Published in Genet Med on October 01, 2010
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation (2010) 3.35
Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping. Clin Pharmacol Ther (2012) 3.16
A translational engine at the national scale: informatics for integrating biology and the bedside. J Am Med Inform Assoc (2011) 2.55
Quality control procedures for genome-wide association studies. Curr Protoc Hum Genet (2011) 2.48
Predicting clopidogrel response using DNA samples linked to an electronic health record. Clin Pharmacol Ther (2011) 2.36
Genome- and phenome-wide analyses of cardiac conduction identifies markers of arrhythmia risk. Circulation (2013) 2.06
Chapter 13: Mining electronic health records in the genomics era. PLoS Comput Biol (2012) 2.00
Predicting warfarin dosage in European-Americans and African-Americans using DNA samples linked to an electronic health record. Pharmacogenomics (2012) 1.66
Modulators of normal electrocardiographic intervals identified in a large electronic medical record. Heart Rhythm (2010) 1.35
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genet Epidemiol (2011) 1.26
The use of a DNA biobank linked to electronic medical records to characterize pharmacogenomic predictors of tacrolimus dose requirement in kidney transplant recipients. Pharmacogenet Genomics (2012) 1.21
Mapping the incidentalome: estimating incidental findings generated through clinical pharmacogenomics testing. Genet Med (2012) 1.17
Secondary use of clinical data: the Vanderbilt approach. J Biomed Inform (2014) 1.12
Leveraging Epidemiologic and Clinical Collections for Genomic Studies of Complex Traits. Hum Hered (2015) 1.00
Accuracy of administratively-assigned ancestry for diverse populations in an electronic medical record-linked biobank. PLoS One (2014) 0.99
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans. Ann Hum Genet (2013) 0.99
Enabling high-throughput genotype-phenotype associations in the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) project as part of the Population Architecture using Genomics and Epidemiology (PAGE) study. Pac Symp Biocomput (2013) 0.93
Characterization of statin dose response in electronic medical records. Clin Pharmacol Ther (2013) 0.93
Inclusion of pediatric samples in an opt-out biorepository linking DNA to de-identified medical records: pediatric BioVU. Clin Pharmacol Ther (2012) 0.91
Assessment of a pharmacogenomic marker panel in a polypharmacy population identified from electronic medical records. Pharmacogenomics (2013) 0.91
Combining billing codes, clinical notes, and medications from electronic health records provides superior phenotyping performance. J Am Med Inform Assoc (2015) 0.90
Racial differences in the prevalence of severe aortic stenosis. J Am Heart Assoc (2014) 0.89
Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records. Front Genet (2014) 0.88
Admixture mapping and subsequent fine-mapping suggests a biologically relevant and novel association on chromosome 11 for type 2 diabetes in African Americans. PLoS One (2014) 0.86
Identifying host genetic risk factors in the context of public health surveillance for invasive pneumococcal disease. PLoS One (2011) 0.86
A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. Pharmacogenomics J (2015) 0.84
Utilization of an EMR-biorepository to identify the genetic predictors of calcineurin-inhibitor toxicity in heart transplant recipients. Pac Symp Biocomput (2014) 0.81
Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations. Hum Genomics (2012) 0.81
DEVELOPMENT AND PERFORMANCE OF TEXT-MINING ALGORITHMS TO EXTRACT SOCIOECONOMIC STATUS FROM DE-IDENTIFIED ELECTRONIC HEALTH RECORDS. Pac Symp Biocomput (2016) 0.77
A common functional promoter variant links CNR1 gene expression to HDL cholesterol level. Nat Commun (2013) 0.77
Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry. BioData Min (2015) 0.77
Genome-wide study of resistant hypertension identified from electronic health records. PLoS One (2017) 0.75
Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases. PLoS One (2016) 0.75
Clinical and Genetic Factors Associated with Cutaneous Squamous Cell Carcinoma in Kidney and Heart Transplant Recipients. Transplant Direct (2015) 0.75
Relation of Obstructive Sleep Apnea and a Common Variant at Chromosome 4q25 to Atrial Fibrillation. Am J Cardiol (2017) 0.75
Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther (2014) 0.75
Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting. Pharmacogenomics (2014) 0.75
Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans. Mol Genet Genomic Med (2016) 0.75
TESTING POPULATION-SPECIFIC QUANTITATIVE TRAIT ASSOCIATIONS FOR CLINICAL OUTCOME RELEVANCE IN A BIOREPOSITORY LINKED TO ELECTRONIC HEALTH RECORDS: LPA AND MYOCARDIAL INFARCTION IN AFRICAN AMERICANS. Pac Symp Biocomput (2016) 0.75
STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION. Pac Symp Biocomput (2016) 0.75
Population Stratification in the Context of Diverse Epidemiologic Surveys Sans Genome-Wide Data. Front Genet (2016) 0.75
Evidence for extensive pleiotropy among pharmacogenes. Pharmacogenomics (2016) 0.75
Extracting Country-of-Origin from Electronic Health Records for Gene- Environment Studies as Part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study. AMIA Jt Summits Transl Sci Proc (2017) 0.75
Replication and fine-mapping of genetic predictors of lipid traits in African-Americans. J Hum Genet (2017) 0.75
Reducing Clinical Noise for Body Mass Index Measures Due to Unit and Transcription Errors in the Electronic Health Record. AMIA Jt Summits Transl Sci Proc (2017) 0.75
