Published in Nature on May 15, 2008
A chemical platform for improved induction of human iPSCs. Nat Methods (2009) 4.54
Technical challenges in using human induced pluripotent stem cells to model disease. Cell Stem Cell (2009) 3.42
Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol (2010) 3.06
S6K1 plays a critical role in early adipocyte differentiation. Dev Cell (2010) 1.74
Molecular roadblocks for cellular reprogramming. Mol Cell (2012) 1.74
Microfabricated biomaterials for engineering 3D tissues. Adv Mater (2012) 1.65
High-throughput cellular microarray platforms: applications in drug discovery, toxicology and stem cell research. Trends Biotechnol (2009) 1.56
Bioprinting for stem cell research. Trends Biotechnol (2012) 1.46
A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J Cell Sci (2011) 1.30
Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell (2013) 1.25
Three-dimensional cell culture microarray for high-throughput studies of stem cell fate. Biotechnol Bioeng (2010) 1.22
Natural and synthetic regulators of embryonic stem cell cardiogenesis. Pediatr Cardiol (2009) 1.20
A chemical biology approach to myocardial regeneration. J Cardiovasc Transl Res (2011) 1.17
Photoactivation of endogenous latent transforming growth factor-β1 directs dental stem cell differentiation for regeneration. Sci Transl Med (2014) 1.16
Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming. J Cell Sci (2012) 1.12
Chemical reprogramming of Caenorhabditis elegans germ cell fate. Nat Chem Biol (2009) 1.11
Towards an optimized culture medium for the generation of mouse induced pluripotent stem cells. J Biol Chem (2010) 1.08
Label-free separation of human embryonic stem cells and their differentiating progenies by phasor fluorescence lifetime microscopy. J Biomed Opt (2012) 1.08
Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol (2013) 1.07
A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors. PLoS One (2011) 1.02
Impaired osteoblastogenesis in a murine model of dominant osteogenesis imperfecta: a new target for osteogenesis imperfecta pharmacological therapy. Stem Cells (2012) 1.00
Induced pluripotent stem cells: paths to new medicines. A catalyst for disease modelling, drug discovery and regenerative therapy. EMBO Rep (2010) 0.98
Identification of select glucocorticoids as Smoothened agonists: potential utility for regenerative medicine. Proc Natl Acad Sci U S A (2010) 0.97
Neurotrophic natural products: chemistry and biology. Angew Chem Int Ed Engl (2013) 0.96
Biomarker-free dielectrophoretic sorting of differentiating myoblast multipotent progenitor cells and their membrane analysis by Raman spectroscopy. Biomicrofluidics (2012) 0.95
Chemical approaches to studying stem cell biology. Cell Res (2012) 0.95
Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors. Stem Cells Transl Med (2013) 0.94
Cell-based screening identifies paroxetine as an inhibitor of diabetic endothelial dysfunction. Diabetes (2012) 0.92
Therapeutic approaches to the challenge of neuronal ceroid lipofuscinoses. Curr Pharm Biotechnol (2011) 0.92
Cytoprotective effects of adenosine and inosine in an in vitro model of acute tubular necrosis. Br J Pharmacol (2009) 0.92
All roads lead to induced pluripotent stem cells: the technologies of iPSC generation. Stem Cells Dev (2014) 0.91
Development of pluripotent stem cells for vascular therapy. Vascul Pharmacol (2012) 0.90
Molecular characterization of heterogeneous mesenchymal stem cells with single-cell transcriptomes. Biotechnol Adv (2012) 0.90
Dynamics of histone lysine methylation: structures of methyl writers and erasers. Prog Drug Res (2011) 0.88
Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS Chem Biol (2010) 0.88
Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation. Biomicrofluidics (2011) 0.88
Multi-lineage MSC differentiation via engineered morphogen fields. J Dent Res (2014) 0.87
Small molecules and stem cells. Potency and lineage commitment: the new quest for the fountain of youth. J Med Chem (2010) 0.86
Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ Cardiovasc Genet (2013) 0.86
Enhanced retinal pigment epithelium regeneration after injury in MRL/MpJ mice. Exp Eye Res (2011) 0.85
Introduction to cell-hydrogel mechanosensing. Interface Focus (2014) 0.84
GSK3 inhibitor-BIO regulates proliferation of immortalized pancreatic mesenchymal stem cells (iPMSCs). PLoS One (2012) 0.84
A synthetic circuit for selectively arresting daughter cells to create aging populations. Nucleic Acids Res (2010) 0.83
