Published in Genet Med on June 06, 2013
The phenotypic legacy of admixture between modern humans and Neandertals. Science (2016) 2.20
How Next-Generation Sequencing and Multiscale Data Analysis Will Transform Infectious Disease Management. Clin Infect Dis (2015) 2.12
Electronic health records-driven phenotyping: challenges, recent advances, and perspectives. J Am Med Inform Assoc (2013) 1.85
Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems. Clin Pharmacol Ther (2014) 1.73
Pharmacogenomics in the clinic. Nature (2015) 1.71
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol (2015) 1.64
Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk. Nat Genet (2014) 1.61
Privacy in the Genomic Era. ACM Comput Surv (2015) 1.40
Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine. Am J Hum Genet (2016) 1.35
Biobanks and electronic medical records: enabling cost-effective research. Sci Transl Med (2014) 1.32
Opportunities for genomic clinical decision support interventions. Genet Med (2013) 1.31
eMERGEing progress in genomics-the first seven years. Front Genet (2014) 1.30
Global implementation of genomic medicine: We are not alone. Sci Transl Med (2015) 1.30
Strategic opportunities in sleep and circadian research: report of the Joint Task Force of the Sleep Research Society and American Academy of Sleep Medicine. Sleep (2014) 1.29
Building the foundation for genomics in precision medicine. Nature (2015) 1.28
Validating drug repurposing signals using electronic health records: a case study of metformin associated with reduced cancer mortality. J Am Med Inform Assoc (2014) 1.25
Imputation and quality control steps for combining multiple genome-wide datasets. Front Genet (2014) 1.21
CSER and eMERGE: current and potential state of the display of genetic information in the electronic health record. J Am Med Inform Assoc (2015) 1.20
Metformin pharmacogenomics: current status and future directions. Diabetes (2014) 1.15
Genetic-based prediction of disease traits: prediction is very difficult, especially about the future. Front Genet (2014) 1.12
Ethical, legal, and social implications of incorporating genomic information into electronic health records. Genet Med (2013) 1.11
PheKB: a catalog and workflow for creating electronic phenotype algorithms for transportability. J Am Med Inform Assoc (2016) 1.10
Big data and biomedical informatics: a challenging opportunity. Yearb Med Inform (2014) 1.02
An eMERGE Clinical Center at Partners Personalized Medicine. J Pers Med (2016) 1.02
Characterizing genetic variants for clinical action. Am J Med Genet C Semin Med Genet (2014) 1.02
Are physicians prepared for whole genome sequencing? a qualitative analysis. Clin Genet (2015) 1.00
Stakeholder engagement: a key component of integrating genomic information into electronic health records. Genet Med (2013) 1.00
Opportunities and challenges in developing risk prediction models with electronic health records data: a systematic review. J Am Med Inform Assoc (2016) 1.00
Return of results in the genomic medicine projects of the eMERGE network. Front Genet (2014) 0.99
Integration of genomics into the electronic health record: mapping terra incognita. Genet Med (2013) 0.98
The need for clinical decision support integrated with the electronic health record for the clinical application of whole genome sequencing information. J Pers Med (2013) 0.97
Extracting research-quality phenotypes from electronic health records to support precision medicine. Genome Med (2015) 0.95
Clinical integration of next generation sequencing: coverage and reimbursement challenges. J Law Med Ethics (2014) 0.95
Defining disease phenotypes using national linked electronic health records: a case study of atrial fibrillation. PLoS One (2014) 0.94
Characterization of statin dose response in electronic medical records. Clin Pharmacol Ther (2013) 0.93
Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index. Front Genet (2014) 0.92
A Template for Authoring and Adapting Genomic Medicine Content in the eMERGE Infobutton Project. AMIA Annu Symp Proc (2014) 0.92
Automated extraction of clinical traits of multiple sclerosis in electronic medical records. J Am Med Inform Assoc (2013) 0.92
Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease. J Crohns Colitis (2014) 0.91
A game theoretic framework for analyzing re-identification risk. PLoS One (2015) 0.91
