Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMC 2519360)

Published in Appl Environ Microbiol on June 06, 2008

Authors

Christina Grosse1, Thorsten Heinekamp, Olaf Kniemeyer, Alexander Gehrke, Axel A Brakhage

Author Affiliations

1: Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Friedrich Schiller University Jena, 07745 Jena, Germany.

Articles citing this

Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus. Appl Environ Microbiol (2008) 1.44

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence. Front Microbiol (2013) 1.10

The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol (2011) 1.09

Fungal model systems and the elucidation of pathogenicity determinants. Fungal Genet Biol (2014) 1.03

Two phosphodiesterase genes, PDEL and PDEH, regulate development and pathogenicity by modulating intracellular cyclic AMP levels in Magnaporthe oryzae. PLoS One (2011) 1.01

PdeH, a high-affinity cAMP phosphodiesterase, is a key regulator of asexual and pathogenic differentiation in Magnaporthe oryzae. PLoS Pathog (2010) 0.98

The small GTPase RacA mediates intracellular reactive oxygen species production, polarized growth, and virulence in the human fungal pathogen Aspergillus fumigatus. Eukaryot Cell (2010) 0.97

Heptahelical receptors GprC and GprD of Aspergillus fumigatus Are essential regulators of colony growth, hyphal morphogenesis, and virulence. Appl Environ Microbiol (2010) 0.94

Reconstruction of signaling networks regulating fungal morphogenesis by transcriptomics. Eukaryot Cell (2009) 0.92

Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus. Mol Microbiol (2011) 0.92

Pyomelanin formation in Aspergillus fumigatus requires HmgX and the transcriptional activator HmgR but is dispensable for virulence. PLoS One (2011) 0.89

A novel family of dehydrin-like proteins is involved in stress response in the human fungal pathogen Aspergillus fumigatus. Mol Biol Cell (2011) 0.86

The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence. Front Microbiol (2015) 0.85

Protein kinase A and fungal virulence: a sinister side to a conserved nutrient sensing pathway. Virulence (2012) 0.83

Deletion of the protein kinase A regulatory subunit leads to deregulation of mitochondrial activation and nuclear duplication in Aspergillus fumigatus. Eukaryot Cell (2009) 0.82

Ras-Mediated Signal Transduction and Virulence in Human Pathogenic Fungi. Fungal Genom Biol (2012) 0.80

Transcriptome analysis of cyclic AMP-dependent protein kinase A-regulated genes reveals the production of the novel natural compound fumipyrrole by Aspergillus fumigatus. Mol Microbiol (2015) 0.80

Adenylate Cyclase AcyA Regulates Development, Aflatoxin Biosynthesis and Fungal Virulence in Aspergillus flavus. Front Cell Infect Microbiol (2016) 0.78

Protein kinase A signaling and calcium ions are major players in PAF mediated toxicity against Aspergillus niger. FEBS Lett (2015) 0.76

Stress is the rule rather than the exception for Metarhizium. Curr Genet (2014) 0.76

A Gβ protein and the TupA Co-Regulator Bind to Protein Kinase A Tpk2 to Act as Antagonistic Molecular Switches of Fungal Morphological Changes. PLoS One (2015) 0.75

A Fungus-Specific Protein Domain Is Essential for RasA-Mediated Morphogenetic Signaling in Aspergillus fumigatus. mSphere (2016) 0.75

Developmental Growth Control Exerted via the Protein A Kinase Tpk2 in Ashbya gossypii. Eukaryot Cell (2015) 0.75

Articles cited by this

Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal Chem (1996) 45.70

Improved staining of proteins in polyacrylamide gels including isoelectric focusing gels with clear background at nanogram sensitivity using Coomassie Brilliant Blue G-250 and R-250. Electrophoresis (1988) 9.38

Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics (2001) 3.54

Glucose signaling in Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2006) 3.16

Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Mol Cell Biol (2001) 3.11

The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence. J Bacteriol (1998) 2.78

Development of a homologous transformation system for the human pathogenic fungus Aspergillus fumigatus based on the pyrG gene encoding orotidine 5'-monophosphate decarboxylase. Curr Genet (1998) 2.69

Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants. Curr Drug Targets (2005) 2.60

cAMP regulates morphogenesis in the fungal pathogen Ustilago maydis. Genes Dev (1994) 2.52

A developmentally regulated gene cluster involved in conidial pigment biosynthesis in Aspergillus fumigatus. J Bacteriol (1999) 2.50

Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence. Med Microbiol Immunol (1998) 2.36

Aspergillus fumigatus: saprophyte or pathogen? Curr Opin Microbiol (2005) 2.32

Divergent cAMP signaling pathways regulate growth and pathogenesis in the rice blast fungus Magnaporthe grisea. Plant Cell (1998) 1.82

The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell (2007) 1.76

Sample extraction techniques for enhanced proteomic analysis of plant tissues. Nat Protoc (2006) 1.69

Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus. Infect Immun (1996) 1.60

