Published in Development on May 21, 2008
Comparative metabolomics reveals endogenous ligands of DAF-12, a nuclear hormone receptor, regulating C. elegans development and lifespan. Cell Metab (2014) 1.60
A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity. PLoS Biol (2012) 1.07
The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity. Aging Cell (2011) 1.03
RNAseq analysis of the parasitic nematode Strongyloides stercoralis reveals divergent regulation of canonical dauer pathways. PLoS Negl Trop Dis (2012) 1.00
Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Dev Biol (2010) 0.98
Hormonal signal amplification mediates environmental conditions during development and controls an irreversible commitment to adulthood. PLoS Biol (2012) 0.94
TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans. PLoS Genet (2013) 0.94
Steroids as central regulators of organismal development and lifespan. PLoS Biol (2012) 0.89
EAK proteins: novel conserved regulators of C. elegans lifespan. Aging (Albany NY) (2010) 0.86
CUP-1 is a novel protein involved in dietary cholesterol uptake in Caenorhabditis elegans. PLoS One (2012) 0.83
A potential biochemical mechanism underlying the influence of sterol deprivation stress on Caenorhabditis elegans longevity. J Biol Chem (2010) 0.79
DANSing with Caenorhabditis elegans. Proc Natl Acad Sci U S A (2009) 0.79
The impact of mitochondrial oxidative stress on bile acid-like molecules in C. elegans provides a new perspective on human metabolic diseases. Worm (2013) 0.78
The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry. Front Endocrinol (Lausanne) (2016) 0.75
Lipid and Carbohydrate Metabolism in Caenorhabditis elegans. Genetics (2017) 0.75
Small-molecule pheromones and hormones controlling nematode development. Nat Chem Biol (2017) 0.75
A uniform system for microRNA annotation. RNA (2003) 20.28
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95
Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol (2002) 7.91
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature (2003) 7.80
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet (2002) 6.26
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature (2004) 5.57
Computational and experimental identification of C. elegans microRNAs. Mol Cell (2003) 5.22
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science (2003) 4.91
DAF-16 target genes that control C. elegans life-span and metabolism. Science (2003) 4.57
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell (2006) 4.50
Functional genomic analysis of RNA interference in C. elegans. Science (2005) 4.36
Fat metabolism links germline stem cells and longevity in C. elegans. Science (2008) 3.95
Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet (2007) 3.83
A systematic RNAi screen for longevity genes in C. elegans. Genes Dev (2005) 3.78
Systematic analysis of genes required for synapse structure and function. Nature (2005) 3.67
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev (2009) 3.42
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev (2003) 3.22
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature (2005) 2.98
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab (2009) 2.85
Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell (2012) 2.81
Polygenic control of Caenorhabditis elegans fat storage. Nat Genet (2006) 2.46
Analysis of xbx genes in C. elegans. Development (2005) 2.39
Functional genomic analysis of C. elegans molting. PLoS Biol (2005) 2.39
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell (2013) 2.35
Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Proc Natl Acad Sci U S A (2011) 2.11
Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A (2009) 1.96
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature (2012) 1.92
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development (2006) 1.86
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev (2007) 1.85
RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods (2011) 1.82
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79
A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol (2007) 1.77
Clarifications on miRNA and cancer. Science (2006) 1.69
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol (2013) 1.69
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature (2009) 1.63
MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev (2008) 1.59
MicroRNA-21 targets LRRFIP1 and contributes to VM-26 resistance in glioblastoma multiforme. Brain Res (2009) 1.55
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature (2008) 1.51
An image analysis toolbox for high-throughput C. elegans assays. Nat Methods (2012) 1.48
Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development (2004) 1.48
Functional tests of enhancer conservation between distantly related species. Development (2003) 1.46
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell (2004) 1.40
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet (2012) 1.36
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol (2008) 1.34
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem (2002) 1.32
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30
Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet (2012) 1.28
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 1.23
Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evol Dev (2003) 1.23
Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe (2013) 1.22
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev (2013) 1.22
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet (2006) 1.20
Expression analysis of ABC transporters reveals differential functions of tandemly duplicated genes in Caenorhabditis elegans. J Mol Biol (2004) 1.19
Miniprimer PCR, a new lens for viewing the microbial world. Appl Environ Microbiol (2007) 1.16
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One (2009) 1.16
A cytoprotective perspective on longevity regulation. Trends Cell Biol (2013) 1.15
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet (2011) 1.13
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development (2002) 1.13
Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics (2007) 1.09
Detection of broadly expressed neuronal genes in C. elegans. Dev Biol (2006) 1.03
MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev (2012) 0.96
Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol (2013) 0.96
The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Curr Biol (2012) 0.96
MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell (2010) 0.95
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet (2012) 0.94
The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development (2003) 0.93
High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res (2013) 0.93
The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2012) 0.91
Regulation of the C. elegans molt by pqn-47. Dev Biol (2011) 0.90
Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One (2012) 0.90
Carboxyl terminus of Hsp70-interacting protein (CHIP) contributes to human glioma oncogenesis. Cancer Sci (2011) 0.89
Characterizing the role of PCDH9 in the regulation of glioma cell apoptosis and invasion. J Mol Neurosci (2013) 0.86
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A (2003) 0.85
The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph (2008) 0.84
High bone sialoprotein (BSP) expression correlates with increased tumor grade and predicts a poorer prognosis of high-grade glioma patients. PLoS One (2012) 0.83
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev (2011) 0.83
Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev (2013) 0.81
Radiation resistance of biological reagents for in situ life detection. Astrobiology (2013) 0.81
High cytoplasmic FOXO1 and pFOXO1 expression in astrocytomas are associated with worse surgical outcome. PLoS One (2013) 0.79
Cancer. Germ cell genes and cancer. Science (2010) 0.79
A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci (2006) 0.79
New insights into siRNA amplification and RNAi. RNA Biol (2012) 0.78
Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet (2013) 0.78
Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. PLoS One (2013) 0.77
MicroRNAs visit the ER. Cell (2013) 0.75
Pathogens. Virulence (2014) 0.75
Longevity: don't hold your breath. Nature (2002) 0.75
Unraveling the secrets of the cell. Newsweek (2003) 0.75
Radiation resistance of sequencing chips for in situ life detection. Astrobiology (2013) 0.75
Relationship between CacyBP/SIP expression and prognosis in astrocytoma. J Clin Neurosci (2011) 0.75
Simultaneous determination of 23 flavor additives in tobacco products using gas chromatography-triple quadrupole mass spectrometry. J Chromatogr A (2013) 0.75