Direct reprogramming for cardiac regeneration: from dream to reality. Circ Res (2012) 0.83
Microarrayed Materials for Stem Cells. Mater Today (Kidlington) (2012) 0.83
Induced pluripotent stem cells in cardiovascular medicine. Stem Cells Int (2011) 0.83
Single vehicular delivery of siRNA and small molecules to control stem cell differentiation. J Am Chem Soc (2013) 0.83
The pharmacology of regenerative medicine. Pharmacol Rev (2013) 0.83
An engineered approach to stem cell culture: automating the decision process for real-time adaptive subculture of stem cells. PLoS One (2011) 0.82
Embryonic stem cell application in drug discovery. Acta Pharmacol Sin (2011) 0.82
The current status of iPS cells in cardiac research and their potential for tissue engineering and regenerative medicine. Stem Cell Rev (2014) 0.80
Microfluidics-integrated time-lapse imaging for analysis of cellular dynamics. Integr Biol (Camb) (2010) 0.80
State of the art in stem cell research: human embryonic stem cells, induced pluripotent stem cells, and transdifferentiation. J Blood Transfus (2012) 0.80
A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of Pluripotency. Stem Cell Reports (2015) 0.80
Stem cells and small molecule screening: haploid embryonic stem cells as a new tool. Acta Pharmacol Sin (2013) 0.79
High-Efficiency Serum-Free Feeder-Free Erythroid Differentiation of Human Pluripotent Stem Cells Using Small Molecules. Stem Cells Transl Med (2016) 0.79
Making a Hematopoietic Stem Cell. Trends Cell Biol (2015) 0.78
Inhibition of Transforming Growth Factor-β Receptor signaling promotes culture expansion of undifferentiated human Endometrial Mesenchymal Stem/stromal Cells. Sci Rep (2015) 0.78
Promoting effects of isobavachin on neurogenesis of mouse embryonic stem cells were associated with protein prenylation. Acta Pharmacol Sin (2011) 0.78
A step closer to complete chemical reprogramming for generating iPS cells. Chembiochem (2010) 0.77
Chemical genetics and its potential in cardiac stem cell therapy. Br J Pharmacol (2013) 0.77
Stem cells: update and impact on craniofacial surgery. J Craniofac Surg (2012) 0.77
Cyclin-dependent kinase 4 signaling acts as a molecular switch between syngenic differentiation and neural transdifferentiation in human mesenchymal stem cells. Cell Cycle (2013) 0.77
Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep (2015) 0.77
Converting cell fates: generating hematopoietic stem cells de novo via transcription factor reprogramming. Ann N Y Acad Sci (2016) 0.77
Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells. Sci Rep (2016) 0.77
The submerged printing of cells onto a modified surface using a continuous flow microspotter. J Vis Exp (2014) 0.76
Conjugated polyelectrolyte materials for promoting progenitor cell growth without serum. Sci Rep (2013) 0.75
Induction of sensory neurons from neuroepithelial stem cells by the ISX9 small molecule. Am J Stem Cells (2016) 0.75
The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1. PLoS One (2012) 0.75
Zinc Chloride Transiently Maintains Mouse Embryonic Stem Cell Pluripotency by Activating Stat3 Signaling. PLoS One (2016) 0.75
Engineering complex tissue-like microgel arrays for evaluating stem cell differentiation. Sci Rep (2016) 0.75
Identification of RSK and TTK as Modulators of Blood Vessel Morphogenesis Using an Embryonic Stem Cell-Based Vascular Differentiation Assay. Stem Cell Reports (2016) 0.75
Micro- and Nanoscale Technologies for Delivery into Adherent Cells. Trends Biotechnol (2016) 0.75
Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury. Protein Cell (2017) 0.75
The role of nuclear factor of activated T cells during phorbol myristate acetate-induced cardiac differentiation of mesenchymal stem cells. Stem Cell Res Ther (2016) 0.75
A Flavonoid Compound Promotes Neuronal Differentiation of Embryonic Stem Cells via PPAR-β Modulating Mitochondrial Energy Metabolism. PLoS One (2016) 0.75
Stem cell manipulation, gene therapy and the risk of cancer stem cell emergence. Stem Cell Investig (2017) 0.75
Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell (2008) 7.79
Standardizing global gene expression analysis between laboratories and across platforms. Nat Methods (2005) 6.23
A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 5.90
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res (2007) 5.75
Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64
Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell (2008) 4.63