Candida albicans septin mutants are defective for invasive growth and virulence. Infect Immun (2003) 1.58

Loss of growth polarity and mislocalization of septa in a Neurospora mutant altered in the regulatory subunit of cAMP-dependent protein kinase. EMBO J (1996) 1.48

The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus. Infect Immun (2004) 1.42

Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog (2007) 1.39

cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages. Mol Genet Genomics (2003) 1.38

Differential expression of the Aspergillus fumigatus pksP gene detected in vitro and in vivo with green fluorescent protein. Infect Immun (2001) 1.33

Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Curr Genet (2005) 1.28

Use of reporter genes to identify recessive trans-acting mutations specifically involved in the regulation of Aspergillus nidulans penicillin biosynthesis genes. J Bacteriol (1995) 1.23

Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulence. Infect Immun (2006) 1.17

Growth and developmental control in the model and pathogenic aspergilli. Eukaryot Cell (2006) 1.16

An Ustilago maydis septin is required for filamentous growth in culture and for full symptom development on maize. Eukaryot Cell (2005) 1.16

The pkaB gene encoding the secondary protein kinase A catalytic subunit has a synthetic lethal interaction with pkaA and plays overlapping and opposite roles in Aspergillus nidulans. Eukaryot Cell (2005) 1.09

Proper regulation of cyclic AMP-dependent protein kinase is required for growth, conidiation, and appressorium function in the anthracnose fungus Colletotrichum lagenarium. Mol Plant Microbe Interact (2001) 1.01

Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product. Cell Mol Life Sci (1999) 0.99

Cyclic AMP-dependent protein kinase is involved in morphogenesis of Aspergillus niger. Microbiology (2002) 0.97

Saccharomyces cerevisiae elongation factor 2 is phosphorylated by an endogenous kinase. FEBS Lett (1991) 0.82

Biosynthesis of the purines. XXII. 2-Amino-N-ribosylacetamide-5'-phosphate kinosynthase. J Biol Chem (1958) 0.77

Articles by these authors

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Nat Chem Biol (2007) 3.14

Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature (2009) 3.07

Intimate bacterial-fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans. Proc Natl Acad Sci U S A (2009) 2.86

Biosynthesis of fungal melanins and their importance for human pathogenic fungi. Fungal Genet Biol (2003) 2.57

The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus. Eukaryot Cell (2006) 2.56

Production of extracellular traps against Aspergillus fumigatus in vitro and in infected lung tissue is dependent on invading neutrophils and influenced by hydrophobin RodA. PLoS Pathog (2010) 2.09

HapX-mediated adaption to iron starvation is crucial for virulence of Aspergillus fumigatus. PLoS Pathog (2010) 1.93

SreA-mediated iron regulation in Aspergillus fumigatus. Mol Microbiol (2008) 1.85

Interaction of HapX with the CCAAT-binding complex--a novel mechanism of gene regulation by iron. EMBO J (2007) 1.83

The Aspergillus fumigatus transcriptional regulator AfYap1 represents the major regulator for defense against reactive oxygen intermediates but is dispensable for pathogenicity in an intranasal mouse infection model. Eukaryot Cell (2007) 1.76

Comparative genomics of MAP kinase and calcium-calcineurin signalling components in plant and human pathogenic fungi. Fungal Genet Biol (2009) 1.66

Phagocytosis of Aspergillus fumigatus conidia by murine macrophages involves recognition by the dectin-1 beta-glucan receptor and Toll-like receptor 2. Cell Microbiol (2006) 1.62

The 2008 update of the Aspergillus nidulans genome annotation: a community effort. Fungal Genet Biol (2008) 1.56

Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. MBio (2012) 1.55

Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus. Appl Environ Microbiol (2008) 1.44

Deletion of the gliP gene of Aspergillus fumigatus results in loss of gliotoxin production but has no effect on virulence of the fungus in a low-dose mouse infection model. Mol Microbiol (2006) 1.42

The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus. Infect Immun (2004) 1.42

Bacteria-induced natural product formation in the fungus Aspergillus nidulans requires Saga/Ada-mediated histone acetylation. Proc Natl Acad Sci U S A (2011) 1.41

Transannular disulfide formation in gliotoxin biosynthesis and its role in self-resistance of the human pathogen Aspergillus fumigatus. J Am Chem Soc (2010) 1.41

Environmental dimensionality controls the interaction of phagocytes with the pathogenic fungi Aspergillus fumigatus and Candida albicans. PLoS Pathog (2007) 1.39

Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biol (2011) 1.34

PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages. Cell Microbiol (2002) 1.34

Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole. Curr Genet (2006) 1.32

Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus. Curr Genet (2005) 1.28

Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis. Arch Microbiol (2004) 1.28

Functional characterization of the Aspergillus fumigatus calcineurin. Fungal Genet Biol (2006) 1.26

Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Appl Microbiol Biotechnol (2011) 1.24

The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response. Fungal Genet Biol (2007) 1.24

Identification of dermatophyte species causing onychomycosis and tinea pedis by MALDI-TOF mass spectrometry. Exp Dermatol (2007) 1.23