Phenome-Wide Association Studies: Leveraging Comprehensive Phenotypic and Genotypic Data for Discovery. Curr Genet Med Rep (2015) 0.90
Design and Implementation of the International Genetics and Translational Research in Transplantation Network. Transplantation (2015) 0.90
Identification of Nonresponse to Treatment Using Narrative Data in an Electronic Health Record Inflammatory Bowel Disease Cohort. Inflamm Bowel Dis (2016) 0.89
A study of active learning methods for named entity recognition in clinical text. J Biomed Inform (2015) 0.89
The Geisinger MyCode community health initiative: an electronic health record-linked biobank for precision medicine research. Genet Med (2016) 0.89
Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records. Front Genet (2014) 0.88
Prioritizing Approaches to Engage Community Members and Build Trust in Biobanks: A Survey of Attitudes and Opinions of Adults within Outpatient Practices at the University of Maryland. J Pers Med (2015) 0.88
Genetic variation in the HLA region is associated with susceptibility to herpes zoster. Genes Immun (2014) 0.87
The electronic health record for translational research. J Cardiovasc Transl Res (2014) 0.86
The potential of translational bioinformatics approaches for pharmacology research. Br J Clin Pharmacol (2015) 0.86
Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example. Front Genet (2014) 0.86
Mechanistic phenotypes: an aggregative phenotyping strategy to identify disease mechanisms using GWAS data. PLoS One (2013) 0.86
Copy number variation analysis in the context of electronic medical records and large-scale genomics consortium efforts. Front Genet (2014) 0.86
Privacy-preserving GWAS analysis on federated genomic datasets. BMC Med Inform Decis Mak (2015) 0.86
Genetic variation among 82 pharmacogenes: The PGRNseq data from the eMERGE network. Clin Pharmacol Ther (2016) 0.86
Update on abdominal aortic aneurysm research: from clinical to genetic studies. Scientifica (Cairo) (2014) 0.85
Development and validation of an electronic phenotyping algorithm for chronic kidney disease. AMIA Annu Symp Proc (2014) 0.85
Data-driven discovery of seasonally linked diseases from an Electronic Health Records system. BMC Bioinformatics (2014) 0.84
R-U policy frontiers for health data de-identification. J Am Med Inform Assoc (2015) 0.84
Genomic medicine, precision medicine, personalized medicine: what's in a name? Clin Pharmacol Ther (2013) 0.84
Penetrance of Hemochromatosis in HFE Genotypes Resulting in p.Cys282Tyr and p.[Cys282Tyr];[His63Asp] in the eMERGE Network. Am J Hum Genet (2015) 0.84
Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity. Circ Res (2014) 0.84
A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. Pharmacogenomics J (2015) 0.84
Adapting bioinformatics curricula for big data. Brief Bioinform (2015) 0.84
Learning statistical models of phenotypes using noisy labeled training data. J Am Med Inform Assoc (2016) 0.83
Biological data sciences in genome research. Genome Res (2015) 0.83
Disease progression subtype discovery from longitudinal EMR data with a majority of missing values and unknown initial time points. AMIA Annu Symp Proc (2014) 0.83
Biology-Driven Gene-Gene Interaction Analysis of Age-Related Cataract in the eMERGE Network. Genet Epidemiol (2015) 0.83
A proposed clinical decision support architecture capable of supporting whole genome sequence information. J Pers Med (2014) 0.83
Genomic architecture of pharmacological efficacy and adverse events. Pharmacogenomics (2014) 0.83
Interdisciplinary training to build an informatics workforce for precision medicine. Appl Transl Genom (2015) 0.83
Creation of an Accurate Algorithm to Detect Snellen Best Documented Visual Acuity from Ophthalmology Electronic Health Record Notes. JMIR Med Inform (2016) 0.83
Personalized medicine going precise: from genomics to microbiomics. Trends Mol Med (2015) 0.83
Surveying Recent Themes in Translational Bioinformatics: Big Data in EHRs, Omics for Drugs, and Personal Genomics. Yearb Med Inform (2014) 0.83
Phenome-Wide Association Studies as a Tool to Advance Precision Medicine. Annu Rev Genomics Hum Genet (2016) 0.83
Practical considerations in genomic decision support: The eMERGE experience. J Pathol Inform (2015) 0.82
The undiscovered country: the future of integrating genomic information into the EHR. Genet Med (2013) 0.82