Inference of population structure using multilocus genotype data. Genetics (2000) 147.76
Genomic control for association studies. Biometrics (1999) 64.39
Use of unlinked genetic markers to detect population stratification in association studies. Am J Hum Genet (1999) 23.67
Association mapping in structured populations. Am J Hum Genet (2000) 16.79
Development of a large-scale de-identified DNA biobank to enable personalized medicine. Clin Pharmacol Ther (2008) 11.67
A high-density admixture map for disease gene discovery in african americans. Am J Hum Genet (2004) 10.87
The genetic structure and history of Africans and African Americans. Science (2009) 10.65
Population stratification and spurious allelic association. Lancet (2003) 10.53
Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol (1986) 8.22
The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med (2003) 7.94
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44
Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39
Ancestry informative marker sets for determining continental origin and admixture proportions in common populations in America. Hum Mutat (2009) 4.65
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Am J Hum Genet (2004) 4.51
Accounting for ancestry: population substructure and genome-wide association studies. Hum Mol Genet (2008) 3.39
Design and estimation for the National Health Interview Survey, 1995-2004. Vital Health Stat 2 (2000) 2.53
Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis. Neurology (2004) 2.50
Elevated male European and female African contributions to the genomes of African American individuals. Hum Genet (2006) 1.97
Self-reported race and genetic admixture. N Engl J Med (2006) 1.85
Medium- to high-throughput SNP genotyping using VeraCode microbeads. Methods Mol Biol (2009) 1.76
Validity of racial/ethnic classifications in medical records data: an exploratory study. Am J Public Health (2003) 1.69
Transition to the new race/ethnicity data collection standards in the Department of Veterans Affairs. Popul Health Metr (2006) 1.44
Racial and ethnic categories in biomedical research: there is no baby in the bathwater. J Law Med Ethics (2006) 0.96
False positive rates in association studies as a function of degree of stratification. J Bone Miner Res (2004) 0.94
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (2003) 9.91
The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics (2011) 9.20
Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet (2009) 8.44
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med (2002) 8.33
Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature (2009) 8.12
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med (2008) 7.13
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (2010) 7.07
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44
MedEx: a medication information extraction system for clinical narratives. J Am Med Inform Assoc (2010) 6.01
Electronic medical records for genetic research: results of the eMERGE consortium. Sci Transl Med (2011) 5.82
Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39
Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet (2007) 5.09
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet (2005) 5.02
Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
Implementing genomic medicine in the clinic: the future is here. Genet Med (2013) 4.89
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am J Hum Genet (2008) 4.79
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature (2011) 4.56
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future. Genet Med (2013) 4.37
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 4.30
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. J Am Med Inform Assoc (2011) 4.20
Concern Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation (2002) 4.16
A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction. Genet Epidemiol (2007) 4.15
Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest (2006) 4.06
A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood (2008) 4.02
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
A rare variant in MYH6 is associated with high risk of sick sinus syndrome. Nat Genet (2011) 3.94
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet (2008) 3.93
Pattern of sequence variation across 213 environmental response genes. Genome Res (2004) 3.93
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet (2011) 3.85
Principles of human subjects protections applied in an opt-out, de-identified biobank. Clin Transl Sci (2010) 3.84
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet (2012) 3.71
The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. Neuron (2006) 3.55
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease. Am J Hum Genet (2009) 3.54
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am J Hum Genet (2003) 3.39
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med (2009) 3.35
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation (2010) 3.35
Genetics, statistics and human disease: analytical retooling for complexity. Trends Genet (2004) 3.35
Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genet Med (2012) 3.29
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet (2013) 3.21
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet (2006) 3.13
Renin-angiotensin system gene polymorphisms and atrial fibrillation. Circulation (2004) 3.02
Validation of electronic medical record-based phenotyping algorithms: results and lessons learned from the eMERGE network. J Am Med Inform Assoc (2013) 3.00