cell Sci (2006) 2.06
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development (2005) 1.93
Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins. Cancer Sci (2008) 1.77
Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation. J Cell Sci (2003) 1.75
Connexin disorders of the ear, skin, and lens. Biochim Biophys Acta (2004) 1.75
Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state. Cardiovasc Res (2009) 1.67
Gap junctional complexes: from partners to functions. Prog Biophys Mol Biol (2007) 1.66
The protein kinase C pathway plays a central role in the fibroblast growth factor-stimulated expression and transactivation activity of Runx2. J Biol Chem (2002) 1.66
The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet (2007) 1.61
Gap junctions in skeletal development and function. Biochim Biophys Acta (2005) 1.53
Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer. J Biol Chem (2002) 1.53
Regulation of purified and reconstituted connexin 43 hemichannels by protein kinase C-mediated phosphorylation of Serine 368. J Biol Chem (2004) 1.51
Attenuated response to in vivo mechanical loading in mice with conditional osteoblast ablation of the connexin43 gene (Gja1). J Bone Miner Res (2008) 1.51
Gap junctional communication modulates gene transcription by altering the recruitment of Sp1 and Sp3 to connexin-response elements in osteoblast promoters. J Biol Chem (2003) 1.50
Key connexin 43 phosphorylation events regulate the gap junction life cycle. J Membr Biol (2007) 1.48
Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways. J Cell Physiol (2008) 1.46
Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress. Front Biosci (2007) 1.34
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Gap junctions regulate extracellular signal-regulated kinase signaling to affect gene transcription. Mol Biol Cell (2004) 1.33
Gap junction- and hemichannel-independent actions of connexins. Biochim Biophys Acta (2004) 1.30
TPA increases conductance but decreases permeability in neonatal rat cardiomyocyte gap junction channels. Exp Cell Res (1995) 1.25
Diversity in protein-protein interactions of connexins: emerging roles. Biochim Biophys Acta (2004) 1.23
Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. Mol Biol Cell (2009) 1.22
The epsilon subtype of protein kinase C is required for cardiomyocyte connexin-43 phosphorylation. Circ Res (2000) 1.18
The roles of PKCdelta and epsilon isoenzymes in the regulation of myocardial ischaemia/reperfusion injury. Biochem Soc Trans (2007) 1.17
The modulatory effects of connexin 43 on cell death/survival beyond cell coupling. Prog Biophys Mol Biol (2007) 1.16
Nuclear protein kinase C. Biochim Biophys Acta (2006) 1.13
Runx2 phosphorylation induced by fibroblast growth factor-2/protein kinase C pathways. Proteomics (2006) 1.12
Remodeling of gap junctions in ischemic and nonischemic forms of heart disease. J Membr Biol (2007) 1.11
Protein kinase C-alpha and -epsilon modulate connexin-43 phosphorylation in human heart. J Mol Cell Cardiol (2001) 1.07
Fibroblast growth factor-2 and cardioprotection. Heart Fail Rev (2007) 1.03
Protein kinase C as a stress sensor. Cell Signal (2007) 1.00
Heterogeneous nuclear ribonucleoprotein K represses transcription from a cytosine/thymidine-rich element in the osteocalcin promoter. Biochem J (2005) 0.97
Divergence in the anti-apoptotic signalling pathways used by nerve growth factor and basic fibroblast growth factor (bFGF) in PC12 cells: rescue by bFGF involves protein kinase C delta. Biochem J (2000) 0.93
Connexin 43 signalling and cardioprotection. Heart (2005) 0.93
Basic fibroblast growth factor maintains calcium homeostasis and granulosa cell viability by stimulating calcium efflux via a PKC delta-dependent pathway. Endocrinology (2001) 0.93
Protein kinases C translocation responses to low concentrations of arachidonic acid. J Biol Chem (2001) 0.91
