Published in BMC Bioinformatics on May 16, 2008
Bioinformatics challenges for genome-wide association studies. Bioinformatics (2010) 4.45
Epistasis and its implications for personal genetics. Am J Hum Genet (2009) 3.52
Finding unique filter sets in PLATO: a precursor to efficient interaction analysis in GWAS data. Pac Symp Biocomput (2010) 1.64
Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses. BMC Bioinformatics (2009) 1.13
Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models. Hum Hered (2008) 1.08
A robust multifactor dimensionality reduction method for detecting gene-gene interactions with application to the genetic analysis of bladder cancer susceptibility. Ann Hum Genet (2010) 1.07
Identification of multiple gene-gene interactions for ordinal phenotypes. BMC Med Genomics (2013) 0.96
Comparison of information-theoretic to statistical methods for gene-gene interactions in the presence of genetic heterogeneity. BMC Genomics (2010) 0.92
A modified entropy-based approach for identifying gene-gene interactions in case-control study. PLoS One (2013) 0.92
Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One (2011) 0.91
MDR-ER: balancing functions for adjusting the ratio in risk classes and classification errors for imbalanced cases and controls using multifactor-dimensionality reduction. PLoS One (2013) 0.89
An R package implementation of multifactor dimensionality reduction. BioData Min (2011) 0.88
A general framework for formal tests of interaction after exhaustive search methods with applications to MDR and MDR-PDT. PLoS One (2010) 0.85
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Analysis of gene-gene interactions. Curr Protoc Hum Genet (2011) 0.83
The effect of retrospective sampling on estimates of prediction error for multifactor dimensionality reduction. Ann Hum Genet (2011) 0.82
A roadmap to multifactor dimensionality reduction methods. Brief Bioinform (2015) 0.81
Using the Generalized Index of Dissimilarity to Detect Gene-Gene Interactions in Multi-Class Phenotypes. PLoS One (2016) 0.80
Cuckoo search epistasis: a new method for exploring significant genetic interactions. Heredity (Edinb) (2014) 0.80
A cross-validation procedure for general pedigrees and matched odds ratio fitness metric implemented for the multifactor dimensionality reduction pedigree disequilibrium test. Genet Epidemiol (2010) 0.79
Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction. BioData Min (2013) 0.78
Weighted risk score-based multifactor dimensionality reduction to detect gene-gene interactions in nasopharyngeal carcinoma. Int J Mol Sci (2014) 0.78
Detecting Genetic Interactions for Quantitative Traits Using m-Spacing Entropy Measure. Biomed Res Int (2015) 0.78
Predictive Potential of Twenty-Two Biochemical Biomarkers for Coronary Artery Disease in Type 2 Diabetes Mellitus. Int J Endocrinol (2015) 0.75
Information metrics in genetic epidemiology. Stat Appl Genet Mol Biol (2011) 0.75
Optimal ligand descriptor for pocket recognition based on the Beta-shape. PLoS One (2015) 0.75
Multiobjective differential evolution-based multifactor dimensionality reduction for detecting gene-gene interactions. Sci Rep (2017) 0.75
Measuring the accuracy of diagnostic systems. Science (1988) 27.46
Index for rating diagnostic tests. Cancer (1950) 27.09
Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet (2001) 17.43
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (2003) 9.91
Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res (2001) 9.41
The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered (2003) 7.42
Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry (2006) 6.68
Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol (2003) 6.31
A perspective on epistasis: limits of models displaying no main effect. Am J Hum Genet (2002) 5.63
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet (2007) 4.46
New strategies for identifying gene-gene interactions in hypertension. Ann Med (2002) 4.19
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol (2007) 4.15
Detecting epistatic interactions contributing to quantitative traits. Genet Epidemiol (2004) 3.43
Genome-wide association study and mouse model identify interaction between RET and EDNRB pathways in Hirschsprung disease. Nat Genet (2002) 2.74
Data simulation software for whole-genome association and other studies in human genetics. Pac Symp Biocomput (2006) 2.49
Multifactor-dimensionality reduction shows a two-locus interaction associated with Type 2 diabetes mellitus. Diabetologia (2004) 2.44
Tree and spline based association analysis of gene-gene interaction models for ischemic stroke. Stat Med (2004) 2.35
A novel method to identify gene-gene effects in nuclear families: the MDR-PDT. Genet Epidemiol (2006) 2.17
Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions. Bioinformatics (2006) 2.08
Multilocus analysis of hypertension: a hierarchical approach. Hum Hered (2004) 1.82
Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. Genes Immun (2006) 1.56
