Published in J Immunol on September 24, 2010
Complement in immune and inflammatory disorders: pathophysiological mechanisms. J Immunol (2013) 2.10
STEC-HUS, atypical HUS and TTP are all diseases of complement activation. Nat Rev Nephrol (2012) 1.89
Complement System Part I - Molecular Mechanisms of Activation and Regulation. Front Immunol (2015) 1.52
Interactions between coagulation and complement--their role in inflammation. Semin Immunopathol (2011) 1.46
Coagulation factor X shields adenovirus type 5 from attack by natural antibodies and complement. Nat Med (2013) 1.45
Thrombotic microangiopathy and associated renal disorders. Nephrol Dial Transplant (2012) 1.44
Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis. Adv Exp Med Biol (2012) 1.34
Thrombomodulin and its role in inflammation. Semin Immunopathol (2011) 1.30
Overview of complement activation and regulation. Semin Nephrol (2013) 1.26
The role of complement in the early immune response to transplantation. Nat Rev Immunol (2012) 1.26
Progress and Trends in Complement Therapeutics. Adv Exp Med Biol (2013) 1.20
A novel view of the adult bone marrow stem cell hierarchy and stem cell trafficking. Leukemia (2014) 1.18
Plasminogen is a complement inhibitor. J Biol Chem (2012) 1.17
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Complement activation in the injured central nervous system: another dual-edged sword? J Neuroinflammation (2012) 1.11
A metalloproteinase karilysin present in the majority of Tannerella forsythia isolates inhibits all pathways of the complement system. J Immunol (2012) 1.07
Fibrinogen and altered hemostasis in Alzheimer's disease. J Alzheimers Dis (2012) 1.06
Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"? J Biomed Sci (2011) 1.04
Tranexamic acid: less bleeding and less thrombosis? Crit Care (2012) 1.04
Staphylococcal proteases aid in evasion of the human complement system. J Innate Immun (2013) 1.02
Innate immunity activation on biomaterial surfaces: a mechanistic model and coping strategies. Adv Drug Deliv Rev (2011) 1.01
Versatility of the complement system in neuroinflammation, neurodegeneration and brain homeostasis. Front Cell Neurosci (2014) 1.01
Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective. Crit Care (2012) 1.00
Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b. PLoS One (2012) 0.98
Novel evidence that crosstalk between the complement, coagulation and fibrinolysis proteolytic cascades is involved in mobilization of hematopoietic stem/progenitor cells (HSPCs). Leukemia (2014) 0.97
Early complementopathy after multiple injuries in humans. Shock (2012) 0.97
Complement in disease: a defence system turning offensive. Nat Rev Nephrol (2016) 0.97
Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One (2011) 0.97
A novel mechanism for hypofibrinolysis in diabetes: the role of complement C3. Diabetologia (2011) 0.95
Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape. Expert Rev Hematol (2014) 0.94
Transcriptome profiling of gill tissue in regionally bred and globally farmed rainbow trout strains reveals different strategies for coping with thermal stress. Mar Biotechnol (NY) (2013) 0.94
Targeted complement inhibition as a promising strategy for preventing inflammatory complications in hemodialysis. Immunobiology (2012) 0.93
The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria. J Biol Chem (2012) 0.92
The Immune Response to Acute Focal Cerebral Ischemia and Associated Post-stroke Immunodepression: A Focused Review. Aging Dis (2014) 0.90
Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond. J Mol Med (Berl) (2013) 0.90
Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Proc Natl Acad Sci U S A (2013) 0.90
A novel role of complement in retinal degeneration. Invest Ophthalmol Vis Sci (2012) 0.89
Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum. Infect Immun (2014) 0.89
Impact of high prevalence of pseudomonas and polymicrobial gram-negative infections in major sub-/total traumatic amputations on empiric antimicrobial therapy: a retrospective study. World J Emerg Surg (2014) 0.89
Effects of MASP-1 of the complement system on activation of coagulation factors and plasma clot formation. PLoS One (2012) 0.89
