Direct reprogramming of mouse fibroblasts to neural progenitors.

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell (2012) 3.66

Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Proc Natl Acad Sci U S A (2012) 3.52

Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell (2012) 3.30

Generation of oligodendroglial cells by direct lineage conversion. Nat Biotechnol (2013) 2.64

In vivo reprogramming of astrocytes to neuroblasts in the adult brain. Nat Cell Biol (2013) 2.56

Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol (2013) 2.53

Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43

Mechanisms and models of somatic cell reprogramming. Nat Rev Genet (2013) 2.09

Conversion of human fibroblasts to angioblast-like progenitor cells. Nat Methods (2012) 1.91

Induced neuronal cells: how to make and define a neuron. Cell Stem Cell (2011) 1.77

Small molecules facilitate the reprogramming of mouse fibroblasts into pancreatic lineages. Cell Stem Cell (2014) 1.76

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat Commun (2013) 1.69

Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors. Cell Res (2011) 1.67

Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. J Mol Cell Cardiol (2013) 1.61

Conversion of human fibroblasts to functional endothelial cells by defined factors. Arterioscler Thromb Vasc Biol (2013) 1.61

Generation of integration-free neural progenitor cells from cells in human urine. Nat Methods (2012) 1.58

Lineage conversion methodologies meet the reprogramming toolbox. Nat Cell Biol (2012) 1.56

Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage. Nat Biotechnol (2015) 1.55

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma. Nat Rev Drug Discov (2012) 1.52

Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies. Nat Rev Mol Cell Biol (2013) 1.52

A blueprint for engineering cell fate: current technologies to reprogram cell identity. Cell Res (2013) 1.50

Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat Biotechnol (2015) 1.48

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc Natl Acad Sci U S A (2013) 1.44

In vivo conversion of astrocytes to neurons in the injured adult spinal cord. Nat Commun (2014) 1.38

Generation of integration-free and region-specific neural progenitors from primate fibroblasts. Cell Rep (2013) 1.36

Generation of neural progenitor cells by chemical cocktails and hypoxia. Cell Res (2014) 1.30

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression. Nature (2016) 1.25

Chemical approaches to stem cell biology and therapeutics. Cell Stem Cell (2013) 1.25

Specimen collection for induced pluripotent stem cell research: harmonizing the approach to informed consent. Stem Cells Transl Med (2012) 1.24

Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc. Proc Natl Acad Sci U S A (2012) 1.22

Induced regeneration--the progress and promise of direct reprogramming for heart repair. Nat Med (2013) 1.17

Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4. Cell Rep (2014) 1.16

Small molecules, big roles -- the chemical manipulation of stem cell fate and somatic cell reprogramming. J Cell Sci (2012) 1.12

Environmental impact on direct neuronal reprogramming in vivo in the adult brain. Nat Commun (2013) 1.11

Pharmacological Reprogramming of Fibroblasts into Neural Stem Cells by Signaling-Directed Transcriptional Activation. Cell Stem Cell (2016) 1.09

Induction of fibroblasts to neurons through adenoviral gene delivery. Cell Res (2011) 1.08

The many roads to Rome: induction of neural precursor cells from fibroblasts. Curr Opin Genet Dev (2012) 1.08

Direct lineage reprogramming to neural cells. Curr Opin Neurobiol (2012) 1.08

SOX2 reprograms resident astrocytes into neural progenitors in the adult brain. Stem Cell Reports (2015) 1.06

Dynamical systems approach to endothelial heterogeneity. Circ Res (2012) 1.03

Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary. J Ovarian Res (2012) 1.02

Deconstructing mitochondrial dysfunction in Alzheimer disease. Oxid Med Cell Longev (2013) 0.99

Reprogramming of the chick retinal pigmented epithelium after retinal injury. BMC Biol (2014) 0.99

Epigenetic landscapes explain partially reprogrammed cells and identify key reprogramming genes. PLoS Comput Biol (2014) 0.99

Do all roads lead to Oct4? the emerging concepts of induced pluripotency. Trends Cell Biol (2013) 0.98

Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein. J Biol Chem (2011) 0.98

Cellular reprogramming: a small molecule perspective. Curr Opin Cell Biol (2012) 0.97

Direct conversion of dermal fibroblasts into neural progenitor cells by a novel cocktail of defined factors. Curr Mol Med (2012) 0.96

Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors. Protein Cell (2014) 0.96

Cellular reprogramming of human peripheral blood cells. Genomics Proteomics Bioinformatics (2013) 0.94

Concise review: chemical approaches for modulating lineage-specific stem cells and progenitors. Stem Cells Transl Med (2013) 0.94