Pharmacogenomics in oncology care. Front Genet (2014) 0.82
Big Data Technologies: New Opportunities for Diabetes Management. J Diabetes Sci Technol (2015) 0.82
The Southeastern Minnesota Beacon Project for Community-driven Health Information Technology: Origins, Achievements, and Legacy. EGEMS (Wash DC) (2014) 0.81
Common Genetic Variants Influence Circulating Vitamin D Levels in Inflammatory Bowel Diseases. Inflamm Bowel Dis (2015) 0.81
Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes. Front Genet (2014) 0.81
Defining Disease Phenotypes in Primary Care Electronic Health Records by a Machine Learning Approach: A Case Study in Identifying Rheumatoid Arthritis. PLoS One (2016) 0.81
Longitudinal SNP-set association analysis of quantitative phenotypes. Genet Epidemiol (2016) 0.80
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci. Circ Res (2016) 0.80
ePhenotyping for Abdominal Aortic Aneurysm in the Electronic Medical Records and Genomics (eMERGE) Network: Algorithm Development and Konstanz Information Miner Workflow. Int J Biomed Data Min (2015) 0.79
Ease of adoption of clinical natural language processing software: An evaluation of five systems. J Biomed Inform (2015) 0.79
At the Interface between Medical Informatics and Personalized Medicine: The eMERGE Network Experience. Healthc Inform Res (2013) 0.79
The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research. Front Genet (2015) 0.78
Advances in risk prediction of type 2 diabetes: integrating genetic scores with Framingham risk models. Diabetes (2015) 0.78
An epidemiological perspective of personalized medicine: the Estonian experience. J Intern Med (2015) 0.78
A conceptual model for translating omic data into clinical action. J Pathol Inform (2015) 0.78
Phenome-Wide Association Study of Rheumatoid Arthritis Subgroups Identifies Association between Seronegative Disease and Fibromyalgia. Arthritis Rheumatol (2016) 0.78
Governing the research-care divide in clinical biobanking: Dutch perspectives. Life Sci Soc Policy (2015) 0.78
Size matters: how population size influences genotype-phenotype association studies in anonymized data. J Biomed Inform (2014) 0.78
Development and validation of method for defining conditions using Chinese electronic medical record. BMC Med Inform Decis Mak (2016) 0.77
Merging Electronic Health Record Data and Genomics for Cardiovascular Research: A Science Advisory From the American Heart Association. Circ Cardiovasc Genet (2016) 0.77
Scalable and High-Throughput Execution of Clinical Quality Measures from Electronic Health Records using MapReduce and the JBoss® Drools Engine. AMIA Annu Symp Proc (2014) 0.77
Boosting for high-dimensional two-class prediction. BMC Bioinformatics (2015) 0.77
KNOWLEDGE DRIVEN BINNING AND PHEWAS ANALYSIS IN MARSHFIELD PERSONALIZED MEDICINE RESEARCH PROJECT USING BIOBIN. Pac Symp Biocomput (2016) 0.77
A map of human genome variation from population-scale sequencing. Nature (2010) 121.13
The "meaningful use" regulation for electronic health records. N Engl J Med (2010) 23.27
A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am J Hum Genet (2009) 17.80
The continuum of translation research in genomic medicine: how can we accelerate the appropriate integration of human genome discoveries into health care and disease prevention? Genet Med (2007) 9.48
Charting a course for genomic medicine from base pairs to bedside. Nature (2011) 9.39
The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics (2011) 9.20
Deploying whole genome sequencing in clinical practice and public health: meeting the challenge one bin at a time. Genet Med (2011) 8.48
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (2010) 7.07
Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group. Circ Cardiovasc Genet (2010) 6.74
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44
Implementing genomic medicine in the clinic: the future is here. Genet Med (2013) 4.89
Subjects matter: a survey of public opinions about a large genetic cohort study. Genet Med (2008) 4.52
Offering individual genetic research results: context matters. Sci Transl Med (2010) 4.51
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study. J Am Med Inform Assoc (2011) 4.20
Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies. Am J Hum Genet (2011) 3.85