Pathogenesis of chronic urticaria: an overview. Dermatol Res Pract (2014) 0.89
Host defense peptides of thrombin modulate inflammation and coagulation in endotoxin-mediated shock and Pseudomonas aeruginosa sepsis. PLoS One (2012) 0.88
Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis. Nat Commun (2016) 0.86
Properdin: a tightly regulated critical inflammatory modulator. Immunol Rev (2016) 0.85
Factors of the lectin pathway of complement activation and their clinical associations in neonates. J Biomed Biotechnol (2012) 0.83
Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin. EBioMedicine (2016) 0.83
Plasma levels of mannan-binding lectin (MBL)-associated serine proteases (MASPs) and MBL-associated protein in cardio- and cerebrovascular diseases. Clin Exp Immunol (2013) 0.83
Role of complement in multiorgan failure. Clin Dev Immunol (2012) 0.83
Complement mediates a primed inflammatory response after traumatic lung injury. J Trauma Acute Care Surg (2014) 0.82
Human mannose-binding lectin inhibitor prevents myocardial injury and arterial thrombogenesis in a novel animal model. Am J Pathol (2014) 0.82
Early onset and enhanced growth of autochthonous mammary carcinomas in C3-deficient Her2/neu transgenic mice. Oncoimmunology (2013) 0.81
Complement, thrombotic microangiopathy and disseminated intravascular coagulation. J Intensive Care (2014) 0.80
Mast Cells and Wound Healing. Adv Wound Care (New Rochelle) (2012) 0.80
Complement depletion deteriorates clinical outcomes of severe abdominal sepsis: a conspirator of infection and coagulopathy in crime? PLoS One (2012) 0.80
The complement system and adverse pregnancy outcomes. Mol Immunol (2015) 0.80
Complement activation: an emerging player in the pathogenesis of cardiovascular disease. Scientifica (Cairo) (2012) 0.80
Novel Evasion Mechanisms of the Classical Complement Pathway. J Immunol (2016) 0.80
Dynamic Cross Talk between S1P and CXCL12 Regulates Hematopoietic Stem Cells Migration, Development and Bone Remodeling. Pharmaceuticals (Basel) (2013) 0.79
Complement-Coagulation Cross-Talk: A Potential Mediator of the Physiological Activation of Complement by Low pH. Front Immunol (2015) 0.79
New insights for C5a and C5a receptors in sepsis. Front Immunol (2012) 0.79
Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing. Sci Rep (2016) 0.78
Complement component C3 - The "Swiss Army Knife" of innate immunity and host defense. Immunol Rev (2016) 0.78
Complement activation and cardiac surgery: a novel target for improving outcomes. Anesth Analg (2012) 0.78
Transcriptome profiles associated to VHSV infection or DNA vaccination in turbot (Scophthalmus maximus). PLoS One (2014) 0.78
Structural and functional characterization of human and murine C5a anaphylatoxins. Acta Crystallogr D Biol Crystallogr (2014) 0.77
The relationship of circulating proteins in early pregnancy with preterm birth. Am J Obstet Gynecol (2015) 0.77
Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. Leukemia (2016) 0.77
Stages of the Inflammatory Response in Pathology and Tissue Repair after Intracerebral Hemorrhage. Semin Neurol (2016) 0.77
Autoantibody-mediated arthritis in the absence of C3 and activating Fcγ receptors: C5 is activated by the coagulation cascade. Arthritis Res Ther (2012) 0.77
MASP-1 Induced Clotting - The First Model of Prothrombin Activation by MASP-1. PLoS One (2015) 0.77
Complementopathies. Blood Rev (2017) 0.76
Histopathologic insights into the mechanism of anti-non-Gal antibody-mediated pig cardiac xenograft rejection. Xenotransplantation (2014) 0.76
Complement: an overview for the clinician. Hematol Oncol Clin North Am (2015) 0.76
Current evidence for the role of complement in the pathogenesis of Shiga toxin haemolytic uraemic syndrome. Pediatr Nephrol (2013) 0.76
A quantitative lateral flow assay to detect complement activation in blood. Anal Biochem (2015) 0.76
The emerging role of coagulation proteases in kidney disease. Nat Rev Nephrol (2015) 0.76
A lack of positive effect of enhanced vegetative nervous system tonus on mobilization of hematopoietic stem and progenitor cells in patients suffering from acute psychotic syndromes. Leukemia (2012) 0.76