Routine Discovery of Complex Genetic Models using Genetic Algorithms. Appl Soft Comput (2004) 1.53
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem (2006) 1.51
Multi-locus nonparametric linkage analysis of complex trait loci with neural networks. Hum Hered (1998) 1.49
Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis (2006) 1.46
Evidence for epistasis between SLC6A4 and ITGB3 in autism etiology and in the determination of platelet serotonin levels. Hum Genet (2007) 1.35
New patient-oriented summary measure of net total gain in certainty for dichotomous diagnostic tests. Epidemiol Perspect Innov (2006) 1.27
Use of tree-based models to identify subgroups and increase power to detect linkage to cardiovascular disease traits. BMC Genet (2003) 1.18
Extension of multifactor dimensionality reduction for identifying multilocus effects in the GAW14 simulated data. BMC Genet (2005) 0.93
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (2003) 9.91
The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics (2011) 9.20
Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med (2008) 7.13
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (2010) 7.07
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol (2007) 4.15
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood (2008) 4.02
Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet (2011) 3.85
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation (2010) 3.35
Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genet Med (2012) 3.29
Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation (2004) 3.02
The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. Am J Epidemiol (2011) 2.98
Different contributions of polymorphisms in VKORC1 and CYP2C9 to intra- and inter-population differences in maintenance dose of warfarin in Japanese, Caucasians and African-Americans. Pharmacogenet Genomics (2006) 2.66
Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation. Heart Rhythm (2007) 2.62
Visualizing SNP statistics in the context of linkage disequilibrium using LD-Plus. Bioinformatics (2010) 2.59
Machine learning for detecting gene-gene interactions: a review. Appl Bioinformatics (2006) 2.56
Data simulation software for whole-genome association and other studies in human genetics. Pac Symp Biocomput (2006) 2.49
Quality control procedures for genome-wide association studies. Curr Protoc Hum Genet (2011) 2.48
Biofilter: a knowledge-integration system for the multi-locus analysis of genome-wide association studies. Pac Symp Biocomput (2009) 2.26
Genetic basis for adverse events after smallpox vaccination. J Infect Dis (2008) 2.09
Assessing the accuracy of observer-reported ancestry in a biorepository linked to electronic medical records. Genet Med (2010) 2.09
Generalization and dilution of association results from European GWAS in populations of non-European ancestry: the PAGE study. PLoS Biol (2013) 2.08
VRILLE feeds back to control circadian transcription of Clock in the Drosophila circadian oscillator. Neuron (2003) 2.07
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Hum Genet (2011) 2.00
Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy. Blood (2008) 1.99
STUDENTJAMA. The challenges of whole-genome approaches to common diseases. JAMA (2004) 1.95
An application of conditional logistic regression and multifactor dimensionality reduction for detecting gene-gene interactions on risk of myocardial infarction: the importance of model validation. BMC Bioinformatics (2004) 1.95
Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study. J Infect Dis (2010) 1.91
Multilocus analysis of hypertension: a hierarchical approach. Hum Hered (2004) 1.82
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82
Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology. Genet Epidemiol (2008) 1.75
Subsets of the major tyrosine phosphorylation sites in Crk-associated substrate (CAS) are sufficient to promote cell migration. J Biol Chem (2004) 1.74
Phenome-wide association study (PheWAS) for detection of pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network. PLoS Genet (2013) 1.70
Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. J Am Med Inform Assoc (2011) 1.67
Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics (2012) 1.66
Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. Am J Hum Genet (2011) 1.66
Finding unique filter sets in PLATO: a precursor to efficient interaction analysis in GWAS data. Pac Symp Biocomput (2010) 1.64
A comparison of analytical methods for genetic association studies. Genet Epidemiol (2008) 1.61
Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet (2009) 1.59
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations. Am J Hum Genet (2013) 1.55
Parallel multifactor dimensionality reduction: a tool for the large-scale analysis of gene-gene interactions. Bioinformatics (2006) 1.53
Routine Discovery of Complex Genetic Models using Genetic Algorithms. Appl Soft Comput (2004) 1.53
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants. Pharmacogenet Genomics (2012) 1.52
