Published in Nat Genet on February 05, 2006
Cilia and developmental signaling. Annu Rev Cell Dev Biol (2007) 4.88
Fat metabolism links germline stem cells and longevity in C. elegans. Science (2008) 3.95
The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia. Cell (2010) 3.83
Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet (2007) 3.83
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev (2009) 3.42
Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy. J Clin Invest (2009) 3.19
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab (2009) 2.85
Insulin, cGMP, and TGF-beta signals regulate food intake and quiescence in C. elegans: a model for satiety. Cell Metab (2008) 2.31
The influence of bacterial diet on fat storage in C. elegans. PLoS One (2009) 2.15
Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biol (2009) 2.15
Bardet-Biedl syndrome: beyond the cilium. Pediatr Nephrol (2007) 2.14
Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Science (2008) 2.09
Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metab (2008) 1.99
Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A (2009) 1.96
Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metab (2008) 1.93
Fat synthesis and adiposity regulation in Caenorhabditis elegans. Trends Endocrinol Metab (2009) 1.91
Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles. Mol Biol Cell (2007) 1.82
A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS One (2010) 1.69
Unraveling the genetics of human obesity. PLoS Genet (2006) 1.63
The Causative Gene in Chanarian Dorfman Syndrome Regulates Lipid Droplet Homeostasis in C. elegans. PLoS Genet (2015) 1.43
Lessons from "lower" organisms: what worms, flies, and zebrafish can teach us about human energy metabolism. PLoS Genet (2007) 1.43
C. elegans feeding. WormBook (2012) 1.42
Genetic and dietary regulation of lipid droplet expansion in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 1.39
Ascaroside signaling in C. elegans. WormBook (2013) 1.35
Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation. Proc Natl Acad Sci U S A (2009) 1.33
Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. Hum Mol Genet (2009) 1.31
Lipid droplets as ubiquitous fat storage organelles in C. elegans. BMC Cell Biol (2010) 1.29
Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins. J Cell Sci (2009) 1.26
Identification of ciliary and ciliopathy genes in Caenorhabditis elegans through comparative genomics. Genome Biol (2006) 1.25
A neuromedin U receptor acts with the sensory system to modulate food type-dependent effects on C. elegans lifespan. PLoS Biol (2010) 1.19
Visualizing digestive organ morphology and function using differential fatty acid metabolism in live zebrafish. Dev Biol (2011) 1.19
Lipid droplets as fat storage organelles in Caenorhabditis elegans: Thematic Review Series: Lipid Droplet Synthesis and Metabolism: from Yeast to Man. J Lipid Res (2011) 1.13
Fluorescence-based fixative and vital staining of lipid droplets in Caenorhabditis elegans reveal fat stores using microscopy and flow cytometry approaches. J Lipid Res (2011) 1.12
Sensory roles of neuronal cilia: cilia development, morphogenesis, and function in C. elegans. Front Biosci (2008) 1.10
Biochemical and high throughput microscopic assessment of fat mass in Caenorhabditis elegans. J Vis Exp (2013) 1.09
The tubby family proteins. Genome Biol (2011) 1.07
An essential role for DYF-11/MIP-T3 in assembling functional intraflagellar transport complexes. PLoS Genet (2008) 1.06
Tripeptidyl peptidase II promotes fat formation in a conserved fashion. EMBO Rep (2007) 1.04
Caenorhabditis elegans as an emerging model for studying the basic biology of obesity. Dis Model Mech (2009) 1.02
Molecular basis of the obesity associated with Bardet-Biedl syndrome. Trends Endocrinol Metab (2011) 1.01
Seasonal and regional differences in gene expression in the brain of a hibernating mammal. PLoS One (2013) 1.00
Two very long chain fatty acid acyl-CoA synthetase genes, acs-20 and acs-22, have roles in the cuticle surface barrier in Caenorhabditis elegans. PLoS One (2010) 0.99
Animal models of gene-nutrient interactions. Obesity (Silver Spring) (2008) 0.95
The EGL-4 PKG acts with KIN-29 salt-inducible kinase and protein kinase A to regulate chemoreceptor gene expression and sensory behaviors in Caenorhabditis elegans. Genetics (2008) 0.93
Autophagy genes are required for normal lipid levels in C. elegans. Autophagy (2013) 0.93
Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. PLoS Biol (2011) 0.93
Nuclear cGMP-dependent kinase regulates gene expression via activity-dependent recruitment of a conserved histone deacetylase complex. PLoS Genet (2011) 0.91
Sensory perception of food and insulin-like signals influence seizure susceptibility. PLoS Genet (2008) 0.91
Imaging lipid metabolism in live Caenorhabditis elegans using fingerprint vibrations. Angew Chem Int Ed Engl (2014) 0.90
Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport. J Biol Chem (2011) 0.89
