Published in Genome Res on January 30, 2013
Ancient and novel small RNA pathways compensate for the loss of piRNAs in multiple independent nematode lineages. PLoS Biol (2015) 1.50
Functional diversification of Argonautes in nematodes: an expanding universe. Biochem Soc Trans (2013) 0.87
Homeland security in the C. elegans germ line: insights into the biogenesis and function of piRNAs. Epigenetics (2013) 0.83
Multiple small RNA pathways regulate the silencing of repeated and foreign genes in C. elegans. Genes Dev (2013) 0.81
Comparative functional characterization of the CSR-1 22G-RNA pathway in Caenorhabditis nematodes. Nucleic Acids Res (2014) 0.80
Identification of MicroRNAs in Meloidogyne incognita Using Deep Sequencing. PLoS One (2015) 0.79
Microevolution of nematode miRNAs reveals diverse modes of selection. Genome Biol Evol (2014) 0.79
The C. elegans SNAPc component SNPC-4 coats piRNA domains and is globally required for piRNA abundance. Dev Cell (2014) 0.78
A novel member of the let-7 microRNA family is associated with developmental transitions in filarial nematode parasites. BMC Genomics (2015) 0.78
Nematode endogenous small RNA pathways. Worm (2014) 0.78
Germ cell and tumor associated piRNAs in the medaka and Xiphophorus melanoma models. BMC Genomics (2016) 0.78
Specific down-regulation of spermatogenesis genes targeted by 22G RNAs in hybrid sterile males associated with an X-Chromosome introgression. Genome Res (2016) 0.77
Piwi Proteins and piRNAs step onto the systems biology stage. Adv Exp Med Biol (2014) 0.76
A microRNA family exerts maternal control on sex determination in C. elegans. Genes Dev (2017) 0.75
The influences of PRG-1 on the expression of small RNAs and mRNAs. BMC Genomics (2014) 0.75
ALG-5 is a miRNA-associated Argonaute required for proper developmental timing in the Caenorhabditis elegans germline. Nucleic Acids Res (2017) 0.75
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol (2009) 235.12
MicroRNAs: genomics, biogenesis, mechanism, and function. Cell (2004) 198.59
Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47
An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans. Science (2001) 44.16
An extensive class of small RNAs in Caenorhabditis elegans. Science (2001) 34.17
Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell (2001) 25.86
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature (2000) 19.15
The microRNAs of Caenorhabditis elegans. Genes Dev (2003) 17.70
Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans. Cell (2006) 15.12
The genome sequence of Caenorhabditis briggsae: a platform for comparative genomics. PLoS Biol (2003) 13.32
Inparanoid: a comprehensive database of eukaryotic orthologs. Nucleic Acids Res (2005) 9.90
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science (2010) 9.78
On the role of RNA amplification in dsRNA-triggered gene silencing. Cell (2001) 9.78
Intronic microRNA precursors that bypass Drosha processing. Nature (2007) 9.65
The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila. Cell (2007) 7.70
Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell (2006) 7.14
A global profile of germline gene expression in C. elegans. Mol Cell (2000) 5.97
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
Computational and experimental identification of C. elegans microRNAs. Mol Cell (2003) 5.22
An epigenetic role for maternally inherited piRNAs in transposon silencing. Science (2008) 5.05
Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans. Development (2003) 4.61
PRG-1 and 21U-RNAs interact to form the piRNA complex required for fertility in C. elegans. Mol Cell (2008) 4.48
piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline. Cell (2012) 3.48
Distinct argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline. Mol Cell (2009) 3.43
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline. Mol Cell (2008) 3.37
The Argonaute CSR-1 and its 22G-RNA cofactors are required for holocentric chromosome segregation. Cell (2009) 3.14
Function, targets, and evolution of Caenorhabditis elegans piRNAs. Science (2012) 3.11
Many families of C. elegans microRNAs are not essential for development or viability. Curr Biol (2010) 2.90
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Nat Genet (2012) 2.85
Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development. Genome Biol (2009) 2.81
C. elegans piRNAs mediate the genome-wide surveillance of germline transcripts. Cell (2012) 2.65
Parent-dependent loss of gene silencing during interspecies hybridization. Curr Biol (2006) 2.58
Distinct phases of siRNA synthesis in an endogenous RNAi pathway in C. elegans soma. Mol Cell (2010) 2.57
A phylogeny and molecular barcodes for Caenorhabditis, with numerous new species from rotting fruits. BMC Evol Biol (2011) 2.56
A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis. Curr Biol (2008) 2.25
Comparison of C. elegans and C. briggsae genome sequences reveals extensive conservation of chromosome organization and synteny. PLoS Biol (2007) 2.02
CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. Cell (2009) 1.94
Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2010) 1.81
Sequential rounds of RNA-dependent RNA transcription drive endogenous small-RNA biogenesis in the ERGO-1/Argonaute pathway. Proc Natl Acad Sci U S A (2010) 1.72