Analysis of the Aspergillus fumigatus proteome reveals metabolic changes and the activation of the pseurotin A biosynthesis gene cluster in response to hypoxia. J Proteome Res (2011) 1.22

Characterisation of the laccase-encoding gene abr2 of the dihydroxynaphthalene-like melanin gene cluster of Aspergillus fumigatus. Arch Microbiol (2006) 1.19

Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia. FEBS J (2005) 1.17

Activation of a silent fungal polyketide biosynthesis pathway through regulatory cross talk with a cryptic nonribosomal peptide synthetase gene cluster. Appl Environ Microbiol (2010) 1.15

Methylcitrate synthase from Aspergillus fumigatus is essential for manifestation of invasive aspergillosis. Cell Microbiol (2008) 1.15

FungiFun: a web-based application for functional categorization of fungal genes and proteins. Fungal Genet Biol (2010) 1.15

The MpkA MAP kinase module regulates cell wall integrity signaling and pyomelanin formation in Aspergillus fumigatus. Fungal Genet Biol (2009) 1.13

The thioredoxin system of the filamentous fungus Aspergillus nidulans: impact on development and oxidative stress response. J Biol Chem (2007) 1.11

Transcriptomic and proteomic analyses of the Aspergillus fumigatus hypoxia response using an oxygen-controlled fermenter. BMC Genomics (2012) 1.11

Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence. Front Microbiol (2013) 1.10

Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis. Infect Immun (2006) 1.10

Members of protein O-mannosyltransferase family in Aspergillus fumigatus differentially affect growth, morphogenesis and viability. Mol Microbiol (2010) 1.09

The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus. Mol Microbiol (2011) 1.09

A dedicated glutathione S-transferase mediates carbon-sulfur bond formation in gliotoxin biosynthesis. J Am Chem Soc (2011) 1.09

The CCAAT-binding complex coordinates the oxidative stress response in eukaryotes. Nucleic Acids Res (2009) 1.08

Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development. Fungal Genet Biol (2006) 1.07

Proteome profiling and functional classification of intracellular proteins from conidia of the human-pathogenic mold Aspergillus fumigatus. J Proteome Res (2010) 1.05

A single subunit of a heterotrimeric CCAAT-binding complex carries a nuclear localization signal: piggy back transport of the pre-assembled complex to the nucleus. J Mol Biol (2004) 1.04

Systems biology of fungal infection. Front Microbiol (2012) 1.04

Conidial Dihydroxynaphthalene Melanin of the Human Pathogenic Fungus Aspergillus fumigatus Interferes with the Host Endocytosis Pathway. Front Microbiol (2011) 1.04

Regulation of penicillin biosynthesis in filamentous fungi. Adv Biochem Eng Biotechnol (2004) 1.03

Functional genomic profiling of Aspergillus fumigatus biofilm reveals enhanced production of the mycotoxin gliotoxin. Proteomics (2010) 1.03

Automated image analysis of the host-pathogen interaction between phagocytes and Aspergillus fumigatus. PLoS One (2011) 1.02

Two-dimensional proteome reference maps for the human pathogenic filamentous fungus Aspergillus fumigatus. Proteomics (2009) 1.01

Missing values in gel-based proteomics. Proteomics (2010) 1.01

Phagocytosis of melanized Aspergillus conidia by macrophages exerts cytoprotective effects by sustained PI3K/Akt signalling. Cell Microbiol (2011) 0.99

Extrinsic extracellular DNA leads to biofilm formation and colocalizes with matrix polysaccharides in the human pathogenic fungus Aspergillus fumigatus. Front Microbiol (2013) 0.99

A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin. J Biomol Screen (2012) 0.98

Secretome analysis of Aspergillus fumigatus reveals Asp-hemolysin as a major secreted protein. Int J Med Microbiol (2011) 0.98

The light-dependent regulator velvet A of Aspergillus nidulans acts as a repressor of the penicillin biosynthesis. Arch Microbiol (2007) 0.98

The opportunistic human pathogenic fungus Aspergillus fumigatus evades the host complement system. Infect Immun (2007) 0.98

Cytotoxic pheofungins from an engineered fungus impaired in posttranslational protein modification. Angew Chem Int Ed Engl (2011) 0.97

Epidithiol formation by an unprecedented twin carbon-sulfur lyase in the gliotoxin pathway. Angew Chem Int Ed Engl (2012) 0.97

Regulatory interactions for iron homeostasis in Aspergillus fumigatus inferred by a Systems Biology approach. BMC Syst Biol (2012) 0.96

Bacterium induces cryptic meroterpenoid pathway in the pathogenic fungus Aspergillus fumigatus. Chembiochem (2013) 0.96

Heptahelical receptors GprC and GprD of Aspergillus fumigatus Are essential regulators of colony growth, hyphal morphogenesis, and virulence. Appl Environ Microbiol (2010) 0.94

Integrative analysis of the heat shock response in Aspergillus fumigatus. BMC Genomics (2010) 0.94