A Novel Interaction between Complement Inhibitor C4b-binding Protein and Plasminogen That Enhances Plasminogen Activation. J Biol Chem (2015) 0.76
Induction of complement C3a receptor responses by kallikrein-related peptidase 14. J Immunol (2013) 0.76
A Pathway Proteomic Profile of Ischemic Stroke Survivors Reveals Innate Immune Dysfunction in Association with Mild Symptoms of Depression - A Pilot Study. Front Neurol (2016) 0.75
Mechanism and early intervention research on ALI during emergence surgery of Stanford type-A AAD: Study protocol for a prospective, double-blind, clinical trial. Medicine (Baltimore) (2016) 0.75
A Rich-Club Organization in Brain Ischemia Protein Interaction Network. Sci Rep (2015) 0.75
Candida albicans Shaving to Profile Human Serum Proteins on Hyphal Surface. Front Microbiol (2015) 0.75
Monitoring of complement activation biomarkers and eculizumab in complement-mediated renal disorders. Clin Exp Immunol (2016) 0.75
Complement C3-Targeted Therapy: Replacing Long-Held Assertions with Evidence-Based Discovery. Trends Immunol (2017) 0.75
A Metalloproteinase Mirolysin of Tannerella forsythia Inhibits All Pathways of the Complement System. J Immunol (2015) 0.75
Tumor-Derived Tissue Factor Aberrantly Activates Complement and Facilitates Lung Tumor Progression via Recruitment of Myeloid-Derived Suppressor Cells. Int J Mol Sci (2017) 0.75
Soluble membrane attack complex is diagnostic for intraventricular shunt infection in children. JCI Insight (2016) 0.75
An AGM model for changes in complement during pregnancy: neutralization of influenza virus by serum is diminished in late third trimester. PLoS One (2014) 0.75
Ecotin-like ISP of L. major promastigotes fine-tunes macrophage phagocytosis by limiting the pericellular release of bradykinin from surface-bound kininogens: a survival strategy based on the silencing of proinflammatory G-protein coupled kinin B2 and B1 receptors. Mediators Inflamm (2014) 0.75
Hypofibrinolysis in type 2 diabetes: the role of the inflammatory pathway and complement C3. Diabetologia (2014) 0.75
Improvement of prognostic performance in severely injured patients by integrated clinico-transcriptomics: a translational approach. Crit Care (2015) 0.75
Action of Nanoparticles on Platelet Activation and Plasmatic Coagulation. Curr Med Chem (2016) 0.75
Evolution of the complement system: from defense of the single cell to guardian of the intravascular space. Immunol Rev (2016) 0.75
A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis. BMC Evol Biol (2015) 0.75
Minor Role of Plasminogen in Complement Activation on Cell Surfaces. PLoS One (2015) 0.75
Tick spit shines a light on the initiation of coagulation. Circulation (2013) 0.75
The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis. Arthritis Res Ther (2016) 0.75
New Insights into Molecular Mechanisms of Immune Complex-Induced Injury in Lung. Front Immunol (2016) 0.75
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The dark side of C5a in sepsis. Nat Rev Immunol (2004) 2.46
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Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood (2007) 1.37
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The immune protein CD3zeta is required for normal development of neural circuits in the retina. Neuron (2010) 1.74
Hydrophobic effect and hydrogen bonds account for the improved activity of a complement inhibitor, compstatin. J Med Chem (2006) 1.72
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7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development. Proc Natl Acad Sci U S A (2009) 1.71
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A one-step homogeneous immunoassay for cancer biomarker detection using gold nanoparticle probes coupled with dynamic light scattering. J Am Chem Soc (2008) 1.67
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Structures of C3b in complex with factors B and D give insight into complement convertase formation. Science (2010) 1.59
Antibodies against the extracellular enveloped virus B5R protein are mainly responsible for the EEV neutralizing capacity of vaccinia immune globulin. Virology (2004) 1.58
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Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood (2010) 1.56