Efficient derivation of human neuronal progenitors and neurons from pluripotent human embryonic stem cells with small molecule induction. J Vis Exp (2011) 0.94

Progress in the reprogramming of somatic cells. Circ Res (2013) 0.92

Pluripotent stem cells for the study of CNS development. Front Mol Neurosci (2011) 0.92

Induced neural stem cells achieve long-term survival and functional integration in the adult mouse brain. Stem Cell Reports (2014) 0.92

Induced neural stem cells: a new tool for studying neural development and neurological disorders. Cell Res (2012) 0.91

Extensive ex vivo expansion of functional human erythroid precursors established from umbilical cord blood cells by defined factors. Mol Ther (2013) 0.90

Bioengineered stem cells in neural development and neurodegeneration research. Ageing Res Rev (2013) 0.89

Non-Viral Generation of Neural Precursor-like Cells from Adult Human Fibroblasts. J Stem Cells Regen Med (2012) 0.89

Comparative neuronal differentiation of self-renewing neural progenitor cell lines obtained from human induced pluripotent stem cells. Front Cell Neurosci (2013) 0.88

MYC gene delivery to adult mouse utricles stimulates proliferation of postmitotic supporting cells in vitro. PLoS One (2012) 0.88

Sensory hair cell development and regeneration: similarities and differences. Development (2015) 0.88

Adult Stem Cells and Diseases of Aging. J Clin Med (2014) 0.88

Counteracting activities of OCT4 and KLF4 during reprogramming to pluripotency. Stem Cell Reports (2014) 0.87

Transitions between epithelial and mesenchymal states during cell fate conversions. Protein Cell (2014) 0.87

Activation of neural cell fate programs toward direct conversion of adult human fibroblasts into tri-potent neural progenitors using OCT-4. Stem Cells Dev (2014) 0.87

Mathematical approaches to modeling development and reprogramming. Proc Natl Acad Sci U S A (2014) 0.87

Calcium phosphate cement with biofunctional agents and stem cell seeding for dental and craniofacial bone repair. Dent Mater (2012) 0.86

Modeling the blood-brain barrier using stem cell sources. Fluids Barriers CNS (2013) 0.86

Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. EMBO J (2015) 0.86

Concise review: the involvement of SOX2 in direct reprogramming of induced neural stem/precursor cells. Stem Cells Transl Med (2013) 0.85

Chemical approaches to cell reprogramming. Curr Opin Genet Dev (2014) 0.85

Induced pluripotent stem cell-derived mesenchymal stem cell seeding on biofunctionalized calcium phosphate cements. Bone Res (2013) 0.85

Induced neuronal reprogramming. J Comp Neurol (2014) 0.85

Therapeutic transdifferentiation: a novel approach for vascular disease. Circ Res (2013) 0.85

The path from skin to brain: generation of functional neurons from fibroblasts. Mol Neurobiol (2012) 0.85

The evolving biology of small molecules: controlling cell fate and identity. Philos Trans R Soc Lond B Biol Sci (2011) 0.85

Stem cells' guided gene therapy of cancer: New frontier in personalized and targeted therapy. J Cancer Res Ther (Manch) (2014) 0.85

Induced neural stem cells (iNSCs) in neurodegenerative diseases. J Neural Transm (Vienna) (2013) 0.84

Generation of Lung Epithelium from Pluripotent Stem Cells. Curr Pathobiol Rep (2013) 0.83

Reprogramming fibroblasts toward cardiomyocytes, neural stem cells and hepatocytes by cell activation and signaling-directed lineage conversion. Nat Protoc (2015) 0.83

Converted neural cells: induced to a cure? Protein Cell (2012) 0.83

Tissue-engineered regeneration of completely transected spinal cord using induced neural stem cells and gelatin-electrospun poly (lactide-co-glycolide)/polyethylene glycol scaffolds. PLoS One (2015) 0.83

Inhibition of Notch signaling enhances transdifferentiation of the esophageal squamous epithelium towards a Barrett's-like metaplasia via KLF4. Cell Cycle (2014) 0.83

Toward directed reprogramming through exogenous factors. Curr Opin Genet Dev (2013) 0.83

The pharmacology of regenerative medicine. Pharmacol Rev (2013) 0.83

Mechanisms for enhancing cellular reprogramming. Curr Opin Genet Dev (2014) 0.82

Forward engineering neuronal diversity using direct reprogramming. EMBO J (2015) 0.82

Inhibition of transforming growth factor β (TGF-β) signaling can substitute for Oct4 protein in reprogramming and maintain pluripotency. J Biol Chem (2014) 0.82

The labyrinth of nuclear reprogramming. J Mol Cell Biol (2011) 0.82

Human pancreatic beta-like cells converted from fibroblasts. Nat Commun (2016) 0.81