Single-nucleotide polymorphisms for diagnosis of salt-sensitive hypertension. Clin Chem (2006) 1.51
Lack of associations of ten candidate coronary heart disease risk genetic variants and subclinical atherosclerosis in four US populations: the Population Architecture using Genomics and Epidemiology (PAGE) study. Atherosclerosis (2013) 1.48
A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes. Circ Cardiovasc Genet (2011) 1.48
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. Hum Genet (2013) 1.47
Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genet Epidemiol (2011) 1.47
Application of Genetic Algorithms to the Discovery of Complex Models for Simulation Studies in Human Genetics. Proc Genet Evol Comput Conf (2002) 1.46
Renin-angiotensin system gene polymorphisms and coronary artery disease in a large angiographic cohort: detection of high order gene-gene interaction. Atherosclerosis (2006) 1.46
Enhancing uterine fibroid research through utilization of biorepositories linked to electronic medical record data. J Womens Health (Larchmt) (2014) 1.45
Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks. PLoS One (2011) 1.42
Mitochondrial haplogroups and peripheral neuropathy during antiretroviral therapy: an adult AIDS clinical trials group study. AIDS (2005) 1.39
Problems with genome-wide association studies. Science (2007) 1.39
Susceptibility and modifier genes in Portuguese transthyretin V30M amyloid polyneuropathy: complexity in a single-gene disease. Hum Mol Genet (2005) 1.38
Synthesis-View: visualization and interpretation of SNP association results for multi-cohort, multi-phenotype data and meta-analysis. BioData Min (2010) 1.37
Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies. Hum Genomics (2006) 1.37
Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics (2004) 1.35
A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. PLoS Genet (2011) 1.35
FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. PLoS One (2010) 1.34
Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study. J Infect Dis (2006) 1.31
Incidence and predictors of end stage renal disease among low-income blacks and whites. PLoS One (2012) 1.29
Genetic risk factors for BMI and obesity in an ethnically diverse population: results from the population architecture using genomics and epidemiology (PAGE) study. Obesity (Silver Spring) (2013) 1.28
Novel methods for detecting epistasis in pharmacogenomics studies. Pharmacogenomics (2007) 1.27
Fine Mapping and Identification of BMI Loci in African Americans. Am J Hum Genet (2013) 1.27
GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease. BMC Bioinformatics (2006) 1.26
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genet Epidemiol (2011) 1.26
The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction. Genet Epidemiol (2006) 1.25
Drosophila CLOCK is constitutively expressed in circadian oscillator and non-oscillator cells. J Biol Rhythms (2006) 1.25
Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia. PLoS Comput Biol (2012) 1.23
Vitamin D receptor gene as a candidate gene for Parkinson disease. Ann Hum Genet (2011) 1.22
The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenet Genomics (2012) 1.21
Model-based multifactor dimensionality reduction for detecting epistasis in case-control data in the presence of noise. Ann Hum Genet (2010) 1.21
Genetic analysis of biological pathway data through genomic randomization. Hum Genet (2011) 1.20
Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity. J Biol Chem (2002) 1.19
Visually integrating and exploring high throughput Phenome-Wide Association Study (PheWAS) results using PheWAS-View. BioData Min (2012) 1.17
Genetic variation in the rhythmonome: ethnic variation and haplotype structure in candidate genes for arrhythmias. Pharmacogenomics (2009) 1.16
High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE. Clin Transl Sci (2012) 1.13
Identifying the genotype behind the phenotype: a role model found in VKORC1 and its association with warfarin dosing. Pharmacogenomics (2007) 1.12
Phase 1 trial of the dengue virus type 4 vaccine candidate rDEN4{Delta}30-4995 in healthy adult volunteers. Am J Trop Med Hyg (2009) 1.11
Vaccinomics, adversomics, and the immune response network theory: individualized vaccinology in the 21st century. Semin Immunol (2013) 1.11
Race-specific impact of atrial fibrillation risk factors in blacks and whites in the southern community cohort study. Am J Cardiol (2012) 1.10
Functional maturation of the human antibody response to rotavirus. J Immunol (2008) 1.09
Patterns of cytokine profiles differ with pregnancy outcome and ethnicity. Hum Reprod (2008) 1.09
Genetic heterogeneity is not as threatening as you might think. Genet Epidemiol (2007) 1.08
Exploring the performance of Multifactor Dimensionality Reduction in large scale SNP studies and in the presence of genetic heterogeneity among epistatic disease models. Hum Hered (2008) 1.08
Alternative Cross-Over Strategies and Selection Techniques for Grammatical Evolution Optimized Neural Networks. Genet Evol Comput Conf (2006) 1.07