Small GTPases and cilia. Protein Cell (2011) 0.89
Generation and modulation of chemosensory behaviors in C. elegans. Pflugers Arch (2007) 0.88
The regulation of feeding and metabolism in response to food deprivation in Caenorhabditis elegans. Invert Neurosci (2010) 0.86
Circannual transitions in gene expression: lessons from seasonal adaptations. Curr Top Dev Biol (2013) 0.86
From the cytoplasm into the cilium: bon voyage. Organogenesis (2014) 0.86
Imaging vertebrate digestive function and lipid metabolism in vivo. Drug Discov Today Dis Models (2013) 0.85
Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. BMC Genomics (2013) 0.85
Pervasive divergence of transcriptional gene regulation in Caenorhabditis nematodes. PLoS Genet (2014) 0.85
3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. Proc Natl Acad Sci U S A (2010) 0.84
Polymorphisms of the TUB gene are associated with body composition and eating behavior in middle-aged women. PLoS One (2008) 0.83
Appetite Control: worm's-eye-view. Animal Cells Syst (Seoul) (2012) 0.83
Mitochondrial-Nuclear Epistasis Impacts Fitness and Mitochondrial Physiology of Interpopulation Caenorhabditis briggsae Hybrids. G3 (Bethesda) (2015) 0.83
Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1. Mol Biol Cell (2014) 0.82
Environmental exposure, obesity, and Parkinson's disease: lessons from fat and old worms. Environ Health Perspect (2010) 0.82
AMP-Activated Kinase Regulates Lipid Droplet Localization and Stability of Adipose Triglyceride Lipase in C. elegans Dauer Larvae. PLoS One (2015) 0.80
Diverse cell type-specific mechanisms localize G protein-coupled receptors to Caenorhabditis elegans sensory cilia. Genetics (2014) 0.79
Behavioral and metabolic effects of the atypical antipsychotic ziprasidone on the nematode Caenorhabditis elegans. PLoS One (2013) 0.79
Cilia, tubby mice, and obesity. Cilia (2013) 0.79
The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans. Genetics (2015) 0.79
Impact of a Complex Food Microbiota on Energy Metabolism in the Model Organism Caenorhabditis elegans. Biomed Res Int (2015) 0.78
Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet (2013) 0.78
Fine tuning of RFX/DAF-19-regulated target gene expression through binding to multiple sites in Caenorhabditis elegans. Nucleic Acids Res (2011) 0.76
Clonorchis sinensis acetoacetyl-CoA thiolase: identification and characterization of its potential role in surviving in the bile duct. Parasit Vectors (2015) 0.76
Isolation and characterization of the TIGA genes, whose transcripts are induced by growth arrest. Nucleic Acids Res (2006) 0.76
Characterization of taurine as anti-obesity agent in C. elegans. J Biomed Sci (2010) 0.75
Quantitative Assessment of Fat Levels in Caenorhabditis elegans Using Dark Field Microscopy. G3 (Bethesda) (2017) 0.75
Sequestration of ubiquitous dietary derived pigments enables mitochondrial light sensing. Sci Rep (2016) 0.75
Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans. Trends Endocrinol Metab (2016) 0.75
Ectopic fat deposition contributes to age-associated pathology in Caenorhabditis elegans. J Lipid Res (2016) 0.75
Aspirin increases metabolism through germline signalling to extend the lifespan of Caenorhabditis elegans. PLoS One (2017) 0.75
A uniform system for microRNA annotation. RNA (2003) 20.28
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95
Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol (2002) 7.91
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature (2003) 7.80
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet (2002) 6.26
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature (2004) 5.57
Computational and experimental identification of C. elegans microRNAs. Mol Cell (2003) 5.22
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science (2003) 4.91
DAF-16 target genes that control C. elegans life-span and metabolism. Science (2003) 4.57
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell (2006) 4.50
Functional genomic analysis of RNA interference in C. elegans. Science (2005) 4.36
Fat metabolism links germline stem cells and longevity in C. elegans. Science (2008) 3.95
Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet (2007) 3.83
A systematic RNAi screen for longevity genes in C. elegans. Genes Dev (2005) 3.78
Systematic analysis of genes required for synapse structure and function. Nature (2005) 3.67
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev (2009) 3.42
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev (2003) 3.22
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature (2005) 2.98
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab (2009) 2.85
Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell (2012) 2.81
Analysis of xbx genes in C. elegans. Development (2005) 2.39
Functional genomic analysis of C. elegans molting. PLoS Biol (2005) 2.39
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell (2013) 2.35
Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A (2009) 1.96