A case of cellular alchemy: lineage reprogramming and its potential in regenerative medicine. J Mol Cell Biol (2012) 0.81

MicroRNA-Mediated In Vitro and In Vivo Direct Conversion of Astrocytes to Neuroblasts. PLoS One (2015) 0.80

Induced pluripotency and direct reprogramming: a new window for treatment of neurodegenerative diseases. Protein Cell (2013) 0.80

Implications and limitations of cellular reprogramming for psychiatric drug development. Exp Mol Med (2013) 0.80

Direct lineage conversion: induced neuronal cells and induced neural stem cells. Protein Cell (2012) 0.80

Induced pluripotent stem cell-derived neural stem cell therapies for spinal cord injury. Neural Regen Res (2015) 0.80

Long-lived engineering of glycans to direct stem cell fate. Angew Chem Int Ed Engl (2014) 0.80

Fast and efficient neural conversion of human hematopoietic cells. Stem Cell Reports (2014) 0.80

Generation of Dopamine Neurons from Rodent Fibroblasts through the Expandable Neural Precursor Cell Stage. J Biol Chem (2015) 0.80

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51

Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell (2007) 101.42

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell (2007) 21.58

Direct conversion of fibroblasts to functional neurons by defined factors. Nature (2010) 18.76

Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21

Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. Cell (2010) 15.58

Generation of mouse induced pluripotent stem cells without viral vectors. Science (2008) 15.25

Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons. Science (2008) 14.26

Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18

New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature (2007) 13.54

Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell (2009) 13.02

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 12.45

Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell (2008) 12.29

Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature (2008) 12.21

Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65

Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Cell (2008) 10.68

Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell (2009) 10.52

Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell (2005) 9.84

Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol (2003) 9.41

Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nat Biotechnol (2007) 9.04

Direct cell reprogramming is a stochastic process amenable to acceleration. Nature (2009) 8.71

Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol (2008) 8.55

A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat Biotechnol (2008) 7.91

Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46

Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature (2009) 7.04

Forcing cells to change lineages. Nature (2009) 5.99

Induced pluripotent stem cell generation using a single lentiviral stem cell cassette. Stem Cells (2009) 5.69

Pax-6, a murine paired box gene, is expressed in the developing CNS. Development (1991) 5.49

Direct conversion of human fibroblasts to multilineage blood progenitors. Nature (2010) 5.35

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage. Genes Dev (2008) 5.34

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64

A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42

Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nat Biotechnol (2010) 3.98

Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell (2010) 3.82

Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors. Nature (2009) 3.70

Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell (2010) 3.42

Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells. Cell Stem Cell (2010) 2.73

Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev (2004) 1.63

Pluripotent stem cells in neurodegenerative and neurodevelopmental diseases. Hum Mol Genet (2010) 1.54

Expression of stem cell pluripotency factors during regeneration in newts. Dev Dyn (2009) 1.52

Direct reprogramming of fibroblasts into epiblast stem cells. Nat Cell Biol (2010) 1.52

A model for genetic and epigenetic regulatory networks identifies rare pathways for transcription factor induced pluripotency. PLoS Comput Biol (2010) 1.08

Dynamic distribution and stem cell characteristics of Sox1-expressing cells in the cerebellar cortex. Cell Res (2009) 1.07

Neural crest and the origin of ectomesenchyme: neural fold heterogeneity suggests an alternative hypothesis. Dev Dyn (2004) 1.00

Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell (2009) 11.65

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell (2008) 7.79

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature (2008) 7.10

A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 5.90

A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science (2006) 5.67

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell (2004) 5.04

Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy. Nat Cell Biol (2011) 4.64

Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell (2008) 4.63

S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature (2006) 4.54

A chemical platform for improved induction of human iPSCs. Nat Methods (2009) 4.54

Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med (2008) 4.46

Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43

S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury. Science (2009) 4.25

Targeted genome modification of crop plants using a CRISPR-Cas system. Nat Biotechnol (2013) 4.19

S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science (2002) 4.13

Seven-year outcomes in ranibizumab-treated patients in ANCHOR, MARINA, and HORIZON: a multicenter cohort study (SEVEN-UP). Ophthalmology (2013) 3.92

Long-term self-renewal and directed differentiation of human embryonic stem cells in chemically defined conditions. Proc Natl Acad Sci U S A (2006) 3.90

Reprogramming of human primary somatic cells by OCT4 and chemical compounds. Cell Stem Cell (2010) 3.82

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med (2008) 3.67

Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell (2011) 3.62

The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev (2010) 3.37

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A (2010) 3.33

Drusen complement components C3a and C5a promote choroidal neovascularization. Proc Natl Acad Sci U S A (2006) 3.25

Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits. Nature (2002) 3.20

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18

Metabolic oxidation regulates embryonic stem cell differentiation. Nat Chem Biol (2010) 3.06

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci U S A (2010) 3.01

Ranibizumab for predominantly classic neovascular age-related macular degeneration: subgroup analysis of first-year ANCHOR results. Am J Ophthalmol (2007) 3.00

Allosteric inhibitors of Bcr-abl-dependent cell proliferation. Nat Chem Biol (2006) 2.96

Molecular pathways to neurodegeneration. Nat Med (2004) 2.94

Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q. Am J Hum Genet (2004) 2.70

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med (2009) 2.66

Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A (2006) 2.65

Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. PLoS One (2009) 2.62

Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease. Nat Med (2007) 2.57

Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci U S A (2004) 2.55

A highly specific inhibitor of matrix metalloproteinase-9 rescues laminin from proteolysis and neurons from apoptosis in transient focal cerebral ischemia. J Neurosci (2005) 2.54

Mitochondrial fission in apoptosis, neurodegeneration and aging. Curr Opin Cell Biol (2003) 2.44

Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43

Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc Natl Acad Sci U S A (2011) 2.39

Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci (2007) 2.36

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol Cell (2004) 2.32

Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells (2009) 2.29

A chemical approach to stem-cell biology and regenerative medicine. Nature (2008) 2.25

Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest (2008) 2.24

Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proc Natl Acad Sci U S A (2007) 2.19

Phosphoproteomic analysis of human embryonic stem cells. Cell Stem Cell (2009) 2.19

Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron (2004) 2.17

The chemical biology of clinically tolerated NMDA receptor antagonists. J Neurochem (2006) 2.13

Memantine and HIV-associated cognitive impairment: a neuropsychological and proton magnetic resonance spectroscopy study. AIDS (2007) 2.09

The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. J Neurosci (2004) 2.07

Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a complex mechanism of retinoic acid synthesis in the developing retina. Mol Cell Biol (2003) 2.07

Systematic review and meta-analysis of the association between complement factor H Y402H polymorphisms and age-related macular degeneration. Hum Mol Genet (2006) 2.07

Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking. Proc Natl Acad Sci U S A (2005) 2.05

Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. Stem Cell Reports (2013) 2.05

CFH Y402H confers similar risk of soft drusen and both forms of advanced AMD. PLoS Med (2005) 2.01

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet (2012) 2.00

VIDEOS IN CLINICAL MEDICINE. Examination of the Retina. N Engl J Med (2015) 1.99

Mechanisms of neuroimmunity and neurodegeneration associated with HIV-1 infection and AIDS. J Neuroimmune Pharmacol (2006) 1.97

Mitochondrial dynamics in cell death and neurodegeneration. Cell Mol Life Sci (2010) 1.97

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J Biol Chem (2007) 1.91

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem (2007) 1.90

Endoscopic Functional Fourier Domain Common Path Optical Coherence Tomography for Microsurgery. IEEE J Sel Top Quantum Electron (2010) 1.88

Transcription factor MEF2C influences neural stem/progenitor cell differentiation and maturation in vivo. Proc Natl Acad Sci U S A (2008) 1.87

Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J Neurophysiol (2002) 1.87

Memantine preferentially blocks extrasynaptic over synaptic NMDA receptor currents in hippocampal autapses. J Neurosci (2010) 1.86

Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. Nat Med (2006) 1.86

Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet (2010) 1.83

Synthesis and activity of ruthenium alkylidene complexes coordinated with phosphine and N-heterocyclic carbene ligands. J Am Chem Soc (2003) 1.82

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. J Neurosci (2005) 1.75

Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol (2009) 1.73

S-nitrosylation of peroxiredoxin 2 promotes oxidative stress-induced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci U S A (2007) 1.73

Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proc Natl Acad Sci U S A (2013) 1.73

Excitatory glycine responses of CNS myelin mediated by NR1/NR3 "NMDA" receptor subunits. J Neurosci (2010) 1.72

An approach to genomewide screens of expressed small interfering RNAs in mammalian cells. Proc Natl Acad Sci U S A (2003) 1.71

Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications. Proc Natl Acad Sci U S A (2008) 1.70

Isolation and characterization of intestinal stem cells based on surface marker combinations and colony-formation assay. Gastroenterology (2013) 1.64

Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements. Hum Genet (2013) 1.63

Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc (2004) 1.63

Cooperation between both Wnt/{beta}-catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion. Genes Dev (2011) 1.63

Mechanisms of neuronal injury and death in HIV-1 associated dementia. Curr HIV Res (2006) 1.61

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nat Med (2013) 1.61

Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. Cell (2013) 1.61