26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2009) 1.71
Repertoire and evolution of miRNA genes in four divergent nematode species. Genome Res (2009) 1.64
Evolution of the Caenorhabditis elegans genome. Mol Biol Evol (2009) 1.64
MIReNA: finding microRNAs with high accuracy and no learning at genome scale and from deep sequencing data. Bioinformatics (2010) 1.53
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet (2012) 1.36
Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans. Genome Res (2010) 1.31
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 1.23
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet (2011) 1.13
Identification of novel and known miRNAs in deep-sequencing data with miRDeep2. Curr Protoc Bioinformatics (2011) 1.04
Promoters recognized by forkhead proteins exist for individual 21U-RNAs. Mol Cell (2012) 1.00
MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev (2012) 0.96
A uniform system for microRNA annotation. RNA (2003) 20.28
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc Natl Acad Sci U S A (2003) 7.95
Control of developmental timing by micrornas and their targets. Annu Rev Cell Dev Biol (2002) 7.91
Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature (2003) 7.80
A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity. Nat Genet (2002) 6.26
MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression. Nat Genet (2004) 6.11
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature (2004) 5.57
Computational and experimental identification of C. elegans microRNAs. Mol Cell (2003) 5.22
Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science (2003) 4.91
DAF-16 target genes that control C. elegans life-span and metabolism. Science (2003) 4.57
Functional proteomics reveals the biochemical niche of C. elegans DCR-1 in multiple small-RNA-mediated pathways. Cell (2006) 4.50
Functional genomic analysis of RNA interference in C. elegans. Science (2005) 4.36
Fat metabolism links germline stem cells and longevity in C. elegans. Science (2008) 3.95
Lifespan regulation by evolutionarily conserved genes essential for viability. PLoS Genet (2007) 3.83
A systematic RNAi screen for longevity genes in C. elegans. Genes Dev (2005) 3.78
Regulation of AUXIN RESPONSE FACTOR3 by TAS3 ta-siRNA affects developmental timing and patterning in Arabidopsis. Curr Biol (2006) 3.71
Systematic analysis of genes required for synapse structure and function. Nature (2005) 3.67
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans. Genes Dev (2009) 3.42
daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev (2003) 3.22
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature (2005) 2.98
C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell Metab (2009) 2.85
Inactivation of conserved C. elegans genes engages pathogen- and xenobiotic-associated defenses. Cell (2012) 2.81
Unique functionality of 22-nt miRNAs in triggering RDR6-dependent siRNA biogenesis from target transcripts in Arabidopsis. Nat Struct Mol Biol (2010) 2.63
Pattern formation via small RNA mobility. Genes Dev (2009) 2.50
Polygenic control of Caenorhabditis elegans fat storage. Nat Genet (2006) 2.46
Analysis of xbx genes in C. elegans. Development (2005) 2.39
Functional genomic analysis of C. elegans molting. PLoS Biol (2005) 2.39
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell (2013) 2.35
Repression of AUXIN RESPONSE FACTOR10 by microRNA160 is critical for seed germination and post-germination stages. Plant J (2007) 2.15
Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice. Food Chem Toxicol (2012) 2.11
Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing. BMC Genomics (2009) 2.04
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev (2008) 2.01
Computational and analytical framework for small RNA profiling by high-throughput sequencing. RNA (2009) 1.97
Biosynthesis of the Caenorhabditis elegans dauer pheromone. Proc Natl Acad Sci U S A (2009) 1.96
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence. Nature (2012) 1.92
The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development (2006) 1.86
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants. Genes Dev (2007) 1.85
RNAi screening for fat regulatory genes with SRS microscopy. Nat Methods (2011) 1.82
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79
A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol (2007) 1.77
Identification of MIR390a precursor processing-defective mutants in Arabidopsis by direct genome sequencing. Proc Natl Acad Sci U S A (2009) 1.72
Clarifications on miRNA and cancer. Science (2006) 1.69
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol (2013) 1.69
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature (2009) 1.63
MicroRNA-183 family conservation and ciliated neurosensory organ expression. Evol Dev (2008) 1.59
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7. Nature (2008) 1.51
Functional analysis of three Arabidopsis ARGONAUTES using slicer-defective mutants. Plant Cell (2012) 1.49
An image analysis toolbox for high-throughput C. elegans assays. Nat Methods (2012) 1.48
Intercellular signaling of reproductive development by the C. elegans DAF-9 cytochrome P450. Development (2004) 1.48
Functional tests of enhancer conservation between distantly related species. Development (2003) 1.46
Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Mol Cell (2004) 1.40
PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet (2012) 1.36
The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi. Nat Struct Mol Biol (2008) 1.34
Insulin receptor substrate and p55 orthologous adaptor proteins function in the Caenorhabditis elegans daf-2/insulin-like signaling pathway. J Biol Chem (2002) 1.32
DAF-16 employs the chromatin remodeller SWI/SNF to promote stress resistance and longevity. Nat Cell Biol (2013) 1.30
Induction of cytoprotective pathways is central to the extension of lifespan conferred by multiple longevity pathways. PLoS Genet (2012) 1.28
Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. Anal Chim Acta (2008) 1.23
Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution? Evol Dev (2003) 1.23
mut-16 and other mutator class genes modulate 22G and 26G siRNA pathways in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2011) 1.23
Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death. Cell Host Microbe (2013) 1.22
ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev (2013) 1.22
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genet (2006) 1.20
Miniprimer PCR, a new lens for viewing the microbial world. Appl Environ Microbiol (2007) 1.16
RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. PLoS One (2009) 1.16
MTML-msBayes: approximate Bayesian comparative phylogeographic inference from multiple taxa and multiple loci with rate heterogeneity. BMC Bioinformatics (2011) 1.15
A cytoprotective perspective on longevity regulation. Trends Cell Biol (2013) 1.15
The ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications. PLoS Genet (2011) 1.13
The C. elegans POU-domain transcription factor UNC-86 regulates the tph-1 tryptophan hydroxylase gene and neurite outgrowth in specific serotonergic neurons. Development (2002) 1.13
Gravity force transduced by the MEC-4/MEC-10 DEG/ENaC channel modulates DAF-16/FoxO activity in Caenorhabditis elegans. Genetics (2007) 1.09
Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control. J Pharm Biomed Anal (2009) 1.06
Structure and function of glucose-6-phosphate dehydrogenase-deficient variants in Chinese population. Hum Genet (2006) 1.04
Detection of broadly expressed neuronal genes in C. elegans. Dev Biol (2006) 1.03
Genetic identification of HSD-1, a conserved steroidogenic enzyme that directs larval development in Caenorhabditis elegans. Development (2008) 1.03
HLA-DRB1*1501 and HLA-DQB1*0301 alleles are positively associated with HPV16 infection-related Kazakh esophageal squamous cell carcinoma in Xinjiang China. Cancer Immunol Immunother (2012) 1.02
PAMAM-triamcinolone acetonide conjugate as a nucleus-targeting gene carrier for enhanced transfer activity. Biomaterials (2009) 0.98
Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. Neurochem Int (2013) 0.98
MUT-16 promotes formation of perinuclear mutator foci required for RNA silencing in the C. elegans germline. Genes Dev (2012) 0.96
Dioscin attenuates hepatic ischemia-reperfusion injury in rats through inhibition of oxidative-nitrative stress, inflammation and apoptosis. Transplantation (2014) 0.96
Human disease locus discovery and mapping to molecular pathways through phylogenetic profiling. Mol Syst Biol (2013) 0.96
Anti-cancer effects of dioscin on three kinds of human lung cancer cell lines through inducing DNA damage and activating mitochondrial signal pathway. Food Chem Toxicol (2013) 0.96
The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Curr Biol (2012) 0.96
MLT-10 defines a family of DUF644 and proline-rich repeat proteins involved in the molting cycle of Caenorhabditis elegans. Mol Biol Cell (2010) 0.95
Repression of germline RNAi pathways in somatic cells by retinoblastoma pathway chromatin complexes. PLoS Genet (2012) 0.94
Anticancer activity, attenuation on the absorption of calcium in mitochondria, and catalase activity for manganese complexes of N-substituted di(picolyl)amine. Inorg Chem (2011) 0.94
Coexistence of plasmid-mediated KPC-2 and IMP-4 carbapenemases in isolates of Klebsiella pneumoniae from China. J Antimicrob Chemother (2011) 0.94
The Caenorhabditis elegans ems class homeobox gene ceh-2 is required for M3 pharynx motoneuron function. Development (2003) 0.93
Effects of flavonoids from Rosa laevigata Michx fruit against high-fat diet-induced non-alcoholic fatty liver disease in rats. Food Chem (2013) 0.91
Synthesis, structure, luminescence and catalytic properties of cadmium(ii) coordination polymers with 9H-carbazole-2,7-dicarboxylic acid. Dalton Trans (2014) 0.91
The mevalonate pathway regulates microRNA activity in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2012) 0.91
Regulation of the C. elegans molt by pqn-47. Dev Biol (2011) 0.90
Prediction of C. elegans longevity genes by human and worm longevity networks. PLoS One (2012) 0.90
Patterns of kinase activation induced by injury in the murine femoral artery. J Surg Res (2007) 0.89
Protective effects of dioscin against alcohol-induced liver injury. Arch Toxicol (2013) 0.89
Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways. J Appl Toxicol (2012) 0.89
AAV-mediated lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene replacement therapy rescues retinal degeneration in rd11 mice. Invest Ophthalmol Vis Sci (2014) 0.89