Published in J Immunol on May 15, 2008
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev (2010) 3.27
The origin of allosteric functional modulation: multiple pre-existing pathways. Structure (2009) 2.33
Inflammasomes and their activation. Crit Rev Immunol (2010) 0.98
A role of IL-1R1 signaling in the differentiation of Th17 cells and the development of autoimmune diseases. Self Nonself (2011) 0.87
Type I IL-1 receptor (IL-1RI) as potential new therapeutic target for bronchial asthma. Mediators Inflamm (2010) 0.87
Interleukin-1 antagonists and other cytokine blockade strategies for type 1 diabetes. Rev Diabet Stud (2012) 0.81
Small-molecule inhibition of inflammatory β-cell death. Diabetes Obes Metab (2013) 0.80
Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration. Nat Commun (2016) 0.80
Activated IL-1RI Signaling Pathway Induces Th17 Cell Differentiation via Interferon Regulatory Factor 4 Signaling in Patients with Relapsing-Remitting Multiple Sclerosis. Front Immunol (2016) 0.75
Recent advances in the prevention of preterm birth. F1000Res (2017) 0.75
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. J Clin Invest (2007) 3.39
Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc (2009) 3.31
The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci (2010) 2.61
Mental health care. Who needs psychiatrists? Science (2012) 2.25
Neurodegenerative disease. Guam's deadly stalker: on the loose worldwide? Science (2006) 2.14
Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. J Biol Chem (2005) 2.10
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med (2008) 2.08
Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood (2011) 2.02
AMD3100 is a CXCR7 ligand with allosteric agonist properties. Mol Pharmacol (2009) 1.99
Is pharma running out of brainy ideas? Science (2010) 1.99
Potential role of microglia in retinal blood vessel formation. Invest Ophthalmol Vis Sci (2006) 1.95
Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1-dependent microvascular degeneration. Nat Med (2005) 1.91
Living in societies. The promise of parallel universes. Science (2007) 1.90
Scientific publishing. A scientist's nightmare: software problem leads to five retractions. Science (2006) 1.87
NIH budget. Boom and bust. Science (2007) 1.70
Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency. J Allergy Clin Immunol (2009) 1.70
Mental health in developing countries. The unseen: mental illness's global toll. Science (2006) 1.69
Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways. Proc Natl Acad Sci U S A (2011) 1.58
Agonist-independent nuclear localization of the Apelin, angiotensin AT1, and bradykinin B2 receptors. J Biol Chem (2003) 1.57
Neuroscience. Brain scans of pain raise questions for the law. Science (2009) 1.56
Effect of an organized lipid matrix on lipid absorption and clinical outcomes in patients with cystic fibrosis. J Pediatr (2002) 1.55
Taxonomy. Linnaeus's legacy carries on. Science (2005) 1.55
Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proc Natl Acad Sci U S A (2007) 1.54
Postmenopausal hormone therapy increases retinal blood flow and protects the retinal nerve fiber layer. Invest Ophthalmol Vis Sci (2009) 1.53
TrkB gene transfer protects retinal ganglion cells from axotomy-induced death in vivo. J Neurosci (2002) 1.51
Sociology. Social scientists wade into the tweet stream. Science (2011) 1.51
Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. J Clin Invest (2010) 1.49
Forgetting and remembering. Learning to forget. Science (2004) 1.49
BRET analysis of GPCR oligomerization: newer does not mean better. Nat Methods (2007) 1.48
Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway. Cardiovasc Res (2013) 1.47
Animal rights. The rise of animal law. Science (2011) 1.46
Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors. Proc Natl Acad Sci U S A (2004) 1.46
Commercial immunoassays in biomarkers studies: researchers beware! Clin Chem Lab Med (2013) 1.44
G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm. Can J Physiol Pharmacol (2006) 1.44
Neuroscience. The dark side of glia. Science (2005) 1.43
Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase. J Biol Chem (2004) 1.40
Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling. Cell Signal (2009) 1.40
Social psychology. Using the psychology of evil to do good. Science (2011) 1.40
Neuroscience. New guidelines aim to improve studies of traumatic brain injury. Science (2010) 1.38
Netrin-4 inhibits angiogenesis via binding to neogenin and recruitment of Unc5B. Proc Natl Acad Sci U S A (2008) 1.36
Intracrine signaling through lipid mediators and their cognate nuclear G-protein-coupled receptors: a paradigm based on PGE2, PAF, and LPA1 receptors. Can J Physiol Pharmacol (2006) 1.35
Decreasing the frameshift efficiency translates into an equivalent reduction of the replication of the human immunodeficiency virus type 1. Virology (2005) 1.34
Gradual increase of miR156 regulates temporal expression changes of numerous genes during leaf development in rice. Plant Physiol (2012) 1.30
Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase. Glycoconj J (2009) 1.29
Optogenetics. Shining new light on neural circuits. Science (2006) 1.28
The pharmacologic closure of the patent ductus arteriosus. Semin Fetal Neonatal Med (2004) 1.27
HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165. Blood (2009) 1.27
Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism. J Neurosci (2009) 1.26
Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry. J Virol (2006) 1.26
Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4. Proc Natl Acad Sci U S A (2012) 1.25
Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res (2010) 1.23
NIH budget. Peer review under stress. Science (2007) 1.23
Interleukin-1β inhibition prevents choroidal neovascularization and does not exacerbate photoreceptor degeneration. Am J Pathol (2011) 1.22
Drug targeting. Breaking down barriers. Science (2002) 1.21
Polymorphism in the microglial cell-mobilizing CX3CR1 gene is associated with survival in patients with glioblastoma. J Clin Oncol (2008) 1.21
Proliferative retinopathies: angiogenesis that blinds. Int J Biochem Cell Biol (2009) 1.20
Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly. J Biol Chem (2005) 1.20
Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. J Immunol (2002) 1.19
Molecular pathology of NEU1 gene in sialidosis. Hum Mutat (2003) 1.19
CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration. J Neuroinflammation (2010) 1.18
Whole-exome sequencing identifies LRIT3 mutations as a cause of autosomal-recessive complete congenital stationary night blindness. Am J Hum Genet (2012) 1.18
Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation (2011) 1.18
Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol (2010) 1.17
Role of the chemokine receptor CX3CR1 in the mobilization of phagocytic retinal microglial cells. J Neuroimmunol (2008) 1.16
Antenatal antioxidant prevents adult hypertension, vascular dysfunction, and microvascular rarefaction associated with in utero exposure to a low-protein diet. Am J Physiol Regul Integr Comp Physiol (2006) 1.16
Bioethics. Students learn how, not what, to think about difficult issues. Science (2008) 1.15
Microglia/macrophages migrate through retinal epithelium barrier by a transcellular route in diabetic retinopathy: role of PKCζ in the Goto Kakizaki rat model. Am J Pathol (2011) 1.15
More than adequate iodine intake may increase subclinical hypothyroidism and autoimmune thyroiditis: a cross-sectional study based on two Chinese communities with different iodine intake levels. Eur J Endocrinol (2011) 1.14
Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1. J Biol Chem (2006) 1.13
Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments. J Biol Chem (2006) 1.13
Mental health in developing countries. China: healing the metaphorical heart. Science (2006) 1.13
Role of brain and peripheral angiotensin II in hypertension and altered arterial baroreflex programmed during fetal life in rat. Pediatr Res (2004) 1.13
Pharmacology. The puzzling rise and fall of a dark-horse Alzheimer's drug. Science (2010) 1.12
Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway. Cancer Res (2009) 1.11