Administration of FGF-2 to the heart stimulates connexin-43 phosphorylation at protein kinase C target sites. Cell Commun Adhes (2006) 0.88
Basic fibroblast growth factor stimulates cytosolic phospholipase A2, phospholipase C-gamma1 and phospholipase D through distinguishable signaling mechanisms. Mol Cell Biochem (1999) 0.84
Phospholipase D1 activation through Src and Ras is involved in basic fibroblast growth factor-induced neurite outgrowth of H19-7 cells. J Cell Biochem (2007) 0.83
Differential modulation of unapposed connexin 43 hemichannel electrical conductance by protein kinase C isoforms. Pflugers Arch (2008) 0.83
Basic fibroblast growth factor (bFGF) regulation of the plasma membrane calcium ATPase (PMCA) as part of an anti-apoptotic mechanism of action. Biochem Pharmacol (2003) 0.80
Basic FGF activates phospholipase D in endothelial cells in the absence of inositol-lipid hydrolysis. Am J Physiol (1994) 0.80
Effects of TPA on dye transfer and dye leakage in fibroblasts transfected with a connexin 43 mutation at ser368. Methods Find Exp Clin Pharmacol (1999) 0.78
Low peak bone mass and attenuated anabolic response to parathyroid hormone in mice with an osteoblast-specific deletion of connexin43. J Cell Sci (2006) 2.06
Obesity and cancer risk: evidence, mechanisms, and recommendations. Ann N Y Acad Sci (2012) 2.04
Beta-catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation. J Cell Biochem (2005) 1.69
Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis. J Cell Sci (2004) 1.49
Connexin43 potentiates osteoblast responsiveness to fibroblast growth factor 2 via a protein kinase C-delta/Runx2-dependent mechanism. Mol Biol Cell (2009) 1.22
Effects of in vivo injury on the neuromuscular junction in healthy and dystrophic muscles. J Physiol (2012) 1.08
ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts. Am J Physiol Cell Physiol (2012) 1.05
The regulation of runt-related transcription factor 2 by fibroblast growth factor-2 and connexin43 requires the inositol polyphosphate/protein kinase Cδ cascade. J Bone Miner Res (2013) 1.04
The transcriptional activity of osterix requires the recruitment of Sp1 to the osteocalcin proximal promoter. Bone (2011) 1.02
Celastrus and its bioactive celastrol protect against bone damage in autoimmune arthritis by modulating osteoimmune cross-talk. J Biol Chem (2012) 1.01
Development of mice with osteoblast-specific connexin43 gene deletion. Cell Commun Adhes (2003) 1.00
Interleukin-1beta increases gap junctional communication among synovial fibroblasts via the extracellular-signal-regulated kinase pathway. Biol Cell (2009) 0.96
An intact connexin43 is required to enhance signaling and gene expression in osteoblast-like cells. J Cell Biochem (2013) 0.93
Molecular mechanisms of osteoblast/osteocyte regulation by connexin43. Calcif Tissue Int (2013) 0.91
Induction of an osteocyte-like phenotype by fibroblast growth factor-2. Biochem Biophys Res Commun (2010) 0.87
Water-soluble polymers for targeted drug delivery to human squamous carcinoma of head and neck. J Drug Target (2005) 0.87
FGF23 is endogenously phosphorylated in bone cells. J Bone Miner Res (2015) 0.85
Recovery of altered neuromuscular junction morphology and muscle function in mdx mice after injury. Cell Mol Life Sci (2014) 0.83
Connexins and pannexins in the skeleton: gap junctions, hemichannels and more. Cell Mol Life Sci (2015) 0.81
PPARgamma-mediated antineoplastic effect of NSAID sulindac on human oral squamous carcinoma cells. Int J Cancer (2002) 0.80
Eccentric Contractions Promote Osteoclast Activity in the Tibia: 1132 Board #6 June 1, 3: 15 PM - 5: 15 PM. Med Sci Sports Exerc (2016) 0.75
Inhibition of cysteine proteinases by autolytic digestion is mediated by CBP2/Hsp47. Connect Tissue Res (2002) 0.75
Pulsatile Lavage of Musculoskeletal Wounds Causes Muscle Necrosis and Dystrophic Calcification in a Rat Model. J Bone Joint Surg Am (2017) 0.75