A chemical platform for improved induction of human iPSCs. Nat Methods (2009) 4.54
Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A (2011) 3.93
Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A (2006) 3.90
Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell (2010) 3.82
Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell (2011) 3.62
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
Highly efficient differentiation of human ES cells and iPS cells into mature pancreatic insulin-producing cells. Cell Res (2009) 3.44
Should we standardize the 1,700-year-old fecal microbiota transplantation? Am J Gastroenterol (2012) 3.38
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev (2010) 3.37
MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest (2006) 3.21
Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol (2010) 3.06
Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A (2010) 3.01
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol (2006) 2.96
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nat Med (2011) 2.82
Antigen retrieval immunohistochemistry: review and future prospects in research and diagnosis over two decades. J Histochem Cytochem (2011) 2.70
Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell (2013) 2.69
Receptor-independent, direct membrane binding leads to cell-surface lipid sorting and Syk kinase activation in dendritic cells. Immunity (2008) 2.67
Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A (2006) 2.65
Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A (2011) 2.39
Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells (2009) 2.29
In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res (2007) 2.28
Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell (2009) 2.19
DNA extraction from archival formalin-fixed, paraffin-embedded tissue sections based on the antigen retrieval principle: heating under the influence of pH. J Histochem Cytochem (2002) 2.16
Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. J Clin Invest (2011) 2.16
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther (2005) 2.15
Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05
Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Res (2010) 2.04
Segmental hair analysis after a single dose of zolpidem: comparison with a previous study. J Anal Toxicol (2013) 1.98
Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion. J Clin Invest (2012) 1.91
Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin Cancer Res (2011) 1.91
Synthesis and activity of ruthenium alkylidene complexes coordinated with phosphine and N-heterocyclic carbene ligands. J Am Chem Soc (2003) 1.82
An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.71
Discovery of the Poly(ADP-ribose) polymerase (PARP) inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the treatment of cancer. J Med Chem (2009) 1.68
The effects of BAFF and BAFF-R-Fc fusion protein in immune thrombocytopenia. Blood (2009) 1.66
Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology (2013) 1.64
Auricular acupuncture treatment for insomnia: a systematic review. J Altern Complement Med (2007) 1.64
Mycophenolate mofetil (MMF) for the treatment of steroid-resistant idiopathic thrombocytopenic purpura. Eur J Haematol (2003) 1.64
Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc (2004) 1.63
Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev (2011) 1.63
Conversion of human fibroblasts to functional endothelial cells by defined factors. Arterioscler Thromb Vasc Biol (2013) 1.61
Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. Chem Biol (2004) 1.60
Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming. Trends Pharmacol Sci (2009) 1.59
Dedifferentiation of lineage-committed cells by a small molecule. J Am Chem Soc (2004) 1.56
Brief report: combined chemical treatment enables Oct4-induced reprogramming from mouse embryonic fibroblasts. Stem Cells (2011) 1.49
In vitro and in vivo induction of apoptosis by capsaicin in pancreatic cancer cells is mediated through ROS generation and mitochondrial death pathway. Apoptosis (2008) 1.44
De novo induction of platelet-specific CD4(+)CD25(+) regulatory T cells from CD4(+)CD25(-) cells in patients with idiopathic thrombocytopenic purpura. Blood (2008) 1.44
A small-molecule agonist of the Wnt signaling pathway. Angew Chem Int Ed Engl (2005) 1.44
Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage. Cancer Biol Ther (2008) 1.43