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature (2012) 1.92
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development (2006) 1.86
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev (2007) 1.85
RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods (2011) 1.82
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79
A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol (2007) 1.77
Clarifications on miRNA and cancer. Science (2006) 1.69
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol (2013) 1.69
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature (2009) 1.63
MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev (2008) 1.59
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature (2008) 1.51
An image analysis toolbox for high-throughput C. elegans assays. Nat Methods (2012) 1.48
Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development (2004) 1.48
Functional tests of enhancer conservation between distantly related species. Development (2003) 1.46
The chitin synthase genes chs-1 and chs-2 are essential for C. elegans development and responsible for chitin deposition in the eggshell and pharynx, respectively. Dev Biol (2005) 1.41
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell (2004) 1.40
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet (2012) 1.36
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol (2008) 1.34
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem (2002) 1.32
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30
Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet (2012) 1.28
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 1.23
Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evol Dev (2003) 1.23
Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe (2013) 1.22
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev (2013) 1.22
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet (2006) 1.20
Miniprimer PCR, a new lens for viewing the microbial world. Appl Environ Microbiol (2007) 1.16
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One (2009) 1.16
A cytoprotective perspective on longevity regulation. Trends Cell Biol (2013) 1.15
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet (2011) 1.13
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development (2002) 1.13
Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics (2007) 1.09
Detection of broadly expressed neuronal genes in C. elegans. Dev Biol (2006) 1.03
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development (2008) 1.03
MicroRNAs loom large in the heart. Nat Med (2007) 1.00
MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev (2012) 0.96
Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol (2013) 0.96
The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Curr Biol (2012) 0.96
MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell (2010) 0.95
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet (2012) 0.94
High-throughput sequencing reveals extraordinary fluidity of miRNA, piRNA, and siRNA pathways in nematodes. Genome Res (2013) 0.93
The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development (2003) 0.93
The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2012) 0.91
Regulation of the C. elegans molt by pqn-47. Dev Biol (2011) 0.90
Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One (2012) 0.90
Activity of the Caenorhabditis elegans UNC-86 POU transcription factor modulates olfactory sensitivity. Proc Natl Acad Sci U S A (2003) 0.85
The most conserved genome segments for life detection on Earth and other planets. Orig Life Evol Biosph (2008) 0.84
The Caenorhabditis elegans SOMI-1 zinc finger protein and SWI/SNF promote regulation of development by the mir-84 microRNA. Genes Dev (2011) 0.83
Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev (2013) 0.81
Radiation resistance of biological reagents for in situ life detection. Astrobiology (2013) 0.81
A novel cyclophilin from parasitic and free-living nematodes with a unique substrate- and drug-binding domain. J Biol Chem (2002) 0.80
Cancer. Germ cell genes and cancer. Science (2010) 0.79
A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans. Nat Neurosci (2006) 0.79
New insights into siRNA amplification and RNAi. RNA Biol (2012) 0.78
Genetic regulation of Caenorhabditis elegans lysosome related organelle function. PLoS Genet (2013) 0.78
Dual regulation of the lin-14 target mRNA by the lin-4 miRNA. PLoS One (2013) 0.77
Singling out heart cells. Nat Med (2007) 0.76
Thalidomide's early effects. Nat Med (2010) 0.75
Pathogens. Virulence (2014) 0.75
Notable advances 2016. Nat Med (2016) 0.75
Notable advances 2011. Nat Med (2011) 0.75
Longevity: don't hold your breath. Nature (2002) 0.75
MicroRNAs visit the ER. Cell (2013) 0.75
Notable advances 2015. Nat Med (2015) 0.75
Radiation resistance of sequencing chips for in situ life detection. Astrobiology (2013) 0.75
Notable advances 2017. Nat Med (2017) 0.75
Unraveling the secrets of the cell. Newsweek (2003) 0.75