National Institutes of Health approaches to dissemination and implementation science: current and future directions. Am J Public Health (2012) 3.72
Effect of clinical decision-support systems: a systematic review. Ann Intern Med (2012) 3.42
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science. Circulation (2010) 3.35
Return of individual research results from genome-wide association studies: experience of the Electronic Medical Records and Genomics (eMERGE) Network. Genet Med (2012) 3.29
Building a robust, scalable and standards-driven infrastructure for secondary use of EHR data: the SHARPn project. J Biomed Inform (2012) 2.97
A genome-wide association meta-analysis identifies new childhood obesity loci. Nat Genet (2012) 2.60
A genome-wide association study of red blood cell traits using the electronic medical record. PLoS One (2010) 2.59
The disclosure of diagnosis codes can breach research participants' privacy. J Am Med Inform Assoc (2010) 2.45
An evaluation of the NQF Quality Data Model for representing Electronic Health Record driven phenotyping algorithms. AMIA Annu Symp Proc (2012) 2.29
Anonymization of electronic medical records for validating genome-wide association studies. Proc Natl Acad Sci U S A (2010) 2.24
Effects of clinical decision-support systems on practitioner performance and patient outcomes: a synthesis of high-quality systematic review findings. J Am Med Inform Assoc (2011) 2.12
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network. Hum Genet (2011) 2.00
Ethical and practical challenges of sharing data from genome-wide association studies: the eMERGE Consortium experience. Genome Res (2011) 1.91
Complement receptor 1 gene variants are associated with erythrocyte sedimentation rate. Am J Hum Genet (2011) 1.66
Crossing the omic chasm: a time for omic ancillary systems. JAMA (2013) 1.59
Never too old for anonymity: a statistical standard for demographic data sharing via the HIPAA Privacy Rule. J Am Med Inform Assoc (2010) 1.57
Leveraging the electronic health record to implement genomic medicine. Genet Med (2012) 1.42
Debating clinical utility. Public Health Genomics (2010) 1.41
The clinical bioinformatics ontology: a curated semantic network utilizing RefSeq information. Pac Symp Biocomput (2005) 1.39
Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality. Genet Epidemiol (2011) 1.26
Modeling and executing electronic health records driven phenotyping algorithms using the NQF Quality Data Model and JBoss® Drools Engine. AMIA Annu Symp Proc (2012) 1.23
Beyond base pairs to bedside: a population perspective on how genomics can improve health. Am J Public Health (2011) 1.21
Effects of computerized clinical decision support systems on practitioner performance and patient outcomes: methods of a decision-maker-researcher partnership systematic review. Implement Sci (2010) 1.19
Status of clinical gene sequencing data reporting and associated risks for information loss. J Biomed Inform (2006) 1.14
Genomics reaches the clinic: from basic discoveries to clinical impact. Cell (2011) 1.07
Secure construction of k-unlinkable patient records from distributed providers. Artif Intell Med (2009) 0.98
Anonymization of administrative billing codes with repeated diagnoses through censoring. AMIA Annu Symp Proc (2010) 0.98
Transforming clinical quality measures for EHR use. NQF refines emeasures for use in EHRs and meaningful use program. J AHIMA (2011) 0.95
Methodological consequences of situation specificity: biases in assessments. Front Psychol (2011) 0.87
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A (2009) 54.68
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res (2010) 43.51
ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing. Genet Med (2013) 22.73
PennCNV: an integrated hidden Markov model designed for high-resolution copy number variation detection in whole-genome SNP genotyping data. Genome Res (2007) 19.07
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature (2012) 16.13
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Rare variants create synthetic genome-wide associations. PLoS Biol (2010) 14.43
Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nat Genet (2007) 14.05
New models of collaboration in genome-wide association studies: the Genetic Association Information Network. Nat Genet (2007) 13.76
Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies. Am J Hum Genet (2010) 13.70
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Mayo clinical Text Analysis and Knowledge Extraction System (cTAKES): architecture, component evaluation and applications. J Am Med Inform Assoc (2010) 13.18
Prepublication data sharing. Nature (2009) 12.24
BioPortal: ontologies and integrated data resources at the click of a mouse. Nucleic Acids Res (2009) 10.58
Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). J Am Med Inform Assoc (2010) 10.51
Identifying patient smoking status from medical discharge records. J Am Med Inform Assoc (2007) 10.35
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
TGF-beta and epithelial-to-mesenchymal transitions. Oncogene (2005) 10.02
Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics (2003) 9.91
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature (2009) 9.47
The eMERGE Network: a consortium of biorepositories linked to electronic medical records data for conducting genomic studies. BMC Med Genomics (2011) 9.20
Gene regulation and DNA damage in the ageing human brain. Nature (2004) 9.01
Genome partitioning of genetic variation for complex traits using common SNPs. Nat Genet (2011) 8.57
Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet (2009) 8.44
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nat Genet (2013) 8.02
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet (2011) 7.98
How to interpret a genome-wide association study. JAMA (2008) 7.54
Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature (2009) 7.39
Identification of ALK as a major familial neuroblastoma predisposition gene. Nature (2008) 7.38
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. PLoS One (2008) 7.16
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
Genetic determinants of response to warfarin during initial anticoagulation. N Engl J Med (2008) 7.13
PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations. Bioinformatics (2010) 7.07
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83
Ethical and practical guidelines for reporting genetic research results to study participants: updated guidelines from a National Heart, Lung, and Blood Institute working group. Circ Cardiovasc Genet (2010) 6.74
The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet (2008) 6.72
Analysing biological pathways in genome-wide association studies. Nat Rev Genet (2010) 6.63
The Group Health medical home at year two: cost savings, higher patient satisfaction, and less burnout for providers. Health Aff (Millwood) (2010) 6.60
Robust replication of genotype-phenotype associations across multiple diseases in an electronic medical record. Am J Hum Genet (2010) 6.44
Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial. JAMA (2008) 6.04
MedEx: a medication information extraction system for clinical narratives. J Am Med Inform Assoc (2010) 6.01
Architecture of the open-source clinical research chart from Informatics for Integrating Biology and the Bedside. AMIA Annu Symp Proc (2007) 5.89
Electronic medical records for genetic research: results of the eMERGE consortium. Sci Transl Med (2011) 5.82
Dementia and Alzheimer disease incidence: a prospective cohort study. Arch Neurol (2002) 5.69
Patient-centered medical home demonstration: a prospective, quasi-experimental, before and after evaluation. Am J Manag Care (2009) 5.65
Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat Genet (2010) 5.52
Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47
Cardiovascular mortality risk in chronic kidney disease: comparison of traditional and novel risk factors. JAMA (2005) 5.46
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat Genet (2004) 5.31
Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes (2006) 5.29
De novo mutations in histone-modifying genes in congenital heart disease. Nature (2013) 5.15
Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet (2007) 5.09
Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol (2007) 5.02
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population. Nat Genet (2010) 4.96
Glucose levels and risk of dementia. N Engl J Med (2013) 4.95
Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94
Implementing genomic medicine in the clinic: the future is here. Genet Med (2013) 4.89
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat Biotechnol (2013) 4.85