The lifting scheme for wavelet bi-frames: theory, structure, and algorithm. IEEE Trans Image Process (2009) 1.43
Ursolic acid suppresses interleukin-17 (IL-17) production by selectively antagonizing the function of RORgamma t protein. J Biol Chem (2011) 1.43
Directed differentiation of human embryonic stem cells into thymic epithelial progenitor-like cells reconstitutes the thymic microenvironment in vivo. Cell Stem Cell (2013) 1.40
Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A (2007) 1.39
The role of uric acid as an endogenous danger signal in immunity and inflammation. Curr Rheumatol Rep (2011) 1.39
Reversine increases the plasticity of lineage-committed mammalian cells. Proc Natl Acad Sci U S A (2007) 1.39
Inflammasome-mediated regulation of hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol (2009) 1.37
ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors. Clin Cancer Res (2009) 1.36
Natural endogenous adjuvants. Springer Semin Immunopathol (2004) 1.34
Assessment of liver viscoelasticity by using shear waves induced by ultrasound radiation force. Radiology (2012) 1.34
Benzyl isothiocyanate-mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of MAPK in human pancreatic cancer cells. Carcinogenesis (2009) 1.31
Potentiation of temozolomide cytotoxicity by poly(ADP)ribose polymerase inhibitor ABT-888 requires a conversion of single-stranded DNA damages to double-stranded DNA breaks. Mol Cancer Res (2008) 1.27
Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways. Mol Cancer Res (2009) 1.26
A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. J Am Chem Soc (2002) 1.26
Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell (2013) 1.25
Synthesis and SAR of novel tricyclic quinoxalinone inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1). Bioorg Med Chem Lett (2009) 1.23
Chemical strategies for stem cell biology and regenerative medicine. Annu Rev Biomed Eng (2011) 1.21
Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells. Differentiation (2007) 1.17
CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer. Gastroenterology (2012) 1.16
Comparison of outcomes for laparoscopically assisted and open radical distal gastrectomy with lymphadenectomy for advanced gastric cancer. Surg Endosc (2011) 1.15
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat Med (2013) 1.14
Improved glycation after ultrasonic pretreatment revealed by high-performance liquid chromatography-linear ion trap/Orbitrap high-resolution mass spectrometry. J Agric Food Chem (2014) 1.14
Adenosine deamination sustains dendritic cell activation in inflammation. J Immunol (2007) 1.13
Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells. Cell Res (2011) 1.13
The PARP inhibitor, ABT-888 potentiates temozolomide: correlation with drug levels and reduction in PARP activity in vivo. Anticancer Res (2008) 1.12
Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol (2011) 1.12
Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming. J Cell Sci (2012) 1.12
Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS One (2012) 1.12
Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells. Stem Cells Transl Med (2012) 1.11
Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Proc Natl Acad Sci U S A (2005) 1.11
Integrin-induced PIP5K1C kinase polarization regulates neutrophil polarization, directionality, and in vivo infiltration. Immunity (2010) 1.10
Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. J Biol Chem (2006) 1.10
Involvement of FOS-mediated miR-181b/miR-21 signalling in the progression of malignant gliomas. Eur J Cancer (2013) 1.09
A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase. PLoS One (2009) 1.08
Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. Stem Cells (2009) 1.08
Direct lineage reprogramming to neural cells. Curr Opin Neurobiol (2012) 1.08
Genome-wide gain-of-function screen identifies novel regulators of pluripotency. Stem Cells (2010) 1.07
Surface-localized spermidine protects the Pseudomonas aeruginosa outer membrane from antibiotic treatment and oxidative stress. J Bacteriol (2011) 1.07
PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice. Nucleic Acids Res (2007) 1.07
Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. J Biol Chem (2010) 1.06
Versatile pathway-centric approach based on high-throughput sequencing to anticancer drug discovery. Proc Natl Acad Sci U S A (2012) 1.05
Inflammasome components Asc and caspase-1 mediate biomaterial-induced inflammation and foreign body response. Proc Natl Acad Sci U S A (2011) 1.04